Jayanta Debnath

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini
    Jayanta Debnath
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 111:29-40. 2002
  2. pmc Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro
    Kenna R Mills
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:3438-43. 2004
  3. doi request reprint p66(Shc) and Ras: controlling anoikis from the inside-out
    J Debnath
    Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA
    Oncogene 29:5556-8. 2010
  4. ncbi request reprint Detachment-induced autophagy during anoikis and lumen formation in epithelial acini
    Jayanta Debnath
    Department of Pathology, University of California, San Francisco, San Francisco, California 94143, USA
    Autophagy 4:351-3. 2008
  5. pmc The multifaceted roles of autophagy in tumors-implications for breast cancer
    Jayanta Debnath
    Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, 513 Parnassus Ave, HSW450B, San Francisco, CA 94143, USA
    J Mammary Gland Biol Neoplasia 16:173-87. 2011
  6. pmc Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation
    Rebecca Lock
    Department of Pathology, University of California, San Francisco Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143, USA
    Mol Biol Cell 22:165-78. 2011
  7. pmc A computational approach to resolve cell level contributions to early glandular epithelial cancer progression
    Sean H J Kim
    UCSF UC Berkeley Joint Graduate Group in Bioengineering, University of California, Berkeley, California 94720, USA
    BMC Syst Biol 3:122. 2009
  8. pmc ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death
    Lilliana Radoshevich
    Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA
    Cell 142:590-600. 2010
  9. pmc Extracellular matrix regulation of autophagy
    Rebecca Lock
    Department of Pathology, University of California, San Francisco, 513 Parnassus Avenue, HSW 514, San Francisco, CA 94143, USA
    Curr Opin Cell Biol 20:583-8. 2008
  10. pmc Induction of autophagy during extracellular matrix detachment promotes cell survival
    Christopher Fung
    Department of Pathology, University of California San Francisco, San Francisco, CA 94143, USA
    Mol Biol Cell 19:797-806. 2008

Detail Information

Publications30

  1. ncbi request reprint The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini
    Jayanta Debnath
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 111:29-40. 2002
    ..Hence, apoptosis can counteract increased proliferation to maintain luminal space, suggesting that tumor cells must restrain apoptosis to populate the lumen...
  2. pmc Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro
    Kenna R Mills
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:3438-43. 2004
    ..Thus, TRAIL regulates an autophagic program during acinar morphogenesis, which together with caspase-mediated apoptotic events, results in lumen formation during MCF-10A morphogenesis...
  3. doi request reprint p66(Shc) and Ras: controlling anoikis from the inside-out
    J Debnath
    Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA
    Oncogene 29:5556-8. 2010
    ....
  4. ncbi request reprint Detachment-induced autophagy during anoikis and lumen formation in epithelial acini
    Jayanta Debnath
    Department of Pathology, University of California, San Francisco, San Francisco, California 94143, USA
    Autophagy 4:351-3. 2008
    ..These results broach the possibility that autophagy contributes to the survival of tumor cells lacking appropriate matrix contact, either during early carcinoma formation or in the later stages of dissemination and metastasis...
  5. pmc The multifaceted roles of autophagy in tumors-implications for breast cancer
    Jayanta Debnath
    Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, 513 Parnassus Ave, HSW450B, San Francisco, CA 94143, USA
    J Mammary Gland Biol Neoplasia 16:173-87. 2011
    ..Here, I discuss the mechanisms and the evidence underlying these diverse roles for autophagy in cancer and speculate on specific circumstances in which autophagy can be most effectively targeted for breast cancer treatment...
  6. pmc Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation
    Rebecca Lock
    Department of Pathology, University of California, San Francisco Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143, USA
    Mol Biol Cell 22:165-78. 2011
    ..Overall, increased glycolysis in autophagy-competent cells facilitates Ras-mediated adhesion-independent transformation, suggesting a unique mechanism by which autophagy may promote Ras-driven tumor growth in specific metabolic contexts...
  7. pmc A computational approach to resolve cell level contributions to early glandular epithelial cancer progression
    Sean H J Kim
    UCSF UC Berkeley Joint Graduate Group in Bioengineering, University of California, Berkeley, California 94720, USA
    BMC Syst Biol 3:122. 2009
    ..We explored selective disruption of individual simulated cell actions. New framework features enabled recording detailed measures of ISEA cell activities and morphology...
  8. pmc ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death
    Lilliana Radoshevich
    Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA
    Cell 142:590-600. 2010
    ..Overall, these results unveil a role for ATG12-ATG3 in mitochondrial homeostasis and implicate the ATG12 conjugation system in cellular functions distinct from the early steps of autophagosome formation...
  9. pmc Extracellular matrix regulation of autophagy
    Rebecca Lock
    Department of Pathology, University of California, San Francisco, 513 Parnassus Avenue, HSW 514, San Francisco, CA 94143, USA
    Curr Opin Cell Biol 20:583-8. 2008
    ..Moreover, autophagy may be a previously unrecognized mechanism utilized by detached cancer cells to survive anoikis, which may facilitate tumor cell dormancy, dissemination, and metastasis...
  10. pmc Induction of autophagy during extracellular matrix detachment promotes cell survival
    Christopher Fung
    Department of Pathology, University of California San Francisco, San Francisco, CA 94143, USA
    Mol Biol Cell 19:797-806. 2008
    ..Thus, autophagy promotes epithelial cell survival during anoikis, including detached cells harboring antiapoptotic lesions...
  11. doi request reprint Detachment-induced autophagy in three-dimensional epithelial cell cultures
    Jayanta Debnath
    Department of Pathology, University of California, San Francisco, San Francisco, California, USA
    Methods Enzymol 452:423-39. 2009
    ....
  12. ncbi request reprint Does autophagy contribute to cell death?
    Jayanta Debnath
    Department of Pathology, University of California San Francisco, San Francisco, California, USA
    Autophagy 1:66-74. 2005
    ..Here, we review the emerging evidence in favor of and against autophagic cell death, discuss the possible roles that autophagic degradation might play in dying cells, and identify salient issues for future investigation...
  13. pmc Cyclic AMP regulates formation of mammary epithelial acini in vitro
    Pavel I Nedvetsky
    Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143 2140, USA
    Mol Biol Cell 23:2973-81. 2012
    ..These data demonstrate that cAMP regulates lumen formation in mammary epithelial cells in vitro, both through acceleration of polarization of outer cells and apoptosis of inner cells of the acinus...
  14. pmc Autophagy and tumorigenesis
    Srirupa Roy
    Department of Pathology and Diller Comprehensive Cancer Center, University of California San Francisco, 513 Parnassus Ave, HSW450B, San Francisco, CA 94143, USA
    Semin Immunopathol 32:383-96. 2010
    ....
  15. pmc Computational investigation of epithelial cell dynamic phenotype in vitro
    Sean H J Kim
    UCSF UC Berkeley Joint Graduate Group in Bioengineering, University of California, Berkeley, California 94720, USA
    Theor Biol Med Model 6:8. 2009
    ..Characterizing essential cell actions and their roles, which constitute the system's dynamic phenotype, is critical to gaining deeper insight into the cystogenesis phenomena...
  16. pmc Autophagy and metastasis: another double-edged sword
    Candia M Kenific
    Department of Pathology and Diller Comprehensive Cancer Center, University of California San Francisco, CA, United States
    Curr Opin Cell Biol 22:241-5. 2010
    ..Because autophagy is titratable, it may serve both prometastatic and antimetastatic functions depending on the contextual demands placed on tumor cells throughout the metastatic process...
  17. pmc Autophagy and tumorigenesis
    Nan Chen
    Department of Pathology, Diller Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA
    FEBS Lett 584:1427-35. 2010
    ....
  18. doi request reprint Autophagy suppression promotes apoptotic cell death in response to inhibition of the PI3K-mTOR pathway in pancreatic adenocarcinoma
    Olga K Mirzoeva
    Divisions of Gastroenterology and Hematology Oncology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA
    J Mol Med (Berl) 89:877-89. 2011
    ..Thus, our studies provide rationale for clinical development of combinations of these compounds for the treatment of pancreatic adenocarcinoma...
  19. pmc FOXO3A directs a protective autophagy program in haematopoietic stem cells
    Matthew R Warr
    The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Medicine, Division of Hematology Oncology, University of California San Francisco, San Francisco, California 94143, USA
    Nature 494:323-7. 2013
    ..Our results demonstrate that autophagy is essential for the life-long maintenance of the HSC compartment and for supporting an old, failing blood system...
  20. doi request reprint Autophagy as a stress-response and quality-control mechanism: implications for cell injury and human disease
    Lyndsay Murrow
    Department of Pathology, Helen Diller Family Comprehensive Cancer Center, and Biomedical Sciences Graduate Program, University of California San Francisco, CA 94143, USA
    Annu Rev Pathol 8:105-37. 2013
    ..This review discusses our current understanding of these two principal functions of autophagy and describes in detail how alterations in autophagy promote human disease...
  21. pmc Clinical utility of LC3 and p62 immunohistochemistry in diagnosis of drug-induced autophagic vacuolar myopathies: a case-control study
    Han S Lee
    Department of Pathology, University of California San Francisco, San Francisco, California, USA
    PLoS ONE 7:e36221. 2012
    ..The goal of the current study was to develop an immunohistochemical diagnostic marker for this pathologic entity...
  22. ncbi request reprint Ubiquilins accelerate autophagosome maturation and promote cell survival during nutrient starvation
    Elsa Noah N'Diaye
    Macrophage Biology Laboratory, Northern California Institute for Research and Education, San Francisco, CA, USA
    Autophagy 5:573-5. 2009
    ..Overall, this work illustrates an important function for UBQLN in cell survival during nutrient starvation, which requires a newly recognized function for UBQLN in autophagosome maturation...
  23. ncbi request reprint Modeling morphogenesis and oncogenesis in three-dimensional breast epithelial cultures
    Christy Hebner
    Department of Surgery and Center for Bioengineering and Tissue Regeneration, University of California, San Francisco, CA, USA
    Annu Rev Pathol 3:313-39. 2008
    ..We review how 3D models are being used to investigate fundamental cellular and biophysical mechanisms associated with breast cancer progression that have not been readily amenable to traditional genetic or biochemical analysis...
  24. ncbi request reprint Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis
    Mauricio J Reginato
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Nat Cell Biol 5:733-40. 2003
    ..Thus, Bim functions as a key sensor of integrin and growth factor signals to the Erk pathway, and loss of such coordinate regulation may contribute to tumour progression...
  25. pmc Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture
    Carolyn N Wrobel
    Dept of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    J Cell Biol 165:263-73. 2004
    ..These findings provide a mechanistic basis whereby CSF-1R could contribute to invasive progression in epithelial cancers...
  26. ncbi request reprint Modelling glandular epithelial cancers in three-dimensional cultures
    Jayanta Debnath
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Rev Cancer 5:675-88. 2005
    ..Here, we review the important features of epithelial structures grown in 3D basement membrane cultures, and how such models have been used to investigate the mechanisms associated with tumour initiation and progression...
  27. ncbi request reprint Genetic interactions between Drosophila melanogaster Atg1 and paxillin reveal a role for paxillin in autophagosome formation
    Guang Chao Chen
    Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
    Autophagy 4:37-45. 2008
    ..Together, these findings reveal a novel evolutionarily conserved role for paxillin in autophagy...
  28. pmc Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner
    Jayanta Debnath
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 163:315-26. 2003
    ....
  29. pmc Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
    Daniel J Klionsky
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Autophagy 4:151-75. 2008
    ..In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to verify an autophagic response...
  30. ncbi request reprint Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures
    Jayanta Debnath
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Methods 30:256-68. 2003
    ....

Research Grants4

  1. Oncogenes and Luminal Apoptosis Within Mammary Acini
    Jayanta Debnath; Fiscal Year: 2007
    ..Dr. Jayanta Debnath, the principal investigator, is an M. D...
  2. Autophagy and Epithelial Cell Fate During Anoikis and 3D Morphogenesis
    Jayanta Debnath; Fiscal Year: 2009
    ....
  3. Autophagy and Epithelial Cell Fate During Anoikis and 3D Morphogenesis
    Jayanta Debnath; Fiscal Year: 2010
    ..Ultimately, these studies may lead to new treatment strategies to prevent the uncontrolled expansion of cancer cells via manipulating autophagy. ..
  4. Autophagy and Epithelial Cell Fate During Anoikis and 3D Morphogenesis
    Jayanta Debnath; Fiscal Year: 2009
    ..Our proposed studies will be the first to test whether autophagy, a fundamental cellular self-digestion process, can be targeted to block carcinoma cell dissemination and metastasis. ..