Christopher R DeFilippi

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. doi request reprint Interpreting cardiac troponin results from high-sensitivity assays in chronic kidney disease without acute coronary syndrome
    Christopher deFilippi
    Division of Cardiology, Department of Medicine, University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD 21201, USA
    Clin Chem 58:1342-51. 2012
  2. pmc Physical activity, change in biomarkers of myocardial stress and injury, and subsequent heart failure risk in older adults
    Christopher R DeFilippi
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21212, USA
    J Am Coll Cardiol 60:2539-47. 2012
  3. ncbi request reprint Cardiac troponin T in chest pain unit patients without ischemic electrocardiographic changes: angiographic correlates and long-term clinical outcomes
    C R deFilippi
    Department of Internal Medicine, University of Texas Medical Branch at Galveston, USA
    J Am Coll Cardiol 35:1827-34. 2000
  4. pmc Left ventricular ejection fraction assessment in older adults: an adjunct to natriuretic peptide testing to identify risk of new-onset heart failure and cardiovascular death?
    Christopher R DeFilippi
    University of Maryland School of Medicine, Baltimore, MD, USA
    J Am Coll Cardiol 58:1497-506. 2011
  5. pmc Dynamic cardiovascular risk assessment in elderly people. The role of repeated N-terminal pro-B-type natriuretic peptide testing
    Christopher R DeFilippi
    Division of Cardiology, Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Am Coll Cardiol 55:441-50. 2010
  6. pmc Association of serial measures of cardiac troponin T using a sensitive assay with incident heart failure and cardiovascular mortality in older adults
    Christopher R DeFilippi
    Department of Medicine, G3K63, University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD 21212, USA
    JAMA 304:2494-502. 2010
  7. ncbi request reprint Frequency and cause of cardiac troponin T elevation in chronic hemodialysis patients from study of cardiovascular magnetic resonance
    Christopher R DeFilippi
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Am J Cardiol 100:885-9. 2007
  8. ncbi request reprint Impact of renal disease on natriuretic peptide testing for diagnosing decompensated heart failure and predicting mortality
    Christopher R DeFilippi
    Division of Cardiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Clin Chem 53:1511-9. 2007
  9. ncbi request reprint Randomized comparison of a strategy of predischarge coronary angiography versus exercise testing in low-risk patients in a chest pain unit: in-hospital and long-term outcomes
    C R deFilippi
    Department of Internal Medicine, University of Texas Medical Branch at Galveston, USA
    J Am Coll Cardiol 37:2042-9. 2001
  10. ncbi request reprint Cardiac troponin T and C-reactive protein for predicting prognosis, coronary atherosclerosis, and cardiomyopathy in patients undergoing long-term hemodialysis
    Christopher deFilippi
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
    JAMA 290:353-9. 2003

Collaborators

Detail Information

Publications31

  1. doi request reprint Interpreting cardiac troponin results from high-sensitivity assays in chronic kidney disease without acute coronary syndrome
    Christopher deFilippi
    Division of Cardiology, Department of Medicine, University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD 21201, USA
    Clin Chem 58:1342-51. 2012
    ..We examined the associations between hs cTnI and cTnT, cardiovascular disease, and renal function in outpatients with stable CKD...
  2. pmc Physical activity, change in biomarkers of myocardial stress and injury, and subsequent heart failure risk in older adults
    Christopher R DeFilippi
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21212, USA
    J Am Coll Cardiol 60:2539-47. 2012
    ....
  3. ncbi request reprint Cardiac troponin T in chest pain unit patients without ischemic electrocardiographic changes: angiographic correlates and long-term clinical outcomes
    C R deFilippi
    Department of Internal Medicine, University of Texas Medical Branch at Galveston, USA
    J Am Coll Cardiol 35:1827-34. 2000
    ....
  4. pmc Left ventricular ejection fraction assessment in older adults: an adjunct to natriuretic peptide testing to identify risk of new-onset heart failure and cardiovascular death?
    Christopher R DeFilippi
    University of Maryland School of Medicine, Baltimore, MD, USA
    J Am Coll Cardiol 58:1497-506. 2011
    ....
  5. pmc Dynamic cardiovascular risk assessment in elderly people. The role of repeated N-terminal pro-B-type natriuretic peptide testing
    Christopher R DeFilippi
    Division of Cardiology, Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Am Coll Cardiol 55:441-50. 2010
    ..This study sought to determine whether serial measurement of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in community-dwelling elderly people would provide additional prognostic information to that from traditional risk factors...
  6. pmc Association of serial measures of cardiac troponin T using a sensitive assay with incident heart failure and cardiovascular mortality in older adults
    Christopher R DeFilippi
    Department of Medicine, G3K63, University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD 21212, USA
    JAMA 304:2494-502. 2010
    ..Older adults comprise the majority of new-onset heart failure (HF) diagnoses, but traditional risk-factor prediction models have limited accuracy in this population to identify those at highest risk for hospitalization or death...
  7. ncbi request reprint Frequency and cause of cardiac troponin T elevation in chronic hemodialysis patients from study of cardiovascular magnetic resonance
    Christopher R DeFilippi
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Am J Cardiol 100:885-9. 2007
    ....
  8. ncbi request reprint Impact of renal disease on natriuretic peptide testing for diagnosing decompensated heart failure and predicting mortality
    Christopher R DeFilippi
    Division of Cardiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Clin Chem 53:1511-9. 2007
    ..We compared the accuracy of B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) for diagnosing decompensated HF and predicting mortality across the spectrum of renal function...
  9. ncbi request reprint Randomized comparison of a strategy of predischarge coronary angiography versus exercise testing in low-risk patients in a chest pain unit: in-hospital and long-term outcomes
    C R deFilippi
    Department of Internal Medicine, University of Texas Medical Branch at Galveston, USA
    J Am Coll Cardiol 37:2042-9. 2001
    ....
  10. ncbi request reprint Cardiac troponin T and C-reactive protein for predicting prognosis, coronary atherosclerosis, and cardiomyopathy in patients undergoing long-term hemodialysis
    Christopher deFilippi
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
    JAMA 290:353-9. 2003
    ..However, for patients with end-stage renal disease (ESRD) the ability of combinations of these markers to predict outcomes, and their association with cardiac pathology, are unclear...
  11. ncbi request reprint N-terminal pro-B-type natriuretic peptide for predicting coronary disease and left ventricular hypertrophy in asymptomatic CKD not requiring dialysis
    Christopher R DeFilippi
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    Am J Kidney Dis 46:35-44. 2005
    ..We sought to determine whether there is an association between NT-proBNP level and coronary artery disease (CAD) and left ventricular hypertrophy (LVH) in this population...
  12. doi request reprint Lack of diagnostic and prognostic utility of circulating plasma myeloperoxidase concentrations in patients presenting with dyspnea
    Keyur B Shah
    The University of Maryland School of Medicine, Department of Medicine, Baltimore, MD, USA
    Clin Chem 55:59-67. 2009
    ..We sought to assess the diagnostic accuracy of MPO for acute decompensated heart failure (ADHF) and its prognostic value for patients with acute dyspnea...
  13. doi request reprint Prognostic utility of ST2 in patients with acute dyspnea and preserved left ventricular ejection fraction
    Keyur B Shah
    Division of Cardiology, Virginia Commonwealth University, Richmond, VA, USA
    Clin Chem 57:874-82. 2011
    ....
  14. doi request reprint Cardiac microinjury measured by troponin T predicts collagen metabolism in adults aged >=65 years with heart failure
    Willem J Kop
    Department of Medicine Cardiology, University of Maryland, Baltimore, MD, USA
    Circ Heart Fail 5:406-13. 2012
    ..Little is known about the longitudinal association between increases in myocardial injury and the biology of collagen synthesis and deposition...
  15. doi request reprint Post-discharge changes in NT-proBNP and quality of life after acute dyspnea hospitalization as predictors of one-year outcomes
    Keyur B Shah
    Virginia Commonwealth University Medical Center, Department of Medicine, Richmond, VA, USA
    Clin Biochem 43:1405-10. 2010
    ..The association of serial NT-proBNP changes and poor quality of life (QOL) with progressive heart failure (HF) and clinical outcomes in emergency department dyspnea patients is poorly understood...
  16. ncbi request reprint Natriuretic peptides and echocardiography in acute dyspnoea: implication of elevated levels with normal systolic function
    Keyur B Shah
    Division of Cardiology, Department of Medicine, The University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Eur J Heart Fail 11:659-67. 2009
    ....
  17. ncbi request reprint N-terminal pro-B-type natriuretic peptide and B-type natriuretic peptide for identifying coronary artery disease and left ventricular hypertrophy in ambulatory chronic kidney disease patients
    Ijaz A Khan
    Division of Cardiology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Am J Cardiol 97:1530-4. 2006
    ..80, p = 0.001 for NT-pro-BNP; AUC 0.82, p = 0.0004 for BNP; p = 0.45 for NT-pro-BNP vs BNP). In conclusion, NT-pro-BNP and BNP levels are significant and equivalent indicators of CAD and LVH in asymptomatic patients with CKD...
  18. pmc High-sensitivity cardiac troponin T levels and secondary events in outpatients with coronary heart disease from the Heart and Soul Study
    Alexis L Beatty
    Department of Medicine, University of California, San Francisco, 4150 Clement St, San Francisco, CA 94121, USA
    JAMA Intern Med 173:763-9. 2013
    ..Levels of high-sensitivity cardiac troponin T (hs-cTnT) predict secondary cardiovascular events in patients with stable coronary heart disease...
  19. doi request reprint Impact of increased body mass index on accuracy of B-type natriuretic peptide (BNP) and N-terminal proBNP for diagnosis of decompensated heart failure and prediction of all-cause mortality
    Robert H Christenson
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Clin Chem 56:633-41. 2010
    ..Whether increased BMI affects accuracy of these biomarkers for diagnosing decompensated heart failure (HF) and predicting outcomes is unknown...
  20. ncbi request reprint Prevalence and significance of detectable troponins as measured by highly sensitive assays in the general population
    James A de Lemos
    aDivision of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas bDivision of Cardiology, University of Maryland Medical Center, Baltimore, Maryland, USA
    Coron Artery Dis 24:705-9. 2013
    ..Additional research is now needed to define the role of highly sensitive troponin assays in screening of the general population and risk assessment. ..
  21. ncbi request reprint Fresh autologous pericardium for leaflet perforation repair in mitral valve infective endocarditis
    Charles F Evans
    Department of Surgery, Division of Cardiac Surgery, The University of Maryland School of Medicine, Baltimore, MD 20201, USA
    J Heart Valve Dis 22:560-6. 2013
    ..In the present study, fresh autologous pericardium (FAP) was used universally to treat leaflet perforation in MV IE, and the mid-term clinical and echocardiographic outcomes were determined...
  22. ncbi request reprint Interpreting cardiac troponin results from highly sensitive assays in patients with chronic kidney disease: acute coronary syndromes and beyond
    Christopher End
    aDepartment of Medicine, Division of Cardiology, University of North Carolina, Chapel Hill, North Carolina bDepartment of Medicine, Division of Nephrology cDepartment of Medicine, Division of Cardiology, University of Maryland, Baltimore, Maryland, USA
    Coron Artery Dis 24:720-3. 2013
    ..Although in the chronic setting the underlying cause of cardiac troponin elevation is likely a combination of factors, it should prompt further investigation for modifiable risk factors. ..
  23. pmc Long-term trajectory of two unique cardiac biomarkers and subsequent left ventricular structural pathology and risk of incident heart failure in community-dwelling older adults at low baseline risk
    Danielle Glick
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland
    JACC Heart Fail 1:353-60. 2013
    ....
  24. ncbi request reprint Cardiac biomarkers in heart failure
    Michael E Liquori
    University of Maryland School of Medicine, Department of Internal Medicine, 22 S Greene St, Baltimore, MD 21201, USA Electronic address
    Clin Biochem 47:327-37. 2014
    ..Therapies and interventions for a variety of cardiac conditions continue to advance and biomarkers will play an increasing role in patient management...
  25. doi request reprint Multi-center determination of galectin-3 assay performance characteristics: Anatomy of a novel assay for use in heart failure
    Robert H Christenson
    University of Maryland School of Medicine, Baltimore, MD, USA
    Clin Biochem 43:683-90. 2010
    ..Key analytical performance characteristics, the reference distribution and association of galectin-3 levels with clinical outcome in heart failure patients are defined...
  26. ncbi request reprint Adjunctive handgrip during dobutamine stress echocardiography: invasive assessment of myocardial oxygen consumption in humans
    Ijaz A Khan
    Division of Cardiology, University of Maryland School of Medicine, Baltimore, Maryland 21201 1595, USA
    Clin Cardiol 28:349-52. 2005
    ..Adjunctive isometric exercise in the form of sustained submaximal handgrip (HG) is considered to increase the sensitivity of dobutamine stress echo (DSE) for detection of functionally significant coronary artery disease...
  27. doi request reprint Heart failure biomarkers at point-of-care: current utilization and future potential
    Eric S Christenson
    Department of Medicine, Johns Hopkins Hospital, Baltimore, MD, USA
    Expert Rev Mol Diagn 14:185-97. 2014
    ..In this paper we review current and promising HF biomarkers with an emphasis on point-of-care testing and its implications in the changing healthcare landscape. ..
  28. doi request reprint Pulmonary hypertension adversely affects short- and long-term survival after mitral valve operation for mitral regurgitation: implications for timing of surgery
    Mehrdad Ghoreishi
    Division of Cardiac Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Thorac Cardiovasc Surg 142:1439-52. 2011
    ..We investigated the impact of preoperative pulmonary hypertension (PH) on early and late outcomes after mitral valve operation for mitral regurgitation...
  29. pmc Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Circulation 119:2545-52. 2009
    ..We conducted a cross-sectional study to test the hypothesis that elevated FGF-23 concentrations are associated with left ventricular hypertrophy and coronary artery calcification in patients with CKD...
  30. doi request reprint Amino-terminal pro-B-type natriuretic peptide testing in renal disease
    Christopher deFilippi
    Division of Cardiology, University of Maryland, Baltimore, MD, USA
    Am J Cardiol 101:82-8. 2008
    ..Thus, NT-proBNP testing remains useful for the diagnostic and prognostic evaluation of patients with CKD...
  31. doi request reprint N-terminal pro-B-type natriuretic peptide is a major predictor of the development of atrial fibrillation: the Cardiovascular Health Study
    Kristen K Patton
    Division of Cardiology, University of Washington, Seattle, WA 98115, USA
    Circulation 120:1768-74. 2009
    ..Elevated B-type natriuretic peptide levels have been associated with the risk of heart failure, AF, and mortality...