James A de Lemos

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Associations of visceral and abdominal subcutaneous adipose tissue with markers of cardiac and metabolic risk in obese adults
    Ian J Neeland
    Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Obesity (Silver Spring) 21:E439-47. 2013
  2. doi request reprint Increasingly sensitive assays for cardiac troponins: a review
    James A de Lemos
    Division of Cardiology, Department of Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8830, USA
    JAMA 309:2262-9. 2013
  3. ncbi request reprint Serial measurement of monocyte chemoattractant protein-1 after acute coronary syndromes: results from the A to Z trial
    James A de Lemos
    Donald W Reynolds Cardiovascular Clinical Research Center, UT Southwestern Medical Center, Dallas, Texas 75390 9047, USA
    J Am Coll Cardiol 50:2117-24. 2007
  4. ncbi request reprint B-type natriuretic peptide in cardiovascular disease
    James A de Lemos
    Donald W Reynolds Cardiovascular Clinical Research Center and Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Lancet 362:316-22. 2003
  5. doi request reprint Screening the population for left ventricular hypertrophy and left ventricular systolic dysfunction using natriuretic peptides: results from the Dallas Heart Study
    James A de Lemos
    Donald W Reynolds Cardiovascular Research Center, UT Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Am Heart J 157:746-53.e2. 2009
  6. ncbi request reprint Current status of risk stratification methods in acute coronary syndromes
    Raphael See
    Cardiology Division, UT Southwestern Medical Center, 5909 Harry Hines Boulevard, HA 9 133, Dallas, TX 75390 9047, USA
    Curr Cardiol Rep 8:282-8. 2006
  7. doi request reprint Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population
    James A de Lemos
    Division of Cardiology, University of Texas Southwestern Medical Center, 5909 Harry Hines Blvd, Dallas, TX 75390 9047, USA
    JAMA 304:2503-12. 2010
  8. ncbi request reprint Early intensive vs a delayed conservative simvastatin strategy in patients with acute coronary syndromes: phase Z of the A to Z trial
    James A de Lemos
    Donald W Reynolds Cardiovascular Clinical Research Center, The University of Texas Southwestern Medical Center, Dallas 75390 9047, USA
    JAMA 292:1307-16. 2004
  9. ncbi request reprint Enoxaparin versus unfractionated heparin in patients treated with tirofiban, aspirin and an early conservative initial management strategy: results from the A phase of the A-to-Z trial
    James A de Lemos
    Donald W Reynolds Cardiovascular Clinical Research Center, 5323 Harry Hines Blvd, Rm HA 9 133, UT Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Eur Heart J 25:1688-94. 2004
  10. ncbi request reprint B-type natriuretic peptide in ischemic heart disease
    Rajat Deo
    Division of Cardiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, HA 9 133, Dallas, TX 75390 9047, USA
    Curr Cardiol Rep 5:271-7. 2003

Detail Information

Publications75

  1. pmc Associations of visceral and abdominal subcutaneous adipose tissue with markers of cardiac and metabolic risk in obese adults
    Ian J Neeland
    Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Obesity (Silver Spring) 21:E439-47. 2013
    ..We sought to determine the associations of abdominal VAT and SAT mass with markers of cardiac and metabolic risk in a large, multiethnic, population-based cohort of obese adults...
  2. doi request reprint Increasingly sensitive assays for cardiac troponins: a review
    James A de Lemos
    Division of Cardiology, Department of Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8830, USA
    JAMA 309:2262-9. 2013
    ....
  3. ncbi request reprint Serial measurement of monocyte chemoattractant protein-1 after acute coronary syndromes: results from the A to Z trial
    James A de Lemos
    Donald W Reynolds Cardiovascular Clinical Research Center, UT Southwestern Medical Center, Dallas, Texas 75390 9047, USA
    J Am Coll Cardiol 50:2117-24. 2007
    ..This study sought to determine whether the novel biomarker monocyte chemoattractant protein (MCP)-1 adds prognostic value to standard risk assessment tools and biomarkers after acute coronary syndromes (ACS)...
  4. ncbi request reprint B-type natriuretic peptide in cardiovascular disease
    James A de Lemos
    Donald W Reynolds Cardiovascular Clinical Research Center and Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Lancet 362:316-22. 2003
    ....
  5. doi request reprint Screening the population for left ventricular hypertrophy and left ventricular systolic dysfunction using natriuretic peptides: results from the Dallas Heart Study
    James A de Lemos
    Donald W Reynolds Cardiovascular Research Center, UT Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Am Heart J 157:746-53.e2. 2009
    ..We performed a comprehensive evaluation of the screening performance of B-type natriuretic peptide (BNP) and N-terminal pro-BNP (NT-proBNP) for LVSD or LVH...
  6. ncbi request reprint Current status of risk stratification methods in acute coronary syndromes
    Raphael See
    Cardiology Division, UT Southwestern Medical Center, 5909 Harry Hines Boulevard, HA 9 133, Dallas, TX 75390 9047, USA
    Curr Cardiol Rep 8:282-8. 2006
    ..Finally, advances in coronary CT angiography and bedside echocardiography offer hope that noninvasive imaging may play a more important role in early risk stratification in the near future...
  7. doi request reprint Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population
    James A de Lemos
    Division of Cardiology, University of Texas Southwestern Medical Center, 5909 Harry Hines Blvd, Dallas, TX 75390 9047, USA
    JAMA 304:2503-12. 2010
    ....
  8. ncbi request reprint Early intensive vs a delayed conservative simvastatin strategy in patients with acute coronary syndromes: phase Z of the A to Z trial
    James A de Lemos
    Donald W Reynolds Cardiovascular Clinical Research Center, The University of Texas Southwestern Medical Center, Dallas 75390 9047, USA
    JAMA 292:1307-16. 2004
    ..Limited data are available evaluating how the timing and intensity of statin therapy following an acute coronary syndrome (ACS) event affect clinical outcome...
  9. ncbi request reprint Enoxaparin versus unfractionated heparin in patients treated with tirofiban, aspirin and an early conservative initial management strategy: results from the A phase of the A-to-Z trial
    James A de Lemos
    Donald W Reynolds Cardiovascular Clinical Research Center, 5323 Harry Hines Blvd, Rm HA 9 133, UT Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Eur Heart J 25:1688-94. 2004
    ..However, less is known about the relative merits of these two forms of heparin in patients receiving concomitant glycoprotein IIb/IIIa inhibitors...
  10. ncbi request reprint B-type natriuretic peptide in ischemic heart disease
    Rajat Deo
    Division of Cardiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, HA 9 133, Dallas, TX 75390 9047, USA
    Curr Cardiol Rep 5:271-7. 2003
    ..Future studies are needed to identify the therapeutic implications of BNP elevation in patients with ACS...
  11. doi request reprint Amino-terminal pro-B-type natriuretic peptides: testing in general populations
    James A de Lemos
    Cardiology Division, University of Texas, Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Am J Cardiol 101:16-20. 2008
    ..Better understanding of these factors may allow optimization of thresholds for screening of apparently well patients and concomitant delineation of patient populations in whom NT-proBNP screening is less appropriate...
  12. ncbi request reprint Associations between soluble CD40 ligand, atherosclerosis risk factors, and subclinical atherosclerosis: results from the Dallas Heart Study
    James A de Lemos
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Arterioscler Thromb Vasc Biol 25:2192-6. 2005
    ..The purpose of this study was to evaluate the associations between plasma levels of soluble CD40 ligand (sCD40L), atherosclerosis risk factors, and evidence of subclinical atherosclerosis...
  13. ncbi request reprint Association between plasma levels of monocyte chemoattractant protein-1 and long-term clinical outcomes in patients with acute coronary syndromes
    James A de Lemos
    TIMI Study Group, Donald W Reynolds Cardiovascular Clinical Research Center, The University of Texas, Southwestern Medical School, Dallas, TX 75390 9047, USA
    Circulation 107:690-5. 2003
    ..MCP-1 appears to play a critical role at multiple stages in atherosclerosis, including the initiation of the fatty streak, promotion of plaque instability, and remodeling after myocardial infarction...
  14. ncbi request reprint The prognostic value of serum myoglobin in patients with non-ST-segment elevation acute coronary syndromes. Results from the TIMI 11B and TACTICS-TIMI 18 studies
    James A de Lemos
    Thrombolysis in Myocardial Infarction TIMI Study Group, Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, TX 75390 9047, USA
    J Am Coll Cardiol 40:238-44. 2002
    ..The goal of this study was to define the prognostic value of serum myoglobin in patients with non-ST-elevation acute coronary syndromes (ACS)...
  15. ncbi request reprint Abciximab and early adjunctive percutaneous coronary intervention are associated with improved ST-segment resolution after thrombolysis: Observations from the TIMI 14 Trial
    J A de Lemos
    Donald W Reynolds Cardiovascular Clinical Research Center, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Room 8 116, Dallas, TX 75390 9034, USA
    Am Heart J 141:592-8. 2001
    ....
  16. ncbi request reprint Early noninvasive detection of failed epicardial reperfusion after fibrinolytic therapy
    J A de Lemos
    Donald W Reynolds Cardiovascular Clinical Research Center and the University of Texas Southwestern Medical Center, Dallas, Texas 75390 9034, USA
    Am J Cardiol 88:353-8. 2001
    ..In conclusion, ST-segment resolution, chest pain resolution, and early washout of serum myoglobin can be used in combination to aid in the early noninvasive identification of candidates for rescue percutaneous coronary intervention...
  17. ncbi request reprint The prognostic value of B-type natriuretic peptide in patients with acute coronary syndromes
    J A de Lemos
    Thrombolysis in Myocardial Infarction Study Group, Boston, USA
    N Engl J Med 345:1014-21. 2001
    ....
  18. ncbi request reprint ST segment resolution as a tool for assessing the efficacy of reperfusion therapy
    J A de Lemos
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75093 9034, USA
    J Am Coll Cardiol 38:1283-94. 2001
    ....
  19. ncbi request reprint Outcomes of patients with acute coronary syndrome and previous coronary artery bypass grafting (from the Pravastatin or Atorvastatin Evaluation and Infection Therapy [PROVE IT-TIMI 22] and the Aggrastat to Zocor [A to Z] trials)
    Emmanouil S Brilakis
    Cardiovascular Division, Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Am J Cardiol 102:552-8. 2008
    ..In conclusion, compared with patients with ACS without previous CABG, those with previous CABG have a higher risk for adverse cardiac events and may derive similar benefit from intensive statin therapy...
  20. doi request reprint Clinical presentation and angiographic characteristics of saphenous vein graft failure after stenting: insights from the SOS (stenting of saphenous vein grafts) trial
    Christopher Lichtenwalter
    Veteran Affairs North Texas Healthcare System, Dallas, Texas, USA
    JACC Cardiovasc Interv 2:855-60. 2009
    ..We sought to compare the clinical presentation and angiographic patterns of saphenous vein graft (SVG) failure after stenting with a paclitaxel-eluting stent (PES) versus a similar bare-metal stent (BMS)...
  21. ncbi request reprint Multimarker approach to risk stratification in non-ST elevation acute coronary syndromes: simultaneous assessment of troponin I, C-reactive protein, and B-type natriuretic peptide
    Marc S Sabatine
    TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Circulation 105:1760-3. 2002
    ..Little is known, however, about the utility of these biomarkers in combination...
  22. doi request reprint Independent associations between metabolic syndrome, diabetes mellitus and atherosclerosis: observations from the Dallas Heart Study
    Karen Chen
    The School of Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75235 9047, USA
    Diab Vasc Dis Res 5:96-101. 2008
    ..In conclusion, both MetS and DM are independently associated with an increased prevalence of atherosclerosis, with the highest observed prevalence in subjects with both DM and MetS...
  23. ncbi request reprint Clinical application of C-reactive protein across the spectrum of acute coronary syndromes
    Benjamin M Scirica
    TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02461, USA
    Clin Chem 53:1800-7. 2007
    ..The ability to formulate recommendations regarding clinical use of hsCRP is limited by a paucity of data regarding several key issues. The purpose of this study was to evaluate hsCRP across the spectrum of ACS...
  24. doi request reprint Continued benefit from paclitaxel-eluting compared with bare-metal stent implantation in saphenous vein graft lesions during long-term follow-up of the SOS (Stenting of Saphenous Vein Grafts) trial
    Emmanouil S Brilakis
    Department of Cardiovascular Diseases, Veteran Affairs North Texas Healthcare System, Dallas, Texas, USA
    JACC Cardiovasc Interv 4:176-82. 2011
    ..This study sought to report the long-term outcomes after drug-eluting stent (DES) implantation in saphenous vein graft (SVG) lesions in the SOS (Stenting of Saphenous Vein Grafts) trial...
  25. doi request reprint The effects of rosiglitazone on myocardial triglyceride content in patients with type 2 diabetes: a randomised, placebo-controlled trial
    Jonathan McGavock
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, TX 75235 9047, USA
    Diab Vasc Dis Res 9:131-7. 2012
    ..Compared with placebo, treatment with rosiglitazone for 6 months had no discernible effect on mTG or left ventricular function in this population with long-standing diabetes and CVD...
  26. ncbi request reprint Effect of glucose-insulin-potassium (GIK) infusion on biomarkers of cardiovascular risk in ST elevation myocardial infarction (STEMI): insight into the failure of GIK
    Shailja V Parikh
    Department of Internal Medicine, the University of Texas Southwestern Medical Center in Dallas, Texas 75235 9047, USA
    Diab Vasc Dis Res 4:222-5. 2007
    ..In conclusion, GIK had no discernible effect on biomarkers associated with inflammation, neurohormonal activation or myonecrosis, three pathways associated with adverse outcomes in STEMI...
  27. ncbi request reprint Infarct-related coronary artery patency and medication use prior to ST-segment elevation myocardial infarction
    Christina R Robinson
    The Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Am J Cardiol 97:7-9. 2006
    ..Further, our data demonstrate a graded association according to the number of such medications being administered: the likelihood of a patent infarct-related artery increased to >50% as the number of these medications increased...
  28. ncbi request reprint Evaluation of B-type natriuretic peptide for risk assessment in unstable angina/non-ST-elevation myocardial infarction: B-type natriuretic peptide and prognosis in TACTICS-TIMI 18
    David A Morrow
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 41:1264-72. 2003
    ....
  29. ncbi request reprint Increased cardiovascular risk associated with diabetes in Dallas County
    Sandeep R Das
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75235 9047, USA
    Am Heart J 151:1087-93. 2006
    ..We assess the prevalence of diabetes in Dallas County, quantify the association between diabetes and subclinical cardiovascular disease, and assess the use of evidence-based cardiovascular disease risk-modifying therapies...
  30. ncbi request reprint A tale of two trials: a comparison of the post-acute coronary syndrome lipid-lowering trials A to Z and PROVE IT-TIMI 22
    Stephen D Wiviott
    The TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 113:1406-14. 2006
    ..We analyzed the design, implementation, and results of the two trials in an attempt to clarify the effects of early intensive statin therapy...
  31. ncbi request reprint Left ventricular hypertrophy, aortic wall thickness, and lifetime predicted risk of cardiovascular disease:the Dallas Heart Study
    Sachin Gupta
    Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    JACC Cardiovasc Imaging 3:605-13. 2010
    ....
  32. pmc Age- and sex-dependent upper reference limits for the high-sensitivity cardiac troponin T assay
    M Odette Gore
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas
    J Am Coll Cardiol 63:1441-8. 2014
    ..The study sought to determine the 99th percentile upper reference limit for the high-sensitivity cardiac troponin T assay (hs-cTnT) in 3 large independent cohorts...
  33. pmc Race-specific associations of myeloperoxidase with atherosclerosis in a population-based sample: the Dallas Heart Study
    Lu Q Chen
    The Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, United States
    Atherosclerosis 219:833-8. 2011
    ..We evaluated the association of circulating MPO with coronary and aortic atherosclerosis in a large, multiethnic population...
  34. ncbi request reprint Association of a pulsatile blood flow pattern on coronary arteriography and short-term clinical outcomes in acute myocardial infarction
    C Michael Gibson
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 43:1170-6. 2004
    ....
  35. ncbi request reprint Effect of intensive lipid-lowering therapy on mortality after acute coronary syndrome (a patient-level analysis of the Aggrastat to Zocor and Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 trials)
    Sabina A Murphy
    TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 100:1047-51. 2007
    ..On the basis of these findings, 1 death was prevented for every 95 patients treated with high-dose statin therapy for 2 years. The results of this pooled analysis provide further evidence for early intensive statin therapy after ACS...
  36. ncbi request reprint B-type natriuretic peptide at presentation and prognosis in patients with ST-segment elevation myocardial infarction: an ENTIRE-TIMI-23 substudy
    Jessica L Mega
    TIMI Study Group, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 44:335-9. 2004
    ....
  37. ncbi request reprint Left ventricular hypertrophy, subclinical atherosclerosis, and inflammation
    Sameer K Mehta
    Donald W Reynolds Cardiovascular Clinical Research Center and Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Hypertension 49:1385-91. 2007
    ..These data likely explain in part why individuals with LVH are at increased risk for myocardial infarction...
  38. ncbi request reprint Interleukin-18, the metabolic syndrome, and subclinical atherosclerosis: results from the Dallas Heart Study
    Andreas Zirlik
    Donald W Reynolds Centers of the Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Arterioscler Thromb Vasc Biol 27:2043-9. 2007
    ..Although IL-18 promotes atherogenesis in animal studies and predicts cardiovascular risk in humans, it is unknown whether elevated IL-18 levels are associated with coronary atherosclerosis in the general population...
  39. ncbi request reprint Sex differences in the association between leptin and CRP: results from the Dallas Heart Study
    Shuaib M Abdullah
    Donald W Reynolds Cardiovascular Clinical Research Center at the University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Atherosclerosis 195:404-10. 2007
    ..Higher C-reactive protein (CRP) levels in women compared with men may reflect sex differences in the relationship between obesity and inflammation. We evaluated how the adipokine leptin influenced these relationships...
  40. ncbi request reprint Soluble CD40L: risk prediction after acute coronary syndromes
    Nerea Varo
    Donald W Reynolds Cardiovascular Clinical Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 108:1049-52. 2003
    ..This study tested the hypothesis that plasma sCD40L, alone or in combination with troponin (cTnI) or C-reactive protein (CRP), may identify patients with acute coronary syndromes at heightened risk for recurrent cardiac events...
  41. ncbi request reprint Prognostic utility of heart-type fatty acid binding protein in patients with acute coronary syndromes
    Michelle O'Donoghue
    Cardiovascular Division, Brigham and Women s Hospital, 350 Longwood Ave, First Floor, Boston, Mass 02115, USA
    Circulation 114:550-7. 2006
    ..Although it has been investigated as an early marker of acute myocardial infarction, its prognostic utility in acute coronary syndromes has not been established...
  42. ncbi request reprint Relation of coronary atherosclerosis determined by electron beam computed tomography and plasma levels of n-terminal pro-brain natriuretic peptide in a multiethnic population-based sample (the Dallas Heart Study)
    Shuaib M Abdullah
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Am J Cardiol 96:1284-9. 2005
    ..In conclusion, these findings support the hypothesis that coronary atherosclerosis may directly influence the activation of the cardiac neurohormonal system...
  43. doi request reprint Diabetes mellitus and trends in hospital survival after myocardial infarction, 1994 to 2006: data from the national registry of myocardial infarction
    M Odette Gore
    Department of Internal Medicine, University of Texas, Southwestern Medical Center, Dallas, TX 75390, USA
    Circ Cardiovasc Qual Outcomes 5:791-7. 2012
    ..We assessed recent trends in hospital mortality for patients with MI according to DM status...
  44. pmc Biomarkers of chronic cardiac injury and hemodynamic stress identify a malignant phenotype of left ventricular hypertrophy in the general population
    Ian J Neeland
    Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Am Coll Cardiol 61:187-95. 2013
    ..The goal of this study was to determine if biomarkers of subclinical myocardial injury and hemodynamic stress identify asymptomatic individuals with left ventricular hypertrophy (LVH) at higher risk for heart failure (HF) and death...
  45. pmc Dysfunctional adiposity and the risk of prediabetes and type 2 diabetes in obese adults
    Ian J Neeland
    Division of Cardiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8830, USA
    JAMA 308:1150-9. 2012
    ..A dysfunctional adiposity phenotype, characterized by excess visceral fat and insulin resistance, may contribute to diabetes development in those with obesity...
  46. pmc Relation of regional fat distribution to left ventricular structure and function
    Ian J Neeland
    Division of Cardiology, Department of Internal Medicine, Department of Clinical Sciences, and Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas and Cardiovascular Research Institute, University of Pennsylvania, Philadelphia
    Circ Cardiovasc Imaging 6:800-7. 2013
    ..The relation of body fat distribution to left ventricular (LV) structure and function is poorly defined...
  47. pmc Left atrial structure and function and clinical outcomes in the general population
    Sachin Gupta
    Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, 75390 9047, USA
    Eur Heart J 34:278-85. 2013
    ..Left atrial (LA) structural and functional abnormalities may be subclinical phenotypes, which identify individuals at increased risk of adverse outcomes...
  48. pmc Concurrent evaluation of novel cardiac biomarkers in acute coronary syndrome: myeloperoxidase and soluble CD40 ligand and the risk of recurrent ischaemic events in TACTICS-TIMI 18
    David A Morrow
    TIMI Study Group Cardiovascular Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Eur Heart J 29:1096-102. 2008
    ....
  49. ncbi request reprint Prognostic value of serial B-type natriuretic peptide testing during follow-up of patients with unstable coronary artery disease
    David A Morrow
    Cardiovascular Division and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 2115, USA
    JAMA 294:2866-71. 2005
    ..Elevated concentrations of B-type natriuretic peptide (BNP) at presentation in patients with acute coronary syndrome (ACS) are associated with long-term mortality. Few data exist regarding serial assessment of BNP levels during follow-up...
  50. pmc Myocardial ischemia induced by rapid atrial pacing causes troponin T release detectable by a highly sensitive assay: insights from a coronary sinus sampling study
    Aslan T Turer
    Department of Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas 75230 9047, USA
    J Am Coll Cardiol 57:2398-405. 2011
    ....
  51. ncbi request reprint Inaccuracy of estimated resting oxygen uptake in the clinical setting
    Nikhil Narang
    Department of Medicine, University of Chicago, Chicago, IL N N Department of Internal Medicine J T T, B D L, M O G, A T T, J A d L, D K M and Cardiovascular Division J T T, B D L, M O G, A T T, J A d L, D K M, The University of Texas Southwestern Medical Center, Dallas, TX Institute of Exercise and Environmental Medicine at the Texas Health Presbyterian Hospital, Dallas, TX B D L the Department of Clinical Sciences at the University of Texas Southwestern Medical Center, Dallas, TX C R A, D K M Cardiology Division, University of Texas Health Science Center at San Antonio, San Antonio, TX R A L and the Cardiovascular Division, Oregon Health and Science University, Portland, OR J E C
    Circulation 129:203-10. 2014
    ..However, estimated rather than measured O2 is commonly used because of complexities of the measurement, though the accuracy of estimation remains uncertain in contemporary clinical practice...
  52. doi request reprint Discordant effects of rosiglitazone on novel inflammatory biomarkers
    Elan Gada
    The Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    Am Heart J 165:609-14. 2013
    ....
  53. pmc Evaluation of multiple biomarkers of cardiovascular stress for risk prediction and guiding medical therapy in patients with stable coronary disease
    Marc S Sabatine
    TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, 350 Longwood Ave, Boston, MA 02115, USA
    Circulation 125:233-40. 2012
    ..Circulating biomarkers can offer insight into subclinical cardiovascular stress and thus have the potential to aid in risk stratification and tailoring of therapy...
  54. ncbi request reprint Relationship between C-reactive protein and subclinical atherosclerosis: the Dallas Heart Study
    Amit Khera
    Donald W Reynolds Cardiovascular Clinical Research Center, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Circulation 113:38-43. 2006
    ..However, less is known regarding the relationship between CRP levels and atherosclerotic burden...
  55. ncbi request reprint Acute changes in circulating natriuretic peptide levels in relation to myocardial ischemia
    Marc S Sabatine
    TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 44:1988-95. 2004
    ..The aim of this study was to determine the effect of transient myocardial ischemia on circulating natriuretic peptide levels...
  56. ncbi request reprint Evaluation of the AccuTnI cardiac troponin I assay for risk assessment in acute coronary syndromes
    David A Morrow
    Department of Medicine and TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Clin Chem 49:1396-8. 2003
  57. doi request reprint A risk score for predicting coronary artery disease in women with angina pectoris and abnormal stress test finding
    Monica Y Lo
    Department of Internal Medicine, Dallas, TX, USA
    Am J Cardiol 111:781-5. 2013
    ..This tool, if validated, could help to guide testing strategies in women with angina pectoris...
  58. ncbi request reprint Association of cystatin C with left ventricular structure and function: the Dallas Heart Study
    Parag C Patel
    Division of Cardiology, Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Circ Heart Fail 2:98-104. 2009
    ..We tested the hypothesis that cystatin C is associated with preclinical cardiac structural and functional abnormalities in a younger population-based sample...
  59. ncbi request reprint Minimal ST-segment deviation: a simple, noninvasive method for identifying patients with a patent infarction-related artery after fibrinolytic administration
    Howard A Cooper
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Am Heart J 144:790-5. 2002
    ..The sum of ST-segment resolution (sum-STRES) has a high positive predictive value (PPV) for a patent IRA, but is quite time-consuming...
  60. ncbi request reprint Evaluation of the association of proximal coronary culprit artery lesion location with clinical outcomes in acute myocardial infarction
    Juhana Karha
    TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Cardiol 92:913-8. 2003
    ..In patients with a LAD culprit lesion, proximal lesion location is a multivariate correlate of adverse outcomes even after adjustment for coronary blood flow and other covariates...
  61. ncbi request reprint Identification of patients at high risk for death and cardiac ischemic events after hospital discharge
    Marc S Sabatine
    TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Am Heart J 143:966-70. 2002
    ..Patients with unstable angina (UA) and non-ST-elevation myocardial infarction (NSTEMI) remain at risk for death and cardiac ischemic events after being discharged from the hospital...
  62. ncbi request reprint Validated risk score predicts the development of congestive heart failure after presentation with unstable angina or non-ST-elevation myocardial infarction: results from OPUS-TIMI 16 and TACTICS-TIMI 18
    John V Wylie
    Division of Cardiology, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, Mass 02215, USA
    Am Heart J 148:173-80. 2004
    ..We developed and validated a risk score to predict which patients will develop CHF...
  63. pmc Disparities in counseling for lifestyle modification among obese adults: insights from the Dallas Heart Study
    Tiffany M Powell-Wiley
    Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Obesity (Silver Spring) 20:849-55. 2012
    ..Systematic education about and application of lifestyle interventions could capitalize on opportunities for primary CV risk prevention...
  64. doi request reprint The association between plasma caspase-3, atherosclerosis, and vascular function in the Dallas Heart Study
    Susan Matulevicius
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Apoptosis 13:1281-9. 2008
    ..Caspase-3, an apoptosis protease, is expressed in atherosclerotic plaques. We examined the relationship between plasma caspase-3 levels, aortic compliance, and atherosclerosis...
  65. doi request reprint Association of lipoprotein-associated phospholipase A2 mass and activity with coronary and aortic atherosclerosis: findings from the Dallas Heart Study
    Emmanouil S Brilakis
    The Donald W Reynolds Cardiovascular Clinical Research Center, Dallas, TX, USA
    Clin Chem 54:1975-81. 2008
    ..Our aim was to characterize the association of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) with coronary and aortic atherosclerosis in a large population-based study...
  66. pmc Evaluation of coronary artery calcium screening strategies focused on risk categories: the Dallas Heart Study
    Mahesh J Patel
    Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA
    Am Heart J 157:1001-9. 2009
    ..A strategy using coronary artery calcium (CAC) screening to refine coronary heart disease risk assessment in moderately high risk (MHR) subjects (10-year risk 10%-20%) has been suggested. The potential impact of this strategy is unknown...
  67. ncbi request reprint Clinical relevance of C-reactive protein during follow-up of patients with acute coronary syndromes in the Aggrastat-to-Zocor Trial
    David A Morrow
    TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, Massachusetts 02115, USA
    Circulation 114:281-8. 2006
    ..Retrospective analyses suggest that this risk may be modified with statin therapy. However, a role for hsCRP in monitoring the success of therapy remains uncertain...
  68. doi request reprint Timing of in-hospital coronary artery bypass graft surgery for non-ST-segment elevation myocardial infarction patients results from the National Cardiovascular Data Registry ACTION Registry-GWTG (Acute Coronary Treatment and Intervention Outcomes Network
    Shailja V Parikh
    Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    JACC Cardiovasc Interv 3:419-27. 2010
    ..The aim of this study was to examine timing of in-hospital coronary artery bypass graft surgery (CABG) for non-ST-segment elevation myocardial infarction (NSTEMI) patients...
  69. ncbi request reprint Association among plasma levels of monocyte chemoattractant protein-1, traditional cardiovascular risk factors, and subclinical atherosclerosis
    Rajat Deo
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Am Coll Cardiol 44:1812-8. 2004
    ..We sought to evaluate the association between plasma levels of monocyte chemoattractant protein (MCP)-1 and the risk for subclinical atherosclerosis...
  70. doi request reprint Assessment of adiponectin and the risk of recurrent cardiovascular events in patients presenting with an acute coronary syndrome: observations from the Pravastatin Or atorVastatin Evaluation and Infection Trial-Thrombolysis in Myocardial Infarction 22 (PR
    Sean R Wilson
    TIMI Study Group, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am Heart J 161:1147-55.e1. 2011
    ..Recent data have suggested a possible discordant adverse risk relationship in acute coronary syndrome (ACS). Therefore, we investigated the association between adiponectin and cardiovascular events in patients with ACS...
  71. ncbi request reprint Recurrent cardiovascular events with paclitaxel-eluting versus bare-metal stents in saphenous vein graft lesions: insights from the SOS (Stenting of Saphenous Vein Grafts) trial
    Tesfaldet T Michael
    Veteran Affairs North Texas Healthcare System, Dallas, Texas, USA
    J Invasive Cardiol 23:216-9. 2011
    ....
  72. ncbi request reprint Influence of pre-analytical and analytical factors on soluble CD40L measurements
    Nerea Varo
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, NRB 741, Boston, MA 02115, USA
    Clin Sci (Lond) 111:341-7. 2006
    ..Samples with high concentrations of bilirubin, haemoglobin and/or triacylglycerols should be excluded, as these substances interfere with the assay...
  73. ncbi request reprint Elevated release of sCD40L from platelets of diabetic patients by thrombin, glucose and advanced glycation end products
    Nerea Varo
    Donald W Reynolds Cardiovascular Clinical Research Center, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Diab Vasc Dis Res 2:81-7. 2005
    ....
  74. ncbi request reprint Elevated plasma levels of the atherogenic mediator soluble CD40 ligand in diabetic patients: a novel target of thiazolidinediones
    Nerea Varo
    Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Ave, Boston, Mass 02115, USA
    Circulation 107:2664-9. 2003
    ..This study therefore evaluated the hypothesis that diabetic patients have elevated plasma levels of soluble CD40L (sCD40L) and that treatment with the insulin-sensitizing thiazolidinediones lowers this index of inflammation...
  75. pmc Interactions between smoking, pulmonary surfactant protein B, and atherosclerosis in the general population: the Dallas Heart Study
    Ann B Nguyen
    Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Arterioscler Thromb Vasc Biol 31:2136-43. 2011
    ..We hypothesized that SP-B may serve as a marker of the vascular effects of smoking and would thus be associated with subclinical measures of atherosclerosis...