Research Topics
Genomes and Genes | Jayanta DebnathSummaryAffiliation: University of California Country: USA Publications
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Publications
Does autophagy contribute to cell death?Jayanta Debnath
Department of Pathology, University of California San Francisco, San Francisco, California, USA
Autophagy 1:66-74. 2005..Here, we review the emerging evidence in favor of and against autophagic cell death, discuss the possible roles that autophagic degradation might play in dying cells, and identify salient issues for future investigation...
Extracellular matrix regulation of autophagyRebecca Lock
Department of Pathology, University of California, San Francisco, 513 Parnassus Avenue, HSW 514, San Francisco, CA 94143, USA
Curr Opin Cell Biol 20:583-8. 2008..Moreover, autophagy may be a previously unrecognized mechanism utilized by detached cancer cells to survive anoikis, which may facilitate tumor cell dormancy, dissemination, and metastasis...- Detachment-induced autophagy during anoikis and lumen formation in epithelial aciniJayanta Debnath
Department of Pathology, University of California, San Francisco, San Francisco, California 94143, USA
Autophagy 4:351-3. 2008..These results broach the possibility that autophagy contributes to the survival of tumor cells lacking appropriate matrix contact, either during early carcinoma formation or in the later stages of dissemination and metastasis... - Induction of autophagy during extracellular matrix detachment promotes cell survivalChristopher Fung
Department of Pathology, University of California San Francisco, San Francisco, CA 94143, USA
Mol Biol Cell 19:797-806. 2008..Thus, autophagy promotes epithelial cell survival during anoikis, including detached cells harboring antiapoptotic lesions... - Autophagy and metastasis: another double-edged swordCandia M Kenific
Department of Pathology and Diller Comprehensive Cancer Center, University of California San Francisco, CA, United States
Curr Opin Cell Biol 22:241-5. 2010..Because autophagy is titratable, it may serve both prometastatic and antimetastatic functions depending on the contextual demands placed on tumor cells throughout the metastatic process... 
Detachment-induced autophagy in three-dimensional epithelial cell culturesJayanta Debnath
Department of Pathology, University of California, San Francisco, San Francisco, California, USA
Methods Enzymol 452:423-39. 2009....- Autophagy facilitates glycolysis during Ras-mediated oncogenic transformationRebecca Lock
Department of Pathology, University of California, San Francisco Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143, USA
Mol Biol Cell 22:165-78. 2011..Overall, increased glycolysis in autophagy-competent cells facilitates Ras-mediated adhesion-independent transformation, suggesting a unique mechanism by which autophagy may promote Ras-driven tumor growth in specific metabolic contexts... - ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell deathLilliana Radoshevich
Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA
Cell 142:590-600. 2010..Overall, these results unveil a role for ATG12-ATG3 in mitochondrial homeostasis and implicate the ATG12 conjugation system in cellular functions distinct from the early steps of autophagosome formation... - Autophagy suppression promotes apoptotic cell death in response to inhibition of the PI3K-mTOR pathway in pancreatic adenocarcinomaOlga K Mirzoeva
Divisions of Gastroenterology and Hematology Oncology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA
J Mol Med (Berl) 89:877-89. 2011..Thus, our studies provide rationale for clinical development of combinations of these compounds for the treatment of pancreatic adenocarcinoma... - Clinical utility of LC3 and p62 immunohistochemistry in diagnosis of drug-induced autophagic vacuolar myopathies: a case-control studyHan S Lee
Department of Pathology, University of California San Francisco, San Francisco, California, USA
PLoS ONE 7:e36221. 2012..The goal of the current study was to develop an immunohistochemical diagnostic marker for this pathologic entity... - Autophagy and tumorigenesisNan Chen
Department of Pathology, Diller Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA
FEBS Lett 584:1427-35. 2010.... - Ubiquilins accelerate autophagosome maturation and promote cell survival during nutrient starvationElsa Noah N'Diaye
Macrophage Biology Laboratory, Northern California Institute for Research and Education, San Francisco, CA, USA
Autophagy 5:573-5. 2009..Overall, this work illustrates an important function for UBQLN in cell survival during nutrient starvation, which requires a newly recognized function for UBQLN in autophagosome maturation... - Modeling morphogenesis and oncogenesis in three-dimensional breast epithelial culturesChristy Hebner
Department of Surgery and Center for Bioengineering and Tissue Regeneration, University of California, San Francisco, CA, USA
Annu Rev Pathol 3:313-39. 2008..We review how 3D models are being used to investigate fundamental cellular and biophysical mechanisms associated with breast cancer progression that have not been readily amenable to traditional genetic or biochemical analysis... - Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architectureCarolyn N Wrobel
Dept of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
J Cell Biol 165:263-73. 2004..These findings provide a mechanistic basis whereby CSF-1R could contribute to invasive progression in epithelial cancers... - Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikisMauricio J Reginato
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Nat Cell Biol 5:733-40. 2003..Thus, Bim functions as a key sensor of integrin and growth factor signals to the Erk pathway, and loss of such coordinate regulation may contribute to tumour progression... - Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotesDaniel J Klionsky
Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
Autophagy 4:151-75. 2008..In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to verify an autophagic response... - Genetic interactions between Drosophila melanogaster Atg1 and paxillin reveal a role for paxillin in autophagosome formationGuang Chao Chen
Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
Autophagy 4:37-45. 2008..Together, these findings reveal a novel evolutionarily conserved role for paxillin in autophagy... - Modelling glandular epithelial cancers in three-dimensional culturesJayanta Debnath
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
Nat Rev Cancer 5:675-88. 2005..Here, we review the important features of epithelial structures grown in 3D basement membrane cultures, and how such models have been used to investigate the mechanisms associated with tumour initiation and progression... - Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitroKenna R Mills
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 101:3438-43. 2004..Thus, TRAIL regulates an autophagic program during acinar morphogenesis, which together with caspase-mediated apoptotic events, results in lumen formation during MCF-10A morphogenesis... - Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent mannerJayanta Debnath
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
J Cell Biol 163:315-26. 2003.... - Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane culturesJayanta Debnath
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
Methods 30:256-68. 2003.... - The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary aciniJayanta Debnath
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Cell 111:29-40. 2002..Hence, apoptosis can counteract increased proliferation to maintain luminal space, suggesting that tumor cells must restrain apoptosis to populate the lumen...