Patrick H Degnan

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. doi request reprint Evolutionary genetics of a defensive facultative symbiont of insects: exchange of toxin-encoding bacteriophage
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, Biosciences West, Room 310, 1041 E Lowell Street, University of Arizona, Tucson, AZ 85721 0088, USA
    Mol Ecol 17:916-29. 2008
  2. pmc Hamiltonella defensa, genome evolution of protective bacterial endosymbiont from pathogenic ancestors
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, Arizona Genomics Institute, University of Arizona, Tucson, AZ 85721 USA
    Proc Natl Acad Sci U S A 106:9063-8. 2009
  3. pmc Diverse phage-encoded toxins in a protective insect endosymbiont
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721 0088, USA
    Appl Environ Microbiol 74:6782-91. 2008
  4. pmc Chimpanzees and humans harbour compositionally similar gut enterotypes
    Andrew H Moeller
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06511, USA
    Nat Commun 3:1179. 2012
  5. pmc Chromosome stability and gene loss in cockroach endosymbionts
    Zakee L Sabree
    Center for Insect Science, University of Arizona, Tucson, Arizona 85721, USA
    Appl Environ Microbiol 76:4076-9. 2010
  6. ncbi request reprint Functional genomics of Buchnera and the ecology of aphid hosts
    Nancy A Moran
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Mol Ecol 15:1251-61. 2006
  7. pmc The players in a mutualistic symbiosis: insects, bacteria, viruses, and virulence genes
    Nancy A Moran
    Departments of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 87521, USA
    Proc Natl Acad Sci U S A 102:16919-26. 2005
  8. pmc Dynamics of genome evolution in facultative symbionts of aphids
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Environ Microbiol 12:2060-9. 2010
  9. pmc Origin and examination of a leafhopper facultative endosymbiont
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA
    Curr Microbiol 62:1565-72. 2011
  10. ncbi request reprint Conservation and diversity in the immunity regions of wild phages with the immunity specificity of phage lambda
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Mol Microbiol 64:232-44. 2007

Detail Information

Publications18

  1. doi request reprint Evolutionary genetics of a defensive facultative symbiont of insects: exchange of toxin-encoding bacteriophage
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, Biosciences West, Room 310, 1041 E Lowell Street, University of Arizona, Tucson, AZ 85721 0088, USA
    Mol Ecol 17:916-29. 2008
    ..pisum, one subclade of H. defensa appears to be universal within a subclade of the aphid genus Uroleucon, suggesting a transition from facultative, horizontal transmission to strictly vertical inheritance...
  2. pmc Hamiltonella defensa, genome evolution of protective bacterial endosymbiont from pathogenic ancestors
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, Arizona Genomics Institute, University of Arizona, Tucson, AZ 85721 USA
    Proc Natl Acad Sci U S A 106:9063-8. 2009
    ..The genome is also littered with mobile DNA, including phage-derived genes, plasmids, and insertion-sequence elements, highlighting its dynamic nature and the continued role horizontal gene transfer plays in shaping it...
  3. pmc Diverse phage-encoded toxins in a protective insect endosymbiont
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721 0088, USA
    Appl Environ Microbiol 74:6782-91. 2008
    ..Thus, phage may act as a conduit for ongoing gene exchange among heritable endosymbionts...
  4. pmc Chimpanzees and humans harbour compositionally similar gut enterotypes
    Andrew H Moeller
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06511, USA
    Nat Commun 3:1179. 2012
    ..These results support the hypothesis that enterotypic variation was present in populations of great apes before the divergence of humans and chimpanzees...
  5. pmc Chromosome stability and gene loss in cockroach endosymbionts
    Zakee L Sabree
    Center for Insect Science, University of Arizona, Tucson, Arizona 85721, USA
    Appl Environ Microbiol 76:4076-9. 2010
    ..We speculate that distant homologs may replace the functions of some eliminated genes through broadened substrate specificity...
  6. ncbi request reprint Functional genomics of Buchnera and the ecology of aphid hosts
    Nancy A Moran
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Mol Ecol 15:1251-61. 2006
    ..Although information for other insect symbioses is relatively limited, studies on symbionts of carpenter ants and tsetse flies indicate many similarities to Buchnera...
  7. pmc The players in a mutualistic symbiosis: insects, bacteria, viruses, and virulence genes
    Nancy A Moran
    Departments of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 87521, USA
    Proc Natl Acad Sci U S A 102:16919-26. 2005
    ..defensa life cycle. We propose that, in these mutualistic symbionts, phage-borne toxin genes provide defense to the aphid host and are a basis for the observed protection against eukaryotic parasites...
  8. pmc Dynamics of genome evolution in facultative symbionts of aphids
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Environ Microbiol 12:2060-9. 2010
    ..The divergence in gene sets and in genome architecture implies a history of rampant recombination and gene inactivation and the ongoing integration of mobile DNA (insertion sequence elements, prophage and plasmids)...
  9. pmc Origin and examination of a leafhopper facultative endosymbiont
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA
    Curr Microbiol 62:1565-72. 2011
    ..However, the slightly reduced genome size, abundance of mobile DNA, fastidious growth in culture, and efficient vertical transmission suggest that symbiosis with E. variegatus has had a significant impact on genome evolution in BEV...
  10. ncbi request reprint Conservation and diversity in the immunity regions of wild phages with the immunity specificity of phage lambda
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Mol Microbiol 64:232-44. 2007
    ..Extensive mosaicism was observed for several elements flanking the immunity region. Very short sequence elements or microhomologies were also identified. Our findings suggest mechanisms by which fine-scale mosaicism arises...
  11. pmc Factors associated with the diversification of the gut microbial communities within chimpanzees from Gombe National Park
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 109:13034-9. 2012
    ..This pattern was reinforced in several chimpanzees sampled over long temporal scales, in which the major constituents of the gut microbiota were maintained for nearly a decade...
  12. pmc Illumina-based analysis of microbial community diversity
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA
    ISME J 6:183-94. 2012
    ..By considering each source of error, we delineate ways to make biologically relevant and robust conclusions from the millions of sequencing reads that can be readily generated by this technology...
  13. ncbi request reprint Nonhomogeneous model of sequence evolution indicates independent origins of primary endosymbionts within the enterobacteriales (gamma-Proteobacteria)
    Joshua T Herbeck
    Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, Massachusetts, USA
    Mol Biol Evol 22:520-32. 2005
    ..This application of a nonhomogeneous model offers a computationally feasible way to test specific phylogenetic hypotheses for taxa with heterogeneous and nonstationary base composition...
  14. ncbi request reprint Genome evolution in an insect cell: distinct features of an ant-bacterial partnership
    Jennifer J Wernegreen
    Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, 7 MBL Street, Woods Hole, Massachusetts 02543, USA
    Biol Bull 204:221-31. 2003
    ..This review describes some recent insights into the evolutionary genetics of obligate insect-bacteria symbioses, with a particular focus on an intriguing association between the bacterial endosymbiont Blochmannia and its ant hosts...
  15. pmc A conservative test of genetic drift in the endosymbiotic bacterium Buchnera: slightly deleterious mutations in the chaperonin groEL
    Joshua T Herbeck
    Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, Massachusetts 02543, USA
    Genetics 165:1651-60. 2003
    ..Rather, they further support the hypothesis that drift is an important force driving accelerated protein evolution in this obligate mutualist...
  16. ncbi request reprint Host-symbiont stability and fast evolutionary rates in an ant-bacterium association: cospeciation of camponotus species and their endosymbionts, candidatus blochmannia
    Patrick H Degnan
    Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, 7 MBL Street, Woods Hole, Massachusetts 02543, USA
    Syst Biol 53:95-110. 2004
    ..These rates are several-fold higher than those for related bacteria Buchnera aphidicola and Escherichia coli. Phylogenetic congruence among Blochmannia genes indicates genome stability that typifies primary endosymbionts of insects...
  17. pmc Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects
    Patrick H Degnan
    Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, Massachusetts 02543, USA
    Genome Res 15:1023-33. 2005
    ..Furthermore, the increased rates of amino acid substitution and gene loss in Blochmannia have occurred in a lineage-specific fashion, which may reflect life history differences of their ant hosts...
  18. ncbi request reprint Small genome of Candidatus Blochmannia, the bacterial endosymbiont of Camponotus, implies irreversible specialization to an intracellular lifestyle
    J J Wernegreen
    Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, 7 MBL Street, Woods Hole, MA 02543, USA
    Microbiology 148:2551-6. 2002
    ..Due to restricted gene exchange in obligate endosymbionts, the substantial gene loss in Blochmannia and other insect mutualists may reflect irreversible specialization to a host cellular environment...