R J DeBerardinis

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Reductive carboxylation supports growth in tumour cells with defective mitochondria
    Andrew R Mullen
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Nature 481:385-8. 2012
  2. pmc A mitochondrial power play in lymphoma
    Ralph J DeBerardinis
    Children s Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8502, USA Electronic address
    Cancer Cell 22:423-4. 2012
  3. pmc Cellular metabolism and disease: what do metabolic outliers teach us?
    Ralph J DeBerardinis
    Children s Research Institute, Department of Pediatrics and McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390 8502, USA
    Cell 148:1132-44. 2012
  4. doi request reprint Good neighbours in the tumour stroma reduce oxidative stress
    Ralph J DeBerardinis
    University of Texas, Southwestern Medical Center, Children s Research Institute, Dallas, Texas 75390 8502, USA
    Nat Cell Biol 14:235-6. 2012
  5. pmc Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer
    R J DeBerardinis
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9063, USA
    Oncogene 29:313-24. 2010
  6. pmc Is cancer a disease of abnormal cellular metabolism? New angles on an old idea
    Ralph J DeBerardinis
    Department of Pediatrics and The McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Genet Med 10:767-77. 2008
  7. doi request reprint Isocitrate dehydrogenase 1/2 mutational analyses and 2-hydroxyglutarate measurements in Wilms tumors
    Dinesh Rakheja
    Department of Pathology, Children s Medical Center and UT Southwestern Medical Center, Dallas, Texas 75390, USA
    Pediatr Blood Cancer 56:379-83. 2011
  8. ncbi request reprint The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche
    Tugba Simsek
    Department of Internal Medicine, Division of Cardiology, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Stem Cell 7:380-90. 2010
  9. pmc Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling
    Chendong Yang
    Department of Pediatrics, McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas, Texas 75390 9063, USA
    Cancer Res 69:7986-93. 2009

Research Grants

  1. Metabolic regulation in growth factor-dependent cells
    RALPH DEBERARDINIS; Fiscal Year: 2007

Collaborators

  • Eunsook S Jin
  • W Marston Linehan
  • Navdeep S Chandel
  • Andrew R Mullen
  • Dinesh Rakheja
  • Tugba Simsek
  • Chendong Yang
  • Pei Hsuan Chen
  • Tzuling Cheng
  • Youfeng Yang
  • William W Wheaton
  • Lucas B Sullivan
  • Richard L Boriack
  • Midori Mitui
  • Ahmed I Mahmoud
  • Eric N Olson
  • Junke Zheng
  • Hesham A Sadek
  • Fatih Kocabas
  • Cheng Cheng Zhang
  • Jay W Schneider
  • Robert M Bachoo
  • Tuyen Dang
  • Jeffrey G McDonald
  • Jessica Sudderth
  • Robert G Bachoo

Detail Information

Publications10

  1. pmc Reductive carboxylation supports growth in tumour cells with defective mitochondria
    Andrew R Mullen
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Nature 481:385-8. 2012
    ....
  2. pmc A mitochondrial power play in lymphoma
    Ralph J DeBerardinis
    Children s Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8502, USA Electronic address
    Cancer Cell 22:423-4. 2012
    ..A study by Caro et al. in this issue of Cancer Cell demonstrates that a subset of lymphomas is defined by reliance on mitochondrial energy generation and is selectively killed when this pathway is impaired...
  3. pmc Cellular metabolism and disease: what do metabolic outliers teach us?
    Ralph J DeBerardinis
    Children s Research Institute, Department of Pediatrics and McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390 8502, USA
    Cell 148:1132-44. 2012
    ....
  4. doi request reprint Good neighbours in the tumour stroma reduce oxidative stress
    Ralph J DeBerardinis
    University of Texas, Southwestern Medical Center, Children s Research Institute, Dallas, Texas 75390 8502, USA
    Nat Cell Biol 14:235-6. 2012
    ..Bone-marrow-derived stromal cells are now shown to provide cysteine, an essential nutrient that enables leukaemia cells to resist oxidative stress...
  5. pmc Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer
    R J DeBerardinis
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9063, USA
    Oncogene 29:313-24. 2010
    ..In this study we review the protean roles of glutamine in cancer, both in the direct support of tumor growth and in mediating some of the complex effects on whole-body metabolism that are characteristic of tumor progression...
  6. pmc Is cancer a disease of abnormal cellular metabolism? New angles on an old idea
    Ralph J DeBerardinis
    Department of Pediatrics and The McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Genet Med 10:767-77. 2008
    ..This review reappraises the notion that dysregulated cellular metabolism is a key feature of cancer, and discusses some metabolic issues that have escaped scrutiny over the years and now deserve closer attention...
  7. doi request reprint Isocitrate dehydrogenase 1/2 mutational analyses and 2-hydroxyglutarate measurements in Wilms tumors
    Dinesh Rakheja
    Department of Pathology, Children s Medical Center and UT Southwestern Medical Center, Dallas, Texas 75390, USA
    Pediatr Blood Cancer 56:379-83. 2011
    ....
  8. ncbi request reprint The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche
    Tugba Simsek
    Department of Internal Medicine, Division of Cardiology, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Stem Cell 7:380-90. 2010
    ..These findings reveal an important transcriptional network that regulates HSC metabolism...
  9. pmc Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling
    Chendong Yang
    Department of Pediatrics, McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas, Texas 75390 9063, USA
    Cancer Res 69:7986-93. 2009
    ....

Research Grants2

  1. Metabolic regulation in growth factor-dependent cells
    RALPH DEBERARDINIS; Fiscal Year: 2007
    ....