GEORGE DEEPE

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. pmc NADPH oxidase regulates efficacy of vaccination in aspergillosis
    George S Deepe
    Division of Infectious Diseases, University of Cincinnati College of Medicine, and The Veterans Affairs Hospital, Cincinnati, Ohio 45267 0560, USA
    J Clin Invest 122:1608-11. 2012
  2. ncbi request reprint Neutralization of endogenous granulocyte-macrophage colony-stimulating factor subverts the protective immune response to Histoplasma capsulatum
    G S Deepe
    Division of Infectious Diseases, Department of Medicine, University of Cincinnati College of Medicine, OH 45267, USA
    J Immunol 163:4985-93. 1999
  3. ncbi request reprint Infection with Histoplasma capsulatum: Host-fungus interface
    R Allendoerfer
    Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0560 and the Cincinnati Veterans Affairs Medical Center, USA
    Rev Iberoam Micol 15:256-60. 1998
  4. pmc TNF-alpha antagonism generates a population of antigen-specific CD4+CD25+ T cells that inhibit protective immunity in murine histoplasmosis
    George S Deepe
    Division of Infectious Diseases, Veterans Affairs Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 180:1088-97. 2008
  5. ncbi request reprint Protective and memory immunity to Histoplasma capsulatum in the absence of IL-10
    George S Deepe
    Veterans Affairs Hospital and Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 171:5353-62. 2003
  6. ncbi request reprint Preventative and therapeutic vaccines for fungal infections: from concept to implementation
    George S Deepe
    University of Cincinnati College of Medicine, Division of Infectious Diseases, Cincinnati, Ohio 45267 0560, USA
    Expert Rev Vaccines 3:701-9. 2004
  7. pmc Tumor necrosis factor-alpha antagonism by the murine tumor necrosis factor-alpha receptor 2-Fc fusion protein exacerbates histoplasmosis in mice
    George S Deepe
    Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0560, USA
    J Interferon Cytokine Res 27:471-80. 2007
  8. ncbi request reprint Tumor necrosis factor inhibition and opportunistic infections
    George S Deepe
    Division of Infectious Diseases, Veterans Affairs Hospital, Cincinnati, Ohio, USA
    Clin Infect Dis 41:S187-8. 2005
  9. ncbi request reprint Tumor necrosis factor-alpha and host resistance to the pathogenic fungus, Histoplasma capsulatum
    George S Deepe
    Division of Infectious Diseases, Veterans Affairs Hospital, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Investig Dermatol Symp Proc 12:34-7. 2007
  10. ncbi request reprint Progress in vaccination for histoplasmosis and blastomycosis: coping with cellular immunity
    George S Deepe
    Veterans Affairs Hospital and Division of Infectious Diseases, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0560, USA
    Med Mycol 43:381-9. 2005

Research Grants

  1. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2006
  2. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
  3. Immunopathogenesis in Histoplasmosis
    GEORGE DEEPE; Fiscal Year: 2009
  4. Immunopathogenesis in Histoplasmosis
    George S Deepe; Fiscal Year: 2010
  5. Chemokine-Cytokine Nexus in Fungal Immunity
    George S Deepe; Fiscal Year: 2010
  6. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 1993
  7. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2002
  8. Immunopathogenesis in Histoplasmosis
    George S Deepe; Fiscal Year: 2010

Collaborators

Detail Information

Publications49

  1. pmc NADPH oxidase regulates efficacy of vaccination in aspergillosis
    George S Deepe
    Division of Infectious Diseases, University of Cincinnati College of Medicine, and The Veterans Affairs Hospital, Cincinnati, Ohio 45267 0560, USA
    J Clin Invest 122:1608-11. 2012
    ..Their thought-provoking findings reveal the complexities of vaccine-induced immunity and could be used to improve vaccine efficacy...
  2. ncbi request reprint Neutralization of endogenous granulocyte-macrophage colony-stimulating factor subverts the protective immune response to Histoplasma capsulatum
    G S Deepe
    Division of Infectious Diseases, Department of Medicine, University of Cincinnati College of Medicine, OH 45267, USA
    J Immunol 163:4985-93. 1999
    ..These findings reveal a new mechanism whereby GM-CSF contributes to host protection and demonstrate differences in control of primary and secondary histoplasmosis...
  3. ncbi request reprint Infection with Histoplasma capsulatum: Host-fungus interface
    R Allendoerfer
    Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0560 and the Cincinnati Veterans Affairs Medical Center, USA
    Rev Iberoam Micol 15:256-60. 1998
    ..This knowledge can be used to improve treatment as well as diagnosis. Hence, this review summarizes some of the most recent findings regarding host-fungus interaction...
  4. pmc TNF-alpha antagonism generates a population of antigen-specific CD4+CD25+ T cells that inhibit protective immunity in murine histoplasmosis
    George S Deepe
    Division of Infectious Diseases, Veterans Affairs Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 180:1088-97. 2008
    ..Thus, neutralization of TNF-alpha is associated with the induction of a population of regulatory T cells that alter protective immunity in an Ag-specific manner to Histoplasma capsulatum...
  5. ncbi request reprint Protective and memory immunity to Histoplasma capsulatum in the absence of IL-10
    George S Deepe
    Veterans Affairs Hospital and Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 171:5353-62. 2003
    ..Memory cell generation was transiently increased in IL-10(-/-) mice, but the protective function conferred by cells from these mice following immunization is strikingly more vigorous than that of wild-type...
  6. ncbi request reprint Preventative and therapeutic vaccines for fungal infections: from concept to implementation
    George S Deepe
    University of Cincinnati College of Medicine, Division of Infectious Diseases, Cincinnati, Ohio 45267 0560, USA
    Expert Rev Vaccines 3:701-9. 2004
    ..The fungi under discussion in this review include Candida spp., Aspergillus spp., Cryptococcus neoformans, Coccidioides spp., Histoplasma capsulatum, Blastomyces dermatitidis, Paracoccidioides brasiliensis and Pneumocystis jirovecii...
  7. pmc Tumor necrosis factor-alpha antagonism by the murine tumor necrosis factor-alpha receptor 2-Fc fusion protein exacerbates histoplasmosis in mice
    George S Deepe
    Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0560, USA
    J Interferon Cytokine Res 27:471-80. 2007
    ..Impaired immunity is not a result of altered cytokine responses or changes in the inflammation and may not be demonstrable in other murine strains...
  8. ncbi request reprint Tumor necrosis factor inhibition and opportunistic infections
    George S Deepe
    Division of Infectious Diseases, Veterans Affairs Hospital, Cincinnati, Ohio, USA
    Clin Infect Dis 41:S187-8. 2005
  9. ncbi request reprint Tumor necrosis factor-alpha and host resistance to the pathogenic fungus, Histoplasma capsulatum
    George S Deepe
    Division of Infectious Diseases, Veterans Affairs Hospital, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Investig Dermatol Symp Proc 12:34-7. 2007
    ..Antagonism of endogenous cytokine is associated with an enhanced susceptibility to histoplasmosis in both mice and humans. The mechanisms by which TNF-alpha modulates the protective immune response will be discussed...
  10. ncbi request reprint Progress in vaccination for histoplasmosis and blastomycosis: coping with cellular immunity
    George S Deepe
    Veterans Affairs Hospital and Division of Infectious Diseases, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0560, USA
    Med Mycol 43:381-9. 2005
    ..More importantly, the studies summarized herein demonstrate that understanding the host response to a protein or mutant fungus is critical to creating a vaccine that may be useful for the immunocompromised patient...
  11. pmc T cells require tumor necrosis factor-alpha to provide protective immunity in mice infected with Histoplasma capsulatum
    George S Deepe
    Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0560, USA
    J Infect Dis 193:322-30. 2006
    ..T cells from infected, TNF-alpha-neutralized mice failed to protect T cell-deficient mice. The absence of TNF-alpha induces a defect in T cell-mediated protection...
  12. pmc Interleukin-1 and host control of pulmonary histoplasmosis
    George S Deepe
    Cincinnati Veterans Affairs Medical Center and Division of Infectious Diseases, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0560, USA
    J Infect Dis 194:855-64. 2006
    ..Conversely, interferon- gamma levels were decreased. Thus, IL-1 contributes to host resistance to infection with H. capsulatum...
  13. pmc Histoplasma capsulatum manifests preferential invasion of phagocytic subpopulations in murine lungs
    George S Deepe
    Veterans Affairs Hospital, Cincinnati, OH, USA
    J Leukoc Biol 84:669-78. 2008
    ..These results reveal the complex nature of intracellular residence of this fungus. Moreover, the findings demonstrate that there is a skewing in the subpopulations of cells that are infected, especially DC...
  14. pmc Interleukins 17 and 23 influence the host response to Histoplasma capsulatum
    George S Deepe
    Division of Infectious Diseases, Veterans Affairs Hospital, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0560, USA
    J Infect Dis 200:142-51. 2009
    ..Generation of functional IL-17(+) cells is dependent on IL-6 and IL-10. Our findings also establish the existence a regulatory IL-17/IL-23 axis in histoplasmosis...
  15. pmc Discordance between T-cell receptor expression and effector function in mice infected with Histoplasma capsulatum
    George S Deepe
    Veterans Affairs Hospital and Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0560, USA
    Infect Immun 70:1648-52. 2002
    ..Elimination of V beta 10(+) and V beta 14(+) cells from naive mice did not alter the course of infection over a period of 21 days. Thus, overexpression of V beta families does not necessarily signify a key role in host defense...
  16. ncbi request reprint Modulation of infection with Histoplasma capsulatum by inhibition of tumor necrosis factor-alpha activity
    George S Deepe
    Division of Infectious Diseases, Veterans Affairs Hospital, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0560, USA
    Clin Infect Dis 41:S204-7. 2005
    ..Recent reports indicate that, in humans, treatment with inhibitors of TNF-alpha is associated with disseminated histoplasmosis. Here, I review the mechanisms by which inhibition of TNF-alpha may exacerbate infection with H. capsulatum...
  17. pmc Cellular and molecular regulation of vaccination with heat shock protein 60 from Histoplasma capsulatum
    George S Deepe
    Veterans Affairs Hospital and Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0560, USA
    Infect Immun 70:3759-67. 2002
    ..These results delineate the complexity of the regulatory elements necessary for vaccination against this fungus...
  18. ncbi request reprint Functional properties of the T cell receptor repertoire in responding to the protective domain of heat-shock protein 60 from Histoplasma capsulatum
    George S Deepe
    Veterans Affairs Hospital and Department of Medicine, Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0560, USA
    J Infect Dis 186:815-22. 2002
    ..Thus, F3-mediated protection is confined to a defined Vbeta population, but exacerbation of disease is mediated by multiple Vbeta families...
  19. pmc Deciphering the pathways of death of Histoplasma capsulatum-infected macrophages: implications for the immunopathogenesis of early infection
    George S Deepe
    Medical Service, Veterans Affairs Hospital, Cincinnati, OH 45220, USA
    J Immunol 188:334-44. 2012
    ....
  20. ncbi request reprint Knockout mice as experimental models of virulence
    G S Deepe
    Department of Medicine, University of Cincinnati College of Medicine and the Veterans Affairs Hospital, Ohio 45267 0560, USA
    Med Mycol 38:87-98. 2000
    ....
  21. pmc Recombinant murine granulocyte-macrophage colony-stimulating factor modulates the course of pulmonary histoplasmosis in immunocompetent and immunodeficient mice
    G S Deepe
    Division of Infectious Diseases, University of Cincinnati College of Medicine and the Veterans Affairs Hospital, Cincinnati, Ohio 45267 0560, USA
    Antimicrob Agents Chemother 44:3328-36. 2000
    ..These results suggest that this cytokine may be useful as an adjunctive treatment for histoplasmosis...
  22. ncbi request reprint Immune response to early and late Histoplasma capsulatum infections
    G S Deepe
    Department of Medicine, University of Cincinnati College of Medicine, Ohio 45267 0560, USA
    Curr Opin Microbiol 3:359-62. 2000
    ..The significance of cytokines and other endogenous soluble mediators to the protective immune response have been analyzed. Moreover, work concerning the relative importance of T cell subsets to protective immunity has been initiated...
  23. ncbi request reprint V beta 6+ T cells are obligatory for vaccine-induced immunity to Histoplasma capsulatum
    G S Deepe
    Division of Infectious Diseases, University of Cincinnati College of Medicine, and Veterans Affairs Hospital, Cincinnati, OH 45267, USA
    J Immunol 167:2219-26. 2001
    ..Thus, a single Vbeta family was essential for vaccine-induced immunity. Moreover, the mechanism by which Vbeta6+ contributed to protective immunity differed between unfractionated splenocytes and T cell clones...
  24. pmc Apoptosis modulates protective immunity to the pathogenic fungus Histoplasma capsulatum
    Holly L Allen
    Division of Infectious Diseases, Veterans Affairs Hospital, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Clin Invest 115:2875-85. 2005
    ..Thus, apoptosis is a critical element of protective immunity to H. capsulatum. Production of IL-4 and IL-10 is markedly elevated when apoptosis is inhibited, and the release of these cytokines exacerbates the severity of infection...
  25. ncbi request reprint B cells and CD4-CD8- T cells are key regulators of the severity of reactivation histoplasmosis
    Holly L Allen
    Division of Infectious Diseases, Veterans Affairs Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 177:1763-71. 2006
    ..The data reveal the complex control by the host to prevent reactivation of this fungus...
  26. pmc A deficiency in gamma interferon or interleukin-10 modulates T-Cell-dependent responses to heat shock protein 60 from Histoplasma capsulatum
    Mark Scheckelhoff
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0560, USA
    Infect Immun 73:2129-34. 2005
    ..These results indicate that the cytokine milieu influences the shape of the T-cell receptor repertoire and support the importance of gamma interferon and interleukin-10 in the efficacy of heat shock protein 60...
  27. pmc Antibodies to a cell surface histone-like protein protect against Histoplasma capsulatum
    Joshua D Nosanchuk
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 112:1164-75. 2003
    ....
  28. ncbi request reprint The protective immune response to heat shock protein 60 of Histoplasma capsulatum is mediated by a subset of V beta 8.1/8.2+ T cells
    Mark Scheckelhoff
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 169:5818-26. 2002
    ..These data indicate that a distinct subset of Vbeta8.1/8.2(+) T cells is crucial for the generation of a protective response to rHsp60...
  29. pmc Antigen-presenting dendritic cells rescue CD4-depleted CCR2-/- mice from lethal Histoplasma capsulatum infection
    Wendy A Szymczak
    Division of Infectious Diseases, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Infect Immun 78:2125-37. 2010
    ..Furthermore, CD4(+) T cells had a deleterious impact on immunity in infected CCR2(-/-) mice...
  30. pmc The CCL7-CCL2-CCR2 axis regulates IL-4 production in lungs and fungal immunity
    Wendy A Szymczak
    Division of Infectious Diseases, University of Cincinnati, Cincinnati, OH 45267, USA
    J Immunol 183:1964-74. 2009
    ..Furthermore, increased phagocyte-derived IL-4 in CCR2(-/-) mice is associated with the presence of alternatively activated phagocytic cells...
  31. ncbi request reprint Regulation of immunoproteasome subunit expression in vivo following pathogenic fungal infection
    Lance F Barton
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, Cincinnati, OH 45267, USA
    J Immunol 169:3046-52. 2002
    ..Thus, both in vitro and in vivo data demonstrate that IFN-gamma is essential for up-regulation, but not constitutive expression, of immunoproteasome subunits in mice...
  32. pmc Overexpression of interleukin-4 in lungs of mice impairs elimination of Histoplasma capsulatum
    Lucy A Gildea
    Division of Immunology, Cincinnati Veterans Affairs Medical Center, and University of Cincinnati College of Medicine, Ohio, USA
    Infect Immun 71:3787-93. 2003
    ..capsulatum by delaying clearance of the organism but does not prevent the generation of a Th1 response that ultimately controls infection...
  33. pmc CCR5 dictates the equilibrium of proinflammatory IL-17+ and regulatory Foxp3+ T cells in fungal infection
    Danielle N Kroetz
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 184:5224-31. 2010
    ..Thus, CCR5 dictates pathogen persistence by tightly regulating the balance between Treg and Th17 cells in H. capsulatum infection...
  34. ncbi request reprint Immune defects in 28-kDa proteasome activator gamma-deficient mice
    Lance F Barton
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, Cincinnati, OH 45267, USA
    J Immunol 172:3948-54. 2004
    ..We conclude that PA28gamma(-/-) mice, like PA28alpha(-/-)/beta(-/-) mice, are deficient in the processing of only specific Ags...
  35. pmc Metallomic analysis of macrophages infected with Histoplasma capsulatum reveals a fundamental role for zinc in host defenses
    Michael S Winters
    Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0560, USA
    J Infect Dis 202:1136-45. 2010
    ..Treatment of cells with GM-CSF altered the host Zn(2+) binding species profile. These results establish that Zn(2+) deprivation may be a host defense mechanism utilized by macrophages...
  36. pmc Expression of hygromycin phosphotransferase alters virulence of Histoplasma capsulatum
    A George Smulian
    Infectious Disease Division, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Eukaryot Cell 6:2066-71. 2007
    ..The lethality was dependent on the kinase activity of hygromycin phosphotransferase. These results should raise awareness of the potential detrimental effects of the hph gene...
  37. ncbi request reprint Macrophage-independent fungicidal action of the pulmonary collectins
    Francis X McCormack
    Veterans Affairs Medical Center, Cincinnati, Ohio 45220, USA
    J Biol Chem 278:36250-6. 2003
    ....
  38. pmc Pulmonary V beta 4+ T cells from Histoplasma capsulatum-infected mice respond to a homologue of Sec31 that confers a protective response
    Mark R Scheckelhoff
    Division of Infectious Diseases, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0560, USA
    J Infect Dis 193:888-97. 2006
    ..Thus, a homologue of Sec31 is a trigger of the expansion of the V beta 4+ T cell population and is important to the generation of protective immunity...
  39. pmc V beta1+ J beta1.1+/V alpha2+ J alpha49+ CD4+ T cells mediate resistance against infection with Blastomyces dermatitidis
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospitals and Clinics, Madison, WI 53792, USA
    Infect Immun 75:193-200. 2007
    ..Thus, the outgrowth of protective T-cell clones against immunodominant antigens of B. dermatitidis is biased by a combination of the TCR repertoire and Th1 cytokine production...
  40. pmc Advances in combating fungal diseases: vaccines on the threshold
    Jim E Cutler
    Department of Pediatrics and Microbiology, Louisiana State University Health Sciences, and Research Institute for Children at Children s Hospital, New Orleans, Louisiana, 70118 USA
    Nat Rev Microbiol 5:13-28. 2007
    ....
  41. ncbi request reprint Innate and adaptive determinants of host susceptibility to medically important fungi
    Gary B Huffnagle
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109 0642, USA
    Curr Opin Microbiol 6:344-50. 2003
    ..Th1 responses are central to limiting infection with many fungi; thus, a great deal of attention has been focused recently on the antigen(s) that trigger such a response...
  42. pmc Heterologous expression, purification, and immunological reactivity of a recombinant HSP60 from Paracoccidioides brasiliensis
    Daniela A Cunha
    Laboratorio de Biologia Molecular, ICB, Universidade Federal de Goias, 74001 970 Goiania, Goias, Brazil
    Clin Diagn Lab Immunol 9:374-7. 2002
    ..3 and 92.5%, respectively) for HSP60 suggested that the recombinant protein can be used singly or in association with other recombinant antigens to detect antibody responses in P. brasiliensis-infected patients...
  43. pmc Vaccine immunity to pathogenic fungi overcomes the requirement for CD4 help in exogenous antigen presentation to CD8+ T cells: implications for vaccine development in immune-deficient hosts
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
    J Exp Med 197:1405-16. 2003
    ....
  44. pmc Vaccination with heat shock protein 60 induces a protective immune response against experimental Paracoccidioides brasiliensis pulmonary infection
    Renata de Bastos Ascenço Soares
    Laboratorio de Biologia Molecular, ICBII, Universidade Federal de Goias, 74001 970 Goiania, Goias, Brazil
    Infect Immun 76:4214-21. 2008
    ..CD4(+) cells were necessary for the efficacy of the vaccination in both the afferent and efferent phases. Thus, we have demonstrated that this immunodominant antigen is a candidate for the development of a vaccine against this fungus...
  45. ncbi request reprint The antigenic and catalytically active formamidase of Paracoccidioides brasiliensis: protein characterization, cDNA and gene cloning, heterologous expression and functional analysis of the recombinant protein
    Clayton L Borges
    Laboratorio de Biologia Molecular, ICBII, Universidade Federal de Goias, 74001 970 Goiania, Goias, Brazil
    Microbes Infect 7:66-77. 2005
    ..The recombinant 45-kDa protein was shown to be catalytically active; FMD activity was detected in P. brasiliensis yeast and mycelium...
  46. ncbi request reprint Structural-functional relationships of TNF-alpha antagonists: next steps
    Frank J Dann
    Amgen Inc, Thousand Oaks, California 91320 1799, USA
    J Investig Dermatol Symp Proc 12:46-7. 2007
    ..The data presented in this supplement highlight the need for further research into these key areas, and illustrate our current understanding of the mode of action of TNF blockers as only the tip of the iceberg...
  47. ncbi request reprint Characterization of a gene which encodes a mannosyltransferase homolog of Paracoccidioides brasiliensis
    Alessandra A Costa
    Laboratorio de Biologia Molecular, Instituto de Ciencias Biologicas, Universidade Federal de Goias, 74001 970, Goiania, Goias, Brazil
    Microbes Infect 4:1027-34. 2002
    ..A recombinant protein was generated in Escherichia coli. Our data suggest that PbYmnt encodes one member of a glycosyltransferase family of proteins and that our strategy was useful in the isolation of differentially expressed genes...
  48. pmc PCR assay for identification of histoplasma capsulatum based on the nucleotide sequence of the M antigen
    Herbert Leonel de Matos Guedes
    Instituto de Pesquisa Clinica Evandro Chagas, FIOCRUZ, Rio de Janeiro, Brazil
    J Clin Microbiol 41:535-9. 2003
    ..This rapid, sensitive, and specific assay provides a way to identify typical and atypical isolates of H. capsulatum var. capsulatum...

Research Grants22

  1. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2006
    ..rhsp 60 serves as a paradigm, and the data emerging from this proposal may be broadly applicable to other antigens against intracellular pathogens. ..
  2. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
    ..abstract_text> ..
  3. Immunopathogenesis in Histoplasmosis
    GEORGE DEEPE; Fiscal Year: 2009
    ..Our work will demonstrate how important it is for lymphocytes and macrophages to die in order that the host can survive. ..
  4. Immunopathogenesis in Histoplasmosis
    George S Deepe; Fiscal Year: 2010
    ..Our work will demonstrate how important it is for lymphocytes and macrophages to die in order that the host can survive. ..
  5. Chemokine-Cytokine Nexus in Fungal Immunity
    George S Deepe; Fiscal Year: 2010
    ..Our work will demonstrate how important it is for appropriate signaling through a surface receptor for a particular chemokine in order that the host can survive. ..
  6. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 1993
    ..Thus, it may be possible to correlate the functional activity of T cells with their expression of specific T cell receptor family. Furthermore, HIS-62 and HIS-80 may serve as a paradigm for the interaction of Hc antigens with T cells...
  7. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2002
    ....
  8. Immunopathogenesis in Histoplasmosis
    George S Deepe; Fiscal Year: 2010
    ..Our work will demonstrate how important it is for lymphocytes and macrophages to die in order that the host can survive. ..