Ralph Defronzo

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi request reprint Free fatty acid-induced peripheral insulin resistance augments splanchnic glucose uptake in healthy humans
    Mandeep Bajaj
    Diabetes Division, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA
    Am J Physiol Endocrinol Metab 283:E346-52. 2002
  2. pmc Pioglitazone and alogliptin combination therapy in type 2 diabetes: a pathophysiologically sound treatment
    Curtis Triplitt
    Diabetes Division, Department of Medicine, University of Texas, Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Vasc Health Risk Manag 6:671-90. 2010
  3. pmc Characterization of renal glucose reabsorption in response to dapagliflozin in healthy subjects and subjects with type 2 diabetes
    Ralph A DeFronzo
    Corresponding author Ralph A DeFronzo
    Diabetes Care 36:3169-76. 2013
  4. pmc Prediction of diabetes based on baseline metabolic characteristics in individuals at high risk
    Ralph A DeFronzo
    Corresponding author Ralph A DeFronzo
    Diabetes Care 36:3607-12. 2013
  5. pmc Is incretin-based therapy ready for the care of hospitalized patients with type 2 diabetes?: The time has come for GLP-1 receptor agonists!
    Stanley Schwartz
    Main Line Health System, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Diabetes Care 36:2107-11. 2013
  6. doi request reprint Pleiotropic effects of thiazolidinediones: implications for the treatment of patients with type 2 diabetes mellitus
    Ralph A DeFronzo
    The University of Texas Health Science Center, San Antonio, TX 78229, USA
    Hosp Pract (1995) 41:132-47. 2013
  7. doi request reprint Efficacy and safety of SGLT2 inhibitors in the treatment of type 2 diabetes mellitus
    Muhammad A Abdul-Ghani
    Division of Diabetes, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Curr Diab Rep 12:230-8. 2012
  8. doi request reprint Efficacy and tolerability of the DPP-4 inhibitor alogliptin combined with pioglitazone, in metformin-treated patients with type 2 diabetes
    R A DeFronzo
    University of Texas Health Sciences Center, Diabetes Division, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA
    J Clin Endocrinol Metab 97:1615-22. 2012
  9. pmc Visceral fat dominant distribution in male type 2 diabetic patients is closely related to hepatic insulin resistance, irrespective of body type
    Yoshinori Miyazaki
    Department of Medicine, Diabetes Division, University of Texas Health Science Center, San Antonio, TX, USA
    Cardiovasc Diabetol 8:44. 2009
  10. pmc Predictive models of insulin resistance derived from simple morphometric and biochemical indices related to obesity and the metabolic syndrome in baboons
    Alberto O Chavez
    Department of Medicine, Diabetes Division, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Cardiovasc Diabetol 8:22. 2009

Research Grants

Detail Information

Publications116 found, 100 shown here

  1. ncbi request reprint Free fatty acid-induced peripheral insulin resistance augments splanchnic glucose uptake in healthy humans
    Mandeep Bajaj
    Diabetes Division, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA
    Am J Physiol Endocrinol Metab 283:E346-52. 2002
    ..Sal infusion study (30 +/- 2 vs. 20 +/- 2%, P < 0.005). In conclusion, an elevation in plasma FFA concentration impairs whole body glucose R(d) and insulin-mediated suppression of EGP in healthy subjects but augments SGU...
  2. pmc Pioglitazone and alogliptin combination therapy in type 2 diabetes: a pathophysiologically sound treatment
    Curtis Triplitt
    Diabetes Division, Department of Medicine, University of Texas, Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Vasc Health Risk Manag 6:671-90. 2010
    ..The alogliptin-pioglitazone combination represents a pathophysiologically sound treatment of T2DM...
  3. pmc Characterization of renal glucose reabsorption in response to dapagliflozin in healthy subjects and subjects with type 2 diabetes
    Ralph A DeFronzo
    Corresponding author Ralph A DeFronzo
    Diabetes Care 36:3169-76. 2013
    ....
  4. pmc Prediction of diabetes based on baseline metabolic characteristics in individuals at high risk
    Ralph A DeFronzo
    Corresponding author Ralph A DeFronzo
    Diabetes Care 36:3607-12. 2013
    ..We examined which characteristics at baseline predicted the development of T2DM versus maintenance of IGT or conversion to normal glucose tolerance...
  5. pmc Is incretin-based therapy ready for the care of hospitalized patients with type 2 diabetes?: The time has come for GLP-1 receptor agonists!
    Stanley Schwartz
    Main Line Health System, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Diabetes Care 36:2107-11. 2013
    ..Schwartz and DeFronzo's contribution, Drs. Umpierrez and Korytkowski provide a defense of insulin in the inpatient setting as the unquestioned gold standard for glycemic management in hospitalized settings...
  6. doi request reprint Pleiotropic effects of thiazolidinediones: implications for the treatment of patients with type 2 diabetes mellitus
    Ralph A DeFronzo
    The University of Texas Health Science Center, San Antonio, TX 78229, USA
    Hosp Pract (1995) 41:132-47. 2013
    ..Rosiglitazone has been associated with an increased risk of myocardial infarction, and its use in the United States is restricted because of cardiovascular safety concerns...
  7. doi request reprint Efficacy and safety of SGLT2 inhibitors in the treatment of type 2 diabetes mellitus
    Muhammad A Abdul-Ghani
    Division of Diabetes, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Curr Diab Rep 12:230-8. 2012
    ..In this review, we summarize the available data concerning the mechanism of action, efficacy, and safety of this novel antidiabetic class of therapeutic agents...
  8. doi request reprint Efficacy and tolerability of the DPP-4 inhibitor alogliptin combined with pioglitazone, in metformin-treated patients with type 2 diabetes
    R A DeFronzo
    University of Texas Health Sciences Center, Diabetes Division, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA
    J Clin Endocrinol Metab 97:1615-22. 2012
    ..Optimal management of type 2 diabetes remains an elusive goal. Combination therapy addressing the core defects of impaired insulin secretion and insulin resistance shows promise in maintaining glycemic control...
  9. pmc Visceral fat dominant distribution in male type 2 diabetic patients is closely related to hepatic insulin resistance, irrespective of body type
    Yoshinori Miyazaki
    Department of Medicine, Diabetes Division, University of Texas Health Science Center, San Antonio, TX, USA
    Cardiovasc Diabetol 8:44. 2009
    ..This ratio defines the predominancy of visceral or subcutaneous abdominal adiposity, independent of the body type of each individual...
  10. pmc Predictive models of insulin resistance derived from simple morphometric and biochemical indices related to obesity and the metabolic syndrome in baboons
    Alberto O Chavez
    Department of Medicine, Diabetes Division, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Cardiovasc Diabetol 8:22. 2009
    ..e. percent body fat by DXA and HbA1c). However, a simple method to screen and identify obese insulin resistant baboons for inclusion in interventional studies is not available...
  11. pmc Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009
    R A DeFronzo
    Diabetes Division, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive MSC 7886, San Antonio, TX, 78229, USA
    Diabetologia 53:1270-87. 2010
    ..Insulin resistance and lipotoxicity represent the missing links (beyond the classical cardiovascular risk factors) that help explain the accelerated rate of CVD in type 2 diabetic patients...
  12. ncbi request reprint Contributions of beta-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucose
    Muhammad A Abdul-Ghani
    Division of Diabetes, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Diabetes Care 29:1130-9. 2006
    ..The distinct metabolic features present in subjects with IFG and IGT may require different therapeutic interventions to prevent their progression to type 2 diabetes...
  13. doi request reprint Relationship of baseline HbA1c and efficacy of current glucose-lowering therapies: a meta-analysis of randomized clinical trials
    R A DeFronzo
    Department of Medicine, Division of Diabetes, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Diabet Med 27:309-17. 2010
    ..The objective of this study is to quantify the relationship between baseline HbA(1c) and reduction of HbA(1c) in clinical trials...
  14. doi request reprint Role of sodium-glucose cotransporter 2 (SGLT 2) inhibitors in the treatment of type 2 diabetes
    Muhammad A Abdul-Ghani
    Diabetes Division, University of Texas Health Science Center, San Antonio, USA
    Endocr Rev 32:515-31. 2011
    ..In this review, we will summarize the available data concerning the mechanism of action, efficacy, and safety of this novel antidiabetic therapeutic approach...
  15. doi request reprint Pioglitazone for diabetes prevention in impaired glucose tolerance
    Ralph A DeFronzo
    Texas Diabetes Institute and University of Texas Health Science Center, San Antonio, TX 78229, USA
    N Engl J Med 364:1104-15. 2011
    ..Impaired glucose tolerance is associated with increased rates of cardiovascular disease and conversion to type 2 diabetes mellitus. Interventions that may prevent or delay such occurrences are of great clinical importance...
  16. doi request reprint Current issues in the treatment of type 2 diabetes. Overview of newer agents: where treatment is going
    Ralph A DeFronzo
    Diabetes Division, University of Texas Health Science Center, San Antonio, Texas 78249 1644, USA
    Am J Med 123:S38-48. 2010
    ..Optimal management of type 2 diabetes should include early initiation of therapy using multiple drugs, with different mechanisms of action, in combination...
  17. pmc Effects of exenatide plus rosiglitazone on beta-cell function and insulin sensitivity in subjects with type 2 diabetes on metformin
    Ralph A DeFronzo
    Division of Diabetes, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
    Diabetes Care 33:951-7. 2010
    ..Study the effects of exenatide (EXE) plus rosiglitazone (ROSI) on beta-cell function and insulin sensitivity using hyperglycemic and euglycemic insulin clamp techniques in participants with type 2 diabetes on metformin...
  18. doi request reprint Determinants of glucose tolerance in impaired glucose tolerance at baseline in the Actos Now for Prevention of Diabetes (ACT NOW) study
    R A DeFronzo
    Diabetes Division, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Diabetologia 53:435-45. 2010
    ..The aim of the study was to examine the determinants of oral glucose tolerance in 602 persons with impaired glucose tolerance (IGT) who participated in the Actos Now for Prevention of Diabetes (ACT NOW) study...
  19. pmc Actos Now for the prevention of diabetes (ACT NOW) study
    Ralph A DeFronzo
    Texas Diabetes Institute and University of Texas Health Science Center, San Antonio, TX, USA
    BMC Endocr Disord 9:17. 2009
    ..TRIAL REGISTRATION: clinical trials.gov identifier: NCT00220961...
  20. ncbi request reprint Fasting hyperglycemia impairs glucose- but not insulin-mediated suppression of glucagon secretion
    Muhammad Abdul-Ghani
    Diabetes Division, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Clin Endocrinol Metab 92:1778-84. 2007
    ..Our aim was to assess the effect of chronic hyperglycemia on glucose- and insulin-mediated suppression of glucagon secretion by the alpha-cell...
  21. pmc The efficacy and safety of saxagliptin when added to metformin therapy in patients with inadequately controlled type 2 diabetes with metformin alone
    Ralph A DeFronzo
    University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Diabetes Care 32:1649-55. 2009
    ..This 24-week trial assessed the efficacy and safety of saxagliptin as add-on therapy in patients with type 2 diabetes with inadequate glycemic control with metformin alone...
  22. ncbi request reprint What is the best predictor of future type 2 diabetes?
    Muhammad A Abdul-Ghani
    Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Diabetes Care 30:1544-8. 2007
    ..We sought to assess insulin secretion/insulin resistance index in predicting the risk for future type 2 diabetes..
  23. pmc Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes and inadequate glycemic control: a randomized, double-blind, placebo-controlled study
    Ralph A DeFronzo
    University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Diabetes Care 31:2315-7. 2008
    ..To evaluate the dipeptidyl peptidase-4 (DPP-4) inhibitor alogliptin in drug-naïve patients with inadequately controlled type 2 diabetes...
  24. ncbi request reprint Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagon secretion, gastric emptying, and caloric intake: a randomized, cross-over study
    Ralph A DeFronzo
    University of Texas Health Science Center, Department of Medicine, Diabetes Division MSC 7886, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Curr Med Res Opin 24:2943-52. 2008
    ..This study evaluated the effects of exenatide, a GLP-1 receptor agonist, and sitagliptin, a DPP-4 inhibitor, on 2-h postprandial glucose (PPG), insulin and glucagon secretion, gastric emptying, and caloric intake in T2D patients...
  25. doi request reprint Adipocytes in subjects with impaired fasting glucose and impaired glucose tolerance are resistant to the anti-lipolytic effect of insulin
    Muhammad A Abdul-Ghani
    Diabetes Division, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Acta Diabetol 45:147-50. 2008
    ....
  26. ncbi request reprint Efficacy of inhaled insulin in patients with type 2 diabetes not controlled with diet and exercise: a 12-week, randomized, comparative trial
    Ralph A DeFronzo
    University of Texas Health Science Center, Diabetes Division, 7703 Floyd Curl Dr, San Antonio, TX 78284, USA
    Diabetes Care 28:1922-8. 2005
    ..This study investigates whether inhaled insulin (INH; Exubera) can achieve target glycemic control in patients failing on diet and exercise...
  27. pmc Type 2 diabetes can be prevented with early pharmacological intervention
    Ralph A DeFronzo
    Diabetes Division, University of Texas Health Science Center, San Antonio, Texas, USA
    Diabetes Care 34:S202-9. 2011
    ....
  28. ncbi request reprint Effect of pioglitazone on circulating adipocytokine levels and insulin sensitivity in type 2 diabetic patients
    Yoshinori Miyazaki
    University of Texas Health Science Center, Diabetes Division, Room 3 380S, 7703 Floyd Curl Drive, San Antonio, Texas 78229 3900, USA
    J Clin Endocrinol Metab 89:4312-9. 2004
    ....
  29. ncbi request reprint Association of high body mass index with low age of disease onset among Arab women with type 2 diabetes in a primary care clinic
    Muhammad A Abdul-Ghani
    Department of Diabetes, Lin Medical Center, Ibelin Clinic, Clalit Health Services, Haifa, Israel
    Isr Med Assoc J 7:360-3. 2005
    ..Type 2 diabetes is usually associated with obesity, and both conditions are frequently detected in the Arab population in Israel. Recent studies have demonstrated that diabetes can be prevented by a change in lifestyle...
  30. doi request reprint Preservation of β-cell function: the key to diabetes prevention
    Ralph A DeFronzo
    University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Clin Endocrinol Metab 96:2354-66. 2011
    ..Therefore, preservation of the remaining 20-30% of β-cell function is critical to prevent future development of T2DM...
  31. doi request reprint Assessment and treatment of cardiovascular risk in prediabetes: impaired glucose tolerance and impaired fasting glucose
    Ralph A DeFronzo
    Diabetes Division, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Am J Cardiol 108:3B-24B. 2011
    ..The treatment of these CV risk factors should follow the same guidelines established for patients with type 2 diabetes, and should be aggressively followed to reduce future CV events...
  32. doi request reprint The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia
    R A DeFronzo
    Diabetes Division, Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Diabetes Obes Metab 14:5-14. 2012
    ..Although the long-term efficacy and safety of SGLT2 inhibitors remain under study, the class represents a novel therapeutic approach with potential for the treatment of both type 2 and 1 diabetes...
  33. ncbi request reprint Addition of pioglitazone and ramipril to intensive insulin therapy in type 2 diabetic patients improves vascular dysfunction by different mechanisms
    Marianella Fernandez
    Texas Diabetes Institute, San Antonio, Texas, USA
    Diabetes Care 31:121-7. 2008
    ..We examined the relationship between glycemic control, vascular reactivity, and inflammation in type 2 diabetic subjects...
  34. ncbi request reprint Decreased plasma adiponectin concentrations are closely related to hepatic fat content and hepatic insulin resistance in pioglitazone-treated type 2 diabetic patients
    Mandeep Bajaj
    Diabetes Division, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284 7886, USA
    J Clin Endocrinol Metab 89:200-6. 2004
    ....
  35. ncbi request reprint Discordant effects of a chronic physiological increase in plasma FFA on insulin signaling in healthy subjects with or without a family history of type 2 diabetes
    Sangeeta R Kashyap
    Diabetes Division, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Am J Physiol Endocrinol Metab 287:E537-46. 2004
    ....
  36. ncbi request reprint Risk of progression to type 2 diabetes based on relationship between postload plasma glucose and fasting plasma glucose
    Muhammad A Abdul-Ghani
    Diabetes Division, University of Texas Health Science Center, 7703 Floyd Curl Dr, MS 7886, San Antonio, 78229, USA
    Diabetes Care 29:1613-8. 2006
    ....
  37. ncbi request reprint Reduction in hematocrit level after pioglitazone treatment is correlated with decreased plasma free testosterone level, not hemodilution, in women with polycystic ovary syndrome
    Rachele Berria
    Division of Diabetes, Department of Medicine Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Clin Pharmacol Ther 80:105-14. 2006
    ..Further studies are necessary to evaluate whether the same scenario is applicable to normoandrogenic women and individuals with type 2 diabetes mellitus...
  38. ncbi request reprint Pioglitazone reduces hepatic fat content and augments splanchnic glucose uptake in patients with type 2 diabetes
    Mandeep Bajaj
    Diabetes Division, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284 7886, USA
    Diabetes 52:1364-70. 2003
    ..Improved splanchnic/peripheral glucose uptake and enhanced suppression of EGP contribute to the improvement in glycemic control in patients with type 2 diabetes...
  39. doi request reprint Retinol-binding protein 4 is associated with impaired glucose tolerance but not with whole body or hepatic insulin resistance in Mexican Americans
    Alberto O Chavez
    Diabetes Division, South Texas Veterans Health Care System, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Am J Physiol Endocrinol Metab 296:E758-64. 2009
    ..Plasma RBP4 levels are elevated in T2DM and associated with impaired glucose tolerance, but not associated with obesity or insulin resistance or impaired insulin secretion in Mexican Americans...
  40. ncbi request reprint A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
    Renata Belfort
    University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    N Engl J Med 355:2297-307. 2006
    ..Pioglitazone is a thiazolidinedione that ameliorates insulin resistance and improves glucose and lipid metabolism in type 2 diabetes mellitus...
  41. pmc NF-κB activity in muscle from obese and type 2 diabetic subjects under basal and exercise-stimulated conditions
    Puntip Tantiwong
    Texas Diabetes Institute, University of Texas Health Science Center at San Antonio, USA
    Am J Physiol Endocrinol Metab 299:E794-801. 2010
    ..Exercise-induced MCP-1 and IL-6 gene expression precedes increases in NF-κB activity, suggesting that other factors promote gene expression of these cytokines during exercise...
  42. ncbi request reprint Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes
    Ralph A DeFronzo
    Division of Diabetes, University of Texas Health Science Center, San Antonio, TX, USA
    Diabetes Care 28:1092-100. 2005
    ..This study evaluates the ability of the incretin mimetic exenatide (exendin-4) to improve glycemic control in patients with type 2 diabetes failing to achieve glycemic control with maximally effective metformin doses...
  43. ncbi request reprint Comparison of glargine insulin versus rosiglitazone addition in poorly controlled type 2 diabetic patients on metformin plus sulfonylurea
    Curtis Triplitt
    Diabetes Division, MSC 7886, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Diabetes Care 29:2371-7. 2006
    ..We sought to examine the mechanisms by which the addition of glargine insulin or rosiglitazone improves glycemic control in type 2 diabetic subjects poorly controlled on maximally effective doses of metformin plus sulfonylurea...
  44. ncbi request reprint Decreased non-insulin-dependent glucose clearance contributes to the rise in fasting plasma glucose in the nondiabetic range
    Rucha Jani
    Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Diabetes Care 31:311-5. 2008
    ..To assess the contribution of decreased glucose clearance to the rise in fasting plasma glucose (FPG) in the nondiabetic range...
  45. ncbi request reprint Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients
    Yoshinori Miyazaki
    University of Texas Health Science Center, San Antonio, Texas, USA
    Diabetes 52:1943-50. 2003
    ..In conclusion, in type 2 diabetic patients, rosiglitazone treatment enhances downstream insulin receptor signaling in muscle and decreases plasma FFA concentration while improving glycemic control...
  46. pmc Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance
    Alberto O Chavez
    Division of Diabetes, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Diabetes Care 32:1542-6. 2009
    ..FGF-21 may play a role in pathogenesis of hepatic and whole-body insulin resistance in type 2 diabetes...
  47. doi request reprint Mechanism of action of exenatide to reduce postprandial hyperglycemia in type 2 diabetes
    Antonio Cervera
    Division of Diabetes, Department of Medicine, University of Texas Health Science Center, San Antonio, TX, USA
    Am J Physiol Endocrinol Metab 294:E846-52. 2008
    ..CON). Acetaminophen((AUC)) was reduced by approximately 80% in EXE vs. CON (P < 0.01). We conclude that exenatide infusion attenuates postprandial hyperglycemia by decreasing EGP (by approximately 50%) and by slowing gastric emptying...
  48. ncbi request reprint Abdominal fat distribution and peripheral and hepatic insulin resistance in type 2 diabetes mellitus
    Yoshinori Miyazaki
    University of Texas Health Science Center and Texas Diabetes Institute, San Antonio, Texas 78229 3900, USA
    Am J Physiol Endocrinol Metab 283:E1135-43. 2002
    ..In male but not female T2DM, deep subcutaneous adipose tissue also is associated with peripheral and hepatic insulin resistance...
  49. ncbi request reprint Lipid infusion decreases the expression of nuclear encoded mitochondrial genes and increases the expression of extracellular matrix genes in human skeletal muscle
    Dawn K Richardson
    Division of Diabetes, Department of Medicine, The University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Biol Chem 280:10290-7. 2005
    ..These data suggest that an experimental increase in FFAs decreases the expression of PGC-1 and nuclear encoded mitochondrial genes and also increases the expression of extracellular matrix genes in a manner reminiscent of inflammation...
  50. ncbi request reprint Sustained reduction in plasma free fatty acid concentration improves insulin action without altering plasma adipocytokine levels in subjects with strong family history of type 2 diabetes
    Mandeep Bajaj
    Diabetes Division, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78284 7886, USA
    J Clin Endocrinol Metab 89:4649-55. 2004
    ....
  51. ncbi request reprint Insulin resistance is associated with impaired nitric oxide synthase activity in skeletal muscle of type 2 diabetic subjects
    Sangeeta R Kashyap
    The University of Texas Health Science Center at San Antonio, Diabetes Division, Texas 78229, USA
    J Clin Endocrinol Metab 90:1100-5. 2005
    ..These results suggest that impaired NOS activity may play an important role in the insulin resistance in type 2 diabetic individuals...
  52. doi request reprint Physiological and molecular determinants of insulin action in the baboon
    Alberto O Chavez
    Diabetes Division, Department of Medicine, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Diabetes 57:899-908. 2008
    ..To quantitate insulin sensitivity in lean and obese nondiabetic baboons and examine the underlying cellular/molecular mechanisms responsible for impaired insulin action to characterize a baboon model of insulin resistance...
  53. pmc Effects of pioglitazone on intramyocellular fat metabolism in patients with type 2 diabetes mellitus
    Mandeep Bajaj
    Diabetes Division, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 77030, USA
    J Clin Endocrinol Metab 95:1916-23. 2010
    ..Objective: The aim was to study the effect of pioglitazone on intramyocellular fat metabolism...
  54. ncbi request reprint Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients
    Yoshinori Miyazaki
    University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Clin Endocrinol Metab 87:2784-91. 2002
    ..These results demonstrate that a shift of fat distribution from visceral to sc adipose depots after pioglitazone treatment is associated with improvements in hepatic and peripheral tissue sensitivity to insulin...
  55. ncbi request reprint A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes
    Sangeeta Kashyap
    Diabetes Division, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284 3900, USA
    Diabetes 52:2461-74. 2003
    ....
  56. ncbi request reprint A meta-analysis comparing the effect of thiazolidinediones on cardiovascular risk factors
    Elaine Chiquette
    University of Texas Health Science Center, San Antonio, TX 78229, USA
    Arch Intern Med 164:2097-104. 2004
    ..We conducted a meta-analysis of randomized controlled trials of pioglitazone hydrochloride and rosiglitazone maleate in patients with type 2 diabetes to evaluate their effect on glycemic control, lipids, blood pressure, and weight...
  57. ncbi request reprint Free fatty acids reduce splanchnic and peripheral glucose uptake in patients with type 2 diabetes
    Mandeep Bajaj
    Diabetes Division, Department of Medicine, University of Texas Health Science Center at San Antonio, 78284, USA
    Diabetes 51:3043-8. 2002
    ..37 +/- 2%, P < 0.01). In conclusion, an elevation in plasma FFA concentration impairs both peripheral and SGU in patients with type 2 diabetes...
  58. ncbi request reprint Effect of IGF-I on FFA and glucose metabolism in control and type 2 diabetic subjects
    Thongchai Pratipanawatr
    Diabetes Division, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Am J Physiol Endocrinol Metab 282:E1360-8. 2002
    ..01-0.001). During the second IGF-I clamp step, suppression of plasma FFA concentration and FFA turnover was impaired in diabetic vs. control subjects (P < 0.05-0.01)...
  59. pmc Effect of short-term free Fatty acids elevation on mitochondrial function in skeletal muscle of healthy individuals
    Alberto O Chavez
    Division of Diabetes, Department of Medicine, University of Texas Health Science Center at San Antonio, Texas 78229, USA
    J Clin Endocrinol Metab 95:422-9. 2010
    ..Mitochondrial dysfunction has been proposed as an underlying mechanism in the pathogenesis of insulin resistance and type 2 diabetes mellitus...
  60. ncbi request reprint Dose-response effect of pioglitazone on insulin sensitivity and insulin secretion in type 2 diabetes
    Yoshinori Miyazaki
    University of Texas Health Science Center and Texas Diabetes Institute, San Antonio, Texas 78229 3900, USA
    Diabetes Care 25:517-23. 2002
    ..To investigate the dose-response effects of pioglitazone on glycemic control, insulin sensitivity, and insulin secretion in patients with type 2 diabetes...
  61. ncbi request reprint Thiazolidinediones improve beta-cell function in type 2 diabetic patients
    Amalia Gastaldelli
    Diabetes Division, Department of Medicine, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Am J Physiol Endocrinol Metab 292:E871-83. 2007
    ..In T2DM patients, TZD treatment leads to improved beta-cell function, which correlates strongly with improved glycemic control...
  62. ncbi request reprint Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects
    Amalia Gastaldelli
    Division of Diabetes, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Gastroenterology 133:496-506. 2007
    ..We examined the relationship between visceral/hepatic fat accumulation and hepatic IR/accelerated gluconeogenesis (GNG)...
  63. ncbi request reprint Dose-response effect of a single administration of oral hexyl-insulin monoconjugate 2 in healthy nondiabetic subjects
    Estela Wajcberg
    University of Texas Health Science Center, Diabetes Division, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Diabetes Care 27:2868-73. 2004
    ....
  64. ncbi request reprint Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients
    Mandeep Bajaj
    Diabetes Division, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
    Diabetes 54:3148-53. 2005
    ....
  65. pmc Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects
    Sara M Reyna
    Diabetes Division, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Diabetes 57:2595-602. 2008
    ..CONCLUSIONS- Abnormal TLR4 expression and signaling, possibly caused by elevated plasma FFA levels, may contribute to the pathogenesis of insulin resistance in humans...
  66. doi request reprint Combined acute hyperglycemic and hyperinsulinemic clamp induced profibrotic and proinflammatory responses in the kidney
    Meenalakshmi M Mariappan
    Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas
    Am J Physiol Cell Physiol 306:C202-11. 2014
    ..This finding could have implications for the control of short-term rises in blood glucose in diabetic individuals at risk of developing kidney disease. ..
  67. ncbi request reprint Muscle and liver insulin resistance indexes derived from the oral glucose tolerance test
    Muhammad A Abdul-Ghani
    Division of Diabetes, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Diabetes Care 30:89-94. 2007
    ..To derive indexes for muscle and hepatic insulin sensitivity from the measurement of plasma glucose and insulin concentrations during an oral glucose tolerance test (OGTT)...
  68. ncbi request reprint Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance: results from the Veterans Administration Genetic Epidemiology Study
    Muhammad A Abdul-Ghani
    Diabetes Division, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Diabetes 55:1430-5. 2006
    ..Differences in insulin sensitivity and insulin secretion may predict different rates of progression to type 2 diabetes and varying susceptibility to cardiovascular disease...
  69. pmc Efficacy and safety of Technosphere inhaled insulin compared with Technosphere powder placebo in insulin-naive type 2 diabetes suboptimally controlled with oral agents
    Julio Rosenstock
    Dallas Diabetes and Endocrine Center at Medical City, Dallas, Texas, USA
    Diabetes Care 31:2177-82. 2008
    ....
  70. ncbi request reprint Relationship between vascular reactivity and lipids in Mexican-Americans with type 2 diabetes treated with pioglitazone
    Estela Wajcberg
    Division of Diabetes, Department of Medicine, University of Texas Health Science Center at San Antonio, Mail Code 7886, 7703 Floyd Curl Drive, San Antonio, Texas 78229 3900, USA
    J Clin Endocrinol Metab 92:1256-62. 2007
    ..Vascular dysfunction and insulin resistance precede atherosclerosis in type 2 diabetes (T2DM). Better knowledge of the interaction between these is of considerable clinical interest...
  71. ncbi request reprint Muscle glucose transport and phosphorylation in type 2 diabetic, obese nondiabetic, and genetically predisposed individuals
    Merri Pendergrass
    Univ of Texas Health Science Center, Diabetes Division, 703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Am J Physiol Endocrinol Metab 292:E92-100. 2007
    ....
  72. ncbi request reprint Tumor necrosis factor alpha and insulin resistance in obese type 2 diabetic patients
    Y Miyazaki
    University of Texas Health Science Center and Texas Diabetes Institute, San Antonio, Texas 78229, USA
    Int J Obes Relat Metab Disord 27:88-94. 2003
    ....
  73. pmc Pancreatic islet amyloidosis, beta-cell apoptosis, and alpha-cell proliferation are determinants of islet remodeling in type-2 diabetic baboons
    Rodolfo Guardado-Mendoza
    Department of Medicine Diabetes Division, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Proc Natl Acad Sci U S A 106:13992-7. 2009
    ..519, P < 0.0001), and different FPG levels were sensitive and specific to predict IA severity. Finally, a predictive model for islet amyloid severity was generated with age and FPG as required variables...
  74. ncbi request reprint Glucagon dose-response curve for hepatic glucose production and glucose disposal in type 2 diabetic patients and normal individuals
    Masafumi Matsuda
    Diabetes Division, Department of Medicine, University of Texas Health Science Center at San Antonio, 78229, USA
    Metabolism 51:1111-9. 2002
    ..The late (120 to 240 minutes) stimulation of hepatic glucose output (which primarily reflects gluconeogenesis) by glucagon tends to be increased, especially at supraphysiologic plasma glucagon concentrations...
  75. ncbi request reprint LKB1-AMPK signaling in muscle from obese insulin-resistant Zucker rats and effects of training
    Apiradee Sriwijitkamol
    Diabetes Division, University of Texas Health Science Center at San Antonio, TX, USA
    Am J Physiol Endocrinol Metab 290:E925-32. 2006
    ..54, P = 0.02), and PGC-1alpha protein content (r = 0.81, P < 0.001). In summary, obese insulin-resistant rodents have abnormalities in the LKB1-AMPK-PGC-1 pathway in muscle, and these abnormalities can be restored by training...
  76. ncbi request reprint Reduced skeletal muscle inhibitor of kappaB beta content is associated with insulin resistance in subjects with type 2 diabetes: reversal by exercise training
    Apiradee Sriwijitkamol
    Diabetes Division, University of Texas Health Science Center at San Antonio, USA
    Diabetes 55:760-7. 2006
    ..In summary, subjects with type 2 diabetes have reduced IkappaB protein abundance in muscle, suggesting excessive activity of the IkappaB/NFkappaB pathway. Moreover, this abnormality is reversed by exercise training...
  77. ncbi request reprint Pathogenesis of type 2 diabetes mellitus
    Ralph A DeFronzo
    Diabetes Division, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Med Clin North Am 88:787-835, ix. 2004
    ....
  78. ncbi request reprint beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis
    Ele Ferrannini
    Diabetes Division, Department of Internal Medicine, University of Texas Health Science Center, San Antonio 78229 3900, USA
    J Clin Endocrinol Metab 90:493-500. 2005
    ....
  79. ncbi request reprint AMP-activated protein kinase: Role in metabolism and therapeutic implications
    Greg Schimmack
    Texas Diabetes Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX 78207, USA
    Diabetes Obes Metab 8:591-602. 2006
    ....
  80. pmc Genome-wide linkage scan for genes influencing plasma triglyceride levels in the Veterans Administration Genetic Epidemiology Study
    Dawn K Coletta
    Division of Diabetes, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Diabetes 58:279-84. 2009
    ..The goal of our study was to perform a genome-wide linkage scan to identify genetic regions that influence variation in plasma triglyceride levels in families that are enriched with individuals with type 2 diabetes...
  81. ncbi request reprint Comprehensive assessment of postischemic vascular reactivity in Hispanic children and adults with and without diabetes mellitus
    Estela Wajcberg
    University of Texas Health Science Center and Texas Diabetes Institute, San Antonio, TX 78229 3900, USA
    Pediatr Diabetes 7:329-35. 2006
    ....
  82. pmc Effect of acute physiological hyperinsulinemia on gene expression in human skeletal muscle in vivo
    Dawn K Coletta
    Division of Diabetes, Department of Medicine, University of Texas Health Science Centre, San Antonio, TX, USA
    Am J Physiol Endocrinol Metab 294:E910-7. 2008
    ..The results of the present study demonstrate that insulin acutely regulates the levels of mRNAs involved in inflammation and transcription and identifies several candidate genes, including HES1 and BHLHB2, for further investigation...
  83. ncbi request reprint Identification of individuals with insulin resistance using routine clinical measurements
    Steven E Stern
    School of Finance and Applied Statistics, Australian National University, Canberra, Australia
    Diabetes 54:333-9. 2005
    ..1%), sensitivity (81.3%), and specificity (76.3%). Thus, insulin-resistant individuals can be identified using simple decision rules that can be tailored to specific needs...
  84. pmc One-hour plasma glucose concentration and the metabolic syndrome identify subjects at high risk for future type 2 diabetes
    Muhammad A Abdul-Ghani
    Divisions of Diabetes and Epidemiology, University of Texas Health Science Center at San Antonio, Texas, USA
    Diabetes Care 31:1650-5. 2008
    ..To assess the efficacy of 1-h plasma glucose concentration and the metabolic syndrome in predicting future risk of type 2 diabetes...
  85. doi request reprint The relationship between fasting hyperglycemia and insulin secretion in subjects with normal or impaired glucose tolerance
    Muhammad A Abdul-Ghani
    Diabetes Division, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Am J Physiol Endocrinol Metab 295:E401-6. 2008
    ....
  86. pmc Peripheral disruption of the Grb10 gene enhances insulin signaling and sensitivity in vivo
    Lixin Wang
    Department of Pharmacology, UTHSCSA, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Mol Cell Biol 27:6497-505. 2007
    ..Taken together, our results provide strong evidence that Grb10 is a negative regulator of insulin signaling and action in vivo...
  87. ncbi request reprint The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients
    Bogdan Balas
    Diabetes Division, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Drive, MC 7886, San Antonio, Texas 78229, USA
    J Clin Endocrinol Metab 92:1249-55. 2007
    ..However, little is known about the mechanism(s) by which vildagliptin promotes reduction in plasma glucose concentration...
  88. ncbi request reprint A quantitative trait locus (QTL) on chromosome 6q influences birth weight in two independent family studies
    Rector Arya
    Division of Clinical Epidemiology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, 78229 3900, USA
    Hum Mol Genet 15:1569-79. 2006
    ..3 to 2.7. Thus, we have found strong evidence for a major gene on chromosome 6q that influences variation in birth weight in both Mexican- and European-Americans...
  89. pmc Fasting versus postload plasma glucose concentration and the risk for future type 2 diabetes: results from the Botnia Study
    Muhammad A Abdul-Ghani
    Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Diabetes Care 32:281-6. 2009
    ....
  90. doi request reprint Association of genetic variation in ENPP1 with obesity-related phenotypes
    Christopher P Jenkinson
    Division of Diabetes, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Obesity (Silver Spring) 16:1708-13. 2008
    ..However, these results indicate that ENPP1 is a genetic determinant of these traits in this population, and are consistent with multiple positive association findings in independent studies in diverse human populations...
  91. ncbi request reprint Mitochondrial dysfunction, insulin resistance, and type 2 diabetes mellitus
    Muhammad A Abdul-Ghani
    Diabetes Division, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Curr Diab Rep 8:173-8. 2008
    ..This review summarizes evidence that implicates a defect in mitochondrial oxidative phosphorylation and its relationship to insulin resistance in common metabolic diseases characterized by impaired insulin action...
  92. doi request reprint Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance
    Muhammad A Abdul-Ghani
    Division of Diabetes, Univ of Texas Health Science Center, San Antonio, TX 78229, USA
    Am J Physiol Endocrinol Metab 295:E678-85. 2008
    ..These acquired mitochondrial defects, caused by a physiological increase in the concentration of FFA metabolites, provide a mechanistic link between lipotoxicity, mitochondrial dysfunction, and muscle insulin resistance...
  93. doi request reprint The shape of plasma glucose concentration curve during OGTT predicts future risk of type 2 diabetes
    Muhammad A Abdul-Ghani
    Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Diabetes Metab Res Rev 26:280-6. 2010
    ..The aim of the study is to assess the relationship between the shape of plasma glucose concentration during the OGTT and future risk for T2DM...
  94. pmc Pathogenesis of insulin resistance in skeletal muscle
    Muhammad A Abdul-Ghani
    Division of Diabetes, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    J Biomed Biotechnol 2010:476279. 2010
    ..In this review, we summarize the cellular and molecular defects that contribute to the development of insulin resistance in skeletal muscle...
  95. ncbi request reprint Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans
    Dawn K Coletta
    Division of Diabetes MC 7886, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Obesity (Silver Spring) 15:809-15. 2007
    ..98). These preliminary results provide evidence for association of SNPs in the NPY5R gene with dyslipidemia (elevated triglyceride concentrations and reduced high-density lipoprotein levels) in our Mexican American population...
  96. ncbi request reprint Pathophysiology of prediabetes
    Muhammad A Abdul-Ghani
    Diabetes Division, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Curr Diab Rep 9:193-9. 2009
    ..In this article, we summarize the metabolic abnormalities that characterize each state and the contribution of these metabolic abnormalities to the increased risk of diabetes and cardiovascular disease...
  97. pmc The ontogeny of insulin signaling in the preterm baboon model
    Cynthia L Blanco
    Department of Pediatrics, Diabetes Division, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Endocrinology 151:1990-7. 2010
    ..Reduced muscle content of key glucose transport-regulating proteins (GLUT1, GLUT4, AS160) could play a role in the pathogenesis of neonatal hyperglycemia and reduced insulin-stimulated glucose disposal...
  98. ncbi request reprint Is insulin resistance atherogenic? Possible mechanisms
    Ralph A DeFronzo
    Diabetes Division, The University of Texas Health Science Center, San Antonio, TX, USA
    Atheroscler Suppl 7:11-5. 2006

Research Grants19

  1. REGULATION OF HEPATIC AND PERIPHERAL GLUCOSE METABOLISM
    Ralph A DeFronzo; Fiscal Year: 2010
    ..We believe that these studies will yield new insights into the etiology of insulin resistance in T2DM and identify novel therapeutic approaches to reverse the defects in insulin action and restore normoglycemia. ..
  2. REGULATION OF HEPATIC & PERIPHERAL GLUCOSE METABOLISM
    Ralph Defronzo; Fiscal Year: 1993
    ..We also shall examine the effects of chronic hyperinsulinemia on the oxidative and non-oxidative pathways of glucose disposal...
  3. REGULATION OF HEPATIC AND PERIPHERAL GLUCOSE METABOLISM
    Ralph Defronzo; Fiscal Year: 1999
    ..Regardless, Mexican Americans comprise 5% of the US population (12 million people) and definition of the cause of NIDDM in this ethnic group alone would have major scientific, therapeutic, and health care delivery significance. ..
  4. REGULATION OF HEPATIC AND PERIPHERAL GLUCOSE METABOLISM
    Ralph A DeFronzo; Fiscal Year: 2010
    ..We believe that these studies will yield new insights into the etiology of insulin resistance in T2DM and identify novel therapeutic approaches to reverse the defects in insulin action and restore normoglycemia. ..