Edward M De Robertis

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Neural induction in Xenopus: requirement for ectodermal and endomesodermal signals via Chordin, Noggin, beta-Catenin, and Cerberus
    Hiroki Kuroda
    Department of Biological Chemistry, Howard Hughes Medical Institute, University of California, Los Angeles, USA
    PLoS Biol 2:E92. 2004
  2. pmc The establishment of Spemann's organizer and patterning of the vertebrate embryo
    E M De Robertis
    Howard Hughes Medical Institute, and Department of Biological Chemistry, University of California, Los Angeles, California 90095 1662, USA
    Nat Rev Genet 1:171-81. 2000
  3. pmc Molecular mechanisms of cell-cell signaling by the Spemann-Mangold organizer
    E M De Robertis
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles 90095 1662, USA
    Int J Dev Biol 45:189-97. 2001
  4. pmc Phosphorylation of Mad controls competition between wingless and BMP signaling
    Edward Eivers
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, CA 90095 1662, USA
    Sci Signal 4:ra68. 2011
  5. pmc Chordin forms a self-organizing morphogen gradient in the extracellular space between ectoderm and mesoderm in the Xenopus embryo
    Jean Louis Plouhinec
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, CA 90095 1662
    Proc Natl Acad Sci U S A 110:20372-9. 2013
  6. pmc Dorsal-ventral patterning: Crescent is a dorsally secreted Frizzled-related protein that competitively inhibits Tolloid proteases
    Diego Ploper
    Department of Biological Chemistry, Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095 1662, USA
    Dev Biol 352:317-28. 2011
  7. pmc Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal
    Luis C Fuentealba
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, CA 90095 1662, USA
    Cell 131:980-93. 2007
  8. pmc Presenilin deficiency or lysosomal inhibition enhances Wnt signaling through relocalization of GSK3 to the late-endosomal compartment
    Radek Dobrowolski
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, CA 90095 1662, USA
    Cell Rep 2:1316-28. 2012
  9. pmc Depletion of Bmp2, Bmp4, Bmp7 and Spemann organizer signals induces massive brain formation in Xenopus embryos
    Bruno Reversade
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, CA 90095 1662, USA
    Development 132:3381-92. 2005
  10. pmc Enzymatic regulation of pattern: BMP4 binds CUB domains of Tolloids and inhibits proteinase activity
    Hojoon X Lee
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California at Los Angeles, Los Angeles, California 90095, USA
    Genes Dev 23:2551-62. 2009

Collaborators

  • Edgar M Pera
  • Gabriele Colozza
  • Oliver Wessely
  • Atsushi Ikeda
  • Edward Eivers
  • Jean Louis Plouhinec
  • Radek Dobrowolski
  • Diego Ploper
  • Hiroki Kuroda
  • Hojoon X Lee
  • Luis C Fuentealba
  • Lise Zakin
  • Peggy P Vorwald-Denholtz
  • Iwona Gumper
  • David D Sabatini
  • Veronika Sander
  • Vincent F Taelman
  • Bruno Reversade
  • Michael Oelgeschlager
  • Yuki Moriyama
  • Harriet Snitkin
  • Philipp Vick
  • Peggy P Vorwald
  • Renee H Choi
  • Radoslaw Dobrowolski
  • Fabio A Mendes
  • Cecilia Hurtado
  • Hojoon Lee
  • Ashley Mays
  • Uyen Tran
  • Kristina Grubisic

Detail Information

Publications21

  1. pmc Neural induction in Xenopus: requirement for ectodermal and endomesodermal signals via Chordin, Noggin, beta-Catenin, and Cerberus
    Hiroki Kuroda
    Department of Biological Chemistry, Howard Hughes Medical Institute, University of California, Los Angeles, USA
    PLoS Biol 2:E92. 2004
    ..The results suggest a model for neural induction in Xenopus in which an early blastula beta-Catenin signal predisposes the prospective neuroectoderm to neural induction by endomesodermal signals emanating from Spemann's organizer...
  2. pmc The establishment of Spemann's organizer and patterning of the vertebrate embryo
    E M De Robertis
    Howard Hughes Medical Institute, and Department of Biological Chemistry, University of California, Los Angeles, California 90095 1662, USA
    Nat Rev Genet 1:171-81. 2000
    ..Recent studies have led to new models for the regulation of cell-cell signalling during development, which may also apply to the homeostasis of adult tissues...
  3. pmc Molecular mechanisms of cell-cell signaling by the Spemann-Mangold organizer
    E M De Robertis
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles 90095 1662, USA
    Int J Dev Biol 45:189-97. 2001
    ....
  4. pmc Phosphorylation of Mad controls competition between wingless and BMP signaling
    Edward Eivers
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, CA 90095 1662, USA
    Sci Signal 4:ra68. 2011
    ..The results show that Mad has distinct signal transduction roles in the BMP and Wnt pathways depending on its phosphorylation state...
  5. pmc Chordin forms a self-organizing morphogen gradient in the extracellular space between ectoderm and mesoderm in the Xenopus embryo
    Jean Louis Plouhinec
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, CA 90095 1662
    Proc Natl Acad Sci U S A 110:20372-9. 2013
    ..We suggest that as ectoderm and mesoderm undergo morphogenetic movements during gastrulation, cells in both germ layers read their positional information coordinately from a single morphogen gradient located in Brachet's cleft...
  6. pmc Dorsal-ventral patterning: Crescent is a dorsally secreted Frizzled-related protein that competitively inhibits Tolloid proteases
    Diego Ploper
    Department of Biological Chemistry, Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095 1662, USA
    Dev Biol 352:317-28. 2011
    ..In sum, Crescent is a new component of the D-V pathway, which functions as the dorsal counterpart of Sizzled, through the regulation of chordinases of the Tolloid family...
  7. pmc Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal
    Luis C Fuentealba
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, CA 90095 1662, USA
    Cell 131:980-93. 2007
    ..Epistatic experiments suggested that the dorsoventral (BMP) and anteroposterior (Wnt/GSK3) patterning gradients are integrated at the level of Smad1 phosphorylations during embryonic pattern formation...
  8. pmc Presenilin deficiency or lysosomal inhibition enhances Wnt signaling through relocalization of GSK3 to the late-endosomal compartment
    Radek Dobrowolski
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, CA 90095 1662, USA
    Cell Rep 2:1316-28. 2012
    ..These results underscore the importance of the endosomal pathway in canonical Wnt signaling and reveal a mechanism for regulation of Wnt signaling by presenilin deficiency...
  9. pmc Depletion of Bmp2, Bmp4, Bmp7 and Spemann organizer signals induces massive brain formation in Xenopus embryos
    Bruno Reversade
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, CA 90095 1662, USA
    Development 132:3381-92. 2005
    ..We conclude that BMP inhibition is sufficient for neural induction in vivo, and that in the absence of ventral BMPs, Spemann organizer signals are not required for brain formation...
  10. pmc Enzymatic regulation of pattern: BMP4 binds CUB domains of Tolloids and inhibits proteinase activity
    Hojoon X Lee
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California at Los Angeles, Los Angeles, California 90095, USA
    Genes Dev 23:2551-62. 2009
    ..Mathematical modeling indicates that feedback inhibition by BMP ligands acts on the ventral side, while on the dorsal side the main regulator of BMP1/Tolloid enzymatic activity is the binding to its substrate, Chordin...
  11. ncbi request reprint Development: scaling to size by protease inhibition
    Edward M De Robertis
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California Los Angeles, CA 90095 1662, USA
    Curr Biol 23:R652-4. 2013
    ..A new study indicates that the removal of ventral tissue generates a steeper Chordin gradient by reducing Sizzled, a secreted inhibitor of Tolloid chordinases. ..
  12. pmc Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes
    Vincent F Taelman
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095 1662, USA
    Cell 143:1136-48. 2010
    ..We conclude that multivesicular endosomes are essential components of the Wnt signal-transduction pathway...
  13. ncbi request reprint Exploration of the extracellular space by a large-scale secretion screen in the early Xenopus embryo
    Edgar M Pera
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, USA
    Int J Dev Biol 49:781-96. 2005
    ..A third protein, termed Xystatin, is related to cysteine proteinase inhibitors. Our results indicate that secretion cloning is an effective and generally useful tool for the unbiased isolation of secreted proteins...
  14. pmc Systems control of BMP morphogen flow in vertebrate embryos
    Jean Louis Plouhinec
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, CA 90095 1662, USA
    Curr Opin Genet Dev 21:696-703. 2011
    ..Pattern robustness is ensured through feedback control of the levels of extracellular BMP pathway modulators that adjust the flow to the dimensions of the embryonic field...
  15. pmc Spemann's organizer and self-regulation in amphibian embryos
    Edward M De Robertis
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, California 90095 1662, USA
    Nat Rev Mol Cell Biol 7:296-302. 2006
    ....
  16. pmc Temporal pattern of the posterior expression of Wingless in Drosophila blastoderm
    Peggy P Vorwald-Denholtz
    Howard Hughes Medical Institute, Department of Biological Chemistry, University of California, Los Angeles, CA 90095 1662, United States
    Gene Expr Patterns 11:456-63. 2011
    ..We propose that this early posterior expression could play a role in the refinement of A-P patterning...
  17. pmc Wnt signaling in axial patterning and regeneration: lessons from planaria
    Edward M De Robertis
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095 1662, USA
    Sci Signal 3:pe21. 2010
    ..Depletion of Smad4 blocks regeneration entirely, which suggests that the bone morphogenetic protein signaling pathway and the Wnt pathway are required for regeneration and body patterning...
  18. pmc Dorsal-ventral patterning and neural induction in Xenopus embryos
    Edward M De Robertis
    Howard Hughes Medical Institute, Department of Biological Chemistry, University of California Los Angeles, Los Angeles, CA 90095 1662, USA
    Annu Rev Cell Dev Biol 20:285-308. 2004
    ..Many of the molecular players that regulate D-V patterning via regulation of BMP signaling have been conserved between Drosophila and the vertebrates...
  19. pmc Identification of a second Xenopus twisted gastrulation gene
    Michael Oelgeschlager
    Howard Hughes Medical Institute, and Department of Biological Chemistry, University of California, Los Angeles, CA 90095 1662, USA
    Int J Dev Biol 48:57-61. 2004
    ..In microinjection experiments, the activity of xTsg-2 mRNA was similar to that of xTsg. We conclude that two Tsg genes act in distinct temporal and spatial territories in the course of Xenopus embryonic development...
  20. pmc Endocytic control of growth factor signalling: multivesicular bodies as signalling organelles
    Radek Dobrowolski
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California Los Angeles, CA 90095 1662, USA
    Nat Rev Mol Cell Biol 13:53-60. 2012
    ..Thus, the role of endocytosis during signal transduction may be more diverse than anticipated, and multivesicular endosomes may constitute a crucial signalling organelle...
  21. pmc Drosophila Smad2 opposes Mad signaling during wing vein development
    Veronika Sander
    Howard Hughes Medical Institute, Department of Biological Chemistry, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e10383. 2010
    ..We propose that the main function of dActivin/dSmad2 in Drosophila wing development is to antagonize Dpp/Mad signaling. Possible molecular mechanisms for the opposition between dSmad2 and Mad signaling are discussed...