Samir S Deeb

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
    S S Deeb
    Department of Medicine, University of Washington, Seattle 98195, USA
    Nat Genet 20:284-7. 1998
  2. ncbi request reprint Interindividual and topographical variation of L:M cone ratios in monkey retinas
    S S Deeb
    Department of Medicine, University of Washington, Seattle 98195, USA
    J Opt Soc Am A Opt Image Sci Vis 17:538-44. 2000
  3. ncbi request reprint Genetics of color vision deficiencies
    Samir S Deeb
    Departments of Medicine and Genome Sciences, University of Washington, Seattle, Wash, USA
    Dev Ophthalmol 37:170-87. 2003
  4. pmc Identification of novel retinal target genes of thyroid hormone in the human WERI cells by expression microarray analysis
    Yan Liu
    Division of Medical Genetics, Departments of Medicine and Genome Sciences, University of Washington, Box 357720, Seattle, WA 98195 7720, USA
    Vision Res 47:2314-26. 2007
  5. ncbi request reprint Transcriptional regulation of the human hepatic lipase (LIPC) gene promoter
    Laura E Rufibach
    Department of Medical Genetics, University of Washington, Seattle, USA
    J Lipid Res 47:1463-77. 2006
  6. pmc The effect of hepatic lipase on coronary artery disease in humans is influenced by the underlying lipoprotein phenotype
    John D Brunzell
    University of Washington, Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, Box 356426, 1959 NE Pacific Avenue, Seattle, Washington 98195, USA
    Biochim Biophys Acta 1821:365-72. 2012
  7. ncbi request reprint Cone visual pigments of the Australian marsupials, the stripe-faced and fat-tailed dunnarts: sequence and inferred spectral properties
    Jessica Strachan
    Department of Medicine, University of Washington, Seattle, USA
    Vis Neurosci 21:223-9. 2004
  8. ncbi request reprint Ethnic differences in hepatic lipase and HDL in Japanese, black, and white Americans: role of central obesity and LIPC polymorphisms
    Molly C Carr
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA
    J Lipid Res 45:466-73. 2004
  9. doi request reprint Distinguishing L from M photopigment coding sequences by hybridization to novel locked nucleic acid (LNA) oligonucleotide probes
    Christina Pettan-Brewer
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Vis Neurosci 25:283-7. 2008
  10. pmc Energy balance in congenital generalized lipodystrophy type I
    Sasha Taleban
    General Clinical Research Center, University of Washington, USA
    Metabolism 57:1155-61. 2008

Collaborators

Detail Information

Publications29

  1. ncbi request reprint A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
    S S Deeb
    Department of Medicine, University of Washington, Seattle 98195, USA
    Nat Genet 20:284-7. 1998
    ..These findings suggest that the PPARgamma2 Pro12Ala variant may contribute to the observed variability in BMI and insulin sensitivity in the general population...
  2. ncbi request reprint Interindividual and topographical variation of L:M cone ratios in monkey retinas
    S S Deeb
    Department of Medicine, University of Washington, Seattle 98195, USA
    J Opt Soc Am A Opt Image Sci Vis 17:538-44. 2000
    ..The correlation between mRNA ratios and physiological cone gain ratio supports the conclusion that both measures reflect the relative number of L and M cones...
  3. ncbi request reprint Genetics of color vision deficiencies
    Samir S Deeb
    Departments of Medicine and Genome Sciences, University of Washington, Seattle, Wash, USA
    Dev Ophthalmol 37:170-87. 2003
    ..A number of mutations in the genes encoding the cone-specific alpha- and beta-subunits of the cation channel and the alpha-subunit of transducin have been implicated in this disorder...
  4. pmc Identification of novel retinal target genes of thyroid hormone in the human WERI cells by expression microarray analysis
    Yan Liu
    Division of Medical Genetics, Departments of Medicine and Genome Sciences, University of Washington, Box 357720, Seattle, WA 98195 7720, USA
    Vision Res 47:2314-26. 2007
    ..In addition, we found a number of novel TH-targets that are not currently known to be retinal genes. This is the first report of human retinal targets regulated by thyroid hormone...
  5. ncbi request reprint Transcriptional regulation of the human hepatic lipase (LIPC) gene promoter
    Laura E Rufibach
    Department of Medical Genetics, University of Washington, Seattle, USA
    J Lipid Res 47:1463-77. 2006
    ..The overall effect these transcription factors have on HL expression will ultimately depend on the interplay between these various factors and their relative intracellular concentrations...
  6. pmc The effect of hepatic lipase on coronary artery disease in humans is influenced by the underlying lipoprotein phenotype
    John D Brunzell
    University of Washington, Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, Box 356426, 1959 NE Pacific Avenue, Seattle, Washington 98195, USA
    Biochim Biophys Acta 1821:365-72. 2012
    ..This article is part of a Special Issue entitled Advances in High Density Lipoprotein Formation and Metabolism: A Tribute to John F. Oram (1945-2010)...
  7. ncbi request reprint Cone visual pigments of the Australian marsupials, the stripe-faced and fat-tailed dunnarts: sequence and inferred spectral properties
    Jessica Strachan
    Department of Medicine, University of Washington, Seattle, USA
    Vis Neurosci 21:223-9. 2004
    ..The MWS pigments of the two species differ by two, and UVS by three amino acid positions. No evidence was obtained for a third cone pigment in either species...
  8. ncbi request reprint Ethnic differences in hepatic lipase and HDL in Japanese, black, and white Americans: role of central obesity and LIPC polymorphisms
    Molly C Carr
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA
    J Lipid Res 45:466-73. 2004
    ....
  9. doi request reprint Distinguishing L from M photopigment coding sequences by hybridization to novel locked nucleic acid (LNA) oligonucleotide probes
    Christina Pettan-Brewer
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Vis Neurosci 25:283-7. 2008
    ..This result strongly suggests that these probes would be instrumental in rapidly distinguishing L from M cone in the entire retina, and in defining the cone mosaic during development and in adults...
  10. pmc Energy balance in congenital generalized lipodystrophy type I
    Sasha Taleban
    General Clinical Research Center, University of Washington, USA
    Metabolism 57:1155-61. 2008
    ..Appetite-regulating hormone levels in CGL-1 suggest that multiple factors act to control appetite in these individuals...
  11. ncbi request reprint Hepatic lipase and dyslipidemia: interactions among genetic variants, obesity, gender, and diet
    Samir S Deeb
    Divisions of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Lipid Res 44:1279-86. 2003
    ..The dyslipidemia with high HL activity is a potentially proatherogenic lipoprotein profile in the metabolic syndrome, in Type 2 diabetes, and in familial combined hyperlipidemia...
  12. doi request reprint Reduced L- and M- and increased S-cone functions in an infant with thyroid hormone resistance due to mutations in the THRβ2 gene
    Avery H Weiss
    Roger H Johnson Clinical Vision Laboratory, Division of Ophthalmology, Seattle Children s Hospital, Seattle, WA 98105, USA
    Ophthalmic Genet 33:187-95. 2012
    ..To document an infant with a cone photoreceptor disorder associated with severe thyroid hormone resistance due to compound heterozygosity in the thyroid hormone receptor beta 2 (TRβ2) encoding gene THRβ2...
  13. ncbi request reprint Genetics of variation in human color vision and the retinal cone mosaic
    Samir S Deeb
    Departments of Medicine, Medical Genetics and Genome Sciences, University of Washington, Seattle, WA 98185, USA
    Curr Opin Genet Dev 16:301-7. 2006
    ..The transcription factors NR2E3, TRbeta2 and RXRgamma play crucial roles in establishment of the retinal cone mosaic during eye development...
  14. ncbi request reprint The cone visual pigments of an Australian marsupial, the tammar wallaby (Macropus eugenii): sequence, spectral tuning, and evolution
    Samir S Deeb
    Department of Medicine, University of Washington, Seattle, USA
    Mol Biol Evol 20:1642-9. 2003
    ..Introns interrupt the coding sequences of the wallaby, mouse, and human MWS pigment sequences at the same corresponding nucleotide positions. However, the length of introns varies widely among these species...
  15. ncbi request reprint Apolipoprotein L-I is positively associated with hyperglycemia and plasma triglycerides in CAD patients with low HDL
    Timothy S E Albert
    Department of Medicine, University of Washington, Seattle, WA, USA
    J Lipid Res 46:469-74. 2005
    ..In conclusion, we found TG and HG to be the strongest predictors of apoL-I within a dyslipidemic CAD population. These data provide further characterization of the novel HDL-associated apoL-I...
  16. ncbi request reprint Structural and functional consequences of missense mutations in exon 5 of the lipoprotein lipase gene
    Jonas Peterson
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, Box 356426, University of Washington Medical Center, Seattle, WA 98195 6426, USA
    J Lipid Res 43:398-406. 2002
    ..These results stress the importance of conformational evaluation of mutant LPL. Absence of catalytic activity does not necessarily imply that the substituted amino acid plays a specific direct role in catalysis...
  17. pmc The Role of the PGC1alpha Gly482Ser Polymorphism in Weight Gain due to Intensive Diabetes Therapy
    Samir S Deeb
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195 7720, USA
    PPAR Res 2009:649286. 2009
    ..We conclude that T2DM and the Gly482Ser polymorphism in PGC1alpha contribute to the effect of intensive diabetes therapy on weight gain in males with T1DM...
  18. ncbi request reprint Mutually exclusive expression of the L and M pigment genes in the human retinoblastoma cell line WERI: Resetting by cell division
    Samir S Deeb
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Vis Neurosci 23:371-8. 2006
    ..Third, determination of L and M cone identity may not require external molecular cues during differentiation, and is consistent with the idea that L and M cones are not intrinsically different...
  19. ncbi request reprint Molecular genetics of color-vision deficiencies
    Samir S Deeb
    Department of Medicine, University of Washington, Seattle, USA
    Vis Neurosci 21:191-6. 2004
    ..A number of mutants in the genes encoding the cone-specific alpha- and beta-subunits of the cGMP-gated cation channel as well as in the alpha-subunit of transducin have been implicated in this disorder...
  20. ncbi request reprint Molecular genetics of colour vision deficiencies
    Samir S Deeb
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA, USA
    Clin Exp Optom 87:224-9. 2004
    ....
  21. ncbi request reprint Köbberling type of familial partial lipodystrophy: an underrecognized syndrome
    Karen L Herbst
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Diabetes Care 26:1819-24. 2003
    ..The latter disorder is associated with mutations in the LMNA gene. FPLD1 is thought to be rare. Here, we report 13 subjects with FPLD1, suggesting that this syndrome is more common than previously thought...
  22. ncbi request reprint Expression of rinx/vsx1 during postnatal eye development in cone-bipolar, differentiating ganglion, and lens fiber cells
    Takaaki Hayashi
    Department of Medicine, University of Washington, Seattle, WA, USA
    Jpn J Ophthalmol 49:93-105. 2005
    ..To investigate the expression pattern of the homeobox transcription factor Rinx (also referred to as Vsx1) during postnatal eye development of the mouse...
  23. ncbi request reprint Hepatic lipase: a marker for cardiovascular disease risk and response to therapy
    Alberto Zambon
    Department of Medical and Surgical Sciences, University of Padova, Italy
    Curr Opin Lipidol 14:179-89. 2003
    ..The potential impact of genetic determinants of hepatic lipase activity in modulating both the development of coronary and carotid atherosclerosis will be discussed based on hepatic lipase proposed roles in lipoprotein metabolism...
  24. ncbi request reprint The molecular basis of dichromatic color vision in males with multiple red and green visual pigment genes
    Wolfgang M Jagla
    Department of Neuro Ophthalmology, University Eye Hospital, Roentgenweg 11, D 72076 Tubingen, Germany
    Hum Mol Genet 11:23-32. 2002
    ....
  25. ncbi request reprint Differential effect of PPARgamma2 variants in the development of type 2 diabetes between native Japanese and Japanese Americans
    Masami Nemoto
    Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Jikei University School of Medicine, 3 25 8 Nishishinbashi, Minato ku, Tokyo 105 8461, Japan
    Diabetes Res Clin Pract 57:131-7. 2002
    ..The data with emigrants suggests the possible interaction of gene-environment in the development of type 2 diabetes...
  26. ncbi request reprint Association between the --514 C-->T polymorphism of the hepatic lipase gene promoter and unstable carotid plaque in patients with severe carotid artery stenosis
    Elisabetta Faggin
    Dipartimento di Medicina Clinica e Sperimentale, Universita di, Padova, Italy
    J Am Coll Cardiol 40:1059-66. 2002
    ..We investigated the potential association between -514 C-->T polymorphism in the promoter of the hepatic lipase gene (LIPC) and the prevalence of inflammatory cells in the plaque of patients with severe carotid artery stenosis...
  27. ncbi request reprint Common hepatic lipase gene promoter variant predicts the degree of neointima formation after carotid endarterectomy: impact of plaque composition and lipoprotein phenotype
    Alberto Zambon
    Department of Medical and Surgical Sciences, University of Padua, Italy
    Atherosclerosis 185:121-6. 2006
    ..We investigated the potential relationship between these polymorphisms and the maximum-intima-media thickness (M-IMT) after carotid endarterectomy...
  28. ncbi request reprint X-linked high myopia associated with cone dysfunction
    Terri L Young
    Department of Ophthalmology, University of Minnesota Medical School, Minneapolis, USA
    Arch Ophthalmol 122:897-908. 2004
    ..We studied a second family from Minnesota with a similar X-linked phenotype, also of Danish descent. All affected males had protanopia instead of deuteranopia...
  29. doi request reprint Cone visual pigments of monotremes: filling the phylogenetic gap
    Matthew J Wakefield
    ARC, Centre for Kangaroo Genomics, Bioinformatics, The Walter and Eliza Hall Institute, Parkville, Australia
    Vis Neurosci 25:257-64. 2008
    ..So far, the echidna and platypus are the only mammals that share the gene structure of the LWS-SWS2 pigment gene complex with reptiles, birds and fishes...