Glyn Dawson

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. pmc Abnormal gangliosides are localized in lipid rafts in Sanfilippo (MPS3a) mouse brain
    G Dawson
    University of Chicago, Chicago, IL, USA
    Neurochem Res 37:1372-80. 2012
  2. pmc American ginseng suppresses Western diet-promoted tumorigenesis in model of inflammation-associated colon cancer: role of EGFR
    Urszula Dougherty
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    BMC Complement Altern Med 11:111. 2011
  3. pmc Palmitoyl:protein thioesterase (PPT1) inhibitors can act as pharmacological chaperones in infantile Batten disease
    Glyn Dawson
    Department of Pediatrics, University of Chicago, Chicago, IL 60637, USA
    Biochem Biophys Res Commun 395:66-9. 2010
  4. pmc Gilenya (FTY720) inhibits acid sphingomyelinase by a mechanism similar to tricyclic antidepressants
    Glyn Dawson
    Department of Pediatrics, University of Chicago, Chicago, IL 60637, USA
    Biochem Biophys Res Commun 404:321-3. 2011
  5. pmc Evidence for coordination of lysosomal (ASMase) and plasma membrane (NSMase2) forms of sphingomyelinase from mutant mice
    Jingdong Qin
    Department of Pediatrics, University of Chicago, Chicago, IL 60637, United States
    FEBS Lett 586:4002-9. 2012
  6. doi request reprint Changes in the cerebrospinal fluid ceramide profile after subarachnoid hemorrhage
    Fernando D Testai
    Department of Neurology and Rehabilitation, University of Illinois at Chicago, Chicago, IL 60612, USA
    Stroke 43:2066-70. 2012
  7. pmc Neurons and oligodendrocytes recycle sphingosine 1-phosphate to ceramide: significance for apoptosis and multiple sclerosis
    Jingdong Qin
    Departments of Pediatrics, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 285:14134-43. 2010
  8. pmc Neutral sphingomyelinase 2 deficiency increases hyaluronan synthesis by up-regulation of Hyaluronan synthase 2 through decreased ceramide production and activation of Akt
    Jingdong Qin
    Department of Pediatrics, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 287:13620-32. 2012
  9. pmc A novel role of the Batten disease gene CLN3: association with BMP synthesis
    Judith A Hobert
    Committee on Molecular Metabolism and Nutrition, Biological Sciences Division, The University of Chicago, Chicago, IL, USA
    Biochem Biophys Res Commun 358:111-6. 2007
  10. pmc Differential regulation of sphingomyelin synthesis and catabolism in oligodendrocytes and neurons
    John P Kilkus
    Department of Pediatrics, University of Chicago, Chicago, Illinois, USA
    J Neurochem 106:1745-57. 2008

Collaborators

Detail Information

Publications17

  1. pmc Abnormal gangliosides are localized in lipid rafts in Sanfilippo (MPS3a) mouse brain
    G Dawson
    University of Chicago, Chicago, IL, USA
    Neurochem Res 37:1372-80. 2012
    ..Thus heparan sulfate-derived oligosaccharide storage is associated with abnormal lipid accumulation in both lysosomal (BMP) and non-lysosomal (GM3 and GM2) compartments...
  2. pmc American ginseng suppresses Western diet-promoted tumorigenesis in model of inflammation-associated colon cancer: role of EGFR
    Urszula Dougherty
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    BMC Complement Altern Med 11:111. 2011
    ..In this study we asked if ginseng could inhibit Western diet (20% fat) promoted colonic tumorigenesis and if compound K, a microbial metabolite of ginseng could suppress colon cancer xenograft growth...
  3. pmc Palmitoyl:protein thioesterase (PPT1) inhibitors can act as pharmacological chaperones in infantile Batten disease
    Glyn Dawson
    Department of Pediatrics, University of Chicago, Chicago, IL 60637, USA
    Biochem Biophys Res Commun 395:66-9. 2010
    ..4 (but not at 4.7) consistent with a mis-folded, unstable PPT1 degraded by the ER stress response. Patients with null mutations did not respond to the pharmacological chaperones...
  4. pmc Gilenya (FTY720) inhibits acid sphingomyelinase by a mechanism similar to tricyclic antidepressants
    Glyn Dawson
    Department of Pediatrics, University of Chicago, Chicago, IL 60637, USA
    Biochem Biophys Res Commun 404:321-3. 2011
    ....
  5. pmc Evidence for coordination of lysosomal (ASMase) and plasma membrane (NSMase2) forms of sphingomyelinase from mutant mice
    Jingdong Qin
    Department of Pediatrics, University of Chicago, Chicago, IL 60637, United States
    FEBS Lett 586:4002-9. 2012
    ..This suggests two distinct subcellular pathways for SM catabolism with distinct functions...
  6. doi request reprint Changes in the cerebrospinal fluid ceramide profile after subarachnoid hemorrhage
    Fernando D Testai
    Department of Neurology and Rehabilitation, University of Illinois at Chicago, Chicago, IL 60612, USA
    Stroke 43:2066-70. 2012
    ..The purpose of this study was to investigate changes in the cerebrospinal fluid sphingolipid profile in patients with subarachnoid hemorrhage in relation to the occurrence of symptomatic vasospasm and outcome at hospital discharge...
  7. pmc Neurons and oligodendrocytes recycle sphingosine 1-phosphate to ceramide: significance for apoptosis and multiple sclerosis
    Jingdong Qin
    Departments of Pediatrics, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 285:14134-43. 2010
    ..The physiological significance of this observation was confirmed by the analysis of affected white matter and plaques from brains of multiple sclerosis patients in which reduced S1P and increased Sph and C(16/18)-ceramides were observed...
  8. pmc Neutral sphingomyelinase 2 deficiency increases hyaluronan synthesis by up-regulation of Hyaluronan synthase 2 through decreased ceramide production and activation of Akt
    Jingdong Qin
    Department of Pediatrics, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 287:13620-32. 2012
    ..We propose that NSMase2/Cer are the key mediators of the regulation of HA synthesis, via microdomains and the Akt/mTOR pathway...
  9. pmc A novel role of the Batten disease gene CLN3: association with BMP synthesis
    Judith A Hobert
    Committee on Molecular Metabolism and Nutrition, Biological Sciences Division, The University of Chicago, Chicago, IL, USA
    Biochem Biophys Res Commun 358:111-6. 2007
    ..These data illustrate a new finding, a strong correlation between CLN3 protein expression and synthesis of bis(monoacylglycerol)phosphate...
  10. pmc Differential regulation of sphingomyelin synthesis and catabolism in oligodendrocytes and neurons
    John P Kilkus
    Department of Pediatrics, University of Chicago, Chicago, Illinois, USA
    J Neurochem 106:1745-57. 2008
    ..Thus, SMS rather than SMases may be more important for sphingolipid homeostasis in oligodendrocytes, whereas the reverse may be true for neurons...
  11. pmc Oxidized phosphatidylcholine formation and action in oligodendrocytes
    Jingdong Qin
    Departments of Pediatrics, University of Chicago, Chicago, Illinois 60637, USA
    J Neurochem 110:1388-99. 2009
    ..We concluded that OxPC initially activated NSMase and converted sphingomyelin into ceramide to mediate a series of downstream pro-apoptotic events in oligodendrocytes...
  12. pmc Nanoparticle targeting to neurons in a rat hippocampal slice culture model
    Ryan Walters
    Committee on Neurobiology, University of Chicago, Chicago, IL 60637, USA
    ASN Neuro 4:383-92. 2012
    ..This suggests a novel and robust way of delivering neurotherapeutics to neurons...
  13. ncbi request reprint Ceramide in rafts (detergent-insoluble fraction) mediates cell death in neurotumor cell lines
    John Kilkus
    Departments of Pediatrics, Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 30637, USA
    J Neurosci Res 72:65-75. 2003
    ..Most of the neutral sphingomyelinase activity is in the Raft fraction, suggesting that the conversion of sphingomyelin to ceramide in Rafts is an important event in neural cell apoptosis...
  14. pmc Expression of the receptor for advanced glycation end products in oligodendrocytes in response to oxidative stress
    Jingdong Qin
    Department of Pediatrics, University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci Res 86:2414-22. 2008
    ....
  15. ncbi request reprint Neuronal ceroid lipofuscinoses therapeutic strategies: past, present and future
    Judith A Hobert
    Committee on Molecular Metabolism and Nutrition, Biological Sciences Division, University of Chicago, Chicago, IL 60637, USA
    Biochim Biophys Acta 1762:945-53. 2006
    ..This review summarizes previous studied therapies, discusses those currently being evaluated and examines possibilities for future therapies for the treatment of patients with NCL...
  16. doi request reprint Proof of concept: endogenous antiangiogenic factors predict the occurrence of symptomatic vasospasm post subarachnoid hemorrhage
    Fernando D Testai
    Department of Neurology of the University of Illinois at Chicago, 912 S Wood Street MC 796, Chicago, IL 60612 7330, USA
    Neurocrit Care 15:416-20. 2011
    ..The authors hypothesize that circulating antiangiogenic factors play an important role in brain injury post SAH and that elevated levels predict the occurrence of symptomatic vasospasm...
  17. ncbi request reprint Anti-tumor promoting effects of palmitoyl: protein thioesterase inhibitors against a human neurotumor cell line
    Glyn Dawson
    Department of Pediatrics, University of Chicago, Chicago, IL 60637, USA
    Cancer Lett 187:163-8. 2002
    ..Overexpression of PPT1 protected against apoptosis induced by etoposide and the ketoamide and the inhibitory effect of the two was additive...

Research Grants16

  1. GLYCOSPHINGOLIPID METABOLISM AND MENTAL RETARDATION
    Glyn Dawson; Fiscal Year: 2007
    ..We believe that our results will show which type of drug or drug combination is most likely to provide an alternative to gene therapy and whether it will primarily affect neurons or glia. ..
  2. Tenth International Congress on Ceroid Lipofuscinoses
    Glyn Dawson; Fiscal Year: 2005
    ....
  3. GLYCOSPHINGOLIPID METABOLISM AND MENTAL RETARDATION
    Glyn Dawson; Fiscal Year: 2005
    ..By precisely characterizing the role of ceramide we hope to identify new sphingolipid-based strategies for the therapy of a range of neurodegenerative diseases including mental retardation. ..
  4. Conference--Neuronal Ceroid Lipofuscinosis
    Glyn Dawson; Fiscal Year: 2003
    ..abstract_text> ..
  5. GLYCOSPHINGOLIPID METABOLISM AND MENTAL RETARDATION
    Glyn Dawson; Fiscal Year: 2000
    ....
  6. GLYCOSPHINGOLIPID METABOLISM AND MENTAL RETARDATION
    Glyn Dawson; Fiscal Year: 2010
    ..We believe that our results will show which type of drug or drug combination is most likely to provide an alternative to gene therapy and whether it will primarily affect neurons or glia. ..