Sharlene Day

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wall
    Sharlene M Day
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Blood 105:192-8. 2005
  2. doi request reprint Exercise in hypertrophic cardiomyopathy
    Sharlene M Day
    Division of Cardiovascular Medicine, University of Michigan Health System, Ann Arbor, MI, 48109, USA
    J Cardiovasc Transl Res 2:407-14. 2009
  3. pmc Cardiac risks associated with marathon running
    Sharlene M Day
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan
    Sports Health 2:301-6. 2010
  4. pmc Cardiovascular health, part 2: sports participation in athletes with cardiovascular conditions
    Timir S Baman
    University of Michigan, Ann Arbor, Michigan
    Sports Health 2:19-28. 2010
  5. pmc Cardiovascular health, part 1: preparticipation cardiovascular screening
    Sanjaya Gupta
    University of Michigan, Ann Arbor, Michigan
    Sports Health 1:500-7. 2009
  6. doi request reprint The ubiquitin proteasome system in human cardiomyopathies and heart failure
    Sharlene M Day
    Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, USA
    Am J Physiol Heart Circ Physiol 304:H1283-93. 2013
  7. ncbi request reprint Chronic iron administration increases vascular oxidative stress and accelerates arterial thrombosis
    Sharlene M Day
    University of Michigan Medical School, Division of Cardiology, Ann Arbor, USA
    Circulation 107:2601-6. 2003
  8. ncbi request reprint Tuning cardiac performance in ischemic heart disease and failure by modulating myofilament function
    Sharlene M Day
    Department of Internal Medicine, University of Michigan, 1150 W Medical Center Drive, 7301 MSRB III, Ann Arbor, MI 48109 0644, USA
    J Mol Med (Berl) 85:911-21. 2007
  9. pmc Ca2+-independent positive molecular inotropy for failing rabbit and human cardiac muscle by alpha-myosin motor gene transfer
    Todd J Herron
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    FASEB J 24:415-24. 2010
  10. ncbi request reprint Histidine button engineered into cardiac troponin I protects the ischemic and failing heart
    Sharlene M Day
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nat Med 12:181-9. 2006

Research Grants

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wall
    Sharlene M Day
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Blood 105:192-8. 2005
    ..Therefore, our results suggest that thrombus formation in the arterial and venous macrovasculature is driven primarily by TF derived from the blood vessel wall as opposed to leukocytes...
  2. doi request reprint Exercise in hypertrophic cardiomyopathy
    Sharlene M Day
    Division of Cardiovascular Medicine, University of Michigan Health System, Ann Arbor, MI, 48109, USA
    J Cardiovasc Transl Res 2:407-14. 2009
    ....
  3. pmc Cardiac risks associated with marathon running
    Sharlene M Day
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan
    Sports Health 2:301-6. 2010
    ..This review discusses the acute and potential long-term risks associated with marathon running and puts these into perspective with the many health benefits afforded by habitual vigorous exercise...
  4. pmc Cardiovascular health, part 2: sports participation in athletes with cardiovascular conditions
    Timir S Baman
    University of Michigan, Ann Arbor, Michigan
    Sports Health 2:19-28. 2010
    ..An athlete's health may be endangered if he or she continues to compete after diagnosis of certain cardiovascular conditions. The most worrisome risk is sudden cardiac death; the annual rate in US athletes is 1 in 50 000 to 200 000...
  5. pmc Cardiovascular health, part 1: preparticipation cardiovascular screening
    Sanjaya Gupta
    University of Michigan, Ann Arbor, Michigan
    Sports Health 1:500-7. 2009
    ..The requirements for preparticipation screening vary among countries and even from state to state within the United States. The mandated use of an electrocardiogram as a screening implement has provoked international controversy...
  6. doi request reprint The ubiquitin proteasome system in human cardiomyopathies and heart failure
    Sharlene M Day
    Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, USA
    Am J Physiol Heart Circ Physiol 304:H1283-93. 2013
    ..Accordingly, this review will focus on UPS dysfunction in human dilated and hypertrophic cardiomyopathies and highlight areas rich for further study in this expanding field...
  7. ncbi request reprint Chronic iron administration increases vascular oxidative stress and accelerates arterial thrombosis
    Sharlene M Day
    University of Michigan Medical School, Division of Cardiology, Ann Arbor, USA
    Circulation 107:2601-6. 2003
    ..Iron overload has been implicated in the pathogenesis of ischemic cardiovascular events. However, the effects of iron excess on vascular function and the thrombotic response to vascular injury are not well understood...
  8. ncbi request reprint Tuning cardiac performance in ischemic heart disease and failure by modulating myofilament function
    Sharlene M Day
    Department of Internal Medicine, University of Michigan, 1150 W Medical Center Drive, 7301 MSRB III, Ann Arbor, MI 48109 0644, USA
    J Mol Med (Berl) 85:911-21. 2007
    ....
  9. pmc Ca2+-independent positive molecular inotropy for failing rabbit and human cardiac muscle by alpha-myosin motor gene transfer
    Todd J Herron
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    FASEB J 24:415-24. 2010
    ..Our data provide evidence for a novel form of calcium-independent positive inotropy in failing cardiac myocytes by fast alpha-myosin motor protein gene transfer...
  10. ncbi request reprint Histidine button engineered into cardiac troponin I protects the ischemic and failing heart
    Sharlene M Day
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nat Med 12:181-9. 2006
    ..Myofilament-based inotropy may represent a therapeutic avenue to improve myocardial performance in the ischemic and failing heart...
  11. ncbi request reprint Murine thrombosis models
    Sharlene M Day
    Department of Internal Medicine, University of Michigan Medical Center, 7301 MSRB III, 1150 W Medical Center Drive, Ann Arbor, Michigan 48109 0644, USA
    Thromb Haemost 92:486-94. 2004
    ..The advantages and limitations of different models are examined. Related topics of mouse anesthesia, phlebotomy, and in vitro hemostasis testing are also reviewed...
  12. ncbi request reprint Genetic engineering and therapy for inherited and acquired cardiomyopathies
    Sharlene Day
    Department of Internal Medicine, University of Michigan, 1301 E Catherine Street, Ann Arbor MI 48109 0622, USA
    Ann N Y Acad Sci 1080:437-50. 2006
    ..Nonetheless, studies focusing on the principles of acute genetic engineering of the sarcomere hold value as they lay the essential foundation on which to build potential gene-based therapies for heart disease...
  13. ncbi request reprint Parvalbumin corrects slowed relaxation in adult cardiac myocytes expressing hypertrophic cardiomyopathy-linked alpha-tropomyosin mutations
    Pierre Coutu
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, Mich 48109 0622, USA
    Circ Res 94:1235-41. 2004
    ..Collectively, these findings show that slow relaxation caused by alpha-Tm mutants can be corrected by modifying calcium handling with Parv...
  14. ncbi request reprint Dystrophic heart failure blocked by membrane sealant poloxamer
    Soichiro Yasuda
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109 0622, USA
    Nature 436:1025-9. 2005
    ....
  15. pmc Ubiquitin proteasome dysfunction in human hypertrophic and dilated cardiomyopathies
    Jaime M Predmore
    1150 W Medical Center Dr, 7301 MSRB III, Ann Arbor, MI 48109 0644, USA
    Circulation 121:997-1004. 2010
    ..The present study evaluated ubiquitin proteasome system function in human heart failure and hypertrophic cardiomyopathy (HCM)...
  16. pmc Single histidine-substituted cardiac troponin I confers protection from age-related systolic and diastolic dysfunction
    Nathan J Palpant
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, 1301 E Catherine Street, 7727 Medical Science II, Ann Arbor, MI 48109 0622, USA
    Cardiovasc Res 80:209-18. 2008
    ..Strategies to protect the aged heart from ischaemia-mediated pump failure are needed. We hypothesized that troponin I-mediated augmentation of myofilament calcium sensitivity would protect cardiac function in aged mice...
  17. ncbi request reprint Rad GTPase deficiency leads to cardiac hypertrophy
    Lin Chang
    Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Circulation 116:2976-83. 2007
    ..Rad (Ras associated with diabetes) GTPase is the prototypic member of a subfamily of Ras-related small G proteins. The aim of the present study was to define whether Rad plays an important role in mediating cardiac hypertrophy...
  18. doi request reprint Cardiac-directed parvalbumin transgene expression in mice shows marked heart rate dependence of delayed Ca2+ buffering action
    Sharlene M Day
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0644, USA
    Physiol Genomics 33:312-22. 2008
    ....

Research Grants2

  1. Regulation of Proteasome Function in Cardiomyopathies
    Sharlene Day; Fiscal Year: 2009
    ....
  2. Regulation of Proteasome Function in Cardiomyopathies
    Sharlene M Day; Fiscal Year: 2010
    ....