J C de La Torre

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Evidence that Alzheimer's disease is a microvascular disorder: the role of constitutive nitric oxide
    J C de La Torre
    Department of Pathology, University of California, San Diego, 1363 Shinly, Suite 100, Escondido, CA 92026, USA
    Brain Res Brain Res Rev 34:119-36. 2000
  2. ncbi Alzheimer's disease: how does it start?
    J C de La Torre
    UCSD Neuropathology Division, 1363 Shinly, Suite 100, Escondido, CA 92026, USA
    J Alzheimers Dis 4:497-512. 2002
  3. ncbi Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics
    Jack C de la Torre
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Lancet Neurol 3:184-90. 2004
  4. ncbi Hippocampal nitric oxide upregulation precedes memory loss and A beta 1-40 accumulation after chronic brain hypoperfusion in rats
    J C de La Torre
    Department of Pathology, University of California, San Diego, CA
    Neurol Res 25:635-41. 2003
  5. ncbi Impaired cerebromicrovascular perfusion. Summary of evidence in support of its causality in Alzheimer's disease
    J C de La Torre
    Department of Neuroscience, University of California, San Diego, La Jolla, California 92093, USA
    Ann N Y Acad Sci 924:136-52. 2000
  6. ncbi Vascular basis of Alzheimer's pathogenesis
    J C de La Torre
    Division of Neuropathology, University of California San Diego, 1363 Shinly, Suite 100, Escondido, CA 92026, USA
    Ann N Y Acad Sci 977:196-215. 2002
  7. ncbi Alzheimer disease as a vascular disorder: nosological evidence
    J C de La Torre
    Department of Neuropathology, University of California at San Diego, CA 92026, USA
    Stroke 33:1152-62. 2002
  8. ncbi Critically attained threshold of cerebral hypoperfusion: can it cause Alzheimer's disease?
    J C de La Torre
    Department of Neurosciences, University of California, San Diego, La Jolla 92093, USA
    Ann N Y Acad Sci 903:424-36. 2000
  9. ncbi Viral persistence in neurons alters synaptic plasticity and cognitive functions without destruction of brain cells
    J C de La Torre
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
    Virology 220:508-15. 1996
  10. ncbi Critical threshold cerebral hypoperfusion causes Alzheimer's disease?
    J C de La Torre
    Department of Neurosciences, UCSD School of Medicine, La Jolla, CA 92093, USA
    Acta Neuropathol 98:1-8. 1999

Collaborators

Detail Information

Publications24

  1. ncbi Evidence that Alzheimer's disease is a microvascular disorder: the role of constitutive nitric oxide
    J C de La Torre
    Department of Pathology, University of California, San Diego, 1363 Shinly, Suite 100, Escondido, CA 92026, USA
    Brain Res Brain Res Rev 34:119-36. 2000
    ....
  2. ncbi Alzheimer's disease: how does it start?
    J C de La Torre
    UCSD Neuropathology Division, 1363 Shinly, Suite 100, Escondido, CA 92026, USA
    J Alzheimers Dis 4:497-512. 2002
    ..A short summary of potential new research lines that may provide novel therapy in the treatment and management of AD is discussed...
  3. ncbi Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics
    Jack C de la Torre
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Lancet Neurol 3:184-90. 2004
    ..The consensus of these studies indicates that chronic brain hypoperfusion is linked to AD risk factors, AD preclinical detection and pharmacotherapeutic action of AD symptoms...
  4. ncbi Hippocampal nitric oxide upregulation precedes memory loss and A beta 1-40 accumulation after chronic brain hypoperfusion in rats
    J C de La Torre
    Department of Pathology, University of California, San Diego, CA
    Neurol Res 25:635-41. 2003
    ..These preliminary findings may be important in understanding, at least in part, the molecular mechanisms that precede memory impairment during chronic brain ischemia and as such, the pre-clinical stage leading to Alzheimer's disease...
  5. ncbi Impaired cerebromicrovascular perfusion. Summary of evidence in support of its causality in Alzheimer's disease
    J C de La Torre
    Department of Neuroscience, University of California, San Diego, La Jolla, California 92093, USA
    Ann N Y Acad Sci 924:136-52. 2000
    ..A brief discussion of target therapy based on the proposed pathogenesis of AD is also reviewed...
  6. ncbi Vascular basis of Alzheimer's pathogenesis
    J C de La Torre
    Division of Neuropathology, University of California San Diego, 1363 Shinly, Suite 100, Escondido, CA 92026, USA
    Ann N Y Acad Sci 977:196-215. 2002
    ....
  7. ncbi Alzheimer disease as a vascular disorder: nosological evidence
    J C de La Torre
    Department of Neuropathology, University of California at San Diego, CA 92026, USA
    Stroke 33:1152-62. 2002
    ..The main stumbling block in the clinical management and in the search for a cure of Alzheimer disease (AD) is that the cause of this disorder has remained uncertain until now...
  8. ncbi Critically attained threshold of cerebral hypoperfusion: can it cause Alzheimer's disease?
    J C de La Torre
    Department of Neurosciences, University of California, San Diego, La Jolla 92093, USA
    Ann N Y Acad Sci 903:424-36. 2000
    ....
  9. ncbi Viral persistence in neurons alters synaptic plasticity and cognitive functions without destruction of brain cells
    J C de La Torre
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
    Virology 220:508-15. 1996
    ..Concurrently, the ability to learn tasks was significantly impaired in these persistently infected mice. Yet, infected neurons remained free from structural injury...
  10. ncbi Critical threshold cerebral hypoperfusion causes Alzheimer's disease?
    J C de La Torre
    Department of Neurosciences, UCSD School of Medicine, La Jolla, CA 92093, USA
    Acta Neuropathol 98:1-8. 1999
    ..A discussion of target therapy based on the proposed pathogenesis of AD is also briefly reviewed...
  11. ncbi Critically attained threshold of cerebral hypoperfusion: the CATCH hypothesis of Alzheimer's pathogenesis
    J C de La Torre
    Department of Neurosciences MTF 0624, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0624, USA
    Neurobiol Aging 21:331-42. 2000
    ..The possible role of CATCH in familial and early onset Alzheimer's disease is briefly discussed from a theoretical vantagepoint. The growing and most recent evidence in support of the CATCH concept is the focus of this review...
  12. ncbi Detection of borna disease virus antigen and RNA in human autopsy brain samples from neuropsychiatric patients
    J C de La Torre
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
    Virology 223:272-82. 1996
    ..This is the first demonstration that BDV can infect human brain tissue, possibly contributing to the pathophysiology of specific human neuropsychiatric disorders...
  13. ncbi Exploring ischemia-induced vascular lesions and potential pharmacological intervention strategies
    G Aliev
    Institute of Pathology, School of Medicine, Case Western Reserve University, Adelbert Road, Cleveland, OH 44106, USA
    Histol Histopathol 20:261-73. 2005
    ....
  14. ncbi Alzheimer's disease is a vasocognopathy: a new term to describe its nature
    Jack C de la Torre
    Institute of Pathology, Case Western Reserve University, Cleveland, OH, USA
    Neurol Res 26:517-24. 2004
    ..Re-classification would allow a new strategy that could result in the tactical development and application of genuinely effective treatments, provide earlier diagnosis and reduce AD prevalence by focusing on the root of the problem...
  15. ncbi Inhibition of vascular nitric oxide after rat chronic brain hypoperfusion: spatial memory and immunocytochemical changes
    Jack C de la Torre
    1Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Cereb Blood Flow Metab 25:663-72. 2005
    ..These findings may identify therapeutic targets for preventing MCI and treating Alzheimer's disease...
  16. ncbi Is nitric oxide a key target in the pathogenesis of brain lesions during the development of Alzheimer's disease?
    Ali Aliyev
    Microscopy Research Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Neurol Res 26:547-53. 2004
    ..We speculate that pharmacological intervention using NO donors and/or NO suppressors will be able to delay or minimize the development of brain pathology and further progression of mental retardation...
  17. ncbi The role of nitric oxide in the pathogenesis of brain lesions during the development of Alzheimer's disease
    Dilara Seyidova
    Microscopy Research Center, Institute of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    In Vivo 18:325-33. 2004
    ..We theorize that pharmacological intervention using NO donors and/or NO suppressors should delay or minimize brain lesion development and further progression of brain pathology and dementia...
  18. ncbi Pathophysiology of neuronal energy crisis in Alzheimer's disease
    Jack C de la Torre
    Institute of Pathology, Case Western Reserve School of Medicine, Cleveland, Ohio, USA
    Neurodegener Dis 5:126-32. 2008
    ..This review offers inductive hypothetical darts relative to that critical question...
  19. ncbi Overexpression of GRK2 in Alzheimer disease and in a chronic hypoperfusion rat model is an early marker of brain mitochondrial lesions
    Mark E Obrenovich
    Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Neurotox Res 10:43-56. 2006
    ....
  20. ncbi How do heart disease and stroke become risk factors for Alzheimer's disease?
    Jack C de la Torre
    Institute of Pathology, Case Western Reserve School of Medicine, Gig Harbor, WA, USA
    Neurol Res 28:637-44. 2006
    ..Heart disease and stroke are two of the major leading causes of death and disability in the world. Mainly affecting the elderly population, heart disease and stroke are important risk factors for Alzheimer's disease (AD)...
  21. ncbi Cerebrovascular gene linked to Alzheimer's disease pathology
    Jack C de la Torre
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Trends Mol Med 11:534-6. 2005
    ..This, together with evidence linking a dysfunctional cerebrovasculature to the pathogenesis of AD, suggests that the homeobox gene MEOX2 downregulation provides a therapeutic target to AD and a better understanding of this disorder...
  22. ncbi Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Azheimer disease
    Gjumrakch Aliev
    The Microscopy Research Center and Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland OH 44106, USA
    Neurotox Res 5:491-504. 2003
    ....
  23. ncbi Ischemic stroke in elderly patients treated with a free radical scavenger-glycolytic intermediate solution: a preliminary pilot trial
    Mustafa Karaca
    Department of Neurosurgery, Ihlas Medical Center, Bursa, Turkey
    Neurol Res 24:73-80. 2002
    ..This preliminary trial indicates that DMSO-FDP is well tolerated by this group of elderly patients and could be of benefit in reducing neurologic disability after stroke...
  24. ncbi Alzheimer's disease prevalence can be lowered with non-invasive testing
    Jack C de la Torre
    Center for Alzheimer s Research, Sun Health Research Institute, Sun City, AR 85351, USA
    J Alzheimers Dis 14:353-9. 2008
    ..This clinical approach may have an important impact in reducing the number of new AD and VaD cases and lessen the catastrophic socio-economic burden these dementias are expected to have on the US healthcare system in the near future...