R Dawson

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. ncbi request reprint The cytoprotective role of taurine in exercise-induced muscle injury
    R Dawson
    Department of Pharmacodynamics, College of Pharmacy, JHMHC Box 100487, University of Florida, Gainesville, FL 32610, U S A
    Amino Acids 22:309-24. 2002
  2. ncbi request reprint Glutamate efflux from rat brain slices and cultures: a comparison of the depolarizing agents potassium, 4-aminopyridine, and veratrine
    T A Patterson
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville 32610, USA
    Neurochem Res 20:225-32. 1995
  3. ncbi request reprint Endogenous excitatory amino acid release from brain slices and astrocyte cultures evoked by trimethyltin and other neurotoxic agents
    R Dawson
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville 32610, USA
    Neurochem Res 20:847-58. 1995
  4. ncbi request reprint Cysteine sulfinate decarboxylase and cysteine dioxygenase activities do not correlate with strain-specific changes in hepatic and cerebellar taurine content in aged rats
    B Eppler
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville 32610, USA
    Mech Ageing Dev 110:57-72. 1999
  5. ncbi request reprint Neural-renal interactions in the hypertension induced by papillary necrosis: role of dietary salt intake
    R Dawson
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville
    Pharmacology 40:42-53. 1990
  6. ncbi request reprint Effects of dietary taurine supplementation or deprivation in aged male Fischer 344 rats
    R Dawson
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville 32610, USA
    Mech Ageing Dev 107:73-91. 1999
  7. ncbi request reprint Taurine is a weak scavenger of peroxynitrite and does not attenuate sodium nitroprusside toxicity to cells in culture
    T R Mehta
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, USA
    Amino Acids 20:419-33. 2001
  8. ncbi request reprint Cytoprotective effect of taurine against hypochlorous acid toxicity to PC12 cells
    S Kearns
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, USA
    Adv Exp Med Biol 483:563-70. 2000
  9. ncbi request reprint Endogenous GABA release is reduced in the striatum of cocaine-sensitized rats
    B J Jung
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA
    Synapse 34:103-10. 1999
  10. ncbi request reprint An age-related decline in striatal taurine is correlated with a loss of dopaminergic markers
    R Dawson
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville 32610, USA
    Brain Res Bull 48:319-24. 1999

Detail Information

Publications15

  1. ncbi request reprint The cytoprotective role of taurine in exercise-induced muscle injury
    R Dawson
    Department of Pharmacodynamics, College of Pharmacy, JHMHC Box 100487, University of Florida, Gainesville, FL 32610, U S A
    Amino Acids 22:309-24. 2002
    ..In summary, taurine supplementation or taurine depletion had measurable cytoprotective actions to attenuate exercise-induced injury...
  2. ncbi request reprint Glutamate efflux from rat brain slices and cultures: a comparison of the depolarizing agents potassium, 4-aminopyridine, and veratrine
    T A Patterson
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville 32610, USA
    Neurochem Res 20:225-32. 1995
    ..This data suggest that both GLU release and uptake are modulated in a regionally selective manner, and that commonly used depolarizing agents affect not only calcium-dependent neuronal release, but also uptake and glial responses...
  3. ncbi request reprint Endogenous excitatory amino acid release from brain slices and astrocyte cultures evoked by trimethyltin and other neurotoxic agents
    R Dawson
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville 32610, USA
    Neurochem Res 20:847-58. 1995
    ..TMT at high concentrations also produced a delayed increase in glial GLU efflux. These studies suggest that excitotoxic mechanisms may contribute to TMT-induced neurotoxicity...
  4. ncbi request reprint Cysteine sulfinate decarboxylase and cysteine dioxygenase activities do not correlate with strain-specific changes in hepatic and cerebellar taurine content in aged rats
    B Eppler
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville 32610, USA
    Mech Ageing Dev 110:57-72. 1999
    ..These results suggest that a decline in hepatic de novo taurine biosynthesis might be partially responsible for a reduction in tissue taurine content in F344 rats...
  5. ncbi request reprint Neural-renal interactions in the hypertension induced by papillary necrosis: role of dietary salt intake
    R Dawson
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville
    Pharmacology 40:42-53. 1990
    ..The primary defect in BEA hypertension appears to be the lack of circulating antihypertensive lipids that attenuate the ability of salt loads to simulate sympathetic nervous system activity...
  6. ncbi request reprint Effects of dietary taurine supplementation or deprivation in aged male Fischer 344 rats
    R Dawson
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville 32610, USA
    Mech Ageing Dev 107:73-91. 1999
    ..These studies suggest that advanced aging results in a taurine-deficient state that can be corrected by dietary supplementation...
  7. ncbi request reprint Taurine is a weak scavenger of peroxynitrite and does not attenuate sodium nitroprusside toxicity to cells in culture
    T R Mehta
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, USA
    Amino Acids 20:419-33. 2001
    ..Combination treatments with taurine and SNP appeared to interact in an additive fashion for both cell proliferation and neurotoxic actions. It appears unlikely that taurine is a major endogenous scavenger of peroxynitrite...
  8. ncbi request reprint Cytoprotective effect of taurine against hypochlorous acid toxicity to PC12 cells
    S Kearns
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, USA
    Adv Exp Med Biol 483:563-70. 2000
    ..Since myeloperoxidase expression in the CNS is increased by ischemia, one function of taurine released during an ischemic event may be to scavenge HOCl and provide neuroprotection...
  9. ncbi request reprint Endogenous GABA release is reduced in the striatum of cocaine-sensitized rats
    B J Jung
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA
    Synapse 34:103-10. 1999
    ..These data are consistent with an overall decrease in GABA transmission, both pre- and postsynaptically, in the striatum of sensitized rats, which could contribute to enhanced striatal output and behavioral sensitization...
  10. ncbi request reprint An age-related decline in striatal taurine is correlated with a loss of dopaminergic markers
    R Dawson
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville 32610, USA
    Brain Res Bull 48:319-24. 1999
    ..These studies suggest (1) a link between age-related declines in striatal dopamine and taurine and (2) that NGF-induced improvement in spatial learning is not related to mechanisms involving changes in taurine or glutamate content...
  11. ncbi request reprint Effects of high salt diets and taurine on the development of hypertension in the stroke-prone spontaneously hypertensive rat
    R Dawson
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville 32610, USA
    Amino Acids 19:643-65. 2000
    ..Taurine supplementation showed cardioprotective and renoprotective effects in SPSHR given high salt diets...
  12. ncbi request reprint Dietary taurine manipulations in aged male Fischer 344 rat tissue: taurine concentration, taurine biosynthesis, and oxidative markers
    B Eppler
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, JHMHC Box 100487, Gainesville, FL 32610, USA
    Biochem Pharmacol 62:29-39. 2001
    ..Our study indicates that a decline in TAU content may exacerbate oxidative stress in aged rats, which can be reversed by dietary TAU supplementation...
  13. ncbi request reprint Neurochemical and neurobehavioral effects of neonatal administration of beta-N-methylamino-L-alanine and 3,3'-iminodipropionitrile
    R Dawson
    Department of Pharmacodynamics, College of Pharmacy, JHMHC, University of Florida, Gainesville 32610, USA
    Neurotoxicol Teratol 20:181-92. 1998
    ..Neonatal exposure to either IDPN or BMAA resulted in permanent changes in adult neurochemistry that may be related to reorganizational effects induced by toxin-mediated neuroplasticity in developing neurons...
  14. ncbi request reprint Effects of sulfur containing amino acids on iron and nitric oxide stimulated catecholamine oxidation
    M Biasetti
    Department of Pharmacodynamics, College of Pharmacy, JHMHC Box 100487, University of Florida, Gainesville, FL 32610, U S A
    Amino Acids 22:351-68. 2002
    ..Our results show that endogenous sulfur containing amino acids, like taurine, could serve a protective role to reduce cellular damage associated with both NO and metal-stimulated catecholamine oxidation...
  15. ncbi request reprint Presynaptic dopaminergic properties of differentiated mouse embryonic stem cells
    Y Nakano
    Department of Pharmacology, College of Pharmacy, University of Florida, P O Box 100267, 1600 SW Archer, Gainesville, FL 32610, USA
    Neurochem Int 45:1067-73. 2004
    ..These results demonstrate that differentiated ES cells have the presynaptic functions for maintaining dopaminergic homeostasis, which may be essential for their long-term use in restoring CNS levels of this transmitter...