Anthony L DeFranco

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Contribution of Toll-like receptor signaling to germinal center antibody responses
    Anthony L DeFranco
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143 0414, USA
    Immunol Rev 247:64-72. 2012
  2. doi request reprint "Dangerous crystals"
    Anthony L DeFranco
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    Immunity 29:670-1. 2008
  3. pmc Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation
    Chrystelle Lamagna
    Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 110:E3311-20. 2013
  4. pmc B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice
    Patrizia Scapini
    Department of Laboratory Medicine and Microbiology Immunology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 108:E823-32. 2011
  5. pmc Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice
    Patrizia Scapini
    Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 207:1757-73. 2010
  6. pmc Unaltered negative selection and Treg development of self-reactive thymocytes in TCR transgenic Fyn-deficient mice
    Alusha A Mamchak
    Department of Microbiology and Immunology, University of California, San Francisco, CA, USA
    Eur J Immunol 40:539-47. 2010
  7. pmc Selective utilization of Toll-like receptor and MyD88 signaling in B cells for enhancement of the antiviral germinal center response
    Baidong Hou
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    Immunity 34:375-84. 2011
  8. pmc Elevated BCR signaling and decreased survival of Lyn-deficient transitional and follicular B cells
    Andrew J Gross
    Division of Rheumatology, Department of Medicine, University of California, San Francisco, CA 94143 0414, USA
    Eur J Immunol 41:3645-55. 2011
  9. pmc Critical coordination of innate immune defense against Toxoplasma gondii by dendritic cells responding via their Toll-like receptors
    Baidong Hou
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 108:278-83. 2011
  10. pmc Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells
    Alusha A Mamchak
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    J Immunol 181:5374-85. 2008

Research Grants

  1. REGULATION OF B LYMPHOCYTE PROLIFERATION BY ANTIGEN
    Anthony DeFranco; Fiscal Year: 2007
  2. REGULATION OF B LYMPHOCYTE PROLIFERATION BY ANTIGEN
    Anthony DeFranco; Fiscal Year: 2009
  3. CYTOSKELETON AND SIGNAL TRANSDUCTION IN HOST DEFENSE
    Anthony DeFranco; Fiscal Year: 2009
  4. REGULATION OF B LYMPHOCYTE PROLIFERATION BY ANTIGEN
    Anthony L DeFranco; Fiscal Year: 2010
  5. REGULATION OF B LYMPHOCYTE PROLIFERATION BY ANTIGEN
    Anthony DeFranco; Fiscal Year: 1993
  6. Cell Type-Specific Roles of TLR Signaling In Immune Responses
    Anthony L DeFranco; Fiscal Year: 2010

Collaborators

Detail Information

Publications18

  1. pmc Contribution of Toll-like receptor signaling to germinal center antibody responses
    Anthony L DeFranco
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143 0414, USA
    Immunol Rev 247:64-72. 2012
    ..This review summarizes recent advances in understanding the roles of TLRs in B cells and also in other cell types for enhancement of antibody responses, with an emphasis on T-cell-dependent and germinal center antibody responses...
  2. doi request reprint "Dangerous crystals"
    Anthony L DeFranco
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    Immunity 29:670-1. 2008
    ..In this issue of Immunity, Ng et al. (2008) provide evidence suggesting that UA activates the Syk kinase via membrane cholesterol...
  3. pmc Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation
    Chrystelle Lamagna
    Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 110:E3311-20. 2013
    ..Thus, we demonstrate that hyperactivation of MyD88-dependent signaling in DCs is sufficient to drive pathogenesis of lupus-like disease, illuminating the fact that dysregulation in innate immune cells alone can lead to autoimmunity. ..
  4. pmc B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice
    Patrizia Scapini
    Department of Laboratory Medicine and Microbiology Immunology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 108:E823-32. 2011
    ....
  5. pmc Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice
    Patrizia Scapini
    Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 207:1757-73. 2010
    ..Our findings uncover an important pathological role of BAFF in autoimmune disorders...
  6. pmc Unaltered negative selection and Treg development of self-reactive thymocytes in TCR transgenic Fyn-deficient mice
    Alusha A Mamchak
    Department of Microbiology and Immunology, University of California, San Francisco, CA, USA
    Eur J Immunol 40:539-47. 2010
    ..Combined, these data indicate that Fyn was not required for the induction of central tolerance by negative selection, the adaptor protein role of c-Cbl, or the normal development and function of Treg...
  7. pmc Selective utilization of Toll-like receptor and MyD88 signaling in B cells for enhancement of the antiviral germinal center response
    Baidong Hou
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    Immunity 34:375-84. 2011
    ..The ability of B cells to discriminate between antigens based on the physical form of a TLR ligand probably reflects an adaptation to facilitate strong antiviral antibody responses...
  8. pmc Elevated BCR signaling and decreased survival of Lyn-deficient transitional and follicular B cells
    Andrew J Gross
    Division of Rheumatology, Department of Medicine, University of California, San Francisco, CA 94143 0414, USA
    Eur J Immunol 41:3645-55. 2011
    ..Overall, these observations suggest that increased BCR signaling is responsible for increased death of weakly self-reactive Lyn-deficient B cells both at the T2 stage and additionally as these cells mature to follicular B cells...
  9. pmc Critical coordination of innate immune defense against Toxoplasma gondii by dendritic cells responding via their Toll-like receptors
    Baidong Hou
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 108:278-83. 2011
    ..These results demonstrate a central role of DCs in orchestrating the innate immune response to an intracellular pathogen and establish that defects in pathogen recognition by DCs can predetermine sensitivity to infection...
  10. pmc Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells
    Alusha A Mamchak
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    J Immunol 181:5374-85. 2008
    ..These data demonstrate that ablation of Fyn expression does not alter most Ag-driven CD4(+) T cell responses, with the exception of cytokine production, which under some circumstances is enhanced in Fyn-deficient CD4(+) T cells...
  11. pmc Prolonged production of reactive oxygen species in response to B cell receptor stimulation promotes B cell activation and proliferation
    Matthew L Wheeler
    Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Immunol 189:4405-16. 2012
    ....
  12. pmc Antiviral memory CD8 T-cell differentiation, maintenance, and secondary expansion occur independently of MyD88
    Adeeb H Rahman
    Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Blood 117:3123-30. 2011
    ..Our findings clarify the importance of MyD88 during distinct phases of the antiviral T-cell response and establish differential dependence on MyD88 signaling as a novel characteristic that distinguishes naive from memory CD8 T cells...
  13. pmc Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance
    Andrew J Gross
    Department of Medicine, University of California, San Francisco, CA 94143, USA
    J Immunol 182:5382-92. 2009
    ....
  14. doi request reprint Diacylglycerol kinase ΞΆ limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses
    Matthew L Wheeler
    1Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA
    Sci Signal 6:ra91. 2013
    ..These results suggest that the magnitude of DAG signaling is important for translating the affinity of the BCR for antigen into the amount of antibody produced during the early stages of an immune response. ..
  15. pmc Toll-like receptors activate innate and adaptive immunity by using dendritic cell-intrinsic and -extrinsic mechanisms
    Baidong Hou
    Department of Microbiology and Immunology, University of California, San Francisco, CA, 94143, USA
    Immunity 29:272-82. 2008
    ....
  16. ncbi request reprint TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements
    Tadashi Nishiya
    Department of Microbiology and Immunology, University of California, San Francisco, California 94143, USA
    J Biol Chem 280:37107-17. 2005
    ....
  17. ncbi request reprint Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors
    Tadashi Nishiya
    George Williams Hooper Foundation, University of California, Sa Francisco, 94143 0414, USA
    J Biol Chem 279:19008-17. 2004
    ....
  18. pmc Visualizing lipid raft dynamics and early signaling events during antigen receptor-mediated B-lymphocyte activation
    Neetu Gupta
    Department of Microbiology and Immunology, G W Hooper Foundation, University of California, San Francisco, 94143, USA
    Mol Biol Cell 14:432-44. 2003
    ..These results provide a window into the morphological and molecular organization of the B-cell membrane during the early phase of BCR signaling...

Research Grants21

  1. REGULATION OF B LYMPHOCYTE PROLIFERATION BY ANTIGEN
    Anthony DeFranco; Fiscal Year: 2007
    ..This function appears to involve changes in a subdomain of the plasma membrane called lipid rafts and the mechanisms of these changes will be studied. ..
  2. REGULATION OF B LYMPHOCYTE PROLIFERATION BY ANTIGEN
    Anthony DeFranco; Fiscal Year: 2009
    ..This function appears to involve changes in a subdomain of the plasma membrane called lipid rafts and the mechanisms of these changes will be studied. ..
  3. CYTOSKELETON AND SIGNAL TRANSDUCTION IN HOST DEFENSE
    Anthony DeFranco; Fiscal Year: 2009
    ..abstract_text> ..
  4. REGULATION OF B LYMPHOCYTE PROLIFERATION BY ANTIGEN
    Anthony L DeFranco; Fiscal Year: 2010
    ..This function appears to involve changes in a subdomain of the plasma membrane called lipid rafts and the mechanisms of these changes will be studied. ..
  5. REGULATION OF B LYMPHOCYTE PROLIFERATION BY ANTIGEN
    Anthony DeFranco; Fiscal Year: 1993
    ..The failure of this process may play a role in the etiology of autoimmune diseases...
  6. Cell Type-Specific Roles of TLR Signaling In Immune Responses
    Anthony L DeFranco; Fiscal Year: 2010
    ..These studies will be useful for improving vaccination strategies and for developing novel strategies to block inflammation for patients with inflammatory diseases. ..