ROBERT DE LISLE

Summary

Affiliation: University of Kansas Medical Center
Country: USA

Publications

  1. pmc Disrupted tight junctions in the small intestine of cystic fibrosis mice
    Robert C De Lisle
    Anatomy and Cell Biology, MS 3038, University of Kansas School of Medicine, 3901 Rainbow Blvd, Kansas City, KS, 66160, USA
    Cell Tissue Res 355:131-42. 2014
  2. pmc cAMP-stimulated Cl- secretion is increased by glucocorticoids and inhibited by bumetanide in semicircular canal duct epithelium
    Satyanarayana R Pondugula
    Dept, Anatomy and Physiology, Kansas State University, Manhattan, KS 66506, USA
    BMC Physiol 13:6. 2013
  3. pmc Intestinal smooth muscle dysfunction develops postnatally in cystic fibrosis mice
    Robert C De Lisle
    University of Kansas School of Medicine, Anatomy and Cell Biology, Kansas City, KS 66160, USA
    J Pediatr Gastroenterol Nutr 55:689-94. 2012
  4. pmc Lubiprostone stimulates small intestinal mucin release
    Robert C De Lisle
    Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
    BMC Gastroenterol 12:156. 2012
  5. pmc Potential genetic modifiers of the cystic fibrosis intestinal inflammatory phenotype on mouse chromosomes 1, 9, and 10
    Oxana Norkina
    Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
    BMC Genet 6:29. 2005
  6. pmc Caerulein-induced acute pancreatitis in mice that constitutively overexpress Reg/PAP genes
    Oxana Norkina
    Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, Kansas, USA
    BMC Gastroenterol 6:16. 2006
  7. ncbi request reprint MUCLIN expression in the cystic fibrosis transmembrane conductance regulator knockout mouse
    R C De Lisle
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, USA
    Gastroenterology 113:521-32. 1997
  8. doi request reprint Altered eicosanoid metabolism in the cystic fibrosis mouse small intestine
    Robert C De Lisle
    Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
    J Pediatr Gastroenterol Nutr 47:406-16. 2008
  9. pmc Mast cells and gastrointestinal dysmotility in the cystic fibrosis mouse
    Robert C De Lisle
    Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, Kansas, United States of America
    PLoS ONE 4:e4283. 2009
  10. pmc Pass the bicarb: the importance of HCO3- for mucin release
    Robert C De Lisle
    Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, Kansas 66160, USA
    J Clin Invest 119:2535-7. 2009

Research Grants

  1. PATHOGENEISIS OF CYSTIC FIBROSIS IN THE GI SYSTEM
    ROBERT DE LISLE; Fiscal Year: 2000
  2. PATHOGENEISIS OF CYSTIC FIBROSIS IN THE GI SYSTEM
    ROBERT DE LISLE; Fiscal Year: 2003
  3. TRANSGENIC MOUSE MODELS OF PANCREATIC EXOCRINE FUNCTION
    ROBERT DE LISLE; Fiscal Year: 2003
  4. PATHOGENEISIS OF CYSTIC FIBROSIS IN THE GI SYSTEM
    ROBERT DE LISLE; Fiscal Year: 2002
  5. PATHOGENEISIS OF CYSTIC FIBROSIS IN THE GI SYSTEM
    ROBERT DE LISLE; Fiscal Year: 2001

Collaborators

Detail Information

Publications29

  1. pmc Disrupted tight junctions in the small intestine of cystic fibrosis mice
    Robert C De Lisle
    Anatomy and Cell Biology, MS 3038, University of Kansas School of Medicine, 3901 Rainbow Blvd, Kansas City, KS, 66160, USA
    Cell Tissue Res 355:131-42. 2014
    ..These changes in TJ protein localization in CF are likely to be involved in the increased permeability of the CF small intestine to macromolecules and TNF╬▒ may be a causative factor...
  2. pmc cAMP-stimulated Cl- secretion is increased by glucocorticoids and inhibited by bumetanide in semicircular canal duct epithelium
    Satyanarayana R Pondugula
    Dept, Anatomy and Physiology, Kansas State University, Manhattan, KS 66506, USA
    BMC Physiol 13:6. 2013
    ..In the current study, we sought to determine the ion transporters involved in Cl- secretion and whether secretion is regulated by PKA and glucocorticoids...
  3. pmc Intestinal smooth muscle dysfunction develops postnatally in cystic fibrosis mice
    Robert C De Lisle
    University of Kansas School of Medicine, Anatomy and Cell Biology, Kansas City, KS 66160, USA
    J Pediatr Gastroenterol Nutr 55:689-94. 2012
    ..The goal of the present study was to use the Cftr knockout mouse to determine when in development circular smooth muscle of the small intestine becomes dysfunctional...
  4. pmc Lubiprostone stimulates small intestinal mucin release
    Robert C De Lisle
    Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
    BMC Gastroenterol 12:156. 2012
    ..The aim of this study was to directly test whether lubiprostone stimulates intestinal mucin release...
  5. pmc Potential genetic modifiers of the cystic fibrosis intestinal inflammatory phenotype on mouse chromosomes 1, 9, and 10
    Oxana Norkina
    Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
    BMC Genet 6:29. 2005
    ..In this work potential modifier loci of the CF intestinal phenotype were identified...
  6. pmc Caerulein-induced acute pancreatitis in mice that constitutively overexpress Reg/PAP genes
    Oxana Norkina
    Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, Kansas, USA
    BMC Gastroenterol 6:16. 2006
    ..These genes are suggested to be involved in protection or recovery from pancreatic injury...
  7. ncbi request reprint MUCLIN expression in the cystic fibrosis transmembrane conductance regulator knockout mouse
    R C De Lisle
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, USA
    Gastroenterology 113:521-32. 1997
    ....
  8. doi request reprint Altered eicosanoid metabolism in the cystic fibrosis mouse small intestine
    Robert C De Lisle
    Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
    J Pediatr Gastroenterol Nutr 47:406-16. 2008
    ..Imbalances in essential fatty acid levels have been reported in cystic fibrosis (CF), which may relate to elevated proinflammatory eicosanoid generation. The aim of this work was to better define eicosanoid metabolism in the CF intestine...
  9. pmc Mast cells and gastrointestinal dysmotility in the cystic fibrosis mouse
    Robert C De Lisle
    Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, Kansas, United States of America
    PLoS ONE 4:e4283. 2009
    ..The aim of this study was to evaluate the potential role of mast cells in gastrointestinal dysmotility using the CF mouse (Cftr(tm1UNC), Cftr knockout)...
  10. pmc Pass the bicarb: the importance of HCO3- for mucin release
    Robert C De Lisle
    Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, Kansas 66160, USA
    J Clin Invest 119:2535-7. 2009
    ..The authors propose a model whereby CFTR-mediated bicarbonate secretion must be concurrent with mucin exocytosis for proper mucin release...
  11. pmc Enteric circular muscle dysfunction in the cystic fibrosis mouse small intestine
    R C De Lisle
    Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS, USA
    Neurogastroenterol Motil 22:341-e87. 2010
    ..CONCLUSIONS & INFERENCES These results suggest that the enteric microbiota modulates PGE(2) levels in a complex manner, which affects enteric smooth muscle activity and contributes to slower small intestinal transit in CF...
  12. pmc Lubiprostone ameliorates the cystic fibrosis mouse intestinal phenotype
    Robert C De Lisle
    Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
    BMC Gastroenterol 10:107. 2010
    ..We investigated whether lubiprostone, which can activate the CLC2 Cl- channel, would improve the intestinal phenotype in CF mice...
  13. pmc Impaired mucosal barrier function in the small intestine of the cystic fibrosis mouse
    Robert C De Lisle
    Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
    J Pediatr Gastroenterol Nutr 53:371-9. 2011
    ..Also tested were the effects of exogenous IAP administration...
  14. ncbi request reprint Role of sulfated O-linked glycoproteins in zymogen granule formation
    Robert C De Lisle
    Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City 66160, USA
    J Cell Sci 115:2941-52. 2002
    ....
  15. ncbi request reprint Changes in the exocrine pancreas secondary to altered small intestinal function in the CF mouse
    R C De Lisle
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Am J Physiol Gastrointest Liver Physiol 281:G899-906. 2001
    ....
  16. ncbi request reprint Processing of pro-Muclin and divergent trafficking of its products to zymogen granules and the apical plasma membrane of pancreatic acinar cells
    R C De Lisle
    Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City 66160, USA
    Eur J Cell Biol 79:892-904. 2000
    ..We present a working model for pro-Muclin as a Golgi cargo receptor for exocrine secretory granule formation at the trans Golgi network...
  17. pmc Effects of Muclin (Dmbt1) deficiency on the gastrointestinal system
    Robert C De Lisle
    Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
    Am J Physiol Gastrointest Liver Physiol 294:G717-27. 2008
    ..Thus Muclin deficiency impairs trafficking of regulated proteins to a stimulus-releasable pool in the exocrine pancreas...
  18. ncbi request reprint Effects of laxative and N-acetylcysteine on mucus accumulation, bacterial load, transit, and inflammation in the cystic fibrosis mouse small intestine
    Robert C De Lisle
    Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
    Am J Physiol Gastrointest Liver Physiol 293:G577-84. 2007
    ..These results suggest that both mucus accumulation and slowed interdigestive small intestinal transit contribute to SIBO in the CF intestine...
  19. ncbi request reprint Altered transit and bacterial overgrowth in the cystic fibrosis mouse small intestine
    Robert C De Lisle
    Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
    Am J Physiol Gastrointest Liver Physiol 293:G104-11. 2007
    ..In conclusion, small intestinal transit was significantly slower in CF mice, and this is likely a major factor in SIBO in CF...
  20. pmc Bacterial overgrowth in the cystic fibrosis transmembrane conductance regulator null mouse small intestine
    Oxana Norkina
    Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, Kansas 66160, USA
    Infect Immun 72:6040-9. 2004
    ..These data suggest that bacterial overgrowth in the CF mouse small intestine has a role in inflammation and contributes to the failure to thrive in this mouse model of CF...
  21. ncbi request reprint Eradication of small intestinal bacterial overgrowth in the cystic fibrosis mouse reduces mucus accumulation
    Robert C De Lisle
    Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, Kansas 66160, USA
    J Pediatr Gastroenterol Nutr 42:46-52. 2006
    ....
  22. ncbi request reprint Expression of pro-Muclin in pancreatic AR42J cells induces functional regulated secretory granules
    Robert C De Lisle
    Anatomy and Cell Biology, MS 3038, University of Kansas School of Medicine, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Am J Physiol Cell Physiol 289:C1169-78. 2005
    ..Overall, the data show that pro-Muclin acts as a sorting receptor that can induce RSG, and that its cytosolic tail is important in this process...
  23. ncbi request reprint Acidic duodenal pH alters gene expression in the cystic fibrosis mouse pancreas
    Simran Kaur
    Dept of Anatomy and Cell Biology, Univ of Kansas School of Medicine, Kansas City, KS 66160, USA
    Am J Physiol Gastrointest Liver Physiol 287:G480-90. 2004
    ..It is concluded that the acidic duodenal pH in CF contributes to the stress on the exocrine pancreas and that normalizing duodenal pH reduces this stress...
  24. ncbi request reprint Inflammation of the cystic fibrosis mouse small intestine
    Oxana Norkina
    Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
    Am J Physiol Gastrointest Liver Physiol 286:G1032-41. 2004
    ..Immune cell infiltration was confirmed histologically by staining for mast cells and neutrophils. These data demonstrate that the CF intestine exhibits an inflammatory state with upregulation of components of the innate immune system...
  25. ncbi request reprint Binding of the Golgi sorting receptor muclin to pancreatic zymogens through sulfated O-linked oligosaccharides
    Igor Boulatnikov
    Department of Anatomy, University of Kansas School of Medicine, Kansas City, Kansas 66160, USA
    J Biol Chem 279:40918-26. 2004
    ..The behavior of Muclin fulfils the requirement of a Golgi cargo receptor to bind to regulated secretory proteins under the mildly acidic pH conditions that exist in the trans-Golgi network...
  26. ncbi request reprint Altered posttranslational processing of glycoproteins in cerulein-induced pancreatitis
    Robert C De Lisle
    Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
    Exp Cell Res 308:101-13. 2005
    ....
  27. ncbi request reprint Decreased gastric bacterial killing and up-regulation of protective genes in small intestine in gastrin-deficient mouse
    Francis J Sun
    Laboratory Animal Resources, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Dig Dis Sci 48:976-85. 2003
    ..Bacterial survival is associated with increased expression of muclin and sprr2a in the intestine, indicating that these genes play protective roles in the intestine...
  28. ncbi request reprint Early embryonic renal tubules of wild-type and polycystic kidney disease kidneys respond to cAMP stimulation with cystic fibrosis transmembrane conductance regulator/Na(+),K(+),2Cl(-) Co-transporter-dependent cystic dilation
    Brenda S Magenheimer
    Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Am Soc Nephrol 17:3424-37. 2006
    ....
  29. ncbi request reprint Apactin is involved in remodeling of the actin cytoskeleton during regulated exocytosis
    Chanderdeep Tandon
    Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
    Eur J Cell Biol 83:79-89. 2004
    ..Thus, apactin is involved in remodeling the apical cytoskeleton during regulated exocytosis in a manner controlled by phosphorylation of the apactin C-Tail...

Research Grants10

  1. PATHOGENEISIS OF CYSTIC FIBROSIS IN THE GI SYSTEM
    ROBERT DE LISLE; Fiscal Year: 2000
    ..Pathology and Muclin expression will be compared in CF mice, and CF mice crossed with gastrin deficient mice (lack gastric acid secretion) to normalize intestinal Ph. ..
  2. PATHOGENEISIS OF CYSTIC FIBROSIS IN THE GI SYSTEM
    ROBERT DE LISLE; Fiscal Year: 2003
    ..Pathology and Muclin expression will be compared in CF mice, and CF mice crossed with gastrin deficient mice (lack gastric acid secretion) to normalize intestinal Ph. ..
  3. TRANSGENIC MOUSE MODELS OF PANCREATIC EXOCRINE FUNCTION
    ROBERT DE LISLE; Fiscal Year: 2003
    ..That over expresses Muclin in the pancreatic acinar cell using the rat elastase promoter to direct cell specific expression. ..
  4. PATHOGENEISIS OF CYSTIC FIBROSIS IN THE GI SYSTEM
    ROBERT DE LISLE; Fiscal Year: 2002
    ..Pathology and Muclin expression will be compared in CF mice, and CF mice crossed with gastrin deficient mice (lack gastric acid secretion) to normalize intestinal Ph. ..
  5. PATHOGENEISIS OF CYSTIC FIBROSIS IN THE GI SYSTEM
    ROBERT DE LISLE; Fiscal Year: 2001
    ..Pathology and Muclin expression will be compared in CF mice, and CF mice crossed with gastrin deficient mice (lack gastric acid secretion) to normalize intestinal Ph. ..