Harriet de Wit

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi request reprint Amphetamine fails to alter cued recollection of emotional images: study of encoding, retrieval, and state-dependency
    Jessica Weafer
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 9:e90423. 2014
  2. pmc Do initial responses to drugs predict future use or abuse?
    Harriet de Wit
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, 5841 S Maryland Ave, MC3077, Chicago, IL 60637, United States
    Neurosci Biobehav Rev 36:1565-76. 2012
  3. ncbi request reprint Evaluation of the abuse potential of pagoclone, a partial GABAA agonist
    Harriet de Wit
    Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA
    J Clin Psychopharmacol 26:268-73. 2006
  4. ncbi request reprint Does stress reactivity or response to amphetamine predict smoking progression in young adults? A preliminary study
    Harriet de Wit
    Department of Psychiatry, The University of Chicago, 5841 S Maryland Ave, MC3077, Chicago, IL 60637, USA
    Pharmacol Biochem Behav 86:312-9. 2007
  5. pmc Impulsivity as a determinant and consequence of drug use: a review of underlying processes
    Harriet de Wit
    Department of Psychiatry, The University of Chicago, USA
    Addict Biol 14:22-31. 2009
  6. pmc Evaluation of genetic variability in the dopamine receptor D2 in relation to behavioral inhibition and impulsivity/sensation seeking: an exploratory study with d-amphetamine in healthy participants
    Ajna Hamidovic
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL 60637, USA
    Exp Clin Psychopharmacol 17:374-83. 2009
  7. pmc Stress-induced changes in mood and cortisol release predict mood effects of amphetamine
    Ajna Hamidovic
    The University of Chicago, Department of Psychiatry and Behavioral Neuroscience, 5841 S Maryland Avenue MC 3077, Chicago, IL 60637, United States
    Drug Alcohol Depend 109:175-80. 2010
  8. ncbi request reprint Serotonin transporter genotype and acute subjective response to amphetamine
    David C Lott
    Linden Oaks Hospital at Edward, Naperville, Illinois, USA
    Am J Addict 15:327-35. 2006
  9. pmc Effects of MDMA on sociability and neural response to social threat and social reward
    Gillinder Bedi
    Human Behavioral Pharmacology Laboratory, Department of Psychiatry, University of Chicago, 5841 S Maryland Ave, MC 3077, Chicago, IL 60637, USA
    Psychopharmacology (Berl) 207:73-83. 2009
  10. ncbi request reprint Subjective, behavioral, and physiological effects of acute caffeine in light, nondependent caffeine users
    Emma Childs
    The University of Chicago, 5841 S Maryland Avenue, MC3077, Chicago, IL 60637, USA
    Psychopharmacology (Berl) 185:514-23. 2006

Research Grants

  1. DETERMINANTS OF DRUG PREFERENCE IN HUMANS
    Harriet de Wit; Fiscal Year: 2009
  2. DRUG ABUSE AND IMPULSIVITY: HUMAN LABORATORY MODELS
    Harriet de Wit; Fiscal Year: 2006
  3. DETERMINANTS OF DRUG PREFERENCE IN HUMANS
    Harriet de Wit; Fiscal Year: 2005
  4. DRUG ABUSE AND IMPULSIVITY: HUMAN LABORATORY MODELS
    Harriet de Wit; Fiscal Year: 2005
  5. DETERMINANTS OF DRUG PREFERENCE IN HUMANS
    Harriet de Wit; Fiscal Year: 2004
  6. Nicotinic Involvement & Consumption of Alcohol in Humans
    Harriet de Wit; Fiscal Year: 2003
  7. DETERMINANTS OF DRUG PREFERENCE
    Harriet de Wit; Fiscal Year: 2002
  8. DETERMINANTS OF DRUG PREFERENCE IN HUMANS
    Harriet de Wit; Fiscal Year: 2006
  9. DRUG ABUSE AND IMPULSIVITY: HUMAN LABORATORY MODELS
    Harriet de Wit; Fiscal Year: 2005
  10. DRUG ABUSE AND IMPULSIVITY: HUMAN LABORATORY MODELS
    Harriet de Wit; Fiscal Year: 2009

Detail Information

Publications98

  1. ncbi request reprint Amphetamine fails to alter cued recollection of emotional images: study of encoding, retrieval, and state-dependency
    Jessica Weafer
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 9:e90423. 2014
    ....
  2. pmc Do initial responses to drugs predict future use or abuse?
    Harriet de Wit
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, 5841 S Maryland Ave, MC3077, Chicago, IL 60637, United States
    Neurosci Biobehav Rev 36:1565-76. 2012
    ..In parallel, additional investigation of initial responses in animal models as predictors of drug use will shed light on the underlying mechanisms...
  3. ncbi request reprint Evaluation of the abuse potential of pagoclone, a partial GABAA agonist
    Harriet de Wit
    Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA
    J Clin Psychopharmacol 26:268-73. 2006
    ..In general, the results with these doses indicate that the abuse potential of pagoclone is similar to that of diazepam, although its profile as a partial agonist suggests that differences between the drugs may emerge at higher doses...
  4. ncbi request reprint Does stress reactivity or response to amphetamine predict smoking progression in young adults? A preliminary study
    Harriet de Wit
    Department of Psychiatry, The University of Chicago, 5841 S Maryland Ave, MC3077, Chicago, IL 60637, USA
    Pharmacol Biochem Behav 86:312-9. 2007
    ....
  5. pmc Impulsivity as a determinant and consequence of drug use: a review of underlying processes
    Harriet de Wit
    Department of Psychiatry, The University of Chicago, USA
    Addict Biol 14:22-31. 2009
    ..The findings lay the groundwork for studying the cognitive and neurobiological substrates of impulsivity, and for future studies on the role of impulsive behavior as both facilitator and a result of drug use...
  6. pmc Evaluation of genetic variability in the dopamine receptor D2 in relation to behavioral inhibition and impulsivity/sensation seeking: an exploratory study with d-amphetamine in healthy participants
    Ajna Hamidovic
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL 60637, USA
    Exp Clin Psychopharmacol 17:374-83. 2009
    ..The significant relationship between DRD2 genotype and both behavioral inhibition and impulsivity suggests a possible common genetic influence on behavioral and self-report measures of impulsivity...
  7. pmc Stress-induced changes in mood and cortisol release predict mood effects of amphetamine
    Ajna Hamidovic
    The University of Chicago, Department of Psychiatry and Behavioral Neuroscience, 5841 S Maryland Avenue MC 3077, Chicago, IL 60637, United States
    Drug Alcohol Depend 109:175-80. 2010
    ....
  8. ncbi request reprint Serotonin transporter genotype and acute subjective response to amphetamine
    David C Lott
    Linden Oaks Hospital at Edward, Naperville, Illinois, USA
    Am J Addict 15:327-35. 2006
    ..The separate and combined analyses of the gene-linked polymorphic region (5-HTTLPR) and the Intron 2 VNTR suggest that these two HTT polymorphisms may contribute to acute subjective responses to d-amphetamine with a small effect...
  9. pmc Effects of MDMA on sociability and neural response to social threat and social reward
    Gillinder Bedi
    Human Behavioral Pharmacology Laboratory, Department of Psychiatry, University of Chicago, 5841 S Maryland Ave, MC 3077, Chicago, IL 60637, USA
    Psychopharmacology (Berl) 207:73-83. 2009
    ..Despite their apparent importance in recreational and potential psychotherapeutic use of MDMA, the defining characteristics and neurobiological mechanisms of these interpersonal effects are poorly understood...
  10. ncbi request reprint Subjective, behavioral, and physiological effects of acute caffeine in light, nondependent caffeine users
    Emma Childs
    The University of Chicago, 5841 S Maryland Avenue, MC3077, Chicago, IL 60637, USA
    Psychopharmacology (Berl) 185:514-23. 2006
    ....
  11. ncbi request reprint Personality and the acute subjective effects of d-amphetamine in humans
    Matthew G Kirkpatrick
    Department of Psychiatry and Behavioral Neurosciences, University of Chicago, Chicago, IL 60637, USA
    J Psychopharmacol 27:256-64. 2013
    ....
  12. pmc Amphetamine as a social drug: effects of d-amphetamine on social processing and behavior
    Margaret C Wardle
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, 5841 S Maryland Ave, MC 3077, Chicago, IL 60637, USA
    Psychopharmacology (Berl) 223:199-210. 2012
    ..One way that drugs may affect social behavior is by altering social processing, for example by decreasing perceptions of negative emotion in others...
  13. pmc Effect of social stress during acute nicotine abstinence
    Margaret C Wardle
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, 5841 S Maryland Ave MC 3077, Chicago, IL 60637, USA
    Psychopharmacology (Berl) 218:39-48. 2011
    ..Relapse to smoking is often precipitated by stress, yet little is known about the effects of nicotine withdrawal on responses to acute stress, or whether nicotine replacement reverses withdrawal-induced changes in stress response...
  14. doi request reprint Further evidence of association between amphetamine response and SLC6A2 gene variants
    Andrea M Dlugos
    Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, 5841 South Maryland Avenue, MC3077 Chicago, IL, USA
    Psychopharmacology (Berl) 206:501-11. 2009
    ..We previously found that the intronic norepinephrine transporter gene (SLC6A2) polymorphism rs36017 modulates feelings of elation after administration of 20 mg D-amphetamine in healthy volunteers...
  15. pmc Hormonal, cardiovascular, and subjective responses to acute stress in smokers
    Emma Childs
    Department of Psychiatry and Behavioural Neuroscience, The University of Chicago, 5841 S Maryland Ave, MC 3077, Chicago, IL, 60637, USA
    Psychopharmacology (Berl) 203:1-12. 2009
    ..It is important to understand how smoking affects physiological and psychological outcomes after stress and how these may interact to motivate smoking...
  16. doi request reprint Effect of d-amphetamine on post-error slowing in healthy volunteers
    Margaret C Wardle
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, 5841 S Maryland Ave, MC 3077, Chicago, IL 60637, USA
    Psychopharmacology (Berl) 220:109-15. 2012
    ..Post-error slowing has long been considered a sign of healthy error detection and an important component of cognitive function. However, the neuropharmacological processes underlying post-error slowing are poorly understood...
  17. doi request reprint Cannabinoid modulation of subgenual anterior cingulate cortex activation during experience of negative affect
    Christine A Rabinak
    Department of Psychiatry, University of Michigan, Rachel Upjohn Building, 4250 Plymouth Road, Box 5765, Ann Arbor, MI 48109 2700, USA
    J Neural Transm 119:701-7. 2012
    ..This observation extends prior findings implicating a cortico-limbic, emotion-related central mechanism underlying cannabinoid function...
  18. pmc Bidirectional interactions between acute psychosocial stress and acute intravenous alcohol in healthy men
    Emma Childs
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois 60637, USA
    Alcohol Clin Exp Res 35:1794-803. 2011
    ..In this study, we investigated whether different phases of response to an acute stress alter the subjective effects of intravenous alcohol, by administering the drug at 2 different times after the stress...
  19. pmc Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety
    Emma Childs
    Department of Psychiatry, The University of Chicago, Chicago, IL 60657, USA
    Neuropsychopharmacology 33:2791-800. 2008
    ..It is likely that other ADORA2A and DRD2 polymorphisms also contribute to responses to caffeine...
  20. ncbi request reprint Effects of THC on behavioral measures of impulsivity in humans
    Jennifer McDonald
    Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA
    Neuropsychopharmacology 28:1356-65. 2003
    ..The dissociations between the four measures of impulsivity suggest that impulsivity is an assemblage of distinct components rather than a unitary process...
  21. ncbi request reprint Effects of stress on responses to methamphetamine in humans
    Anna Söderpalm
    Department of Psychiatry, MC3077, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Psychopharmacology (Berl) 170:188-99. 2003
    ..Similarly, stress may also alter the acute subjective effects of drugs or the tendency to seek and consume drugs in humans...
  22. pmc More aroused, less fatigued: fatty acid amide hydrolase gene polymorphisms influence acute response to amphetamine
    Andrea M Dlugos
    Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA
    Neuropsychopharmacology 35:613-22. 2010
    ....
  23. doi request reprint Polymorphisms in dopamine transporter (SLC6A3) are associated with stimulant effects of D-amphetamine: an exploratory pharmacogenetic study using healthy volunteers
    Ajna Hamidovic
    The University of Chicago, Chicago, IL, USA
    Behav Genet 40:255-61. 2010
    ..These findings suggest a pleiotropic effect of this polymorphic locus on both ADHD and sensitivity to the subjective effects of amphetamine...
  24. doi request reprint Cardiovascular, hormonal, and emotional responses to the TSST in relation to sex and menstrual cycle phase
    Emma Childs
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois 60637, USA
    Psychophysiology 47:550-9. 2010
    ..We discuss our findings in the context of sex differences in the prevalence of stress-linked disorders...
  25. doi request reprint Rewarding, stimulant, and sedative alcohol responses and relationship to future binge drinking
    Andrea C King
    Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL 60637, USA
    Arch Gen Psychiatry 68:389-99. 2011
    ..It has been postulated that either lower or greater acute responses to alcohol, or both, depending on the limb of the breath alcohol concentration curve, contribute to propensity for alcohol misuse...
  26. pmc Lack of association between COMT and working memory in a population-based cohort of healthy young adults
    Margaret C Wardle
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL 60637, USA
    Neuropsychopharmacology 38:1253-63. 2013
    ....
  27. pmc Amping up effort: effects of d-amphetamine on human effort-based decision-making
    Margaret C Wardle
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 31:16597-602. 2011
    ..These findings help elucidate neurochemical substrates of choice, with implications for neuropsychiatric diseases characterized by dopaminergic dysfunction and motivational deficits...
  28. pmc Catechol-O-methyltransferase val158met genotype modulates sustained attention in both the drug-free state and in response to amphetamine
    Ajna Hamidovic
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois 60637, USA
    Psychiatr Genet 20:85-92. 2010
    ..Here, we extend these observations by examining two measures of cognitive function, lapses in attention and visuo-spatial-motor speed of processing, in both the drug-free state and after administration of d-amphetamine...
  29. ncbi request reprint Differential effects of nicotine on alcohol consumption in men and women
    Ashley Acheson
    Department of Psychiatry, MC3077, The University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Psychopharmacology (Berl) 186:54-63. 2006
    ..Furthermore, because men and women differ in their responses to both drugs, it is possible that men and women also differ in their responses to the combination of nicotine and alcohol...
  30. ncbi request reprint Genetic variation associated with euphorigenic effects of d-amphetamine is associated with diminished risk for schizophrenia and attention deficit hyperactivity disorder
    Amy B Hart
    Departments of Human Genetics, Medicine, and Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL 60637
    Proc Natl Acad Sci U S A 111:5968-73. 2014
    ....
  31. pmc Conditioned preference to a methamphetamine-associated contextual cue in humans
    Leah M Mayo
    Human Behavioral Pharmacology Laboratory, Department of Psychiatry and Behavioral Neuroscience, MC 3077, The University of Chicago, Chicago, IL, USA
    Neuropsychopharmacology 38:921-9. 2013
    ..Preference was unrelated to subjective drug effects, and did not change in the unpaired group. These data support the translational utility of our conditioning procedure for studies of reward mechanisms in humans...
  32. pmc Psychopharmacology of theobromine in healthy volunteers
    Matthew J Baggott
    University of Chicago, Chicago, IL, USA
    Psychopharmacology (Berl) 228:109-18. 2013
    ..Theobromine, a methylxanthine related to caffeine and present in high levels in cocoa, may contribute to the appeal of chocolate. However, current evidence for this is limited...
  33. pmc Effects of delta-9-tetrahydrocannabinol on evaluation of emotional images
    Michael E Ballard
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA
    J Psychopharmacol 26:1289-98. 2012
    ..These results support our previous work, and show that THC reduces perception of facial threat. Nevertheless, THC does not appear to positively bias evaluation of emotional stimuli in general...
  34. pmc Varenicline potentiates alcohol-induced negative subjective responses and offsets impaired eye movements
    Emma Childs
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Illinois 60637, USA
    Alcohol Clin Exp Res 36:906-14. 2012
    ..In this study, we examined the effects of an acute dose of VAR upon subjective, physiological, and objective responses to low and moderate doses of alcohol in healthy social drinkers...
  35. pmc Effects of amphetamine on reactivity to emotional stimuli
    Margaret C Wardle
    Department of Psychiatry and Behavioral Neuroscience, MC 3077, University of Chicago, 5841 S Maryland Ave, Chicago, IL, USA
    Psychopharmacology (Berl) 220:143-53. 2012
    ..e., euphoria). However, recent findings suggest drugs may also alter emotional reactivity to external stimuli, and that this may occur independently of direct effects on mood...
  36. pmc Amphetamine-induced place preference in humans
    Emma Childs
    Department of Psychiatry and Behavioural Neuroscience, The University of Chicago, Chicago, Illinois 60637, USA
    Biol Psychiatry 65:900-4. 2009
    ..Further, we investigated the relationship between conditioned place preference and the mood-altering effects of the drug...
  37. ncbi request reprint Mecamylamine and ethanol preference in healthy volunteers
    Elizabeth M Young
    Department of Psychiatry, The University of Chicago, Chicago, Illinois 60637, USA
    Alcohol Clin Exp Res 29:58-65. 2005
    ..This experiment was designed to investigate the effects of mecamylamine on consumption of alcohol in healthy social drinkers...
  38. pmc Sleep deprivation increases cigarette smoking
    Ajna Hamidovic
    Department of Psychiatry, The University of Chicago, 5841 S Maryland Avenue, MC3077, Chicago, IL 60637, United States
    Pharmacol Biochem Behav 93:263-9. 2009
    ..Thus, the findings suggest that sleep loss may increase the likelihood of smoking during abstinence not through inhibitory or attentional mechanisms but because of the potential of nicotine to reduce subjective sleepiness...
  39. ncbi request reprint Effects of acute social stress on alcohol consumption in healthy subjects
    Harriet de Wit
    Department of Psychiatry, University of Chicago, Chicago, Illinois 60615, USA
    Alcohol Clin Exp Res 27:1270-7. 2003
    ..Here we examined the effects of an acute social stressor (performing a mental arithmetic task in front of an audience) on consumption of ethanol or placebo beverages in healthy social drinkers...
  40. doi request reprint Effects of low to moderate acute doses of pramipexole on impulsivity and cognition in healthy volunteers
    Ajna Hamidovic
    Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA
    J Clin Psychopharmacol 28:45-51. 2008
    ..The sedative-like effects observed in this study may reflect presynaptic actions of the drug. Higher doses with postsynaptic actions may be needed to produce either behavioral or subjective stimulant-like effects...
  41. doi request reprint Enhanced mood and psychomotor performance by a caffeine-containing energy capsule in fatigued individuals
    Emma Childs
    The University of Chicago, Chicago, IL 60637, USA
    Exp Clin Psychopharmacol 16:13-21. 2008
    ..These findings indicate that consumption of a caffeine-containing food supplement improves subjective state and cognitive performance in fatigued individuals that is likely a result of its caffeine content...
  42. ncbi request reprint Therapeutic doses of diazepam do not alter impulsive behavior in humans
    Brady Reynolds
    Department of Psychiatry, The University of Chicago, MC3077, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Pharmacol Biochem Behav 79:17-24. 2004
    ..These results suggest that low doses of diazepam, including doses that are used therapeutically, do not increase impulsive behavior. Whether higher doses would increase impulsivity remains to be determined...
  43. doi request reprint Effects of acute progesterone administration upon responses to acute psychosocial stress in men
    Emma Childs
    Department of Psychiatry and Behavioral Neurosciences, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Exp Clin Psychopharmacol 18:78-86. 2010
    ..Thus, progesterone dampened some of the psychological effects of stress but produced inconsistent effects on physiological stress responses...
  44. ncbi request reprint Responses to the Trier Social Stress Test (TSST) in single versus grouped participants
    Emma Childs
    Department of Psychiatry, The University of Chicago, Chicago, Illinois 60637, USA
    Psychophysiology 43:366-71. 2006
    ..The findings suggest that the TSST may be conducted with multiple participants without significantly affecting subjective and cortisol responses to the task...
  45. ncbi request reprint Attenuated cortisol response to alcohol in heavy social drinkers
    Andrea King
    University of Chicago, Pritzker School of Medicine, Department of Psychiatry, Chicago, IL 60637, USA
    Int J Psychophysiol 59:203-9. 2006
    ..Further research may help determine whether alteration in cortisol response to alcohol is a biological marker of the propensity to abuse alcohol...
  46. ncbi request reprint Association between the casein kinase 1 epsilon gene region and subjective response to D-amphetamine
    Jeremy Veenstra-Vanderweele
    Institute of Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60637, USA
    Neuropsychopharmacology 31:1056-63. 2006
    ..001), which corresponded to a leftward shift in the dose-response curve. These findings demonstrate the successful translation of pharmacogenetic results from mice to humans...
  47. pmc In the company of others: social factors alter acute alcohol effects
    Matthew G Kirkpatrick
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, 5841 S Maryland Ave, MC 3077, Chicago, IL, 60637, USA
    Psychopharmacology (Berl) 230:215-26. 2013
    ..Alcohol is usually consumed in social contexts. However, the drug has been studied mainly under socially isolated conditions, and our understanding of how social setting affects response to alcohol is limited...
  48. pmc Inattention, impulsive action, and subjective response to D-amphetamine
    Jessica Weafer
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, United States
    Drug Alcohol Depend 133:127-33. 2013
    ..The aim of the current study was to examine the degree to which both inattention and impulsive action predicted subjective response to amphetamine...
  49. pmc Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13)
    Amy B Hart
    Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 7:e42646. 2012
    ..Our approach provides a case study for analysis of high-dimensional intermediate pharmacogenomic phenotypes, which may be more tractable than clinical diagnoses...
  50. pmc Candidate gene studies of a promising intermediate phenotype: failure to replicate
    Amy B Hart
    Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Neuropsychopharmacology 38:802-16. 2013
    ..Many of these factors may have contributed to our failure to replicate our previous findings. Our results should instill caution in those considering similarly designed studies...
  51. pmc Pre-encoding administration of amphetamine or THC preferentially modulates emotional memory in humans
    Michael E Ballard
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, 5841 S Maryland Ave, MC3077, Chicago, IL 60637, USA
    Psychopharmacology (Berl) 226:515-29. 2013
    ..Specifically, addictive drugs may affect memory of emotional events and experiences in ways that are attractive to some users. However, few studies have investigated the effects of addictive drugs on emotional memory in humans...
  52. pmc Quantifying talk: developing reliable measures of verbal productivity
    Margaret Wardle
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, 5841 S Maryland Ave, MC 3077, Chicago, IL 60637, USA
    Behav Res Methods 43:168-78. 2011
    ..Recommendations for the measurement of "Voluntary Talkativeness" are made...
  53. doi request reprint Effects of nicotine on attention and inhibitory control in healthy nonsmokers
    Nicholas D Wignall
    Department of Psychiatry, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Exp Clin Psychopharmacol 19:183-91. 2011
    ..The findings of this study contribute to a growing literature indicating that nicotine differentially affects specific subtypes of cognitive performance in healthy nonsmokers...
  54. ncbi request reprint Mecamylamine attenuates the subjective stimulant-like effects of alcohol in social drinkers
    Henry Chi
    Department of Psychiatry, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Alcohol Clin Exp Res 27:780-6. 2003
    ..It was hypothesized that mecamylamine (7.5 and 15 mg) would attenuate the stimulant-like subjective effects of alcohol (0.8 g/kg) and decrease the self-reported desire to consume additional alcohol beverages...
  55. ncbi request reprint Acute administration of d-amphetamine decreases impulsivity in healthy volunteers
    Harriet de Wit
    Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA
    Neuropsychopharmacology 27:813-25. 2002
    ..These results suggest that acute doses of amphetamine decrease several forms of impulsive behavior. These findings extend and confirm previous findings in humans and laboratory animals...
  56. ncbi request reprint Differential subjective effects of D-amphetamine by gender, hormone levels and menstrual cycle phase
    Tara L White
    Department of Psychiatry MC3077, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Pharmacol Biochem Behav 73:729-41. 2002
    ..Thus, higher levels of estrogen and lower levels of progesterone are associated with greater subjective stimulation after AMPH in women, and these hormonal influences contribute to sex differences in amphetamine responding...
  57. pmc Negative emotionality: monoamine oxidase B gene variants modulate personality traits in healthy humans
    Andrea M Dlugos
    Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, 5841 S Maryland Ave, Chicago, IL, USA
    J Neural Transm 116:1323-34. 2009
    ..If confirmed, these results could lead to a better understanding of personality traits and inter-individual susceptibility developing psychiatric disorders such as major depression...
  58. ncbi request reprint Diazepam impairs behavioral inhibition but not delay discounting or risk taking in healthy adults
    Ashley Acheson
    Department of Psychiatry, University of Chicago, IL 60637, USA
    Exp Clin Psychopharmacol 14:190-8. 2006
    ..These results are discussed in the context of other recent findings suggesting that different behavioral indices of impulsivity are dissociable and governed by separate underlying mechanisms...
  59. ncbi request reprint Moderate doses of ethanol fail to increase plasma levels of neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one-like immunoreactivity in healthy men and women
    Louis Holdstock
    Department of Psychiatry, The University of Chicago, MC3077, 5841 S Maryland Avenue, 60637, Chicago, IL 60637, USA
    Psychopharmacology (Berl) 186:442-50. 2006
    ..Humans synthesize 3alpha,5alpha-THP, but its role in response to systemic administration of ethanol is unclear...
  60. doi request reprint Psychoactive drugs and false memory: comparison of dextroamphetamine and δ-9-tetrahydrocannabinol on false recognition
    Michael E Ballard
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, 5841 S Maryland Ave, MC3077, Chicago, IL 60637, USA
    Psychopharmacology (Berl) 219:15-24. 2012
    ..Several psychoactive drugs are known to influence episodic memory. However, these drugs' effects on false memory, or the tendency to incorrectly remember nonstudied information, remain poorly understood...
  61. pmc Caffeine increases psychomotor performance on the effort expenditure for rewards task
    Margaret C Wardle
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, 5841 S Maryland Ave, MC 3077, Chicago, IL 60637, USA
    Pharmacol Biochem Behav 102:526-31. 2012
    ..This study provides a starting point for exploring contributions of the adenosine system to motivation in humans...
  62. pmc Is ecstasy an "empathogen"? Effects of ±3,4-methylenedioxymethamphetamine on prosocial feelings and identification of emotional states in others
    Gillinder Bedi
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Illinois 60637, USA
    Biol Psychiatry 68:1134-40. 2010
    ..However, they have yet to be characterized in controlled studies. Here, we investigate effects of MDMA on an important social cognitive capacity, the identification of emotional expression in others, and on socially relevant mood states...
  63. ncbi request reprint Dual determinants of drug use in humans: reward and impulsivity
    Harriet de Wit
    University of Chicago, USA
    Nebr Symp Motiv 50:19-55. 2004
  64. pmc Incubation of cue-induced cigarette craving during abstinence in human smokers
    Gillinder Bedi
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois 60637, USA
    Biol Psychiatry 69:708-11. 2011
    ..It is unknown whether cue-induced craving increases, decreases, or remains constant with abstinence in humans. We investigated effects of abstinence on cue-induced craving in cigarette smokers...
  65. pmc The prescription opioid, oxycodone, does not alter behavioral measures of impulsivity in healthy volunteers
    James P Zacny
    Department of Anesthesia and Critical Care, MC4028, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Pharmacol Biochem Behav 94:108-13. 2009
    ..Lack of effect on impulsivity stands in contrast to other studies in which other psychoactive drugs including ethanol, delta-9-tetrahydrocannabinol, and amphetamine altered behavior on one or more behavioral measures of impulsivity...
  66. pmc The drug effects questionnaire: psychometric support across three drug types
    Meghan E Morean
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, Office S 229, 34 Park Street, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 227:177-92. 2013
    ..Thus, the field would benefit from demonstrating the reliability and validity of the DEQ for use across multiple substances...
  67. ncbi request reprint Preference for immediate over delayed rewards is associated with magnitude of ventral striatal activity
    Ahmad R Hariri
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 26:13213-7. 2006
    ..They also highlight a specific neurocognitive mechanism that may contribute to increased risk for addiction...
  68. ncbi request reprint The effects of acute haloperidol or risperidone on subjective responses to methamphetamine in healthy volunteers
    Stephen R Wachtel
    The University of Chicago Department of Psychiatry, MC 3077, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Drug Alcohol Depend 68:23-33. 2002
    ....
  69. ncbi request reprint Nucleus accumbens lesions decrease sensitivity to rapid changes in the delay to reinforcement
    Ashley Acheson
    University of Chicago, Department of Psychiatry, Chicago, IL 60637, United States
    Behav Brain Res 173:217-28. 2006
    ..NAC lesions may disrupt the ability of the animals to predict the timing of delayed rewards when the delay to reward is changed frequently...
  70. ncbi request reprint Biphasic alcohol response differs in heavy versus light drinkers
    Andrea C King
    University of Chicago, Pritzker School of Medicine, Department of Psychiatry, Illinois 60637, USA
    Alcohol Clin Exp Res 26:827-35. 2002
    ..However, other factors, such as early-age heavy drinking, are also risk factors for sustained or progressive heavy consumption. Little is currently known about the mechanisms underlying binge or heavy drinking...
  71. ncbi request reprint Efficacy of naltrexone in smoking cessation: a preliminary study and an examination of sex differences
    Andrea King
    Department of Psychiatry, The University of Chicago, IL 60637, USA
    Nicotine Tob Res 8:671-82. 2006
    ..The results suggest continued examination of naltrexone as an adjunct in smoking cessation, particularly in female smokers, who have historically shown worse outcomes with traditional treatment methods...
  72. pmc Combined effects of acute, very-low-dose ethanol and delta(9)-tetrahydrocannabinol in healthy human volunteers
    Michael E Ballard
    Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL 60637, USA
    Pharmacol Biochem Behav 97:627-31. 2011
    ..Data from an in vitro study suggests that combined, sub-threshold doses of these drugs may interact to produce synergistic effects. Very low doses of the two drugs in combination have not been tested in humans...
  73. pmc Cannabinoid modulation of amygdala reactivity to social signals of threat in humans
    K Luan Phan
    Department of Psychiatry, University of Michigan and Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan 48109, USA
    J Neurosci 28:2313-9. 2008
    ....
  74. doi request reprint Genetics of caffeine consumption and responses to caffeine
    Amy Yang
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, 5841 S Maryland Ave, MC 3077, Chicago, IL 60637, USA
    Psychopharmacology (Berl) 211:245-57. 2010
    ..Despite its widespread use, relatively little is understood regarding how genetics affects consumption, acute response, or the long-term effects of caffeine...
  75. pmc Effects of acute psychosocial stress on cigarette craving and smoking
    Emma Childs
    Department of Psychiatry and Behavioral Neurosciences, The University of Chicago, 5841 South Maryland Avenue MC3077, Chicago, IL 60637, USA
    Nicotine Tob Res 12:449-53. 2010
    ..In this study, we investigated the effects of acute psychosocial stress on cigarette craving, the subjective effects of smoking, and smoking behavior in daily smokers...
  76. ncbi request reprint Effect of tryptophan depletion on impulsive behavior in men with or without a family history of alcoholism
    John Crean
    Department of Psychiatry, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Behav Brain Res 136:349-57. 2002
    ..Parallel studies in rats and humans are important to validate the large body of neurobiological research with non-human species to humans...
  77. ncbi request reprint Menstrual cycle phase and responses to drugs of abuse in humans
    Jolan M Terner
    Department of Psychiatry, The University of Chicago, 5841 S Maryland Ave, MC 3077, Chicago, IL 60637, USA
    Drug Alcohol Depend 84:1-13. 2006
    ..With other drugs, the evidence to date suggests that ovarian hormones have modest, if any, effects on responses to abused drugs. We discuss methodological issues relating to inclusion of women with regular menstrual cycles...
  78. ncbi request reprint Lack of effects of acute estradiol on mood in postmenopausal women
    Laura A Schleifer
    Department of Psychiatry MC3077, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Pharmacol Biochem Behav 71:71-7. 2002
    ..The finding that acute administration of exogenous estradiol did not alter mood suggests that more chronic exposure to estradiol is needed to produce mood-enhancing effects...
  79. ncbi request reprint GABA(B) receptor agonists for the treatment of drug addiction: a review of recent findings
    Michael S Cousins
    Department of Psychiatry, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Drug Alcohol Depend 65:209-20. 2002
    ..This line of research may also improve our understanding of the neurochemical mechanisms underlying the drug dependence process...
  80. ncbi request reprint Effects of stress and alcohol on subjective state in humans
    Anna H V Söderpalm
    Department of Psychiatry, University of Chicago, Illinois 60637, USA
    Alcohol Clin Exp Res 26:818-26. 2002
    ..The stressor was a modified version of the Trier Social Stress Test, an arithmetic task that increases cortisol levels...
  81. ncbi request reprint Effects of d-amphetamine and smoking abstinence on cue-induced cigarette craving
    Karen M Alsene
    Department of Psychiatry, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Exp Clin Psychopharmacol 13:209-18. 2005
    ..These results suggest that both AMPH and smoking abstinence can increase cigarette craving, but they do not appear to specifically affect responses to conditioned smoking-related cues...
  82. pmc An association study of the brain-derived neurotrophic factor Val66Met polymorphism and amphetamine response
    Brody A Flanagin
    Department of Psychiatry, The University of Chicago, Chicago, Illinois 60637, USA
    Am J Med Genet B Neuropsychiatr Genet 141:576-83. 2006
    ..These results suggest that BDNF is related to the subjective and physical response to low doses of AMPH...
  83. ncbi request reprint Association between A2a receptor gene polymorphisms and caffeine-induced anxiety
    Karen Alsene
    Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA
    Neuropsychopharmacology 28:1694-702. 2003
    ..The study shows that an adenosine receptor gene polymorphism that has been associated with Panic Disorder is also associated with anxiogenic responses to an acute dose of caffeine...
  84. ncbi request reprint Dopamine transporter gene associated with diminished subjective response to amphetamine
    David C Lott
    Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA
    Neuropsychopharmacology 30:602-9. 2005
    ..The current findings have important implications for understanding the genetic determinants of variability in stimulant response and risk of abuse...
  85. ncbi request reprint Norepinephrine transporter gene variation modulates acute response to D-amphetamine
    Andrea Dlugos
    Department of Psychiatry, University of Munster, Munster, Germany
    Biol Psychiatry 61:1296-305. 2007
    ..Because the effects of amphetamine are mediated in part by the norepinephrine transporter (SLC6A2), we examined interindividual differences in mood response to amphetamine in relation to SLC6A2 gene polymorphisms...
  86. doi request reprint Bupropion improves attention but does not affect impulsive behavior in healthy young adults
    Ashley Acheson
    Department of Pharmacology, Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Exp Clin Psychopharmacol 16:113-23. 2008
    ..These results suggest that bupropion improves attention without affecting impulsive behavior in healthy adults. Improvements in attention may contribute to the effectiveness of bupropion as a pharmacotherapy for smoking...
  87. ncbi request reprint Effects of morphine and naltrexone on impulsive decision making in rats
    Artur K Kieres
    Division of Behavioral Medicine, Farber Hall, Room G56, Building No 26, University at Buffalo, The State University of New York, 3435 Main Street, Buffalo, NY 14214 3000, USA
    Psychopharmacology (Berl) 173:167-74. 2004
    ..However, it is not clear whether this difference reflects pre-existing traits, or the effects of exposure to the opiates...
  88. doi request reprint Personality and gender differences in effects of d-amphetamine on risk taking
    Tara L White
    Center for Alcohol and Addiction Studies, Brown University, Providence, RI 02912, USA
    Exp Clin Psychopharmacol 15:599-609. 2007
    ..There was evidence of discriminant validity between the AgPEM, NEM, and CON dimensions and behavioral responses to amphetamine. Implications for treatment and addiction are discussed. (c) 2008 APA, all rights reserved...
  89. ncbi request reprint Personality and the subjective effects of acute amphetamine in healthy volunteers
    Tara L White
    Department of Psychiatry and Human Behavior, Center for Alcohol and Addiction Studies, Brown University, Providence, RI 02912, USA
    Neuropsychopharmacology 31:1064-74. 2006
    ..Implications for the vulnerability to psychostimulant addiction in healthy nonaddicts are discussed...
  90. ncbi request reprint Subjective effects of slow-release bupropion versus caffeine as determined in a quasi-naturalistic setting
    Gerald Zernig
    Department of Psychiatry, University of Innsbruck, Innsbruck, Austria
    Pharmacology 70:206-15. 2004
    ..e., 6% each of the present sample), and it may transiently increase, rather than decrease, smoking during early phases of treatment in continuing smokers...
  91. ncbi request reprint Cortisol effects of D-amphetamine relate to traits of fearlessness and aggression but not anxiety in healthy humans
    Tara L White
    Center for Alcohol and Addiction Studies, Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02912, USA
    Pharmacol Biochem Behav 85:123-31. 2006
    ..The goal of the study was to better understand variations in responses to psychostimulants in healthy volunteers...
  92. ncbi request reprint Effects of sleep deprivation on impulsive behaviors in men and women
    Ashley Acheson
    Research Imaging Center, University of Texas Health Science Center at San Antonio, TX, USA
    Physiol Behav 91:579-87. 2007
    ..The results indicate that sleep deprivation does not specifically increase impulsive behaviors but may differentially affect risk taking in men and women...
  93. ncbi request reprint Acute-alcohol effects on the Experiential Discounting Task (EDT) and a question-based measure of delay discounting
    Brady Reynolds
    Columbus Children s Research Institute, Department of Pediatrics, The Ohio State University, 700 Children s Drive, J1401, Columbus, Ohio 43205, USA
    Pharmacol Biochem Behav 83:194-202. 2006
    ..The EDT was more sensitive to the acute effects of alcohol than previously used discounting tasks. Procedural differences between the EDT and question-based measures are discussed in the context of these divergent findings...
  94. ncbi request reprint Interindividual variation in anxiety response to amphetamine: possible role for adenosine A2A receptor gene variants
    Christa Hohoff
    Department of Psychiatry, University of Muenster, Muenster, Germany
    Am J Med Genet B Neuropsychiatr Genet 139:42-4. 2005
    ..This is consistent with recent observations indicating a role for adenosine A(2A) receptor gene polymorphisms in anxiety...
  95. ncbi request reprint Biological and behavioral markers of alcohol sensitivity
    Kim Fromme
    Department of Psychology, The University of Texas at Austin, Austin, Texas 78712, USA
    Alcohol Clin Exp Res 28:247-56. 2004
    ..Dr. David Goldman provides concluding remarks...
  96. ncbi request reprint The alcohol clamp: applications, challenges, and new directions--an RSA 2004 symposium summary
    Vijay A Ramchandani
    Laboratory of Clinical and Translational Studies, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892 1108, USA
    Alcohol Clin Exp Res 30:155-64. 2006
    ..b>Harriet de Wit summarized and discussed the research presented at the symposium and provided her perspective on future ..
  97. doi request reprint Treatment of methamphetamine dependence
    John Mendelson
    Mayo Clin Proc 83:369-70; author reply 370-1. 2008
  98. ncbi request reprint The reinstatement model of drug relapse: history, methodology and major findings
    Yavin Shaham
    Behavioral Neuroscience Branch, NIDA IRP, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 168:3-20. 2003
    ....

Research Grants41

  1. DETERMINANTS OF DRUG PREFERENCE IN HUMANS
    Harriet de Wit; Fiscal Year: 2009
    ....
  2. DRUG ABUSE AND IMPULSIVITY: HUMAN LABORATORY MODELS
    Harriet de Wit; Fiscal Year: 2006
    ..Clinically, the projects may lead to novel strategies for preventing and treating substance abuse. ..
  3. DETERMINANTS OF DRUG PREFERENCE IN HUMANS
    Harriet de Wit; Fiscal Year: 2005
    ..The results of these studies will improve our understanding of mechanisms by which stress increases drug use, and could lead to improved methods for preventing and treating stress-related drug use. ..
  4. DRUG ABUSE AND IMPULSIVITY: HUMAN LABORATORY MODELS
    Harriet de Wit; Fiscal Year: 2005
    ..Clinically, the projects may lead to novel strategies for preventing and treating substance abuse. ..
  5. DETERMINANTS OF DRUG PREFERENCE IN HUMANS
    Harriet de Wit; Fiscal Year: 2004
    ..The results of these studies will improve our understanding of mechanisms by which stress increases drug use, and could lead to improved methods for preventing and treating stress-related drug use. ..
  6. Nicotinic Involvement & Consumption of Alcohol in Humans
    Harriet de Wit; Fiscal Year: 2003
    ..abstract_text> ..
  7. DETERMINANTS OF DRUG PREFERENCE
    Harriet de Wit; Fiscal Year: 2002
    ..Together, the studies will extend our understanding of the source of individual differences in responses to abused drugs, and they will further our knowledge of the interactions of drugs and hormones in the brain. ..
  8. DETERMINANTS OF DRUG PREFERENCE IN HUMANS
    Harriet de Wit; Fiscal Year: 2006
    ..The results of these studies will improve our understanding of mechanisms by which stress increases drug use, and could lead to improved methods for preventing and treating stress-related drug use. ..
  9. DRUG ABUSE AND IMPULSIVITY: HUMAN LABORATORY MODELS
    Harriet de Wit; Fiscal Year: 2005
    ..Clinically, the projects may lead to novel strategies for preventing and treating substance abuse. ..
  10. DRUG ABUSE AND IMPULSIVITY: HUMAN LABORATORY MODELS
    Harriet de Wit; Fiscal Year: 2009
    ..Clinically, the projects may lead to novel strategies for preventing and treating substance abuse. ..
  11. DETERMINANTS OF DRUG PREFERENCE IN HUMANS
    Harriet de Wit; Fiscal Year: 2006
    ..The results of these studies will improve our understanding of mechanisms by which stress increases drug use, and could lead to improved methods for preventing and treating stress-related drug use. ..
  12. Craving During Smoking Abstinence: Does it Abate or Incubate?
    Harriet de Wit; Fiscal Year: 2007
    ..The project is the result of a unique collaboration among basic and clinical scientists at the University of Chicago and the NIDA Intramural Research Program. ..
  13. DETERMINANTS OF DRUG PREFERENCE IN HUMANS
    Harriet de Wit; Fiscal Year: 2007
    ..The results of these studies will improve our understanding of mechanisms by which stress increases drug use, and could lead to improved methods for preventing and treating stress-related drug use. ..
  14. DRUG ABUSE AND IMPULSIVITY: HUMAN LABORATORY MODELS
    Harriet de Wit; Fiscal Year: 2007
    ..Clinically, the projects may lead to novel strategies for preventing and treating substance abuse. ..
  15. DETERMINANTS OF DRUG PREFERENCE
    Harriet de Wit; Fiscal Year: 2002
    ..Together, the studies will extend our understanding of the source of individual differences in responses to abused drugs, and they will further our knowledge of the interactions of drugs and hormones in the brain. ..
  16. DETERMINANTS OF DRUG PREFERENCE
    Harriet de Wit; Fiscal Year: 2001
    ..Together, the studies will extend our understanding of the source of individual differences in responses to abused drugs, and they will further our knowledge of the interactions of drugs and hormones in the brain. ..
  17. DETERMINANTS OF DRUG PREFERENCE
    Harriet de Wit; Fiscal Year: 1999
    ..Together, the studies will extend our understanding of the source of individual differences in responses to abused drugs, and they will further our knowledge of the interactions of drugs and hormones in the brain. ..
  18. DETERMINANTS OF DRUG PREFERENCE IN HUMANS
    Harriet de Wit; Fiscal Year: 1990
    ..The experiments are designed to explore variables that affect the reinforcing effects of drugs, and the results may elucidate some of the determinants of drug abuse...
  19. DETERMINANTS OF DRUG PREFERENCE
    Harriet de Wit; Fiscal Year: 2000
    ..Together, the studies will extend our understanding of the source of individual differences in responses to abused drugs, and they will further our knowledge of the interactions of drugs and hormones in the brain. ..
  20. DETERMINANTS OF DRUG PREFERENCE IN HUMANS
    Harriet de Wit; Fiscal Year: 1993
    ..The experiments are designed to explore variables that affect the reinforcing effects of drugs, and the results may elucidate some of the determinants of drug abuse...
  21. DETERMINANTS OF DRUG PREFERENCE IN HUMANS
    Harriet de Wit; Fiscal Year: 1992
    ..The experiments are designed to explore variables that affect the reinforcing effects of drugs, and the results may elucidate some of the determinants of drug abuse...
  22. DETERMINANTS OF DRUG PREFERENCE IN HUMANS
    Harriet de Wit; Fiscal Year: 1991
    ..The experiments are designed to explore variables that affect the reinforcing effects of drugs, and the results may elucidate some of the determinants of drug abuse...