Research Topics
Species | Mark Daniel DeBoerSummaryAffiliation: University of Virginia Country: USA Publications
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Detail Information
Publications
Ability among adolescents for the metabolic syndrome to predict elevations in factors associated with type 2 diabetes and cardiovascular disease: data from the national health and nutrition examination survey 1999-2006Mark D DeBoer
Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia, USA
Metab Syndr Relat Disord 8:343-53. 2010..These surrogate factors were fasting insulin, hemoglobin A1c (HbA1c), high-sensitivity C-reactive protein (hsCRP), and uric acid...
Longitudinal evaluation of milk type consumed and weight status in preschoolersRebecca J Scharf
Division of Pediatric Endocrinology, University of Virginia School of Medicine, PO Box 800386, Charlottesville, VA 22908, USA
Arch Dis Child 98:335-40. 2013..To evaluate relationships between type of milk consumed and weight status among preschool children...- Obesity, systemic inflammation, and increased risk for cardiovascular disease and diabetes among adolescents: A need for screening tools to target interventionsMark D DeBoer
Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA Electronic address
Nutrition 29:379-86. 2013..Such tests may have utility in motivating physicians and patients' families toward lifestyle changes, ultimately improving prevention efforts... - Early childhood growth failure and the developmental origins of adult disease: do enteric infections and malnutrition increase risk for the metabolic syndrome?Mark D DeBoer
Division of Pediatric Endocrinology, Department of Pediatrics, University of Virginia, Charlottesville, VA, USA
Nutr Rev 70:642-53. 2012.... - Racial/ethnic and sex differences in the ability of metabolic syndrome criteria to predict elevations in fasting insulin levels in adolescentsMark D DeBoer
Department of Pediatrics, University of Virginia, Charlottesville, VA, USA
J Pediatr 159:975-81.e3. 2011..To evaluate racial/ethnic and sex differences in the relationship between metabolic syndrome (MetS) diagnosis and fasting insulin in adolescents... 
The use of ghrelin and ghrelin receptor agonists as a treatment for animal models of disease: efficacy and mechanismMark D DeBoer
Department of Pediatrics, Division of Pediatric Endocrinology, University of Virginia, P O Box 800386, Charlottesville, VA 22908, USA
Curr Pharm Des 18:4779-99. 2012..Further investigation using animal models may help to determine mechanisms that are most operative in these disease states and narrow treatment parameters helpful for human application...- Partial normalization of pubertal timing in female mice with DSS colitis treated with anti-TNF-α antibodyMark Daniel DeBoer
Division of Pediatric Endocrinology, University of Virginia, Charlottesville, VA 22908, USA
J Gastroenterol 47:647-54. 2012..Our objective in this study was to determine whether there is a normalization of the timing of puberty during treatment of colitis using monoclonal antibodies (abs) to tumor necrosis factor (TNF)-α... - Changes in inflammation and QoL after a single dose of infliximab during ongoing IBD treatmentMark D DeBoer
Division of Pediatric Endocrinology, University of Virginia, Charlottesville, VA 22908, USA
J Pediatr Gastroenterol Nutr 54:486-90. 2012.... - Racial/ethnic and sex differences in the relationship between uric acid and metabolic syndrome in adolescents: an analysis of National Health and Nutrition Survey 1999-2006Mark D DeBoer
Department of Pediatrics, University of Virginia, PO Box 800386, Charlottesville, VA 22908, USA
Metabolism 61:554-61. 2012..These data may have implications for the use of uric acid as a marker of future risk among adolescents... - Increased systemic inflammation overnight correlates with insulin resistance among children evaluated for obstructive sleep apneaMark D DeBoer
Division of Pediatric Endocrinology, P O Box 800386, Charlottesville, VA 22908, USA
Sleep Breath 16:349-54. 2012..Our goal was to evaluate whether inflammation increases overnight among children suspected of having OSA and to determine whether worsened inflammation is associated with the degree of OSA severity, obesity, and/or insulin resistance... - Low sensitivity for the metabolic syndrome to detect uric acid elevations in females and non-Hispanic-black male adolescents: an analysis of NHANES 1999-2006Mark D DeBoer
Department of Pediatrics, University of Virginia, Charlottesville, VA 22908, United States
Atherosclerosis 220:575-80. 2012..Uric acid is tightly linked to the metabolic syndrome (MetS) and among adults higher uric acid levels are associated with future risk for diabetes, cardiovascular disease, hypertension and renal disease... - Ghrelin and cachexia: will treatment with GHSR-1a agonists make a difference for patients suffering from chronic wasting syndromes?Mark D DeBoer
Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
Mol Cell Endocrinol 340:97-105. 2011..Questions regarding the long-term safety of ghrelin treatment are still unanswered, as is the important question of whether successful treatment of cachexia will improve the prognosis of the underlying disease itself... - Diagnosis of the metabolic syndrome is associated with disproportionately high levels of high-sensitivity C-reactive protein in non-Hispanic black adolescents: an analysis of NHANES 1999-2008Mark D DeBoer
Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA
Diabetes Care 34:734-40. 2011..Our goal was to determine whether elevations of hsCRP vary by race/ethnicity among adolescents with MetS... - Puberty is delayed in male mice with dextran sodium sulfate colitis out of proportion to changes in food intake, body weight, and serum levels of leptinMark D DeBoer
Department of Pediatrics, University of Virginia, Charlottesville, Virginia 22908, USA
Pediatr Res 69:34-9. 2011..These experiments provide support for the hypothesis that pubertal delay in colitis is influenced by factors beyond poor weight gain alone... - Colitis causes delay in puberty in female mice out of proportion to changes in leptin and corticosteroneMark D DeBoer
Division of Pediatric Endocrinology, Department of Pediatrics, University of Virginia, P O Box 800386, Charlottesville, VA 22908, USA
J Gastroenterol 45:277-84. 2010..A major cause of this pubertal delay is likely due in part to the effect of decreased levels of leptin on the function of the hypothalamic-pituitary-gonadal axis, though systemic inflammation is also thought to play a role... - Update on melanocortin interventions for cachexia: progress toward clinical applicationMark Daniel DeBoer
Division of Pediatric Endocrinology, University of Virginia, Charlottesville, Virginia, USA
Nutrition 26:146-51. 2010..However, to date, human application has remained elusive and it is unclear when we will know whether humans with cachexia would benefit from treatment with these compounds... - Failure-to-thrive in an infant following injection of capillary hemangioma with triamcinolone acetonideMark D DeBoer
Division of Pediatric Endocrinology, Department of Pediatrics, University of Virginia, Charlottesville, Virginia 22908, USA
Clin Pediatr (Phila) 47:296-9. 2008 - Administration of IL-1beta to the 4th ventricle causes anorexia that is blocked by agouti-related peptide and that coincides with activation of tyrosine-hydroxylase neurons in the nucleus of the solitary tractMark D DeBoer
Department of Pediatrics, Oregon Health and Science University, USA
Peptides 30:210-8. 2009..This provides evidence that the brainstem may be an important mediator of anorexia in the setting of inflammation... - Emergence of ghrelin as a treatment for cachexia syndromesMark Daniel DeBoer
Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA
Nutrition 24:806-14. 2008..Also uncertain--but an intriguing possibility--is whether the improved weight gain with ghrelin treatment might also lessen the severity of the underlying disease and improve outcomes... - Cachexia: lessons from melanocortin antagonismMark D DeBoer
Department of Pediatrics, Oregon Health and Science University, 707 SW Gaines Rd, Portland, Oregon 97239, USA
Trends Endocrinol Metab 17:199-204. 2006..This successful inhibition of cachexia is important because loss of appetite and lean body mass worsen the prognosis of many the diseases with which cachexia is associated... - Differential presentation for children with autoimmune thyroiditis discovered because of symptom development or screeningMark D DeBoer
Department of Pediatrics, Division of Pediatric Endocrinology, University of Virginia, Charlottesville, VA 22908 0386, USA
J Pediatr Endocrinol Metab 21:753-61. 2008.... - Melanocortin interventions in cachexia: how soon from bench to bedside?Mark D DeBoer
Division of Endocrinology, University of Virginia, Charlottesville, Virginia 22908, USA
Curr Opin Clin Nutr Metab Care 10:457-62. 2007..This review focuses on cachexia treatment interventions that act via melanocortin antagonism, by direct or indirect means... - Ghrelin treatment of chronic kidney disease: improvements in lean body mass and cytokine profileMark D DeBoer
Department of Pediatrics, University of Virginia, Charlottesville, VA 22908, USA
Endocrinology 149:827-35. 2008..We conclude that ghrelin treatment in uremia results in improved lean mass accrual in part due to suppressed muscle proteolysis and possibly related to antiinflammatory effects... - Ghrelin treatment causes increased food intake and retention of lean body mass in a rat model of cancer cachexiaMark D DeBoer
Center for the Study of Weight Regulation, Oregon Health and Science University, 707 SW Gaines Road, Portland, OR 97239, USA
Endocrinology 148:3004-12. 2007..We conclude that ghrelin and a synthetic ghrelin receptor agonist improve weight gain and lean body mass retention via effects involving orexigenic neuropeptides and antiinflammatory changes... - Therapy insight: Use of melanocortin antagonists in the treatment of cachexia in chronic diseaseMark D DeBoer
Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239-2901, USA
Nat Clin Pract Endocrinol Metab 2:459-66. 2006..Although this research needs to be substantiated in humans, it provides a promising direction for treating the wasting that is associated with a variety of disease states... - Socioeconomic factors in the development of childhood obesity and diabetesDAVID C LIEB
Department of Medicine, Division of Endocrinology, University of Virginia School of Medicine, PO Box 800793, Charlottesville, VA 22908, USA
Clin Sports Med 28:349-78. 2009..As our society attempts to improve the lifestyle of our children and decrease rates of obesity, it will be important to give focus to children of lower socioeconomic backgrounds in planning these potential interventions... - Pediatric thyroid testing issuesMark D DeBoer
Department of Pediatrics, Division of Endocrinology, University of Virginia, VA, USA
Pediatr Endocrinol Rev 5:570-7. 2007..Additionally, heterophile and anti-T4 or anti-TSH antibodies can interfere with accurate T4 or TSH measurement...