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Species | Patrick H DegnanSummaryAffiliation: University of Arizona Country: USA Publications
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Publications
Evolutionary genetics of a defensive facultative symbiont of insects: exchange of toxin-encoding bacteriophagePatrick H Degnan
Department of Ecology and Evolutionary Biology, Biosciences West, Room 310, 1041 E Lowell Street, University of Arizona, Tucson, AZ 85721 0088, USA
Mol Ecol 17:916-29. 2008..pisum, one subclade of H. defensa appears to be universal within a subclade of the aphid genus Uroleucon, suggesting a transition from facultative, horizontal transmission to strictly vertical inheritance...
Hamiltonella defensa, genome evolution of protective bacterial endosymbiont from pathogenic ancestorsPatrick H Degnan
Department of Ecology and Evolutionary Biology, Arizona Genomics Institute, University of Arizona, Tucson, AZ 85721 USA
Proc Natl Acad Sci U S A 106:9063-8. 2009..The genome is also littered with mobile DNA, including phage-derived genes, plasmids, and insertion-sequence elements, highlighting its dynamic nature and the continued role horizontal gene transfer plays in shaping it...- Diverse phage-encoded toxins in a protective insect endosymbiontPatrick H Degnan
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721 0088, USA
Appl Environ Microbiol 74:6782-91. 2008..Thus, phage may act as a conduit for ongoing gene exchange among heritable endosymbionts... - Chimpanzees and humans harbour compositionally similar gut enterotypesAndrew H Moeller
Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06511, USA
Nat Commun 3:1179. 2012..These results support the hypothesis that enterotypic variation was present in populations of great apes before the divergence of humans and chimpanzees... - Chromosome stability and gene loss in cockroach endosymbiontsZakee L Sabree
Center for Insect Science, University of Arizona, Tucson, Arizona 85721, USA
Appl Environ Microbiol 76:4076-9. 2010..We speculate that distant homologs may replace the functions of some eliminated genes through broadened substrate specificity... 
Functional genomics of Buchnera and the ecology of aphid hostsNancy A Moran
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
Mol Ecol 15:1251-61. 2006..Although information for other insect symbioses is relatively limited, studies on symbionts of carpenter ants and tsetse flies indicate many similarities to Buchnera...- The players in a mutualistic symbiosis: insects, bacteria, viruses, and virulence genesNancy A Moran
Departments of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 87521, USA
Proc Natl Acad Sci U S A 102:16919-26. 2005..defensa life cycle. We propose that, in these mutualistic symbionts, phage-borne toxin genes provide defense to the aphid host and are a basis for the observed protection against eukaryotic parasites... - Dynamics of genome evolution in facultative symbionts of aphidsPatrick H Degnan
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
Environ Microbiol 12:2060-9. 2010..The divergence in gene sets and in genome architecture implies a history of rampant recombination and gene inactivation and the ongoing integration of mobile DNA (insertion sequence elements, prophage and plasmids)... - Origin and examination of a leafhopper facultative endosymbiontPatrick H Degnan
Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA
Curr Microbiol 62:1565-72. 2011..However, the slightly reduced genome size, abundance of mobile DNA, fastidious growth in culture, and efficient vertical transmission suggest that symbiosis with E. variegatus has had a significant impact on genome evolution in BEV... - Conservation and diversity in the immunity regions of wild phages with the immunity specificity of phage lambdaPatrick H Degnan
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
Mol Microbiol 64:232-44. 2007..Extensive mosaicism was observed for several elements flanking the immunity region. Very short sequence elements or microhomologies were also identified. Our findings suggest mechanisms by which fine-scale mosaicism arises... - Factors associated with the diversification of the gut microbial communities within chimpanzees from Gombe National ParkPatrick H Degnan
Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 109:13034-9. 2012..This pattern was reinforced in several chimpanzees sampled over long temporal scales, in which the major constituents of the gut microbiota were maintained for nearly a decade... - Illumina-based analysis of microbial community diversityPatrick H Degnan
Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA
ISME J 6:183-94. 2012..By considering each source of error, we delineate ways to make biologically relevant and robust conclusions from the millions of sequencing reads that can be readily generated by this technology... - Nonhomogeneous model of sequence evolution indicates independent origins of primary endosymbionts within the enterobacteriales (gamma-Proteobacteria)Joshua T Herbeck
Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, Massachusetts, USA
Mol Biol Evol 22:520-32. 2005..This application of a nonhomogeneous model offers a computationally feasible way to test specific phylogenetic hypotheses for taxa with heterogeneous and nonstationary base composition... - Genome evolution in an insect cell: distinct features of an ant-bacterial partnershipJennifer J Wernegreen
Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, 7 MBL Street, Woods Hole, Massachusetts 02543, USA
Biol Bull 204:221-31. 2003..This review describes some recent insights into the evolutionary genetics of obligate insect-bacteria symbioses, with a particular focus on an intriguing association between the bacterial endosymbiont Blochmannia and its ant hosts... - A conservative test of genetic drift in the endosymbiotic bacterium Buchnera: slightly deleterious mutations in the chaperonin groELJoshua T Herbeck
Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, Massachusetts 02543, USA
Genetics 165:1651-60. 2003..Rather, they further support the hypothesis that drift is an important force driving accelerated protein evolution in this obligate mutualist... - Host-symbiont stability and fast evolutionary rates in an ant-bacterium association: cospeciation of camponotus species and their endosymbionts, candidatus blochmanniaPatrick H Degnan
Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, 7 MBL Street, Woods Hole, Massachusetts 02543, USA
Syst Biol 53:95-110. 2004..These rates are several-fold higher than those for related bacteria Buchnera aphidicola and Escherichia coli. Phylogenetic congruence among Blochmannia genes indicates genome stability that typifies primary endosymbionts of insects... - Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insectsPatrick H Degnan
Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, Massachusetts 02543, USA
Genome Res 15:1023-33. 2005..Furthermore, the increased rates of amino acid substitution and gene loss in Blochmannia have occurred in a lineage-specific fashion, which may reflect life history differences of their ant hosts... - Small genome of Candidatus Blochmannia, the bacterial endosymbiont of Camponotus, implies irreversible specialization to an intracellular lifestyleJ J Wernegreen
Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, 7 MBL Street, Woods Hole, MA 02543, USA
Microbiology 148:2551-6. 2002..Due to restricted gene exchange in obligate endosymbionts, the substantial gene loss in Blochmannia and other insect mutualists may reflect irreversible specialization to a host cellular environment...