Ivana De Domenico

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. pmc Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice
    Ivana De Domenico
    Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, Utah 84132, USA
    J Clin Invest 120:2395-405. 2010
  2. pmc Hepcidin is elevated in mice injected with Mycoplasma arthritidis
    Curry L Koening
    Division of Hematology, Department of Internal Medicine, University of Utah, School of Medicine, 30 North 1900 East, Salt Lake City, 84132, Utah, USA
    J Inflamm (Lond) 6:33. 2009
  3. pmc The molecular mechanism of hepcidin-mediated ferroportin down-regulation
    Ivana De Domenico
    Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Mol Biol Cell 18:2569-78. 2007
  4. pmc The role of ubiquitination in hepcidin-independent and hepcidin-dependent degradation of ferroportin
    Ivana De Domenico
    Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Cell Metab 14:635-46. 2011
  5. pmc The hepcidin-binding site on ferroportin is evolutionarily conserved
    Ivana De Domenico
    Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Cell Metab 8:146-56. 2008
  6. pmc Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding
    Collin Kieffer
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112 5650, USA
    Dev Cell 15:62-73. 2008
  7. pmc Toll-like receptors mediate induction of hepcidin in mice infected with Borrelia burgdorferi
    Curry L Koening
    Division of Rheumatology, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Blood 114:1913-8. 2009
  8. pmc Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2
    Ivana De Domenico
    Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT 84132 2501, USA
    Proc Natl Acad Sci U S A 106:3800-5. 2009
  9. pmc Human mutation D157G in ferroportin leads to hepcidin-independent binding of Jak2 and ferroportin down-regulation
    Ivana De Domenico
    Division of Hematology, Department of Medicine, School of Medicine, University of Utah, Salt Lake City, USA
    Blood 115:2956-9. 2010
  10. pmc Decoupling ferritin synthesis from free cytosolic iron results in ferritin secretion
    Ivana De Domenico
    Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT 84132 2501, USA
    Cell Metab 13:57-67. 2011

Collaborators

Detail Information

Publications25

  1. pmc Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice
    Ivana De Domenico
    Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, Utah 84132, USA
    J Clin Invest 120:2395-405. 2010
    ..The results of our study suggest a new function for hepcidin in modulating acute inflammatory responses...
  2. pmc Hepcidin is elevated in mice injected with Mycoplasma arthritidis
    Curry L Koening
    Division of Hematology, Department of Internal Medicine, University of Utah, School of Medicine, 30 North 1900 East, Salt Lake City, 84132, Utah, USA
    J Inflamm (Lond) 6:33. 2009
    ..Both mice had an increase in serum ferritin but a decrease in serum transferrin saturation. In conclusion, serum hepcidin regulation in C3H/HeJ mice does not appear to be solely dependent upon TLR4 or IL-6...
  3. pmc The molecular mechanism of hepcidin-mediated ferroportin down-regulation
    Ivana De Domenico
    Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Mol Biol Cell 18:2569-78. 2007
    ..Depletion of proteins involved in multivesicular body trafficking (Endosome Sorting Complex Required for Transport proteins), by small-interfering RNA, reduces the trafficking of Fpn-green fluorescent to the lysosome...
  4. pmc The role of ubiquitination in hepcidin-independent and hepcidin-dependent degradation of ferroportin
    Ivana De Domenico
    Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Cell Metab 14:635-46. 2011
    ....
  5. pmc The hepcidin-binding site on ferroportin is evolutionarily conserved
    Ivana De Domenico
    Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Cell Metab 8:146-56. 2008
    ..The affinity of hepcidin for the HBD permits a rapid, sensitive assay of hepcidin from all species and yields insights into the evolution of hepcidin...
  6. pmc Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding
    Collin Kieffer
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112 5650, USA
    Dev Cell 15:62-73. 2008
    ....
  7. pmc Toll-like receptors mediate induction of hepcidin in mice infected with Borrelia burgdorferi
    Curry L Koening
    Division of Rheumatology, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Blood 114:1913-8. 2009
    ..Hepcidin expression induced by B burgdorferi was mediated primarily by activation of Toll-like receptor 2...
  8. pmc Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2
    Ivana De Domenico
    Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT 84132 2501, USA
    Proc Natl Acad Sci U S A 106:3800-5. 2009
    ..These results provide a molecular explanation for the dominant inheritance of hepcidin resistant iron overload disease...
  9. pmc Human mutation D157G in ferroportin leads to hepcidin-independent binding of Jak2 and ferroportin down-regulation
    Ivana De Domenico
    Division of Hematology, Department of Medicine, School of Medicine, University of Utah, Salt Lake City, USA
    Blood 115:2956-9. 2010
    ..These results identify a hepcidin-independent regulation of Fpn that can result in alterations in iron homeostasis...
  10. pmc Decoupling ferritin synthesis from free cytosolic iron results in ferritin secretion
    Ivana De Domenico
    Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT 84132 2501, USA
    Cell Metab 13:57-67. 2011
    ..Secretion of ferritin chains provides a mechanism that limits ferritin nanocage assembly and ferritin-mediated iron sequestration in the absence of the translational inhibition of ferritin synthesis...
  11. pmc Iron depletion limits intracellular bacterial growth in macrophages
    Prasad N Paradkar
    Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah 84132, USA
    Blood 112:866-74. 2008
    ....
  12. pmc Induction of FPN1 transcription by MTF-1 reveals a role for ferroportin in transition metal efflux
    Marie Berengere Troadec
    Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT, USA
    Blood 116:4657-64. 2010
    ..We demonstrate that Fpn can transport zinc and can protect zinc sensitive cells from high zinc toxicity...
  13. pmc Specific iron chelators determine the route of ferritin degradation
    Ivana De Domenico
    Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Blood 114:4546-51. 2009
    ..These results indicate that ferritin degradation occurs by 2 routes: a DFO-induced entry of ferritin into lysosomes and a cytosolic route in which iron is extracted from ferritin before degradation by the proteasome...
  14. doi request reprint The molecular basis of iron overload disorders and iron-linked anemias
    Jerry Kaplan
    Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT 84312, USA
    Int J Hematol 93:14-20. 2011
    ..Genetic disorders of iron overload of iron-linked anemia can be explained by changes in the level of hepcidin or ferroportin and of the ability of ferroportin to be internalized by hepcidin...
  15. pmc Zebrafish as a model for defining the functional impact of mammalian ferroportin mutations
    Ivana De Domenico
    Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Blood 110:3780-3. 2007
    ..Expression of wild-type ferroportin or hepcidin-resistant ferroportin (N144H) does not affect erythropoiesis. Zebrafish provides a facile way of identifying which ferroportin mutants may lead to macrophage iron loading...
  16. pmc Hepcidin and ferroportin: the new players in iron metabolism
    Ivana De Domenico
    Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, Utah, USA
    Semin Liver Dis 31:272-9. 2011
    ..Ferroportin degradation can occur by hepcidin-dependent and hepcidin-independent internalization. Ferroportin expression is regulated transcriptionally and posttranslationally...
  17. doi request reprint A heme export protein is required for red blood cell differentiation and iron homeostasis
    Siobán B Keel
    Division of Hematology, University of Washington, Seattle, WA 98195, USA
    Science 319:825-8. 2008
    ..Thus, the trafficking of heme, and not just elemental iron, facilitates erythropoiesis and systemic iron balance...
  18. pmc Ferroportin-mediated mobilization of ferritin iron precedes ferritin degradation by the proteasome
    Ivana De Domenico
    Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah 84132, USA
    EMBO J 25:5396-404. 2006
    ..Thus, ferritin degradation can occur through two different mechanisms...
  19. pmc Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin
    Ivana De Domenico
    Department of Pathology, School of Medicine, University of Utah, 50 North Medical Drive, Salt Lake City, UT 84132, USA
    EMBO J 26:2823-31. 2007
    ..The requirement for a ferroxidase to maintain iron transport activity represents a new mechanism of regulating cellular iron export, a new function for Cp and an explanation for brain iron overload in patients with aceruloplasminemia...
  20. pmc Hepcidin regulation: ironing out the details
    Ivana De Domenico
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84106, USA
    J Clin Invest 117:1755-8. 2007
    ..These results demonstrate that recombinant HJV may be a useful therapeutic agent for treatment of the anemia of chronic disease, a disorder resulting from high levels of hepcidin expression...
  21. ncbi request reprint Chediak-Higashi syndrome
    Jerry Kaplan
    Department of Pathology, University of Utah School of Medicine, 30 N 1900 E, Salt Lake City, UT 84132, USA
    Curr Opin Hematol 15:22-9. 2008
    ..This review will discuss the advances made in understanding the clinical aspects of the syndrome and the function of CHS1/LYST/Beige...
  22. ncbi request reprint Regulation of iron acquisition and storage: consequences for iron-linked disorders
    Ivana De Domenico
    Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah 84132, USA
    Nat Rev Mol Cell Biol 9:72-81. 2008
    ..Discoveries of iron transporters and insights into their regulation have provided important information about iron metabolism and genetic iron disorders...
  23. pmc Evidence for the multimeric structure of ferroportin
    Ivana De Domenico
    Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Blood 109:2205-9. 2007
    ..These results support the hypothesis that the dominant inheritance of Fpn-iron overload disease is due to the dominant-negative effects of mutant Fpn proteins...
  24. doi request reprint A new wrinkle in the fold: hepcidin links inflammation to the unfolded protein response
    Ivana De Domenico
    Department of Internal Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Cell Metab 10:245-6. 2009
    ..Two recent papers (Oliveira et al., 2009; Vecchi et al., 2009) show that the UPR modulates transcription of the hormone hepcidin, which controls plasma iron levels and perhaps innate immunity...
  25. pmc Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release
    Charles Langelier
    Department of Biochemistry, 15 N Medical Drive East, Room 4100, University of Utah School of Medicine, Salt Lake City, UT 84112 5650, USA
    J Virol 80:9465-80. 2006
    ..These observations indicate that there are probably multiple pathways for protein sorting/MVB vesicle formation in human cells and that HIV-1 does not utilize an ESCRT-II-dependent pathway to leave the cell...