Research Topics
Genomes and Genes | Jose de LeonSummaryAffiliation: University of Kentucky Country: USA Publications
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Publications
Genetics of schizophrenia and smoking: an approach to studying their comorbidity based on epidemiological findingsJose de Leon
University of Kentucky Mental Health Research Center at Eastern State Hospital, 627 West Fourth St, Lexington, KY 40508, USA
Hum Genet 131:877-901. 2012....
Interactions between antiepileptics and second-generation antipsychoticsJose de Leon
University of Kentucky Mental Health Research Center at Eastern State Hospital, 627 West Fourth St, Lexington, KY 40508, USA
Expert Opin Drug Metab Toxicol 8:311-34. 2012....- Fagerstrom test for nicotine dependence vs heavy smoking index in a general population surveyM Pérez-Ríos
Directorate General for Public Health, Galician Regional Health Authority, Santiago de Compostela, Spain
BMC Public Health 9:493. 2009..A shorter test derived from the FTND used for the general population is the Heavy Smoking Index (HSI) (six questions vs. two). The objective of this study is to compare the validity of the HSI versus the FTND... 
A study of genetic (CYP2D6 and ABCB1) and environmental (drug inhibitors and inducers) variables that may influence plasma risperidone levelsJ de Leon
University of Kentucky Mental Health Research Center at Eastern State Hospital, Lexington, Kentucky
Pharmacopsychiatry 40:93-102. 2007..CYP inducers and inhibitors appear to be relevant to R dosing. New studies are needed, particularly to further assess the role of the CYP2D6 UM phenotype and ABCB1 variants in R pharmacokinetics...- Practical guidelines for the use of new generation antipsychotic drugs (except clozapine) in adult individuals with intellectual disabilitiesJose de Leon
University of Kentucky Mental Health Research Center, Lexington, KY 40508, USA
Res Dev Disabil 30:613-69. 2009.... - Clinical guidelines for psychiatrists for the use of pharmacogenetic testing for CYP450 2D6 and CYP450 2C19Jose de Leon
University of Kentucky Mental Health Research Center at Eastern State Hospital, Lexington, KY 40508, USA
Psychosomatics 47:75-85. 2006..Practical recommendations for dealing with laboratories offering CYP2D6 and CYP2C29 genotyping are provided... - Polymorphic variations in GSTM1, GSTT1, PgP, CYP2D6, CYP3A5, and dopamine D2 and D3 receptors and their association with tardive dyskinesia in severe mental illnessJose de Leon
University of Kentucky Mental Health Research Center at Eastern State Hospital, Lexington, KY 40508, USA
J Clin Psychopharmacol 25:448-56. 2005..New studies need to replicate whether these or other genes could be used conjointly with clinical variables to identify subjects at risk for TD in clinical settings... - The AmpliChip CYP450 genotyping test: Integrating a new clinical toolJose de Leon
University of Kentucky Mental Health Research Center at Eastern State Hospital, Lexington, Kentucky 40508, USA
Mol Diagn Ther 10:135-51. 2006.... - DNA microarray technology in the clinical environment: the AmpliChip CYP450 test for CYP2D6 and CYP2C19 genotypingJose de Leon
Mental Health Research Center, Eastern State Hospital, Lexington, KY 40508, USA
CNS Spectr 14:19-34. 2009..The objectives of this study were to identify CYP2D6 and CYP2C19 alleles and phenotypes in a psychiatric patient population in Kentucky, and to describe practical issues associated with DNA microarray technology... - Does clozapine decrease smoking?Jose de Leon
Mental Health Research Center at Eastern State Hospital, 627 West Fourth St, Lexington, KY 40508, USA
Prog Neuropsychopharmacol Biol Psychiatry 29:757-62. 2005..New prospective longitudinal studies using repeated cotinine and clozapine levels are needed to explore whether clozapine may reduce smoking in some patients... - A meta-analysis of worldwide studies demonstrates an association between schizophrenia and tobacco smoking behaviorsJose de Leon
Mental Health Research Center at Eastern State Hospital, 627 West Fourth St, Lexington, KY 40508, USA
Schizophr Res 76:135-57. 2005..Thus, people who are going to develop schizophrenia have risk factors that make them more vulnerable to start smoking... - Variables associated with alcohol, drug, and daily smoking cessation in patients with severe mental illnessesJose de Leon
University of Kentucky Mental Health Research Center at Eastern State Hospital, 627 West Fourth Street, Lexington, KY 40508, USA
J Clin Psychiatry 66:1447-55. 2005..S. public health issue, although the role of tobacco is usually neglected. This study explored variables associated with alcohol, drug, and smoking cessation in a naturalistic setting... - The dosing of atypical antipsychoticsJose de Leon
Mental Health Research Center at Eastern State Hospital, 627 West Fourth St, Lexington, KY 40508, USA
Psychosomatics 46:262-73. 2005..Adding inducers may be associated with a gradual development of lost efficacy... - AmpliChip CYP450 test: personalized medicine has arrived in psychiatryJose de Leon
University of Kentucky, Mental Health Research Center at Eastern State Hospital, 627 West Fourth St, Lexington, KY 40508, USA
Expert Rev Mol Diagn 6:277-86. 2006..In this review, the major obstacles to the wide implementation of pharmacogenetic testing in the clinical environment are summarized... - The future (or lack of future) of personalized prescription in psychiatryJose de Leon
University of Kentucky, Mental Health Research Center at Eastern State Hospital, Lexington, KY 40508, United States
Pharmacol Res 59:81-9. 2009..Personalized dosing has immediate application if one understands it as the use of our current scientific knowledge of genetic, environmental and personal variables to determine dosing; its sole requirement is well-trained psychiatrists... - Planning for the optimal design of studies to personalize antipsychotic prescriptions in the post-CATIE era: the clinical and pharmacoepidemiological data suggest that pursuing the pharmacogenetics of metabolic syndrome complications (hypertension, diabetJose de Leon
University of Kentucky Mental Health Research Center at Eastern State Hospital, Lexington, KY 40508, USA
Schizophr Res 96:185-97. 2007..It is hypothesized that it may be easier to design studies focusing on these three aspects than to design pharmacogenetic studies focusing on antipsychotic-induced weight gain or metabolic syndrome, which require long-term follow-up... - A clinical study of the association of antipsychotics with hyperlipidemiaJose de Leon
University of Kentucky Mental Health Research Center at Eastern State Hospital, Lexington, KY, USA
Schizophr Res 92:95-102. 2007..The effect sizes of olanzapine and quetiapine on hyperlipidemia were about 0.40 in this naturalistic study... - Exploring genetic variations that may be associated with the direct effects of some antipsychotics on lipid levelsJose de Leon
University of Kentucky Mental Health Research Center at Eastern State Hospital, College of Medicine, Lexington, Kentucky 40508, United States
Schizophr Res 98:40-6. 2008..These genes may be promising candidates for studies of the direct effects of some antipsychotics on hyperlipidemia... - Weight gain during a double-blind multidosage clozapine studyJose de Leon
Mental Health Research Center, Eastern State Hospital, Lexington, KY 40508, USA
J Clin Psychopharmacol 27:22-7. 2007..32, n = 43), but seems to be strongly correlated in nonsmokers. Despite its limitations, this study indicates that baseline BMI, dosing, and, possibly, the African-American race may be major determinants of clozapine-induced weight gain... - The effect of atypical versus typical antipsychotics on tardive dyskinesia: a naturalistic studyJose de Leon
Mental Health Research Center at Eastern State Hospital, University of Kentucky, Lexington, KY 40508, USA
Eur Arch Psychiatry Clin Neurosci 257:169-72. 2007..The aim was testing whether atypical antipsychotics (versus typicals) were associated with less risk of tardive dyskinesia (TD) in 516 severely mentally ill patients... - A preliminary attempt to personalize risperidone dosing using drug-drug interactions and genetics: part IJose de Leon
University of Kentucky Mental Health Research Center, Eastern State Hospital, Lexington, KY 40508, USA
Psychosomatics 49:258-70. 2008..Personalized prescription is described even in lay journals, but there has been no attempt to propose personalizing dosing for any specific psychiatric drug... - A preliminary attempt to personalize risperidone dosing using drug-drug interactions and genetics: part IIJose de Leon
University of Kentucky Mental Health Research Center at Eastern State Hospital, 627 West 4th St, Lexington, KY 40508, USA
Psychosomatics 49:347-61. 2008 - Does smoking reduce akathisia? Testing a narrow version of the self-medication hypothesisJose de Leon
Mental Health Research Center at Eastern State Hospital, Lexington, KY 40508, USA
Schizophr Res 86:256-68. 2006..A narrow version of the self-medication hypothesis, heavy smoking reduces akathisia, is explored... - Association between smoking and alcohol use in the general population: stable and unstable odds ratios across two years in two different countriesJose de Leon
Uuniversity of Kentucky Mental Health Research Center at Eastern State Hospital, 627 West Fourth St, Lexington, KY 40508, USA
Alcohol Alcohol 42:252-7. 2007..These comparisons may provide a rational basis for exploring the associations between alcohol and cigarette use that are influenced by changes in use prevalences... - Pharmacogenomics: the promise of personalized medicine for CNS disordersJose de Leon
Mental Health Research Center, Eastern State Hospital, University of Kentucky, Lexington, KY 40508, USA
Neuropsychopharmacology 34:159-72. 2009.... - A brief measure of high nicotine dependence for busy clinicians and large epidemiological surveysFrancisco J Diaz
Mental Health Research Center at Eastern State Hospital, Lexington, KY 40508, USA
Aust N Z J Psychiatry 39:161-8. 2005.... - The CYP2D6 poor metabolizer phenotype may be associated with risperidone adverse drug reactions and discontinuationJose de Leon
University of Kentucky Mental Health Research Center at Eastern State Hospital, Lexington, KY 40508, USA
J Clin Psychiatry 66:15-27. 2005..CYP2D6 poor metabolizers have no CYP2D6 activity (7% of whites and 1%-2% of other races). This study tested whether the CYP2D6 poor metabolizer phenotype was associated with adverse drug reactions (ADRs) and discontinuation due to ADRs... - Serum antimuscarinic activity during clozapine treatmentJose de Leon
Mental Health Research Center, Eastern State Hospital, 627 West Fourth Street, Lexington, KY 40508, USA
J Clin Psychopharmacol 23:336-41. 2003..In vitro studies and new clinical studies are needed to verify whether norclozapine may significantly contribute to antimuscarinic activity during clozapine treatment... - Glucuronidation enzymes, genes and psychiatryJose de Leon
University of Kentucky Mental Health Research Center at Eastern State Hospital, Department of Psychiatry, College of Medicine, Lexington, KY 40508, USA
Int J Neuropsychopharmacol 6:57-72. 2003..However, UGTs may be localized in certain brain areas to provide a neuroprotective function. This review illustrates the importance of glucuronidation and the implications for psychiatry... - Polydipsia--a study in a long-term psychiatric unitJose de Leon
Mental Health Research Center at Eastern State Hospital and Department of Psychiatry, University of Kentucky, Lexington, KY 40508, USA
Eur Arch Psychiatry Clin Neurosci 253:37-9. 2003..Polydipsic patients should not be switched to other atypical antipsychotics, unless new prospective studies prove that they are as effective as clozapine for polydipsia... - Pharmacogenetic testing in psychiatry: a review of features and clinical realitiesJose de Leon
University of Kentucky Mental Health Research Center at Eastern State Hospital, 627 West Fourth Street, Lexington, KY 40508, USA
Clin Lab Med 28:599-617. 2008..Finally, the future of these and other pharmacogenetic tests in psychiatry is discussed... - A pilot study of plasma caffeine concentrations in a US sample of smoker and nonsmoker volunteersJose de Leon
University of Kentucky UK Mental Health Research Center at Eastern State Hospital, 627 West Fourth Street, Lexington, KY 40508, USA
Prog Neuropsychopharmacol Biol Psychiatry 27:165-71. 2003..Additional studies are needed to replicate the model. This model may help epidemiologists to correct for the effects of smoking on caffeine intake and pharmacologists to screen for the activity of CYP1A2... - Paradoxical excitation on diphenhydramine may be associated with being a CYP2D6 ultrarapid metabolizer: three case reportsJose de Leon
Mental Health Research Center, Eastern State Hospital, Lexington, KY, USA
CNS Spectr 13:133-5. 2008..Although these are only three anecdotal cases of paradoxical excitation from three CYP2D6 UMs, the reports illustrate the need for larger, more formal studies of diphenhydramine responses in CYP2D6 UMs and of diphenhydramine metabolism... - Total cotinine in plasma: a stable biomarker for exposure to tobacco smokeJose de Leon
University of Kentucky Mental Health Research Center at Eastern State Hospital, Lexington, 40508, USA
J Clin Psychopharmacol 22:496-501. 2002..New studies of total cotinine in plasma using more than two blood collections during the day are needed to definitively establish that it is a stable biomarker for epidemiological studies... - Polydipsia and schizophrenia in a psychiatric hospital: a replication studyJose de Leon
Mental Health Research Center at Eastern State Hospital, 627 West Fourth St, Lexington, KY 40508, USA
Schizophr Res 57:293-301. 2002..Psychiatric medications do not appear to explain most cases of polydipsia in these patients... - Serious respiratory infections can increase clozapine levels and contribute to side effects: a case reportJose de Leon
University of Kentucky Mental Health Research Center at Eastern State Hospital, 627 West Fourth Street, Lexington, KY 40508, USA
Prog Neuropsychopharmacol Biol Psychiatry 27:1059-63. 2003..If any of these signs appear, the psychiatrist may need to consider cutting the clozapine dose in half until the patient has recovered from the infection... - Exploring brief measures of nicotine dependence for epidemiological surveysJose de Leon
Mental Health Research Center at Eastern State Hospital, 627 West Fourth Street, Lexington, KY 40508, USA
Addict Behav 28:1481-6. 2003..Researchers needing definition of nicotine dependence briefer than FTND may want to only use Items 1 and 4 of FTND with a cutting score > or = 4... - Haloperidol half-life after chronic dosingJose de Leon
Mental Health Research Center at Eastern State Hospital, Lexington, KY, USA
J Clin Psychopharmacol 24:656-60. 2004..This study suggests that haloperidol half-life following repeated drug administration is substantially more prolonged than what has been observed after acute haloperidol administration... - Possible individual and gender differences in the small increases in plasma prolactin levels seen during clozapine treatmentJose de Leon
Clinical Research Center, Norristown State Hospital, Norristown, PA, USA
Eur Arch Psychiatry Clin Neurosci 254:318-25. 2004..6) correlation between clozapine and prolactin levels. This study suggests that clozapine has effects on prolactin levels but effects are small and may be more evident in some individuals, particularly females... - The pharmacokinetics of paliperidone versus risperidoneJose de Leon
Mental Health Research Center, Eastern State Hospital, 627 West Fourth St, Lexington, KY 40508, USA
Psychosomatics 51:80-8. 2010..Several new atypical antipsychotics have become available for use, but knowledge about their pharmacology may not be widespread... - Paying attention to pharmacokinetic and pharmacodynamic mechanisms to progress in the area of anticholinergic use in geriatric patientsJ de Leon
University of Kentucky Mental Health Research Center and Department of Psychiatry, School of Medicine, University of Kentucky, Lexington, KY, USA
Curr Drug Metab 12:635-46. 2011..If one agrees that antimuscarinic ADRs are probably dose-related, future studies must consider all drugs, administration routes, doses, muscarinic receptor affinity, DDIs, and brain access... - Psychopharmacology: atypical antipsychotic dosing: the effect of co-medication with anticonvulsantsJose de Leon
University of Kentucky Mental Health Research Center at Eastern State Hospital, Lexington, Kentucky 40508, USA
Psychiatr Serv 55:125-8. 2004 - Lack of replication of the association of low serum cholesterol and attempted suicide in another country raises more questionsJose de Leon
Mental Health Research Center, Eastern State Hospital, 627 West Fourth Street, Lexington, KY 40508, USA
Ann Clin Psychiatry 23:163-70. 2011..In 2 Spanish case-control studies, low cholesterol levels in males were consistently associated with suicide attempts... - Atypical antipsychotic dosing: the effect of smoking and caffeineJose de Leon
University of Kentucky Mental Health Research Center at Eastern State Hospital, 627 West Fourth Street, Lexington, Kentucky 40508, USA
Psychiatr Serv 55:491-3. 2004 - The association between high nicotine dependence and severe mental illness may be consistent across countriesJose de Leon
Mental Health Research Center at Eastern State Hospital, Lexington, KY 40508, USA
J Clin Psychiatry 63:812-6. 2002.... - Variables associated with high olanzapine dosing in a state hospitalSheila Botts
Mental Health Research Center at Eastern State Hospital, University of Kentucky, Lexington, KY 40508, USA
J Clin Psychiatry 65:1138-43. 2004..The association of increased length of stay with high dose suggests that treatment resistance may be an important factor in receiving high daily doses of olanzapine... - Obesity and associated complications in patients with severe mental illnesses: a cross-sectional surveyMargaret T Susce
University of Kentucky Mental Health Research Center at Eastern State Hospital, Lexington, KY 40508, USA
J Clin Psychiatry 66:167-73. 2005..The former may be more important in females, while the latter may be more important in males. Clinical diagnoses (schizophrenic or mood disorders) or current treatment did not appear to be fundamental factors... - Estimating the effects of co-medications on plasma olanzapine concentrations by using a mixed modelSheila Botts
College of Pharmacy, University of Kentucky, Mental Health Research Center, Eastern State Hospital, Lexington, KY 40508, United States
Prog Neuropsychopharmacol Biol Psychiatry 32:1453-8. 2008..Other limitations were the small sample size of some drug sub-samples and the lack of testing for plasma olanzapine metabolites... - Schizophrenia and tobacco smoking: a replication study in another US psychiatric hospitalJose de Leon
Mental Health Research Center at Eastern State Hospital, 627 West Fourth Street, Lexington, KY 40508, USA
Schizophr Res 56:55-65. 2002..In summary, these two studies suggest that schizophrenia is strongly associated with smoking. Neither substance use, antipsychotics, nor institutionalism can explain this relationship... - A poor metabolizer for cytochromes P450 2D6 and 2C19: a case report on antidepressant treatmentMaria Johnson
University of Kentucky Mental Health Research Center, Eastern State Hospital, Lexington, KY 40508, USA
CNS Spectr 11:757-60. 2006..As genotyping reaches clinical practice, it will be interesting to prospectively establish whether mirtazapine is a reasonable choice as an antidepressant for these patients, as the data and this case suggest... - Nicotine exposure can be detected in cerebrospinal fluid of active and passive smokersAhmad H Malkawi
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
J Pharm Biomed Anal 49:129-32. 2009..6-81.1 ng/ml). The concentrations of cotinine in CSF samples suggests that nicotine easily passes into the CSF, which makes it an excellent CSF marker for tobacco-smoke exposure... - Initiation of daily smoking and nicotine dependence in schizophrenia and mood disordersJose de Leon
University of Kentucky Mental Health Research Center at Eastern State Hospital, 627 West Fourth St, Lexington, KY 40508, USA
Schizophr Res 56:47-54. 2002..Schizophrenia was associated with a greater probability of ever daily smoking than mood disorders and with higher rates of initiation of daily smoking after 20 years old... - Excessive antipsychotic dosing in 2 U.S. State hospitalsFrancisco J Diaz
Mental Health Research Center at Eastern State Hospital, Lexington, KY 40508, USA
J Clin Psychiatry 63:998-1003. 2002..In future studies, pharmacogenetic tests and control for confounding factors, such as smoking, will help to establish whether racial differences in dosing are influenced by different metabolic capacities or physician biases... - Fewer but heavier caffeine consumers in schizophrenia: a case-control studyManuel Gurpegui
Department of Psychiatry and Institute of Neurosciences, University of Granada Medical School, Av Madrid 11, Granada, Spain
Schizophr Res 86:276-83. 2006..In future studies, the measurement of plasma caffeine levels will help both to better define heavy caffeine intake and to control for smoking pharmacokinetic effects... - Respiratory infections rather than antibiotics may increase clozapine levels: a critical review of the literatureJose de Leon
J Clin Psychiatry 65:1144-5. 2004 - Smoking is associated with schizophrenia, but not with mood disorders, within a population with low smoking rates: a matched case-control study in Bucaramanga, ColombiaAdalberto Campo-Arias
Neuropsychiatry Research Group, , Colombia
Schizophr Res 83:269-76. 2006.... - High vulnerability to acute dystonic reactions: a case of antipsychotic exposure and uncontrolled seizure activityGara L Coffey
University of Kentucky (UK, College of Pharmacy, Lexington, KY, USA
Prog Neuropsychopharmacol Biol Psychiatry 29:770-4. 2005..None of the gene variations tested (CYP2D6 phenotype, two dopamine D2 receptor variants and one D3 receptor variant) appeared to explain the patient's vulnerability to acute dystonic reactions... - Incorporating pharmacogenetics into clinical practice: reality of a new tool in psychiatry. Current issues in clinical implementationJose de Leon
CNS Spectr 11:8-12. 2006 - Comparison of two CYP2D6 genotyping methods and assessment of genotype-phenotype relationshipsWen Hwei Chou
Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky and UK Mental Health Research Center at Eastern State Hospital, Lexington 40536, USA
Clin Chem 49:542-51. 2003..There have been no published reports comparing the CYP450 GeneChip microarray assay with more standard methods of genetic testing... - Subjective effects and the main reason for smoking in outpatients with schizophrenia: a case-control studyManuel Gurpegui
Department of Psychiatry and Institute of Neurosciences, University of Granada Medical School, Av Madrid 11, E 18071 Granada, Spain
Compr Psychiatry 48:186-91. 2007..These survey data call for confirmation through experimental studies and may help in the design of more focused smoking cessation programs for these patients... - Using data mining to explore complex clinical decisions: A study of hospitalization after a suicide attemptEnrique Baca-Garcia
Department of Psychiatry, Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Madrid, Spain
J Clin Psychiatry 67:1124-32. 2006..A new set of statistical techniques called data mining (or machine learning) is being used by different industries to explore complex databases and can be used to explore large clinical databases... - Caffeine intake in outpatients with schizophreniaManuel Gurpegui
Department of Psychiatry and Institute of Neurosciences, University of Granada, Spain
Schizophr Bull 30:935-45. 2004..Among caffeine consumers, smoking was associated with the amount of caffeine intake. Cross-sectional schizophrenia symptomatology was not associated with caffeine intake... - Plasma clozapine concentration coefficients of variation in a long-term studyFrancisco J Diaz
Department of Statistics, Universidad Nacional, Medellin, Colombia
Schizophr Res 72:131-5. 2005..Clozapine CVs may be important in order to understand the importance of variations around the therapeutic range and to interpret drug interactions above the usual noise of measuring plasma concentrations... - Metabolic drug interactions with newer antipsychotics: a comparative reviewEdoardo Spina
Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina and IRCCS Neurological Center Bonino Pulejo, Messina, Italy, and Eastern State Hospital, Lexington, KY, USA
Basic Clin Pharmacol Toxicol 100:4-22. 2007.... - A gender-specific association between the serotonin transporter gene and suicide attemptsEnrique Baca-Garcia
Department of Psychiatry, Hospital Ramon y Cajal, Universidad de Alcala Madrid, Madrid, Spain
Neuropsychopharmacology 26:692-5. 2002..Further studies are needed to replicate that the serotonin genotype polymorphism may influence suicide attempts only in females... - Smoking in bipolar and schizophrenic patientsJose de Leon
J Clin Psychiatry 63:368-9; author reply 369. 2002 - Association between the T102C polymorphism of the serotonin-2A receptor gene and schizophreniaConcepcion Vaquero Lorenzo
Department of Genetics, Autonoma University of Madrid, Edificio de Biología, Facultad de Ciencias, Calle Darwin, 2 28049, Cantoblanco, Madrid, Spain
Prog Neuropsychopharmacol Biol Psychiatry 30:1136-8. 2006..The C allele was more frequent in schizophrenia patients than in healthy controls. The Cochrane-Armitage test for trend indicated a significant dosage effect for schizophrenia of the risk allele (C)... - The crucial role of the therapeutic window in understanding the clinical relevance of the poor versus the ultrarapid metabolizer phenotypes in subjects taking drugs metabolized by CYP2D6 or CYP2C19Jose de Leon
J Clin Psychopharmacol 27:241-5. 2007 - A pilot study on differences in aggression in New York City and Madrid, Spain, and their possible impact on suicidal behaviorEnrique Baca-Garcia
Department of Psychiatry, Fundacion Jimenez Diaz, Madrid, Spain
J Clin Psychiatry 67:375-80. 2006..The study goals were (1) to compare aggression scores in attempters and healthy volunteers between the 2 cities and (2) to determine whether higher aggression scores are associated with greater medical lethality of suicide attempts... - Beyond the "hype" on the association between metabolic syndrome and atypical antipsychotics: the confounding effects of cohort, typical antipsychotics, severe mental illness, comedications, and comorbid substance useJose de Leon
J Clin Psychopharmacol 28:125-31. 2008 - Cytochrome P450 2D6 and antidepressant toxicity and response: what is the evidence?Peter J Wedlund
College of Pharmacy and Medicine, University of Kentucky, Lexington, KY 403536, USA
Clin Pharmacol Ther 75:373-5. 2004 - Smoking cessation in patients with psychiatric disordersAlan J Gelenberg
Department of Psychiatry, University of Arizona, Tucson, USA
J Clin Psychiatry 68:1404-10. 2007 - Guidelines for the use of clozapine in individuals with developmental disabilitiesMohamed Sabaawi
Department of Psychiatry, College of Medicine, University of Kentucky, Lexington, 40509, USA
Res Dev Disabil 27:309-36. 2006..We also include requirements regarding informed consent, dosage and special laboratory and clinical monitoring... - An HPLC method for the simultaneous determination of neurotoxic dipyridyl isomers in human plasmaAhmad H Malkawi
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
J Pharm Biomed Anal 45:120-4. 2007.... - Response to hydrocodone, codeine and oxycodone in a CYP2D6 poor metabolizerMargaret T Susce
University of Kentucky, Mental Health Research Center at Eastern State Hospital, Lexington, KY 40508, USA
Prog Neuropsychopharmacol Biol Psychiatry 30:1356-8. 2006..Large case-control naturalistic studies followed by randomized trials in patients taking opioid analgesics may be needed to definitively establish that CYP2D6 genotyping has clinical relevance in the use of several opioid analgesics... - Plasma cotinine, 3'-hydroxycotinine, and their glucuronides in white and black smokersJose de Leon
J Clin Psychopharmacol 23:209-11. 2003 - Low plasma cholesterol levels in suicidal males: a gender- and body mass index-matched case-control study of suicide attempters and nonattemptersCarmen Diaz Sastre
Centro de Salud Mental de Hortaleza, Avenida de Mar Caspio, Madrid 28050, Spain
Prog Neuropsychopharmacol Biol Psychiatry 31:901-5. 2007..Serum cholesterol levels were significantly lower in suicide attempters than in controls. After gender stratification, the difference remained significant in men, but not in women... - Hypertriglyceridemia associated with direct effects of olanzapine rather than with weight gain: a case reportCourtney Markham-Abedi
J Clin Psychiatry 67:1473-4. 2006 - Datapoints: Smoking and smoking cessation among persons with severe mental illnessesFrancisco J Diaz
Department of Statistics, Universidad Nacional, Medellin, Colombia
Psychiatr Serv 57:462. 2006 - An investigation of the alpha1A-adrenergic receptor gene and antipsychotic-induced side-effectsPilar A Saiz
Clinical Neuropharmacology, Institute of Psychiatry King s College, London, UK
Hum Psychopharmacol 23:107-14. 2008..These results do not support a major role of alpha(1A)-adrenergic genetic variants in obesity and other side-effects observed after prolonged treatment with antipsychotic medications... - A case report with ziprasidone-induced catatonic symptomsCourtney Markham-Abedi
J Neuropsychiatry Clin Neurosci 19:476-7. 2007 - Probable association between ziprasidone and worsening hypertensionNoemi Villanueva
Johnson and Johnson, Madrid, Madrid, Spain
Pharmacotherapy 26:1352-7. 2006..If this occurs, replacement of ziprasidone with a different antipsychotic should be considered... - Clobazam therapeutic drug monitoring: a comprehensive review of the literature with proposals to improve future studiesJose de Leon
University of Kentucky Mental Health Research Center at Eastern State Hospital, Lexington, Kentucky Psychiatry and Neurosciences Research Group CTS 549, Institute of Neurosciences, University of Granada, Granada, Spain Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy Department of Biostatistics, The University of Kansas Medical Center, Kansas City, Kansas
Ther Drug Monit 35:30-47. 2013..Clobazam was recently approved for Lennox-Gastaut syndrome in the United States. There is no published review article focused on clobazam therapeutic drug monitoring (TDM) in English... - Lack of association between testosterone and suicide attemptsM Mercedes Perez-Rodriguez
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
Neuropsychobiology 63:125-30. 2011.... - Two case reports of oral ulcers with lamotrigine several weeks after oxcarbazepine withdrawalJose de Leon
University of Kentucky, Mental Health Research Center at Eastern State Hospital and the Department of Psychiatry, University of Kentucky, Lexington, KY 40508, USA
Bipolar Disord 9:310-3. 2007..To report two cases of mouth ulcers in lamotrigine patients after oxcarbazepine withdrawal... - Toxicity of dipyridyl compounds and related compoundsShenggang Li
University of Kentucky Mental Health Research Center at Eastern State Hospital, Lexington, Kentucky 40508, USA
Crit Rev Toxicol 34:447-60. 2004..These results are consistent with earlier studies in Sherman rats using high 2,2'- and 4,4'-dipyridyl doses. New studies are needed to further explore the toxicological properties of dipyridyls and their potential public health impact...