C DeCarli

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Vascular and degenerative processes differentially affect regional interhemispheric connections in normal aging, mild cognitive impairment, and Alzheimer disease
    Dong Young Lee
    Imaging of Dementia and Aging IDeA Laboratory, Department of Neurology and Center for Neuroscience, University of California at Davis, Davis, Calif 95616, USA
    Stroke 41:1791-7. 2010
  2. pmc Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline
    S Debette
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    Neurology 77:461-8. 2011
  3. pmc Clinically asymptomatic vascular brain injury: a potent cause of cognitive impairment among older individuals
    Charles DeCarli
    Alzheimer s Disease Center, Imaging of Dementia and Aging IDeA Laboratory, Department of Neurology and Center for Neuroscience, University of California at Davis, CA 95817, USA
    J Alzheimers Dis 33:S417-26. 2013
  4. pmc Coevolution of white matter hyperintensities and cognition in the elderly
    Pauline Maillard
    Imaging of Dementia and Aging Laboratory, University of California, Davis, Davis, CA, USA
    Neurology 79:442-8. 2012
  5. pmc Memory impairment, but not cerebrovascular disease, predicts progression of MCI to dementia
    C DeCarli
    Department of Neurology, University of California at San Francisco, USA
    Neurology 63:220-7. 2004
  6. ncbi request reprint Vascular factors in dementia: an overview
    Charles DeCarli
    Department of Neurology, University of California at Davis, 4860 Y St Suite 3700, Sacramento CA 95817, USA
    J Neurol Sci 226:19-23. 2004
  7. ncbi request reprint Anatomical mapping of white matter hyperintensities (WMH): exploring the relationships between periventricular WMH, deep WMH, and total WMH burden
    Charles DeCarli
    Department of Neurology, University of California at Davis, Davis, Calif, USA
    Stroke 36:50-5. 2005
  8. ncbi request reprint Mild cognitive impairment: prevalence, prognosis, aetiology, and treatment
    Charles DeCarli
    Alzheimer s Disease Center, Department of Neurology, University of California at Davis, Sacramento, California 95817, USA
    Lancet Neurol 2:15-21. 2003
  9. ncbi request reprint Measures of brain morphology and infarction in the framingham heart study: establishing what is normal
    Charles DeCarli
    Department of Neurology and Center for Neuroscience, 4860 Y Street, Suite 3700, Sacramento, CA 95817, USA
    Neurobiol Aging 26:491-510. 2005
  10. ncbi request reprint The role of cerebrovascular disease in dementia
    Charles DeCarli
    Department of Neurology, University of California at Davis, Sacramento, USA
    Neurologist 9:123-36. 2003

Detail Information

Publications103 found, 100 shown here

  1. pmc Vascular and degenerative processes differentially affect regional interhemispheric connections in normal aging, mild cognitive impairment, and Alzheimer disease
    Dong Young Lee
    Imaging of Dementia and Aging IDeA Laboratory, Department of Neurology and Center for Neuroscience, University of California at Davis, Davis, Calif 95616, USA
    Stroke 41:1791-7. 2010
    ..Here, we examine these changes in subjects with mild cognitive impairment, with Alzheimer disease, and in cognitively normal elderly adults...
  2. pmc Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline
    S Debette
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    Neurology 77:461-8. 2011
    ..Our aim was to test the association of vascular risk factor exposure in midlife with progression of MRI markers of brain aging and measures of cognitive decline...
  3. pmc Clinically asymptomatic vascular brain injury: a potent cause of cognitive impairment among older individuals
    Charles DeCarli
    Alzheimer s Disease Center, Imaging of Dementia and Aging IDeA Laboratory, Department of Neurology and Center for Neuroscience, University of California at Davis, CA 95817, USA
    J Alzheimers Dis 33:S417-26. 2013
    ..Results of this review emphasize the need for early detection and treatment of vascular risk factors to improve the cognitive health of our rapidly aging population...
  4. pmc Coevolution of white matter hyperintensities and cognition in the elderly
    Pauline Maillard
    Imaging of Dementia and Aging Laboratory, University of California, Davis, Davis, CA, USA
    Neurology 79:442-8. 2012
    ..To investigate the effects of baseline white matter hyperintensity (WMH) and rates of WMH extension and emergence on rate of change in cognition (episodic memory and executive function)...
  5. pmc Memory impairment, but not cerebrovascular disease, predicts progression of MCI to dementia
    C DeCarli
    Department of Neurology, University of California at San Francisco, USA
    Neurology 63:220-7. 2004
    ....
  6. ncbi request reprint Vascular factors in dementia: an overview
    Charles DeCarli
    Department of Neurology, University of California at Davis, 4860 Y St Suite 3700, Sacramento CA 95817, USA
    J Neurol Sci 226:19-23. 2004
    ..Such evidence suggests that these two diseases may act additively or synergistically to cause clinical dementia. This review focuses on evolving data that support this hypothesis...
  7. ncbi request reprint Anatomical mapping of white matter hyperintensities (WMH): exploring the relationships between periventricular WMH, deep WMH, and total WMH burden
    Charles DeCarli
    Department of Neurology, University of California at Davis, Davis, Calif, USA
    Stroke 36:50-5. 2005
    ..Separate pathophysiologies and behavioral consequences are often attributed to these 2 classes of WMH. However, evidence to support these empirical distinctions has not been rigorously sought...
  8. ncbi request reprint Mild cognitive impairment: prevalence, prognosis, aetiology, and treatment
    Charles DeCarli
    Alzheimer s Disease Center, Department of Neurology, University of California at Davis, Sacramento, California 95817, USA
    Lancet Neurol 2:15-21. 2003
    ..In this review, I attempt to recognise workable definitions of MCI to discuss the prevalence, pathophysiology, prognosis, and possibilities for treatment of this disorder...
  9. ncbi request reprint Measures of brain morphology and infarction in the framingham heart study: establishing what is normal
    Charles DeCarli
    Department of Neurology and Center for Neuroscience, 4860 Y Street, Suite 3700, Sacramento, CA 95817, USA
    Neurobiol Aging 26:491-510. 2005
    ....
  10. ncbi request reprint The role of cerebrovascular disease in dementia
    Charles DeCarli
    Department of Neurology, University of California at Davis, Sacramento, USA
    Neurologist 9:123-36. 2003
    ..The potential impact of cerebrovascular disease on general cognitive health is not yet well understood, but is now being actively explored and clarified...
  11. ncbi request reprint Qualitative estimates of medial temporal atrophy as a predictor of progression from mild cognitive impairment to dementia
    Charles DeCarli
    Department of Neurology and Imaging of Dementia and Aging Laboratory, Center for Neuroscience, University of California at Davis, Sacramento 95817, USA
    Arch Neurol 64:108-15. 2007
    ..Prognostic uncertainty suggests the need for additional measures to assist the clinician...
  12. ncbi request reprint Cerebrovascular and brain morphologic correlates of mild cognitive impairment in the National Heart, Lung, and Blood Institute Twin Study
    C DeCarli
    Department of Neurology, University of California at Davis, 4860 Y St, Suite 3700, Sacramento, CA 95817, USA
    Arch Neurol 58:643-7. 2001
    ..To evaluate the relative risk (RR) of mild cognitive impairment (MCI) associated with cerebrovascular risk factors and cerebrovascular-related brain changes...
  13. pmc Brain behavior relationships among African Americans, whites, and Hispanics
    Charles DeCarli
    Department of Neurology, University of California at Davis, Sacramento, CA 95817, USA
    Alzheimer Dis Assoc Disord 22:382-91. 2008
    ..Moreover, interesting and potentially biologically relevant differences were found that might stimulate further research related to the understanding of dementia etiology within an increasingly racially and ethnically diverse population...
  14. pmc Longitudinal volumetric MRI change and rate of cognitive decline
    D Mungas
    Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Neurology 65:565-71. 2005
    ..To examine how baseline and change of volumetric MRI relate to cognitive decline in older individuals...
  15. pmc Psychological symptoms correlate with reduced hippocampal volume in fragile X premutation carriers
    P E Adams
    M I N D Institute, University of California, Davis Health System, Sacramento, California, USA
    Am J Med Genet B Neuropsychiatr Genet 153:775-85. 2010
    ..Though the presentation of FXTAS symptoms is less common in females, anxiety-related problems are common both prior to and after the onset of FXTAS, and may be related to hippocampal changes...
  16. pmc Association of parental dementia with cognitive and brain MRI measures in middle-aged adults
    S Debette
    Department of Neurology, Boston University School of Medicine, B602, 72 East Concord Street, Boston, MA 02118, USA
    Neurology 73:2071-8. 2009
    ..We related prospectively verified parental dementia to brain MRI and cognitive testing in the offspring, within a 2-generational community-based cohort...
  17. ncbi request reprint Impact of apolipoprotein E epsilon4 and vascular disease on brain morphology in men from the NHLBI twin study
    C DeCarli
    Department of Neurology, University of Kansas, Kansas City, MO 66160, USA
    Stroke 30:1548-53. 1999
    ..Since age-related brain atrophy and the extent of white matter hyperintensities (WMH) share similar risk factors, we examined the combined effect of ApoE4 and history of vascular disease on brain volume, WMH, and MRI evidence of stroke...
  18. pmc White matter lesions impair frontal lobe function regardless of their location
    M Tullberg
    Department of Neurology, School of Medicine, University of California, Davis, USA
    Neurology 63:246-53. 2004
    ....
  19. ncbi request reprint Volumetric brain changes in females with fragile X-associated tremor/ataxia syndrome (FXTAS)
    J S Adams
    M I N D Institute, University of California, Davis, CA, USA
    Neurology 69:851-9. 2007
    ..Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder occurring in male and rare female carriers of a premutation expansion (55 to 200 CGG repeats) of the fragile X mental retardation 1 (FMR1) gene...
  20. pmc Subtypes based on cerebrospinal fluid and magnetic resonance imaging markers in normal elderly predict cognitive decline
    J Nettiksimmons
    Division of Biostatistics, Department of Public Health Sciences, University of California, Davis, Davis, CA 95616, USA
    Neurobiol Aging 31:1419-28. 2010
    ..Subtypes among NC based on multiple biomarkers may represent the earliest stages of subclinical cognitive decline and AD...
  21. pmc FLAIR and diffusion MRI signals are independent predictors of white matter hyperintensities
    P Maillard
    Imaging of Dementia and Aging Laboratory, University of California, Davis, Davis, California, USA
    AJNR Am J Neuroradiol 34:54-61. 2013
    ..We investigated the ability of FLAIR and DTI to characterize the longitudinal course of WMH development...
  22. ncbi request reprint Stroke risk profile, brain volume, and cognitive function: the Framingham Offspring Study
    S Seshadri
    Department of Neurology, School of Medicine, Boston University, MA 02118 2526, USA
    Neurology 63:1591-9. 2004
    ..This association may result not only from clinical strokes but also from subclinical brain injury, such as a global atrophy demonstrable on quantitative brain MRI...
  23. ncbi request reprint Predictors of brain morphology for the men of the NHLBI twin study
    C DeCarli
    Department of Neurology, University of Kansas, Kansas City, USA
    Stroke 30:529-36. 1999
    ..We extend these findings by examining the relationship between midlife cerebrovascular risk factors and later-life differences in brain atrophy, amount of abnormal white matter, and stroke on MRI...
  24. pmc Volumetric MRI predicts rate of cognitive decline related to AD and cerebrovascular disease
    D Mungas
    Department of Neurology, School of Medicine, University of California, Davis, USA
    Neurology 59:867-73. 2002
    ..To examine volumetric MRI correlates of longitudinal cognitive decline in normal aging, AD, and subcortical cerebrovascular brain injury (SCVBI)...
  25. ncbi request reprint Earlier onset of Alzheimer disease symptoms in latino individuals compared with anglo individuals
    Christopher M Clark
    Department of Neurology, Alzheimer s Disease Center, University of Pennsylvania, Philadelphia 19104, USA
    Arch Neurol 62:774-8. 2005
    ....
  26. pmc Association of plasma total homocysteine levels with subclinical brain injury: cerebral volumes, white matter hyperintensity, and silent brain infarcts at volumetric magnetic resonance imaging in the Framingham Offspring Study
    Sudha Seshadri
    Department of Neurology, School of Medicine, Boston University, Boston, Massachusetts 02118 2526, USA
    Arch Neurol 65:642-9. 2008
    ..Elevated plasma total homocysteine (tHcy) levels have been associated with increased risk of dementia and stroke, but it is uncertain whether the mediating mechanisms are predominantly cellular, vascular, or both...
  27. pmc The contributions of MRI-based measures of gray matter, white matter hyperintensity, and white matter integrity to late-life cognition
    J He
    Imaging of Dementia and Aging IDeA Laboratory, Department of Neurology, University of California, Davis, 1544 Newton Ct, Davis, CA 95618, USA
    AJNR Am J Neuroradiol 33:1797-803. 2012
    ..To detect their extent of contribution to cognitive performance, we explored the independent and additive contributions of GM atrophy, white matter injury, and white matter integrity to cognition in elderly patients...
  28. pmc Regional pattern of white matter microstructural changes in normal aging, MCI, and AD
    D Y Lee
    Imaging of Dementia and Aging IDeA Laboratory, Department of Neurology and Center for Neuroscience, University of California at Davis, Davis, CA 95616, USA
    Neurology 73:1722-8. 2009
    ....
  29. pmc Inflammatory biomarkers are associated with total brain volume: the Framingham Heart Study
    A L Jefferson
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
    Neurology 68:1032-8. 2007
    ..We hypothesized that inflammatory biomarkers would be associated with neuroimaging markers of ischemia (i.e., white matter hyperintensities [WMH]) and AD (i.e., total brain volume [TCB])...
  30. ncbi request reprint Rate of progression differs in frontotemporal dementia and Alzheimer disease
    K Rascovsky
    University of California, San Diego, La Jolla, CA 92093 0948, USA
    Neurology 65:397-403. 2005
    ..To compare survival and rates of cognitive and functional decline in patients with autopsy-confirmed frontotemporal dementia (FTD) and Alzheimer disease (AD) in a large multicenter study...
  31. pmc Quantitative brain measurements in community-dwelling elderly persons with mild parkinsonian signs
    Elan D Louis
    Unit 198, Department of Neurology, Columbia University, 710 W 168th St, New York, NY 10032, USA
    Arch Neurol 65:1649-54. 2008
    ..Also, if MPS are a marker for developing Alzheimer-type changes, hippocampal volume on MRI might be diminished in individuals with MPS...
  32. pmc White matter changes compromise prefrontal cortex function in healthy elderly individuals
    Christine Wu Nordahl
    University of California at Davis, Sacramento, CA 95817, USA
    J Cogn Neurosci 18:418-29. 2006
    ..These results suggest that disruption of white matter tracts, especially within the PFC, may be a mechanism for age-related changes in memory functioning...
  33. pmc Age and education effects on relationships of cognitive test scores with brain structure in demographically diverse older persons
    Dan Mungas
    Department of Neurology, School of Medicine, University of California, Davis, Sacremento, CA 95817, USA
    Psychol Aging 24:116-28. 2009
    ....
  34. pmc Carotid artery atherosclerosis, MRI indices of brain ischemia, aging, and cognitive impairment: the Framingham study
    Jose R Romero
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
    Stroke 40:1590-6. 2009
    ..The relation of carotid atherosclerosis to cognitive impairment and MRI indices of ischemia and aging in midlife is less clear...
  35. pmc MCI is associated with deficits in everyday functioning
    Sarah T Farias
    Department of Neurology, University of California, Davis, CA, USA
    Alzheimer Dis Assoc Disord 20:217-23. 2006
    ..The current findings suggest that individuals with MCI demonstrate deficits in a wide range of everyday functions but that the magnitude of these changes is greatest for those functional abilities that rely heavily on memory...
  36. ncbi request reprint Oxidized plasma high-density lipoprotein is decreased in Alzheimer's disease
    Constanze Bergt
    Department of Internal Medicine, University of California, Davis, CA 95616, USA
    Free Radic Biol Med 41:1542-7. 2006
    ..We suggest that additional mechanisms, including increased antioxidant production and/or altered lipoprotein metabolism, might be involved in AD pathology...
  37. pmc Different mechanisms of episodic memory failure in mild cognitive impairment
    Christine Wu Nordahl
    Center for Neuroscience, University of California at Davis, Davis, CA, USA
    Neuropsychologia 43:1688-97. 2005
    ..Although both syndromes are associated with episodic memory deficits, CVD is additionally associated with working memory and executive control deficits...
  38. pmc Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:10256-61. 2010
    ....
  39. pmc Spatially localized hippocampal shape analysis in late-life cognitive decline
    Jing Xie
    Department of Computer Science, University of California, Davis, California 95618, USA
    Hippocampus 19:526-32. 2009
    ..Furthermore, the energy function minimized by the shape component optimization technique is shown to be smooth with few local minima, suggesting that the method may be relatively easy to apply in practice...
  40. pmc Progression of mild cognitive impairment to dementia in clinic- vs community-based cohorts
    Sarah Tomaszewski Farias
    Department of Neurology, University of California, Davis, 4860 Y St, Ste 3700, Sacramento, CA 95817, USA
    Arch Neurol 66:1151-7. 2009
    ..Annual conversion rates, however, vary across different studies with clinic samples showing higher rates of conversion than community-based samples...
  41. pmc Measuring cognitive reserve based on the decomposition of episodic memory variance
    Bruce R Reed
    Department of Neurology, School of Medicine, University of California, Davis, CA, USA
    Brain 133:2196-209. 2010
    ..Decomposing the variance in cognitive function scores offers a promising new approach to the measure and study of cognitive reserve...
  42. pmc Heterogeneity of cognitive trajectories in diverse older persons
    Dan Mungas
    Department of Neurology, School of Medicine, University of California, Sacramento, CA 95817, USA
    Psychol Aging 25:606-19. 2010
    ....
  43. pmc Brain structure and cerebrovascular risk in cognitively impaired patients: Shanghai Community Brain Health Initiative-pilot phase
    Jing He
    Department of Neurology, University of California at Davis, Sacramento, CA 95817, USA
    Arch Neurol 67:1231-7. 2010
    ....
  44. pmc Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer disease neuroimaging initiative
    Owen Carmichael
    Department of Neurology, School of Medicine, University of California, Davis, CA, USA
    Arch Neurol 67:1370-8. 2010
    ....
  45. pmc The measurement of everyday cognition (ECog): scale development and psychometric properties
    Sarah Tomaszewski Farias
    Department of Neurology, University of California, CA 95817, USA
    Neuropsychology 22:531-44. 2008
    ..Different subtypes of MCI also showed different patterns. Results suggest the ECog shows promise as a useful tool for the measurement of general and domain-specific everyday functions in the elderly...
  46. pmc Differences in brain volume, hippocampal volume, cerebrovascular risk factors, and apolipoprotein E4 among mild cognitive impairment subtypes
    Jing He
    Department of Neurology, and the Imaging of Dementia and Aging Laboratory, Center for Neuroscience Preventive Medicine, University of California at Davis, Sacramento, CA 95817, USA
    Arch Neurol 66:1393-9. 2009
    ..To evaluate demographics, magnetic resonance imaging (MRI) measures, and vascular risk among mild cognitive impairment (MCI) subtypes...
  47. pmc Criterion-referenced validity of a neuropsychological test battery: equivalent performance in elderly Hispanics and non-Hispanic Whites
    Dan Mungas
    Department of Neurology, School of Medicine, University of California, Davis, Sacramento, California 95817, USA
    J Int Neuropsychol Soc 11:620-30. 2005
    ..Object naming improved discrimination of CIND from demented beyond that of verbal memory alone. These results provide evidence of equivalent validity across Hispanics and Whites...
  48. pmc MRI non-uniformity correction through interleaved bias estimation and B-spline deformation with a template
    E Fletcher
    Imaging of Dementia and Aging IDeA Laboratory, Department of Neurology, University of California, Davis, CA 95616, USA
    Conf Proc IEEE Eng Med Biol Soc 2012:106-9. 2012
    ..This bias field correction method has the potential to be more accurate than correction schemes based solely on intrinsic image properties or hypothetical image intensity distributions...
  49. pmc Memory after silent stroke: hippocampus and infarcts both matter
    S Blum
    Gertrude H Sergievsky Center, Department of Neurology, Columbia University, New York, NY, USA
    Neurology 78:38-46. 2012
    ..However, the contribution of vascular lesions, such as brain infarcts, to hippocampal integrity and age-associated memory decline remains unclear...
  50. ncbi request reprint The role of neuroimaging in dementia
    C DeCarli
    Department of Neurology, University of California, Davis, California, USA
    Clin Geriatr Med 17:255-79. 2001
    ..This article reviews the basic concepts of brain imaging and clinical application. It concludes with a brief discussion of future directions in neuroimaging for the diagnosis and longitudinal follow-up of Alzheimer's disease...
  51. pmc Alzheimer abnormalities of the amygdala with Klüver-Bucy syndrome symptoms: an amygdaloid variant of Alzheimer disease
    Shawn J Kile
    Department of Neurology, University of California at Davis, 4860 Y St, Ste 3700, Sacramento, CA 95817, USA
    Arch Neurol 66:125-9. 2009
    ..Neurofibrillary tangles and beta-amyloid plaques have been observed in the amygdala in Alzheimer disease. A disproportionate abundance of this abnormality in the amygdala may cause behavioral symptoms similar to Klüver-Bucy syndrome...
  52. pmc Profiles by sex of brain MRI and cognitive function in the framingham offspring study
    Mark Albert
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118 2526, USA
    Alzheimer Dis Assoc Disord 24:190-3. 2010
    ..To examine whether there are sex-specific associations between brain magnetic resonance imaging (MRI) measures and neuropsychologic (NP) test performance...
  53. ncbi request reprint Association of white matter hyperintensity volume with decreased cognitive functioning: the Framingham Heart Study
    Rhoda Au
    Department of Neurology, Boston University School of Medicine, Boston, Mass 02118 2526, USA
    Arch Neurol 63:246-50. 2006
    ..To examine the relationship between white matter hyperintensity (WMH) volume on magnetic resonance images and cognitive tests in a large, population-based sample...
  54. ncbi request reprint A pilot study of vitamins to lower plasma homocysteine levels in Alzheimer disease
    Paul S Aisen
    Department of Neurology, Georgetown University Medical Center, Washington, DC 20007, USA
    Am J Geriatr Psychiatry 11:246-9. 2003
    ..Authors determined the impact of high-dose vitamin supplements on plasma homocysteine levels in patients with Alzheimer disease (AD)...
  55. ncbi request reprint Sex, apolipoprotein E epsilon 4 status, and hippocampal volume in mild cognitive impairment
    Adam Fleisher
    Department of Neurosciences, University of California San Diego, La Jolla, Calif, USA
    Arch Neurol 62:953-7. 2005
    ..The presence of the apolipoprotein E epsilon4 (APOE*E4) allele has been associated with greater hippocampal atrophy in women than in men with Alzheimer disease. This relationship has not been demonstrated in MCI...
  56. ncbi request reprint Molecular and imaging correlates of the fragile X-associated tremor/ataxia syndrome
    S Cohen
    Department of Human Development, University of California Davis Medical Center, 2825 50 St, Sacramento, CA 95817, USA
    Neurology 67:1426-31. 2006
    ..To assess changes in regional brain volumes associated with the fragile X-associated tremor/ataxia syndrome (FXTAS) and the molecular correlates of these changes...
  57. ncbi request reprint What does fluorodeoxyglucose PET imaging add to a clinical diagnosis of dementia?
    W Jagust
    Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720 3190, USA
    Neurology 69:871-7. 2007
    ..Few studies have compared the accuracy of [(18)F]fluorodeoxyglucose (FDG) PET to the accuracy of clinical and pathologic diagnosis in dementia patients...
  58. ncbi request reprint Genetic variation in white matter hyperintensity volume in the Framingham Study
    Larry D Atwood
    Department of Neurology, Boston University School of Medicine, 715 Albany Street, B 609, Boston, Mass 02118, USA
    Stroke 35:1609-13. 2004
    ..73). We investigated heritability of WMH in a family-based sample of the Framingham Heart Study for sex differences and the impact of age...
  59. pmc Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study
    Stephanie Debette
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
    Stroke 41:600-6. 2010
    ..We simultaneously assessed the relation of white matter hyperintensities and BI with incident stroke, mild cognitive impairment, dementia, and mortality in a middle-aged community-based cohort...
  60. pmc Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE Consortium
    Stephanie Debette
    Department of Neurology, Boston University School of Medicine, Boston, Mass, USA
    Stroke 41:210-7. 2010
    ..We performed meta-analysis of genome-wide association studies of white participants in 6 studies comprising the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium...
  61. pmc Current concepts of analysis of cerebral white matter hyperintensities on magnetic resonance imaging
    Mitsuhiro Yoshita
    Imaging of Dementia and Aging Laboratory, Department of Neurology and Center for Neuroscience, University of California at Davis, Davis, CA 95817, USA
    Top Magn Reson Imaging 16:399-407. 2005
    ..We conclude by discussing future analytic methods designed to better understand the pathophysiology and cognitive consequences of WMHs...
  62. pmc Prevalence and correlates of silent cerebral infarcts in the Framingham offspring study
    Rohit R Das
    Department of Neurology, Boston University, Boston, MA 02118, USA
    Stroke 39:2929-35. 2008
    ..8% and 17.7% depending on age, ethnicity, presence of comorbidities, and imaging techniques. We document the prevalence and risk factors associated with SCI at midlife in the community-based Framingham sample...
  63. ncbi request reprint Cerebrospinal fluid tau and beta-amyloid: how well do these biomarkers reflect autopsy-confirmed dementia diagnoses?
    Christopher M Clark
    Departments of Neurology, Center for Neuerodegenerative Disease Research, Alzheimer s Disease Center, Philadelphia, PA 19104, USA
    Arch Neurol 60:1696-702. 2003
    ..To understand their value as predictors of disease-specific pathology, levels determined during life must be correlated with definitive diagnoses in mixed dementia groups and cognitively normal subjects...
  64. pmc White matter hyperintensities and subclinical infarction: associations with psychomotor speed and cognitive flexibility
    Clinton B Wright
    Division of Stroke and Critical Care, Department of Neurology, College of Physicians and Surgeons of Columbia University, NI Room 640, 710 W168th Street, New York, NY 10032, USA
    Stroke 39:800-5. 2008
    ..We examined white matter hyperintensity volume (WMHV) and subclinical infarction (no history of clinical stroke; SI) in relation to performance on tests of sequencing, cognitive flexibility, and sensorimotor ability...
  65. pmc Cardiac index is associated with brain aging: the Framingham Heart Study
    Angela L Jefferson
    Department of Neurology, Alzheimer s Disease Center, Boston University School of Medicine, 72 E Concord St, B 7800, Boston, MA 02118, USA
    Circulation 122:690-7. 2010
    ..We hypothesized that cardiac function, as measured by cardiac index, would be associated with preclinical brain magnetic resonance imaging (MRI) and neuropsychological markers of ischemia and Alzheimer disease in the community...
  66. pmc Visceral fat is associated with lower brain volume in healthy middle-aged adults
    Stephanie Debette
    Department of Neurology, Boston University School of Medicine, MA, USA
    Ann Neurol 68:136-44. 2010
    ....
  67. pmc A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
    April J Ho
    Laboratory of Neuroimaging, Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:8404-9. 2010
    ..These brain maps reveal that a commonly carried susceptibility allele for obesity is associated with structural brain atrophy, with implications for the health of the elderly...
  68. pmc White matter hyperintensity penumbra
    Pauline Maillard
    Department of Neurology and Center for Neuroscience, School of Medicine, University of California, Davis, Davis, CA, USA
    Stroke 42:1917-22. 2011
    ..Diffusion tensor imaging provides more sensitive indications of subtle white matter disruption and can therefore clarify whether WMHs represent foci of generalized white matter damage that extends over a broader neighborhood...
  69. pmc Late life cognitive control deficits are accentuated by white matter disease burden
    Adriane B V Mayda
    Centre for Neuroscience, University of California, Davis, Department of Neurology 4860 Y St, Suite 3700 Sacramento, CA 95817, USA
    Brain 134:1673-83. 2011
    ..These results suggest that age-related goal maintenance impairments and associated dorsolateral prefrontal cortex dysfunction may partly reflect incipient white matter disease of interconnected cognitive networks...
  70. pmc Heritability of lobar brain volumes in twins supports genetic models of cerebral laterality and handedness
    Daniel H Geschwind
    Program in Neurogenetics, Department of Neurology, University of California School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Proc Natl Acad Sci U S A 99:3176-81. 2002
    ....
  71. ncbi request reprint Prevention of white-matter lesions through control of cerebrovascular risk factors
    Charles DeCarli
    UC Davis Alzheimer s Disease Center, Sacramento, CA 95817, USA
    Int Psychogeriatr 15:147-51. 2003
    ..Treatment strategies, therefore, should focus on early and aggressive management of elevated blood pressure, but definitions of elevated blood pressure may need to be revised downward to achieve best results...
  72. pmc Total homocysteine is associated with white matter hyperintensity volume: the Northern Manhattan Study
    Clinton B Wright
    Department of Neurology, Columbia University College of Physicians and Surgeons and the Mailman School of Public Health, New York, NY, USA
    Stroke 36:1207-11. 2005
    ..White matter hyperintensities may be a risk factor for both, but studies of the relationship between tHcy and quantitative measures of white matter hyperintensity volume (WMHV) are lacking, especially in minority populations...
  73. pmc Inflammatory biomarkers of vascular risk as correlates of leukoariosis
    Clinton B Wright
    Department of Neurology, Miller School of Medicine, University of Miami, Evelyn F McKnight Center for Age related Memory Loss, Miami, FL 33136, USA
    Stroke 40:3466-71. 2009
    ..White matter hyperintensities (WMH) seen on brain MRI scans are associated with vascular risk factors and an increased risk of incident stroke, but their relation to inflammatory biomarkers is unclear...
  74. pmc Estimating uncertainty in brain region delineations
    Karl R Beutner
    University of California at Davis, Davis CA 95616, USA
    Inf Process Med Imaging 21:479-90. 2009
    ..The approach is also general enough to accommodate a wide range of shape models and brain regions...
  75. pmc Fully-automated white matter hyperintensity detection with anatomical prior knowledge and without FLAIR
    Christopher Schwarz
    Computer Science Department, University of California, Davis, CA 95618, USA
    Inf Process Med Imaging 21:239-51. 2009
    ..The method is also shown to perform well when training and test data are drawn from distinct scanners and subject pools...
  76. pmc Chronic kidney disease is associated with white matter hyperintensity volume: the Northern Manhattan Study (NOMAS)
    Minesh Khatri
    Division of Stroke and Critical Care, Department of Neurology, College of Physicians and Surgeons of Columbia University, NI Room 640, 710 W 168th Street, New York, NY 10032, USA
    Stroke 38:3121-6. 2007
    ..Few studies have explored the relationship between chronic kidney disease and white matter hyperintensities...
  77. ncbi request reprint A bivariate genetic analysis of cerebral white matter hyperintensities and cognitive performance in elderly male twins
    Dorit Carmelli
    Center for Health Sciences, SRI International, Menlo Park, CA, USA
    Neurobiol Aging 23:413-20. 2002
    ..We conclude from these analyses that common genetic influences explain to a large extent previously observed phenotypic associations between large amounts of WMHs and poor cognitive and physical function in the elderly...
  78. ncbi request reprint Vascular cognitive impairment
    John T O'Brien
    Institute for Aging and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Lancet Neurol 2:89-98. 2003
    ..Clinical trials in vascular cognitive impairment are in their infancy but support the value of therapeutic interventions for symptomatic treatment...
  79. pmc Multiple SNPs within and surrounding the apolipoprotein E gene influence cerebrospinal fluid apolipoprotein E protein levels
    Lynn M Bekris
    Geriatric Research, Education, and Clinical Center GRECC, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    J Alzheimers Dis 13:255-66. 2008
    ..Further investigation of the genetic influence of these loci on apoE expression levels in the central nervous system is likely to provide new insight into apoE regulation as well as AD pathogenesis...
  80. ncbi request reprint Hippocampal volume is associated with memory but not monmemory cognitive performance in patients with mild cognitive impairment
    Michael Grundman
    Department of Neurosciences, University of California, San Diego, La Jolla 92093 0949, USA
    J Mol Neurosci 20:241-8. 2003
    ..We conclude that the relationship between hippocampal volume and risk of AD is likely tied to reduced memory performance and not associated with impairment in nonmemory cognitive domains...
  81. pmc Intensity non-uniformity correction using N3 on 3-T scanners with multichannel phased array coils
    Richard G Boyes
    Dementia Research Centre, Institute of Neurology, Box 16, University College London, Queen Square, London, UK
    Neuroimage 39:1752-62. 2008
    ....
  82. ncbi request reprint Radial width of the temporal horn: a sensitive measure in Alzheimer disease
    Giovanni B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, via Pilastroni 4, I 25123 Brescia, Italy
    AJNR Am J Neuroradiol 23:35-47. 2002
    ..The aim of this study was to explore the validity of a CT- and MR-based measure of MTL atrophy that would be feasible for routine clinical use...
  83. pmc Neuropathological basis of magnetic resonance images in aging and dementia
    William J Jagust
    School of Public Health and Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720 3190, USA
    Ann Neurol 63:72-80. 2008
    ..Magnetic resonance (MR) imaging is used widely for assessment of patients with cognitive impairment, but the pathological correlates are unclear, especially when multiple pathologies are present...
  84. ncbi request reprint Quantitative genetic modeling of regional brain volumes and cognitive performance in older male twins
    Dorit Carmelli
    Center for Health Sciences, SRI International formerly Stanford Research Institute, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Biol Psychol 61:139-55. 2002
    ..These data may shed light on the genetic liability for brain diseases that affect the elderly...
  85. ncbi request reprint Brain MRI hippocampal volume and prediction of clinical status in a mild cognitive impairment trial
    Michael Grundman
    Department of Neurosciences, University of California, San Diego, La Jolla, USA
    J Mol Neurosci 19:23-7. 2002
    ..In summary, these data suggest that MRI hippocampal volume may be a useful correlate of disease severity in MCI subjects and a prognostic indicator of subsequent AD...
  86. ncbi request reprint Framingham stroke risk profile and lowered cognitive performance
    Merrill F Elias
    Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA
    Stroke 35:404-9. 2004
    ....
  87. pmc Association of alcohol consumption with brain volume in the Framingham study
    Carol Ann Paul
    Neuroscience Program, Wellesley College, 106 Central St, Wellesley, MA 02418, USA
    Arch Neurol 65:1363-7. 2008
    ..There is evidence that drinking large amounts of alcohol is related to brain atrophy. It is uncertain what the effects of low to moderate consumption might be...
  88. pmc Brain morphology in older African Americans, Caribbean Hispanics, and whites from northern Manhattan
    Adam M Brickman
    Departmentof Neurology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032
    Arch Neurol 65:1053-61. 2008
    ..Aging is accompanied by a decrease in brain volume and by an increase in cerebrovascular disease...
  89. ncbi request reprint National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards
    Vladimir Hachinski
    London Health Sciences Centre, University Campus, London, Ontario, Canada
    Stroke 37:2220-41. 2006
    ....
  90. pmc High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial
    Paul S Aisen
    Department of Neurosciences, University of California, San Diego, 9500 Gilman Dr, M C 0949, La Jolla, CA 92093, USA
    JAMA 300:1774-83. 2008
    ..Prior studies of B vitamins to reduce homocysteine in AD have not had sufficient size or duration to assess their effect on cognitive decline...
  91. ncbi request reprint Age and apolipoprotein E*4 allele effects on cerebrospinal fluid beta-amyloid 42 in adults with normal cognition
    Elaine R Peskind
    VA Puget Sound Health Care System, Mental Illness Research, Education, and Clinical Center, Seattle, WA 98108, USA
    Arch Neurol 63:936-9. 2006
    ..Normal aging and the presence of the apolipoprotein E (APOE*4) allele are the most important known risk factors for Alzheimer disease...
  92. ncbi request reprint Cerebral microbleeds: prevalence and associations with cardiovascular risk factors in the Framingham Study
    Tom Jeerakathil
    Department of Neurology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton
    Stroke 35:1831-5. 2004
    ..We examined these relationships in the Framingham Study (FHS)...
  93. pmc Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study
    Sudha Seshadri
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S15. 2007
    ..We conducted a genome-wide association (GWA) and linkage analysis exploring the genetic basis of these endophenotypes in a community-based sample...
  94. ncbi request reprint Safety and acceptability of the research lumbar puncture
    Elaine R Peskind
    VA Puget Sound Health Care System, Mental Illness Research, Education and Clinical Center MIRECC, University of Washington School of Medicine, Seattle, WA 98108, USA
    Alzheimer Dis Assoc Disord 19:220-5. 2005
    ....
  95. ncbi request reprint The Uniform Data Set (UDS): clinical and cognitive variables and descriptive data from Alzheimer Disease Centers
    John C Morris
    Washington University, St Louis, MO 63108, USA
    Alzheimer Dis Assoc Disord 20:210-6. 2006
    ..Data obtained with the UDS are submitted to the National Alzheimer's Coordinating Center and represent a unique and valuable source of data to support and stimulate collaborative research...
  96. ncbi request reprint Genome-wide scan for white matter hyperintensity: the Framingham Heart Study
    Anita L Destefano
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Stroke 37:77-81. 2006
    ..We performed a genome-wide linkage analysis to identify chromosomal regions that may harbor genes influencing WMH in a family-based sample of the Framingham Heart Study...
  97. ncbi request reprint Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis
    Thor D Stein
    Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin 53705 2222, USA
    J Neurosci 24:7707-17. 2004
    ..Therefore, the elevated expression of transthyretin is mediated by sAPPalpha and protects APP(Sw) mice from developing many of the neuropathologies observed in AD...
  98. ncbi request reprint Heritability of magnetic resonance imaging (MRI) traits in Alzheimer disease cases and their siblings in the MIRAGE study
    Kathryn L Lunetta
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Alzheimer Dis Assoc Disord 21:85-91. 2007
    ..In the Multi-Institutional Research in Alzheimer's Genetic Epidemiology Study of AD-discordant siblings, MRI traits are heritable and are potential endophenotypes for genetic association studies...
  99. ncbi request reprint Regional NAD(P)H:quinone oxidoreductase activity in Alzheimer's disease
    Karen S SantaCruz
    Department of Pathology and Laboratory Medicine, University of Kansas School of Medicine, KS 66160, USA
    Neurobiol Aging 25:63-9. 2004
    ....
  100. ncbi request reprint Diagnostic criteria for the behavioral variant of frontotemporal dementia (bvFTD): current limitations and future directions
    Katya Rascovsky
    Memory and Aging Center, University of California, San Francisco, CA 94117, USA
    Alzheimer Dis Assoc Disord 21:S14-8. 2007
    ..In this article, we discuss the limitations of current diagnostic criteria and propose the establishment of an international consortium to revise diagnostic and research criteria for the behavioral variant of frontotemporal dementia...
  101. ncbi request reprint Vascular dementia: emerging trends
    Neelum T Aggarwal
    Rush Alzheimer s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Semin Neurol 27:66-77. 2007
    ..Primary treatment is through primary or secondary modification of cerebrovascular risk factors such as hypertension, although symptomatic treatments with cholinesterase inhibitors have shown modest symptomatic benefit...