Ian H De Boer

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Obesity and change in estimated GFR among older adults
    Ian H De Boer
    Division of Nephrology, University of Washington, Seattle, WA 98195, USA
    Am J Kidney Dis 54:1043-51. 2009
  2. pmc The serum 24,25-dihydroxyvitamin D concentration, a marker of vitamin D catabolism, is reduced in chronic kidney disease
    Cortney R Bosworth
    Department of Medicine, Division of Nephrology and Kidney Research Institute, University of Washington, Seattle, WA 98104, USA
    Kidney Int 82:693-700. 2012
  3. pmc Kidney disease and related findings in the diabetes control and complications trial/epidemiology of diabetes interventions and complications study
    Ian H De Boer
    Corresponding author Ian H de Boer
    Diabetes Care 37:24-30. 2014
  4. pmc Invited commentary: Quantifying salt in urine--a complex solution
    Ian H De Boer
    Am J Epidemiol 177:1193-5; discussion 1196-8. 2013
  5. pmc Paricalcitol does not improve glucose metabolism in patients with stage 3-4 chronic kidney disease
    Ian H De Boer
    Division of Nephrology and Kidney Research Institute, Department of Medicine, University of Washington, Seattle, Washington 98104, USA
    Kidney Int 83:323-30. 2013
  6. pmc Serum 25-hydroxyvitamin D concentration and risk for major clinical disease events in a community-based population of older adults: a cohort study
    Ian H De Boer
    University of Washington, Seattle, USA
    Ann Intern Med 156:627-34. 2012
  7. pmc Insulin resistance, cystatin C, and mortality among older adults
    Ian H De Boer
    University of Washington, Seattle, Washington, USA
    Diabetes Care 35:1355-60. 2012
  8. pmc 25-hydroxyvitamin D levels inversely associate with risk for developing coronary artery calcification
    Ian H De Boer
    Department of Medicine, Division of Nephrology, University of Washington, Seattle, WA 98195, USA
    J Am Soc Nephrol 20:1805-12. 2009
  9. pmc Cystatin C, albuminuria, and mortality among older adults with diabetes
    Ian H De Boer
    University of Washington, Seattle, Washington, USA
    Diabetes Care 32:1833-8. 2009
  10. pmc Serum 25-hydroxyvitamin D and change in estimated glomerular filtration rate
    Ian H De Boer
    Department of Medicine, University of Washington, Seattle, WA 98195, USA Tele
    Clin J Am Soc Nephrol 6:2141-9. 2011

Detail Information

Publications70

  1. pmc Obesity and change in estimated GFR among older adults
    Ian H De Boer
    Division of Nephrology, University of Washington, Seattle, WA 98195, USA
    Am J Kidney Dis 54:1043-51. 2009
    ..Obesity assessed in midlife has been associated with chronic kidney disease...
  2. pmc The serum 24,25-dihydroxyvitamin D concentration, a marker of vitamin D catabolism, is reduced in chronic kidney disease
    Cortney R Bosworth
    Department of Medicine, Division of Nephrology and Kidney Research Institute, University of Washington, Seattle, WA 98104, USA
    Kidney Int 82:693-700. 2012
    ..Thus, chronic kidney disease is a state of stagnant vitamin D metabolism characterized by decreases in both 1,25(OH)(2)D production and vitamin D catabolism...
  3. pmc Kidney disease and related findings in the diabetes control and complications trial/epidemiology of diabetes interventions and complications study
    Ian H De Boer
    Corresponding author Ian H de Boer
    Diabetes Care 37:24-30. 2014
    ..CONCLUSIONS In the DCCT/EDIC, INT resulted in clinically important, durable reductions in the risks of microalbuminuria, macroalbuminuria, impaired GFR, and hypertension. ..
  4. pmc Invited commentary: Quantifying salt in urine--a complex solution
    Ian H De Boer
    Am J Epidemiol 177:1193-5; discussion 1196-8. 2013
    ..Further work is needed to extend estimation to additional populations and improve individual-level assessment...
  5. pmc Paricalcitol does not improve glucose metabolism in patients with stage 3-4 chronic kidney disease
    Ian H De Boer
    Division of Nephrology and Kidney Research Institute, Department of Medicine, University of Washington, Seattle, Washington 98104, USA
    Kidney Int 83:323-30. 2013
    ..Thus, despite substantial effects on vitamin D metabolism, paricalcitol did not improve glucose metabolism in nondiabetic patients with stage 3-4 chronic kidney disease...
  6. pmc Serum 25-hydroxyvitamin D concentration and risk for major clinical disease events in a community-based population of older adults: a cohort study
    Ian H De Boer
    University of Washington, Seattle, USA
    Ann Intern Med 156:627-34. 2012
    ..Current clinical 25-(OH)D targets based on associations with intermediate markers of bone metabolism may not reflect optimal levels for other chronic diseases and do not account for known seasonal variation in 25-(OH)D concentration...
  7. pmc Insulin resistance, cystatin C, and mortality among older adults
    Ian H De Boer
    University of Washington, Seattle, Washington, USA
    Diabetes Care 35:1355-60. 2012
    ..Insulin resistance is a risk factor for cardiovascular and noncardiovascular diseases. Impaired kidney function is linked with insulin resistance and may affect relationships of insulin resistance with health outcomes...
  8. pmc 25-hydroxyvitamin D levels inversely associate with risk for developing coronary artery calcification
    Ian H De Boer
    Department of Medicine, Division of Nephrology, University of Washington, Seattle, WA 98195, USA
    J Am Soc Nephrol 20:1805-12. 2009
    ..Accelerated development of atherosclerosis may underlie, in part, the increased cardiovascular risk associated with vitamin D deficiency...
  9. pmc Cystatin C, albuminuria, and mortality among older adults with diabetes
    Ian H De Boer
    University of Washington, Seattle, Washington, USA
    Diabetes Care 32:1833-8. 2009
    ..Joint associations of albuminuria and impaired GFR with mortality have not been comprehensively evaluated in this population...
  10. pmc Serum 25-hydroxyvitamin D and change in estimated glomerular filtration rate
    Ian H De Boer
    Department of Medicine, University of Washington, Seattle, WA 98195, USA Tele
    Clin J Am Soc Nephrol 6:2141-9. 2011
    ..Mounting evidence suggests that 1,25-dihydroxyvitamin D prevents the progression of chronic kidney disease (CKD). It is not clear whether "nutritional" forms of vitamin D affect GFR...
  11. pmc Long-term renal outcomes of patients with type 1 diabetes mellitus and microalbuminuria: an analysis of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications cohort
    Ian H De Boer
    Kidney Research Institute and Division of Nephrology, University of Washington, Campus Box 359606, 325 Ninth Ave, Seattle, WA 98104, USA
    Arch Intern Med 171:412-20. 2011
    ..Microalbuminuria is a common diagnosis in the clinical care of patients with type 1 diabetes mellitus. Long-term outcomes after the development of microalbuminuria are variable...
  12. pmc Vitamin D and glucose metabolism in chronic kidney disease
    Ian H De Boer
    Division of Nephrology, University of Washington, Seattle, Washington 98195, USA
    Curr Opin Nephrol Hypertens 17:566-72. 2008
    ..The present review examines the potential role of vitamin D in improving glucose metabolism and clinical health outcomes in chronic kidney disease...
  13. pmc Vitamin D in chronic kidney disease: is the jury in?
    Ian H De Boer
    University of Washington, Division of Nephrology, Seattle, Washington 98195, USA
    Kidney Int 74:985-7. 2008
    ..However, such studies are limited by the potential for confounding by indication. A large randomized controlled trial is now needed to test the hypothesis that vitamin D therapy improves clinical outcomes in patients with kidney disease...
  14. pmc Temporal trends in the prevalence of diabetic kidney disease in the United States
    Ian H De Boer
    Kidney Research Institute and Division of Nephrology, Department of Medicine, University of Washington, Seattle, WA 98104, USA
    JAMA 305:2532-9. 2011
    ..Over time, the prevalence of diabetic kidney disease (DKD) may increase due to the expanding size of the diabetes population or decrease due to the implementation of diabetes therapies...
  15. pmc Central obesity, incident microalbuminuria, and change in creatinine clearance in the epidemiology of diabetes interventions and complications study
    Ian H De Boer
    Division of Nephrology, University of Washington, Seattle, Washington 98195, USA
    J Am Soc Nephrol 18:235-43. 2007
    ..In conclusion, waist circumference predicts the subsequent development of microalbuminuria in type 1 diabetes. In contrast, no association of waist circumference with decline in creatinine clearance was observed...
  16. ncbi request reprint 25-Hydroxyvitamin D levels and albuminuria in the Third National Health and Nutrition Examination Survey (NHANES III)
    Ian H De Boer
    Division of Nephrology, University of Washington, Seattle, WA 98117, USA
    Am J Kidney Dis 50:69-77. 2007
    ..Albuminuria is a risk factor for chronic kidney disease progression, end-stage renal disease, cardiovascular events, and mortality. Animal studies suggested that vitamin D insufficiency may contribute to the pathogenesis of albuminuria...
  17. pmc Mild elevations of urine albumin excretion are associated with atherogenic lipoprotein abnormalities in the Multi-Ethnic Study of Atherosclerosis (MESA)
    Ian H De Boer
    Division of Nephrology, University of Washington, Seattle, WA 98195, USA
    Atherosclerosis 197:407-14. 2008
    ....
  18. pmc Lipoprotein abnormalities associated with mild impairment of kidney function in the multi-ethnic study of atherosclerosis
    Ian H De Boer
    Division of Nephrology, University of Washington, Seattle, Washington 98195, USA
    Clin J Am Soc Nephrol 3:125-32. 2008
    ..Abnormal lipoprotein metabolism has been implicated as a possible cause of these complications, but lipoproteins have not been described at the earliest stages of kidney disease...
  19. pmc Calcium plus vitamin D supplementation and the risk of incident diabetes in the Women's Health Initiative
    Ian H De Boer
    Division of Nephrology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Diabetes Care 31:701-7. 2008
    ..We examined the effect of calcium plus vitamin D supplementation on the incidence of drug-treated diabetes in postmenopausal women...
  20. pmc Insulin therapy, hyperglycemia, and hypertension in type 1 diabetes mellitus
    Ian H De Boer
    Division of Nephrology, University of Washington, Box 356521, 1959 NE Pacific St, Seattle, WA 98117, USA
    Arch Intern Med 168:1867-73. 2008
    ..Diabetes mellitus and hypertension are closely linked, but the long-term blood pressure effects of glucose-lowering therapy and hyperglycemia are not clear...
  21. pmc Chronic kidney disease, insulin resistance, and incident diabetes in older adults
    Hien Pham
    Division of Nephrology and Kidney Research Institute, Department of Medicine, University of Washington, Seattle, 98195, USA
    Clin J Am Soc Nephrol 7:588-94. 2012
    ..Insulin resistance is a complication of advanced CKD. Insulin resistance is less well characterized in earlier stages of CKD. The response of the pancreatic β cell, effects on glucose tolerance, and risk of diabetes are not clear...
  22. pmc Incidence and progression of coronary calcification in chronic kidney disease: the Multi-Ethnic Study of Atherosclerosis
    Bryan R Kestenbaum
    Division of Nephrology, Department of Medicine, Harborview Medical Center, Kidney Research Institute, University of Washington, Seattle, Washington 98104 2499, USA
    Kidney Int 76:991-8. 2009
    ..Our study shows that coronary artery calcification is common in people with stage 3 disease, progresses rapidly, and may contribute to cardiovascular risk...
  23. pmc Insulin resistance and incident peripheral artery disease in the Cardiovascular Health Study
    Kathryn A Britton
    Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Vasc Med 17:85-93. 2012
    ..15-4.58). As expected, further adjustment for potential mediators led to some attenuation of effect estimates. In conclusion, insulin resistance is associated with a higher risk of PAD in older adults...
  24. pmc Parathyroid hormone and arterial dysfunction in the multi-ethnic study of atherosclerosis
    Cortney Bosworth
    Division of Nephrology and Kidney Research Institute, Department of Medicine, University of Washington, Seattle, WA, USA
    Clin Endocrinol (Oxf) 79:429-36. 2013
    ..Impaired arterial function is a potential mechanism for these associations. We tested whether serum PTH concentration is associated with measures of arterial function...
  25. pmc Circulating vitamin D metabolites and kidney disease in type 1 diabetes
    Ian H De Boer
    Kidney Research Institute and Division of Nephrology, University of Washington, Box 359606, 325 Ninth Avenue, Seattle, Washington 98104, USA
    J Clin Endocrinol Metab 97:4780-8. 2012
    ..Impaired vitamin D metabolism may contribute to the development and progression of diabetic kidney disease...
  26. pmc Genetic variants and associations of 25-hydroxyvitamin D concentrations with major clinical outcomes
    Gregory P Levin
    Department of Biostatistics, University of Washington, Seattle, USA
    JAMA 308:1898-905. 2012
    ....
  27. pmc Differences in kidney function and incident hypertension: the multi-ethnic study of atherosclerosis
    Bryan Kestenbaum
    University of Washington, Division of Nephrology, Harborview Medical Center, Seattle, Washington 98104 2499, USA
    Ann Intern Med 148:501-8. 2008
    ..Kidney disease and hypertension commonly coexist, yet the direction of their association is still debated...
  28. pmc Influence of estrogen therapy on calcium, phosphorus, and other regulatory hormones in postmenopausal women: the MESA study
    Nisha Bansal
    MD, MAS, Kidney Research Institute, University of Washington, 908 Jefferson Street, Third Floor, Seattle, WA 98104
    J Clin Endocrinol Metab 98:4890-8. 2013
    ..Other biomarkers of mineral metabolism may help understand the biological basis of these actions...
  29. doi request reprint 25-Hydroxyvitamin D and parathyroid hormone are not associated with carotid intima-media thickness or plaque in the multi-ethnic study of atherosclerosis
    Marc Blondon
    From the Department of Epidemiology M B, D S S, J D K, B K, I H d B, Division of Nephrology and Kidney Research Institute M S, B K, I H d B, Department of Laboratory Medicine A N H, Department of Environmental and Occupational Health Sciences J D K, Department of Medicine D S S, J D K, B K, I H d B, Cardiovascular Health Research Unit M B, D S S, University of Washington, Seattle, WA Department of Medicine, Geneva University Hospitals, Geneva, Switzerland M B Division of Nephrology, University of California, San Diego, CA J H I Department of Medicine, Johns Hopkins University, Baltimore, MD E D M and Divison of Cardiovascular Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI C K, A D G, J H S
    Arterioscler Thromb Vasc Biol 33:2639-45. 2013
    ..Observational evidence supports independent associations of 25-hydroxyvitamin D (25-OHD) and parathyroid hormone (PTH) with cardiovascular risk. A plausible hypothesis for these associations is accelerated development of atherosclerosis...
  30. doi request reprint Racial differences in the association of serum 25-hydroxyvitamin D concentration with coronary heart disease events
    Cassianne Robinson-Cohen
    Department of Medicine, Kidney Research Institute, University of Washington, Seattle 98104, USA
    JAMA 310:179-88. 2013
    ..This association has not been rigorously evaluated in other races or ethnicities, in which the distributions of 25(OH)D concentration and possibly other aspects of 25(OH)D metabolism differ...
  31. pmc Association of chronic kidney disease with the spectrum of ankle brachial index the CHS (Cardiovascular Health Study)
    Joachim H Ix
    Department of Medicine, University of California San Diego, USA
    J Am Coll Cardiol 54:1176-84. 2009
    ..This study sought to determine the association of chronic kidney disease (CKD) with high ankle brachial index (ABI) measurement and to compare its strength with that of CKD with a low ABI...
  32. pmc Measures of adiposity and future risk of ischemic stroke and coronary heart disease in older men and women
    Jorge R Kizer
    Department of Medicine, Weill Medical College of Cornell University, New York, New York, USA
    Am J Epidemiol 173:10-25. 2011
    ..Whether these differences translate to better risk prediction will require meta-analytical approaches, as will determination of prognostic cutpoints...
  33. pmc Apolipoprotein E and kidney function in older adults
    Rebecca Kurnik Seshasai
    Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, MA 02111, USA
    Clin Nephrol 78:174-80. 2012
    ..We evaluated the associations of apolipoprotein E alleles with kidney function among older adults in the cardiovascular health study (CHS)...
  34. pmc Albuminuria, impaired kidney function and cardiovascular outcomes or mortality in the elderly
    Dena E Rifkin
    Tufts Medical Center and Tufts University School of Medicine, University of Washington, Seattle, USA
    Nephrol Dial Transplant 25:1560-7. 2010
    ..Kidney disease is a risk factor for mortality and cardiovascular disease in older adults, but the separate and combined effects of albuminuria and cystatin C, a novel marker of glomerular filtration, are not known...
  35. pmc Cystatin C and carotid intima-media thickness in asymptomatic adults: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Anh L Bui
    Department of Medicine, University of California, San Francisco, CA, USA
    Am J Kidney Dis 53:389-98. 2009
    ..We therefore explored whether serum cystatin C level is associated with carotid intima-media thickness (IMT) in ambulatory adults without clinical heart disease...
  36. pmc Estimating mean annual 25-hydroxyvitamin D concentrations from single measurements: the Multi-Ethnic Study of Atherosclerosis
    Michael C Sachs
    Kidney Research Institute and Division of Nephrology, University of Washington, Seattle, WA, USA
    Am J Clin Nutr 97:1243-51. 2013
    ..Single measurements may misclassify annual exposure, which may lead to bias in research and complicate clinical decision making...
  37. pmc Circulating vitamin D metabolites and subclinical atherosclerosis in type 1 diabetes
    Michael C Sachs
    University of Washington, Seattle, Washington, USA
    Diabetes Care 36:2423-9. 2013
    ..We tested associations of circulating vitamin D metabolite concentrations with subclinical atherosclerosis among 1,193 participants with type 1 diabetes in the DCCT/EDIC study...
  38. ncbi request reprint The effect of combined calcium and cholecalciferol supplementation on bone mineral density in elderly women with moderate chronic kidney disease
    Cortney Bosworth
    University of Washington, Division of Nephrology and Kidney Research Institute, Seattle, WA, USA
    Clin Nephrol 77:358-65. 2012
    ..To examine the effect of combined calcium and vitamin D3 supplementation on bone mineral density (BMD) inpatients with chronic kidney disease (CKD)...
  39. pmc Alcohol consumption and kidney function decline in the elderly: alcohol and kidney disease
    Vandana Menon
    Division of Nephrology, Tufts Medical Center, Boston, MA, USA
    Nephrol Dial Transplant 25:3301-7. 2010
    ..Alcohol consumption appears to be protective for cardiovascular disease; however, its relationship with kidney disease is unclear...
  40. ncbi request reprint Longitudinal changes in estimated and measured GFR in type 1 diabetes
    Ian H De Boer
    Division of Nephrology and Kidney Research Institute, University of Washington, Seattle, Washington
    J Am Soc Nephrol 25:810-8. 2014
    ....
  41. ncbi request reprint Fibroblast growth factor-23 and cardiovascular disease in the general population: the multi-ethnic study of atherosclerosis
    Bryan Kestenbaum
    From the Kidney Research Institute, Department of Medicine, Division of Nephrology B K, M C S, C R C, J R, D R, I H d B, Department of Laboratory Medicine A N H, Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology D S S, and Department of Epidemiology M B, University of Washington, Seattle Division of Nephrology, Department of Medicine, University of California at San Diego J H I Nephrology Section, Veterans Affairs San Diego Healthcare System, CA J H I and Division of Preventive Medicine, Department of Family and Preventive Medicine, University of California at San Diego J H I Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD J A C L and Department of Radiology, Tufts New England Medical Center, Boston, MA J F P
    Circ Heart Fail 7:409-17. 2014
    ..The role of FGF-23 in cardiovascular disease development in the general population is unclear. We tested associations of FGF-23 with major subclinical and clinical cardiovascular disease outcomes in a large prospective cohort...
  42. pmc Mineral metabolism markers and the long-term risk of hip fracture: the cardiovascular health study
    Cassianne Robinson-Cohen
    Kidney Research Institute, Division of Nephrology, University of Washington, Seattle, Washington 98104, USA
    J Clin Endocrinol Metab 96:2186-93. 2011
    ..Disturbances in mineral metabolism are associated with lower bone mineral density and fracture; however, previous human studies have assessed individual mineral metabolism markers in isolation...
  43. pmc Effects of a high-protein diet on regulation of phosphorus homeostasis
    Robin A Kremsdorf
    Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98105, USA
    J Clin Endocrinol Metab 98:1207-13. 2013
    ..High-protein diets, which are popular for weight loss, contain large quantities of phosphorus. Phosphorus excess and consequent changes in phosphorus regulatory hormones are implicated in vascular calcification and cardiovascular disease...
  44. doi request reprint Chronic kidney disease, plasma lipoproteins, and coronary artery calcium incidence: the Multi-Ethnic Study of Atherosclerosis
    Julio A Lamprea-Montealegre
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    Arterioscler Thromb Vasc Biol 33:652-8. 2013
    ..To determine the association of chronic kidney disease and coronary artery calcium (CAC) incidence, and the distribution of lipoproteins across categories of kidney function and their association with CAC risk...
  45. pmc Fasting and post-glucose load measures of insulin resistance and risk of ischemic stroke in older adults
    Evan L Thacker
    Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, SM, 1730 Minor Avenue, Ste 1360, Seattle, WA 98101, USA
    Stroke 42:3347-51. 2011
    ..We investigated whether fasting and post-glucose load measures of insulin resistance were related to incident ischemic stroke in nondiabetic, older adults...
  46. pmc Urinary creatinine excretion rate and mortality in persons with coronary artery disease: the Heart and Soul Study
    Joachim H Ix
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, and VA San Diego Healthcare System, 3350 La Jolla Village Dr, Mail Code 111 H, San Diego, CA 92161, USA
    Circulation 121:1295-303. 2010
    ..In persons with coronary artery disease, low body mass index is associated with greater mortality; however, it is uncertain whether low muscle mass is a risk factor for mortality in this setting...
  47. pmc Serum phosphorus concentrations and arterial stiffness among individuals with normal kidney function to moderate kidney disease in MESA
    Joachim H Ix
    Department of Medicine, Division of Nephrology and Hypertension, University of California San Diego, San Diego, CA 92161, USA
    Clin J Am Soc Nephrol 4:609-15. 2009
    ..Higher phosphorus levels are associated with cardiovascular disease (CVD) events and mortality. Whether vascular stiffness may be responsible is unknown...
  48. pmc Body mass index is associated with increased creatinine clearance by a mechanism independent of body fat distribution
    Fernando Gerchman
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, Washington 98108, USA
    J Clin Endocrinol Metab 94:3781-8. 2009
    ..Although obesity has been, in general, associated with glomerular hyperfiltration, visceral adiposity has been suggested to be associated with reduced glomerular filtration...
  49. pmc Kidney disease and increased mortality risk in type 2 diabetes
    Maryam Afkarian
    Kidney Research Institute and Division of Nephrology, Department of Medicine, University of Washington, Seattle, WA 98014, USA
    J Am Soc Nephrol 24:302-8. 2013
    ..2%-29.6%) when further adjusted. We observed similar patterns for cardiovascular and noncardiovascular mortality. In conclusion, those with kidney disease predominantly account for the increased mortality observed in type 2 diabetes...
  50. pmc Association of body mass index with peripheral arterial disease in older adults: the Cardiovascular Health Study
    Joachim H Ix
    Division of Nephrology and Hypertension, Department of Medicine, University of California, San Diego and San Diego VA HealthCare System, San Diego, CA 92161, USA
    Am J Epidemiol 174:1036-43. 2011
    ..00, 1.76) among never smokers in good health. Greater BMI is associated with PAD in older persons who remain healthy and have never smoked. Normal weight maintenance may decrease PAD incidence and associated comorbidity in older age...
  51. pmc Association between adiposity in midlife and older age and risk of diabetes in older adults
    Mary L Biggs
    Department of Biostatistics, School of Public Health and Community Medicine, University of Washington, Seattle, WA, USA
    JAMA 303:2504-12. 2010
    ..Adiposity is a well-recognized risk factor for type 2 diabetes among young and middle-aged adults, but the relationship between body composition and type 2 diabetes is not well described among older adults...
  52. pmc Association between physical performance and all-cause mortality in CKD
    Baback Roshanravan
    Division of Nephrology, Department of Medicine, University of Washington Kidney Research Institute, Box 359606, 325 9th Avenue, Seattle, WA 98104, USA
    J Am Soc Nephrol 24:822-30. 2013
    ..In summary, impaired physical performance of the lower extremities is common in CKD and strongly associates with all-cause mortality...
  53. pmc Associations of socioeconomic status and processed food intake with serum phosphorus concentration in community-living adults: the Multi-Ethnic Study of Atherosclerosis (MESA)
    ORLANDO M GUTIERREZ
    Department of Medicine, University of Alabama at Birmingham, 35294 0006, USA
    J Ren Nutr 22:480-9. 2012
    ..Accordingly, we hypothesized that excess intake of these foods accounts for a relationship between lower socioeconomic status and higher serum phosphorus concentration...
  54. ncbi request reprint Fracture risk after parathyroidectomy among chronic hemodialysis patients
    Kyle D Rudser
    Division of Biostatistics, Harborview Medical Center, University of Washington, Seattle, WA 98104 2499, USA
    J Am Soc Nephrol 18:2401-7. 2007
    ..Surgical amelioration of secondary hyperparathyroidism may outweigh the risk of parathyroid hormone oversuppression in terms of bone health...
  55. pmc The risk of infection-related hospitalization with decreased kidney function
    Lorien S Dalrymple
    Department of Medicine, University of California Davis, USA
    Am J Kidney Dis 59:356-63. 2012
    ..Moderate kidney disease may predispose to infection. We sought to determine whether decreased kidney function, estimated by serum cystatin C level, was associated with the risk of infection-related hospitalization in older individuals...
  56. pmc Association of serum phosphate levels with aortic valve sclerosis and annular calcification: the cardiovascular health study
    Jason P Linefsky
    Health Services Research and Development Northwest Center for Excellence, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98195 6422, USA
    J Am Coll Cardiol 58:291-7. 2011
    ..This study was conducted to evaluate mineral metabolism markers as potential risk factors for calcific aortic valve disease...
  57. pmc Association of oral calcitriol with improved survival in nondialyzed CKD
    Abigail B Shoben
    Department of Biostatistics, Puget Sound Veterans Affairs Medical Center, Seattle, WA, USA
    J Am Soc Nephrol 19:1613-9. 2008
    ..Calcitriol use was associated with a greater risk for hypercalcemia. In conclusion, oral calcitriol use is associated with lower mortality in nondialysis patients with CKD...
  58. pmc Common genetic determinants of vitamin D insufficiency: a genome-wide association study
    Thomas J Wang
    Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Lancet 376:180-8. 2010
    ..We aimed to identify common genetic variants affecting vitamin D concentrations and risk of insufficiency...
  59. pmc Racial differences in the association of pentraxin-3 with kidney dysfunction: the Multi-Ethnic Study of Atherosclerosis
    Ruth Dubin
    Department of Medicine, Division of Nephrology, University of California San Francisco, San Francisco, CA, USA
    Nephrol Dial Transplant 26:1903-8. 2011
    ..Pentraxin-3 (PTX3), an inflammatory marker thought to be related to vascular inflammation, is elevated in advanced chronic kidney disease (CKD). Whether PTX3 is associated with mild to moderate kidney dysfunction is unknown...
  60. pmc A prospective study of frailty in nephrology-referred patients with CKD
    Baback Roshanravan
    Department of Medicine, Division of Nephrology, University of Washington Kidney Research Institute, 325 9th Ave, Seattle, WA 98104, USA
    Am J Kidney Dis 60:912-21. 2012
    ..However, there are limited data describing the prevalence or consequences of frailty in middle-aged patients with chronic kidney disease (CKD)...
  61. ncbi request reprint The severity of secondary hyperparathyroidism in chronic renal insufficiency is GFR-dependent, race-dependent, and associated with cardiovascular disease
    Ian H De Boer
    Division of Nephrology, Department of Medicine, University of California San Francisco, 94118, USA
    J Am Soc Nephrol 13:2762-9. 2002
    ..0; 95% CI, 1.3 to 2.9 per unit natural log PTH) and not associated with other co-morbid conditions. These factors should be considered when screening and managing SHPT in CRI...
  62. pmc A high ankle brachial index is associated with greater left ventricular mass MESA (Multi-Ethnic Study of Atherosclerosis)
    Joachim H Ix
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, California 92161, USA
    J Am Coll Cardiol 55:342-9. 2010
    ..This study sought to determine the association of high ankle brachial index (ABI) measurements with left ventricular (LV) mass, and to compare its strength with that of low ABI with LV mass...
  63. pmc Serum phosphorus concentrations in the third National Health and Nutrition Examination Survey (NHANES III)
    Ian H De Boer
    Division of Nephrology, University of Washington, Seattle, WA 98104 2499, USA
    Am J Kidney Dis 53:399-407. 2009
    ..Reasons for interindividual variation in steady-state serum phosphorus concentrations are largely unknown...
  64. pmc Impaired vitamin D metabolism in CKD
    Cortney Bosworth
    Division of Nephrology and Kidney Research Institute, University of Washington, Seattle, WA, USA
    Semin Nephrol 33:158-68. 2013
    ..New insights into the mechanisms and regulation of vitamin D metabolism may lead to novel approaches to assess and treat impaired vitamin D metabolism in chronic kidney disease...
  65. pmc Measurement of insulin resistance in chronic kidney disease
    Hien Pham
    Division of Nephrology and Kidney Research Institute, Department of Medicine, Seattle VA Puget Sound Healthcare System, Washington, USA
    Curr Opin Nephrol Hypertens 20:640-6. 2011
    ..It is a risk factor for cardiovascular disease and an important potential therapeutic target in this population. Measurement of insulin resistance is reviewed in the context of known pathophysiologic abnormalities in CKD...
  66. pmc Common genetic variants associate with serum phosphorus concentration
    Bryan Kestenbaum
    Division of Nephrology, Department of Medicine, University of Washington, Kidney Research Institute, Seattle, Washington 98104 2499, USA
    J Am Soc Nephrol 21:1223-32. 2010
    ..05 for each). In conclusion, common genetic variants associate with serum phosphorus in the general population. Further study of the loci identified in this study may help elucidate mechanisms of phosphorus regulation...
  67. pmc Dual renin-angiotensin-aldosterone system blockade for diabetic kidney disease
    Raimund H Pichler
    Division of Nephrology, University of Washington, Box 356521, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Curr Diab Rep 10:297-305. 2010
    ....
  68. doi request reprint National Kidney Foundation consensus conference on cardiovascular and kidney diseases and diabetes risk: an integrated therapeutic approach to reduce events
    George Bakris
    Department of Medicine, University of Chicago, Pritzker School of Medicine, Chicago, Illinois 60637, USA
    Kidney Int 78:726-36. 2010
    ..This paper summarizes the results of a consensus conference utilizing a patient case to discuss the integrated management of hypertension, kidney disease, dyslipidemia, diabetes, and heart failure across disciplines...
  69. pmc Characterizing antibody cross-reactivity for immunoaffinity purification of analytes prior to multiplexed liquid chromatography-tandem mass spectrometry
    Thomas J Laha
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    Clin Chem 58:1711-6. 2012
    ....
  70. pmc Higher levels of leflunomide are associated with hemolysis and are not superior to lower levels for BK virus clearance in renal transplant patients
    Nicolae Leca
    Department of Medicine, Division of Nephrology, University of Washington, Seattle, Washington 98195, USA
    Clin J Am Soc Nephrol 3:829-35. 2008
    ..The goals of this study were to report one center's experience with leflunomide, specifically the correlation of leflunomide levels with the outcomes of BK nephropathy and the observed toxic effects during the treatment with leflunomide...

Research Grants2

  1. Randomized trial of vitamin D and omega-3 fatty acids for diabetic kidney disease
    Ian H De Boer; Fiscal Year: 2010
    ..This study will evaluate whether vitamin D3 and/or omega-3 fatty acids are safe and effective interventions to reduce the burden of DKD among the large and growing diabetic population. ..
  2. Insulin Resistance in Chronic Kidney Disease
    Ian H De Boer; Fiscal Year: 2010
    ..The ultimate goal of this work is to reduce the high morbidity and mortality in the large group of patients with moderate-severe CKD. ..