Research Topics
Genomes and Genes | Maria De LucaSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
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Publications
Association of a common LAMA5 variant with anthropometric and metabolic traits in an Italian cohort of healthy elderly subjectsMaria De Luca
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Exp Gerontol 46:60-4. 2011..Future studies are warranted to replicate these findings in independent and larger populations and to investigate whether rs659822 is the causal variant responsible for the observed associations...
Mapping quantitative trait loci affecting variation in Drosophila triacylglycerol storageMaria De Luca
Department of Environmental Health Sciences, University of Alabama, Birmingham, AL 35294, USA
Obes Res 13:1596-605. 2005..The objective of our study was to identify quantitative trait loci (QTLs) that contribute to variation in triacylglycerol (TAG) storage in two D. melanogaster laboratory strains...- A conserved role for syndecan family members in the regulation of whole-body energy metabolismMaria De Luca
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
PLoS ONE 5:e11286. 2010..035) and intra-abdominal fat (P = 0.049), and SNP rs2267871 with insulin sensitivity (P = 0.037). Collectively, our results in Drosophila and humans argue that syndecan family members play a key role in the regulation of body metabolism... - Genetic variation in a member of the laminin gene family affects variation in body composition in Drosophila and humansMaria De Luca
Department of Nutrition Sciences, School of Health Professions, University of Alabama at Birmingham, 3rd Avenue South, Birmingham, AL 35294 3360, USA
BMC Genet 9:52. 2008..Based on our results from Drosophila, we performed a human population-based association study to investigate the effect of natural variation in LAMA5 gene on body composition in humans... - Systems genetics analysis of body weight and energy metabolism traits in Drosophila melanogasterPatricia Jumbo-Lucioni
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 3360, USA
BMC Genomics 11:297. 2010.... - Mapping genetic polymorphisms affecting natural variation in Drosophila longevityMaria De Luca
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA
Methods Mol Biol 371:307-20. 2007..This chapter reports details of quantitative complementation tests and linkage disequilibrium mapping to identify positional genes and causative genetic polymorphisms determining variation in Drosophila longevity... - Polymorphism in the transcription factor 7-like 2 (TCF7L2) gene is associated with reduced insulin secretion in nondiabetic womenJulian Munoz
Department of Nutrition Sciences, 1675 Webb Nutrition Sciences Building, Room 241, University of Alabama, Birmingham, AL 35294, USA
Diabetes 55:3630-4. 2006..Our data suggest that the TCF7L2 gene is an important factor regulating insulin secretion, which could explain its association with type 2 diabetes... - Methods for nutrigenomics and longevity studies in Drosophila: effects of diets high in sucrose, palmitic acid, soy, or beefJiatao Ye
Department of Environmental Health Sciences, University of Alabama at Birmingham, Birmingham, AL, USA
Methods Mol Biol 371:111-41. 2007..The significance of these results and other types of nutrigenomics and longevity analyses is discussed... - Nuclear genomic control of naturally occurring variation in mitochondrial function in Drosophila melanogasterPatricia Jumbo-Lucioni
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
BMC Genomics 13:659. 2012..Here, we used Drosophila melanogaster as our model organism to address this question... - Drosophila nutrigenomics can provide clues to human gene-nutrient interactionsDouglas M Ruden
Department of Environmental Health Sciences, University of Alabama at Birmingham, Alabama 35294, USA
Annu Rev Nutr 25:499-522. 2005..This review summarizes what has already been learned in Drosophila nutrigenomics (with an emphasis on lipids and sterols), critically evaluates the data, and discusses fruitful areas for future research... - Dopa decarboxylase (Ddc) affects variation in Drosophila longevityMaria De Luca
Department of Genetics, Box 7614, North Carolina State University, Raleigh, North Carolina 27695, USA
Nat Genet 34:429-33. 2003..DDC catalyzes the final step in the synthesis of the neurotransmitters, dopamine and serotonin. Thus, these data implicate variation in the synthesis of bioamines as a factor contributing to natural variation in individual life span... - A functional interplay between Aurora-A, Plk1 and TPX2 at spindle poles: Plk1 controls centrosomal localization of Aurora-A and TPX2 spindle associationMaria De Luca
Institute of Molecular Biology and Pathology, CNR, University of Rome La Sapienza, Rome, Italy
Cell Cycle 5:296-303. 2006..Based on these results therefore a hierarchical functional relation between Plk1 and the Aurora-A/TPX2 pathway emerges...
Research Grants
- QTL mapping age-related changes in lipid storageMaria De Luca; Fiscal Year: 2007..Moreover, knowledge of the nature and frequency of causative genetic polymorphisms will lead to a better understanding of the mechanisms that maintain genetic variation in these traits in natural populations. ..
- QTL mapping age-related changes in lipid storageMaria De Luca; Fiscal Year: 2007..Moreover, knowledge of the nature and frequency of causative genetic polymorphisms will lead to a better understanding of the mechanisms that maintain genetic variation in these trait in natural populations. ..
- Genetic control of quantitative traits associated with the metabolic syndromeMaria De Luca; Fiscal Year: 2010..Using this information, human population-based association studies will be performed to investigate the effect of natural variation in the identified regulatory genes on quantitative traits associated with the metabolic syndrome. ..