Mark Daniel DeBoer

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc Ability among adolescents for the metabolic syndrome to predict elevations in factors associated with type 2 diabetes and cardiovascular disease: data from the national health and nutrition examination survey 1999-2006
    Mark D DeBoer
    Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Metab Syndr Relat Disord 8:343-53. 2010
  2. doi request reprint Sugar-sweetened beverages and weight gain in 2- to 5-year-old children
    Mark D DeBoer
    MSc, MCR, Division of Pediatric Endocrinology, University of Virginia School of Medicine, PO Box 800386, Charlottesville, VA 22908
    Pediatrics 132:413-20. 2013
  3. doi request reprint Early childhood diarrhea and cardiometabolic risk factors in adulthood: the Institute of Nutrition of Central America and Panama Nutritional Supplementation Longitudinal Study
    Mark D DeBoer
    Department of Pediatrics, University of Virginia, Charlottesville, VA 22901, USA
    Ann Epidemiol 23:314-20. 2013
  4. doi request reprint Longitudinal evaluation of milk type consumed and weight status in preschoolers
    Rebecca J Scharf
    Division of Pediatric Endocrinology, University of Virginia School of Medicine, PO Box 800386, Charlottesville, VA 22908, USA
    Arch Dis Child 98:335-40. 2013
  5. pmc Obesity, systemic inflammation, and increased risk for cardiovascular disease and diabetes among adolescents: a need for screening tools to target interventions
    Mark D DeBoer
    Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA
    Nutrition 29:379-86. 2013
  6. pmc Racial/ethnic and sex differences in the ability of metabolic syndrome criteria to predict elevations in fasting insulin levels in adolescents
    Mark D DeBoer
    Department of Pediatrics, University of Virginia, Charlottesville, VA, USA
    J Pediatr 159:975-81.e3. 2011
  7. pmc Early childhood growth failure and the developmental origins of adult disease: do enteric infections and malnutrition increase risk for the metabolic syndrome?
    Mark D DeBoer
    Division of Pediatric Endocrinology, Department of Pediatrics, University of Virginia, Charlottesville, VA, USA
    Nutr Rev 70:642-53. 2012
  8. ncbi request reprint The use of ghrelin and ghrelin receptor agonists as a treatment for animal models of disease: efficacy and mechanism
    Mark D DeBoer
    Department of Pediatrics, Division of Pediatric Endocrinology, University of Virginia, P O Box 800386, Charlottesville, VA 22908, USA
    Curr Pharm Des 18:4779-99. 2012
  9. pmc Partial normalization of pubertal timing in female mice with DSS colitis treated with anti-TNF-α antibody
    Mark Daniel DeBoer
    Division of Pediatric Endocrinology, University of Virginia, Charlottesville, VA 22908, USA
    J Gastroenterol 47:647-54. 2012
  10. pmc Racial/ethnic and sex differences in the relationship between uric acid and metabolic syndrome in adolescents: an analysis of National Health and Nutrition Survey 1999-2006
    Mark D DeBoer
    Department of Pediatrics, University of Virginia, PO Box 800386, Charlottesville, VA 22908, USA
    Metabolism 61:554-61. 2012

Detail Information

Publications29

  1. pmc Ability among adolescents for the metabolic syndrome to predict elevations in factors associated with type 2 diabetes and cardiovascular disease: data from the national health and nutrition examination survey 1999-2006
    Mark D DeBoer
    Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Metab Syndr Relat Disord 8:343-53. 2010
    ..These surrogate factors were fasting insulin, hemoglobin A1c (HbA1c), high-sensitivity C-reactive protein (hsCRP), and uric acid...
  2. doi request reprint Sugar-sweetened beverages and weight gain in 2- to 5-year-old children
    Mark D DeBoer
    MSc, MCR, Division of Pediatric Endocrinology, University of Virginia School of Medicine, PO Box 800386, Charlottesville, VA 22908
    Pediatrics 132:413-20. 2013
    ..Our objective was to evaluate longitudinal and cross-sectional relationships between SSB consumption and weight status among children aged 2 to 5 years...
  3. doi request reprint Early childhood diarrhea and cardiometabolic risk factors in adulthood: the Institute of Nutrition of Central America and Panama Nutritional Supplementation Longitudinal Study
    Mark D DeBoer
    Department of Pediatrics, University of Virginia, Charlottesville, VA 22901, USA
    Ann Epidemiol 23:314-20. 2013
    ..Our objective was to examine associations between early childhood diarrhea burden and later development of MetS...
  4. doi request reprint Longitudinal evaluation of milk type consumed and weight status in preschoolers
    Rebecca J Scharf
    Division of Pediatric Endocrinology, University of Virginia School of Medicine, PO Box 800386, Charlottesville, VA 22908, USA
    Arch Dis Child 98:335-40. 2013
    ..To evaluate relationships between type of milk consumed and weight status among preschool children...
  5. pmc Obesity, systemic inflammation, and increased risk for cardiovascular disease and diabetes among adolescents: a need for screening tools to target interventions
    Mark D DeBoer
    Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA
    Nutrition 29:379-86. 2013
    ..Such tests may have utility in motivating physicians and patients' families toward lifestyle changes, ultimately improving prevention efforts...
  6. pmc Racial/ethnic and sex differences in the ability of metabolic syndrome criteria to predict elevations in fasting insulin levels in adolescents
    Mark D DeBoer
    Department of Pediatrics, University of Virginia, Charlottesville, VA, USA
    J Pediatr 159:975-81.e3. 2011
    ..To evaluate racial/ethnic and sex differences in the relationship between metabolic syndrome (MetS) diagnosis and fasting insulin in adolescents...
  7. pmc Early childhood growth failure and the developmental origins of adult disease: do enteric infections and malnutrition increase risk for the metabolic syndrome?
    Mark D DeBoer
    Division of Pediatric Endocrinology, Department of Pediatrics, University of Virginia, Charlottesville, VA, USA
    Nutr Rev 70:642-53. 2012
    ....
  8. ncbi request reprint The use of ghrelin and ghrelin receptor agonists as a treatment for animal models of disease: efficacy and mechanism
    Mark D DeBoer
    Department of Pediatrics, Division of Pediatric Endocrinology, University of Virginia, P O Box 800386, Charlottesville, VA 22908, USA
    Curr Pharm Des 18:4779-99. 2012
    ..Further investigation using animal models may help to determine mechanisms that are most operative in these disease states and narrow treatment parameters helpful for human application...
  9. pmc Partial normalization of pubertal timing in female mice with DSS colitis treated with anti-TNF-α antibody
    Mark Daniel DeBoer
    Division of Pediatric Endocrinology, University of Virginia, Charlottesville, VA 22908, USA
    J Gastroenterol 47:647-54. 2012
    ..Our objective in this study was to determine whether there is a normalization of the timing of puberty during treatment of colitis using monoclonal antibodies (abs) to tumor necrosis factor (TNF)-α...
  10. pmc Racial/ethnic and sex differences in the relationship between uric acid and metabolic syndrome in adolescents: an analysis of National Health and Nutrition Survey 1999-2006
    Mark D DeBoer
    Department of Pediatrics, University of Virginia, PO Box 800386, Charlottesville, VA 22908, USA
    Metabolism 61:554-61. 2012
    ..These data may have implications for the use of uric acid as a marker of future risk among adolescents...
  11. pmc Changes in inflammation and QoL after a single dose of infliximab during ongoing IBD treatment
    Mark D DeBoer
    Division of Pediatric Endocrinology, University of Virginia, Charlottesville, VA 22908, USA
    J Pediatr Gastroenterol Nutr 54:486-90. 2012
    ....
  12. pmc Increased systemic inflammation overnight correlates with insulin resistance among children evaluated for obstructive sleep apnea
    Mark D DeBoer
    Division of Pediatric Endocrinology, P O Box 800386, Charlottesville, VA 22908, USA
    Sleep Breath 16:349-54. 2012
    ..Our goal was to evaluate whether inflammation increases overnight among children suspected of having OSA and to determine whether worsened inflammation is associated with the degree of OSA severity, obesity, and/or insulin resistance...
  13. pmc Low sensitivity for the metabolic syndrome to detect uric acid elevations in females and non-Hispanic-black male adolescents: an analysis of NHANES 1999-2006
    Mark D DeBoer
    Department of Pediatrics, University of Virginia, Charlottesville, VA 22908, United States
    Atherosclerosis 220:575-80. 2012
    ..Uric acid is tightly linked to the metabolic syndrome (MetS) and among adults higher uric acid levels are associated with future risk for diabetes, cardiovascular disease, hypertension and renal disease...
  14. pmc Ghrelin and cachexia: will treatment with GHSR-1a agonists make a difference for patients suffering from chronic wasting syndromes?
    Mark D DeBoer
    Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Mol Cell Endocrinol 340:97-105. 2011
    ..Questions regarding the long-term safety of ghrelin treatment are still unanswered, as is the important question of whether successful treatment of cachexia will improve the prognosis of the underlying disease itself...
  15. pmc Diagnosis of the metabolic syndrome is associated with disproportionately high levels of high-sensitivity C-reactive protein in non-Hispanic black adolescents: an analysis of NHANES 1999-2008
    Mark D DeBoer
    Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA
    Diabetes Care 34:734-40. 2011
    ..Our goal was to determine whether elevations of hsCRP vary by race/ethnicity among adolescents with MetS...
  16. pmc Puberty is delayed in male mice with dextran sodium sulfate colitis out of proportion to changes in food intake, body weight, and serum levels of leptin
    Mark D DeBoer
    Department of Pediatrics, University of Virginia, Charlottesville, Virginia 22908, USA
    Pediatr Res 69:34-9. 2011
    ..These experiments provide support for the hypothesis that pubertal delay in colitis is influenced by factors beyond poor weight gain alone...
  17. pmc Colitis causes delay in puberty in female mice out of proportion to changes in leptin and corticosterone
    Mark D DeBoer
    Division of Pediatric Endocrinology, Department of Pediatrics, University of Virginia, P O Box 800386, Charlottesville, VA 22908, USA
    J Gastroenterol 45:277-84. 2010
    ..A major cause of this pubertal delay is likely due in part to the effect of decreased levels of leptin on the function of the hypothalamic-pituitary-gonadal axis, though systemic inflammation is also thought to play a role...
  18. pmc Update on melanocortin interventions for cachexia: progress toward clinical application
    Mark Daniel DeBoer
    Division of Pediatric Endocrinology, University of Virginia, Charlottesville, Virginia, USA
    Nutrition 26:146-51. 2010
    ..However, to date, human application has remained elusive and it is unclear when we will know whether humans with cachexia would benefit from treatment with these compounds...
  19. ncbi request reprint Failure-to-thrive in an infant following injection of capillary hemangioma with triamcinolone acetonide
    Mark D DeBoer
    Division of Pediatric Endocrinology, Department of Pediatrics, University of Virginia, Charlottesville, Virginia 22908, USA
    Clin Pediatr (Phila) 47:296-9. 2008
  20. pmc Administration of IL-1beta to the 4th ventricle causes anorexia that is blocked by agouti-related peptide and that coincides with activation of tyrosine-hydroxylase neurons in the nucleus of the solitary tract
    Mark D DeBoer
    Department of Pediatrics, Oregon Health and Science University, USA
    Peptides 30:210-8. 2009
    ..This provides evidence that the brainstem may be an important mediator of anorexia in the setting of inflammation...
  21. doi request reprint Emergence of ghrelin as a treatment for cachexia syndromes
    Mark Daniel DeBoer
    Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA
    Nutrition 24:806-14. 2008
    ..Also uncertain--but an intriguing possibility--is whether the improved weight gain with ghrelin treatment might also lessen the severity of the underlying disease and improve outcomes...
  22. ncbi request reprint Cachexia: lessons from melanocortin antagonism
    Mark D DeBoer
    Department of Pediatrics, Oregon Health and Science University, 707 SW Gaines Rd, Portland, Oregon 97239, USA
    Trends Endocrinol Metab 17:199-204. 2006
    ..This successful inhibition of cachexia is important because loss of appetite and lean body mass worsen the prognosis of many the diseases with which cachexia is associated...
  23. ncbi request reprint Differential presentation for children with autoimmune thyroiditis discovered because of symptom development or screening
    Mark D DeBoer
    Department of Pediatrics, Division of Pediatric Endocrinology, University of Virginia, Charlottesville, VA 22908 0386, USA
    J Pediatr Endocrinol Metab 21:753-61. 2008
    ....
  24. ncbi request reprint Melanocortin interventions in cachexia: how soon from bench to bedside?
    Mark D DeBoer
    Division of Endocrinology, University of Virginia, Charlottesville, Virginia 22908, USA
    Curr Opin Clin Nutr Metab Care 10:457-62. 2007
    ..This review focuses on cachexia treatment interventions that act via melanocortin antagonism, by direct or indirect means...
  25. pmc Ghrelin treatment of chronic kidney disease: improvements in lean body mass and cytokine profile
    Mark D DeBoer
    Department of Pediatrics, University of Virginia, Charlottesville, VA 22908, USA
    Endocrinology 149:827-35. 2008
    ..We conclude that ghrelin treatment in uremia results in improved lean mass accrual in part due to suppressed muscle proteolysis and possibly related to antiinflammatory effects...
  26. ncbi request reprint Ghrelin treatment causes increased food intake and retention of lean body mass in a rat model of cancer cachexia
    Mark D DeBoer
    Center for the Study of Weight Regulation, Oregon Health and Science University, 707 SW Gaines Road, Portland, OR 97239, USA
    Endocrinology 148:3004-12. 2007
    ..We conclude that ghrelin and a synthetic ghrelin receptor agonist improve weight gain and lean body mass retention via effects involving orexigenic neuropeptides and antiinflammatory changes...
  27. ncbi request reprint Therapy insight: Use of melanocortin antagonists in the treatment of cachexia in chronic disease
    Mark D DeBoer
    Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239 2901, USA
    Nat Clin Pract Endocrinol Metab 2:459-66. 2006
    ..Although this research needs to be substantiated in humans, it provides a promising direction for treating the wasting that is associated with a variety of disease states...
  28. doi request reprint Socioeconomic factors in the development of childhood obesity and diabetes
    DAVID C LIEB
    Department of Medicine, Division of Endocrinology, University of Virginia School of Medicine, PO Box 800793, Charlottesville, VA 22908, USA
    Clin Sports Med 28:349-78. 2009
    ..As our society attempts to improve the lifestyle of our children and decrease rates of obesity, it will be important to give focus to children of lower socioeconomic backgrounds in planning these potential interventions...
  29. ncbi request reprint Pediatric thyroid testing issues
    Mark D DeBoer
    Department of Pediatrics, Division of Endocrinology, University of Virginia, VA, USA
    Pediatr Endocrinol Rev 5:570-7. 2007
    ..Additionally, heterophile and anti-T4 or anti-TSH antibodies can interfere with accurate T4 or TSH measurement...