G Dawson

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Genetic investigation of quantitative traits related to autism: use of multivariate polygenic models with ascertainment adjustment
    Yun Ju Sung
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195 7720, USA
    Am J Hum Genet 76:68-81. 2005
  2. ncbi request reprint Neurocognitive and electrophysiological evidence of altered face processing in parents of children with autism: implications for a model of abnormal development of social brain circuitry in autism
    Geraldine Dawson
    University of Washington Autism Center and Center on Human Development and Disability, Seattle 98195, USA
    Dev Psychopathol 17:679-97. 2005
  3. ncbi request reprint Infants of depressed and nondepressed mothers exhibit differences in frontal brain electrical activity during the expression of negative emotions
    G Dawson
    Department of Psychology, University of Washington, Seattle 98195, USA
    Dev Psychol 33:650-6. 1997
  4. ncbi request reprint Understanding the nature of face processing impairment in autism: insights from behavioral and electrophysiological studies
    Geraldine Dawson
    University of Washington Autism Center, University of Washington, Seattle 98195, USA
    Dev Neuropsychol 27:403-24. 2005
  5. ncbi request reprint Validation of the phenomenon of autistic regression using home videotapes
    Emily Werner
    UW Autism Center and Department of Psychology and Psychiatry, University of Washington, Seattle, WA 98195, USA
    Arch Gen Psychiatry 62:889-95. 2005
  6. ncbi request reprint Young children with autism show atypical brain responses to fearful versus neutral facial expressions of emotion
    Geraldine Dawson
    Department of Psychology, University of Washington, Seattle, 98195, USA
    Dev Sci 7:340-59. 2004
  7. ncbi request reprint Preschool outcomes of children of depressed mothers: role of maternal behavior, contextual risk, and children's brain activity
    Geraldine Dawson
    Department of Psychology, Center on Human Development and Disability, University of Washington, Seattle, WA 98195, USA
    Child Dev 74:1158-75. 2003
  8. ncbi request reprint Quantitative assessment of autism symptom-related traits in probands and parents: Broader Phenotype Autism Symptom Scale
    Geraldine Dawson
    University of Washington Autism Center and Department of Psychology, University of Washington, Seattle, WA 98195, USA
    J Autism Dev Disord 37:523-36. 2007
  9. ncbi request reprint Early social attention impairments in autism: social orienting, joint attention, and attention to distress
    Geraldine Dawson
    Department of Psychology, Center on Human Development and Disability, University of Washington, Seattle, WA, USA
    Dev Psychol 40:271-83. 2004
  10. pmc Neural correlates of face and object recognition in young children with autism spectrum disorder, developmental delay, and typical development
    Geraldine Dawson
    Center on Human Development and Disability, University of Washington, Seattle 98195, USA
    Child Dev 73:700-17. 2002

Research Grants

  1. NEUROBIOLOGY AND GENETICS OF AUTISM
    Geraldine Dawson; Fiscal Year: 2003
  2. NEUROBIOLOGY AND GENETICS OF AUTISM
    Geraldine Dawson; Fiscal Year: 2006
  3. UW Autism Research Center of Excellence
    Elizabeth Aylward; Fiscal Year: 2007

Detail Information

Publications79

  1. pmc Genetic investigation of quantitative traits related to autism: use of multivariate polygenic models with ascertainment adjustment
    Yun Ju Sung
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195 7720, USA
    Am J Hum Genet 76:68-81. 2005
    ..92). This finding suggests a shared genetic basis of these two traits and that they may be most promising for future gene mapping and for extending pedigrees by phenotyping additional relatives...
  2. ncbi request reprint Neurocognitive and electrophysiological evidence of altered face processing in parents of children with autism: implications for a model of abnormal development of social brain circuitry in autism
    Geraldine Dawson
    University of Washington Autism Center and Center on Human Development and Disability, Seattle 98195, USA
    Dev Psychopathol 17:679-97. 2005
    ..The hypothesis that genetic-mediated dysfunction of the dopamine reward system, especially its functioning in social contexts, might account for altered face processing in individuals with autism and their relatives is discussed...
  3. ncbi request reprint Infants of depressed and nondepressed mothers exhibit differences in frontal brain electrical activity during the expression of negative emotions
    G Dawson
    Department of Psychology, University of Washington, Seattle 98195, USA
    Dev Psychol 33:650-6. 1997
    ..Compared with infants of nondepressed mothers, infants of depressed mothers exhibit greater frontal EEG activation during the expression of negative emotions...
  4. ncbi request reprint Understanding the nature of face processing impairment in autism: insights from behavioral and electrophysiological studies
    Geraldine Dawson
    University of Washington Autism Center, University of Washington, Seattle 98195, USA
    Dev Neuropsychol 27:403-24. 2005
    ..This article discusses implications for intervention...
  5. ncbi request reprint Validation of the phenomenon of autistic regression using home videotapes
    Emily Werner
    UW Autism Center and Department of Psychology and Psychiatry, University of Washington, Seattle, WA 98195, USA
    Arch Gen Psychiatry 62:889-95. 2005
    ..To date, there has been no objective validation of the phenomenon of autistic regression early in life...
  6. ncbi request reprint Young children with autism show atypical brain responses to fearful versus neutral facial expressions of emotion
    Geraldine Dawson
    Department of Psychology, University of Washington, Seattle, 98195, USA
    Dev Sci 7:340-59. 2004
    ..These data suggest that children with ASD, as young as 3 years of age, show a disordered pattern of neural responses to emotional stimuli...
  7. ncbi request reprint Preschool outcomes of children of depressed mothers: role of maternal behavior, contextual risk, and children's brain activity
    Geraldine Dawson
    Department of Psychology, Center on Human Development and Disability, University of Washington, Seattle, WA 98195, USA
    Child Dev 74:1158-75. 2003
    ..g., marital discord and stress) and their children had more behavior problems. Children's frontal brain activation and contextual risk level mediated the relation between maternal depression and child behavior problems...
  8. ncbi request reprint Quantitative assessment of autism symptom-related traits in probands and parents: Broader Phenotype Autism Symptom Scale
    Geraldine Dawson
    University of Washington Autism Center and Department of Psychology, University of Washington, Seattle, WA 98195, USA
    J Autism Dev Disord 37:523-36. 2007
    ..BPASS scores were not correlated with ethnicity or parent education; however, some domains were correlated with IQ. The BPASS holds promise as a quantitative phenotypic assessment for genetic studies...
  9. ncbi request reprint Early social attention impairments in autism: social orienting, joint attention, and attention to distress
    Geraldine Dawson
    Department of Psychology, Center on Human Development and Disability, University of Washington, Seattle, WA, USA
    Dev Psychol 40:271-83. 2004
    ..These results help to clarify the nature of social attention impairments in autism, offer clues to developmental mechanisms, and suggest targets for early intervention...
  10. pmc Neural correlates of face and object recognition in young children with autism spectrum disorder, developmental delay, and typical development
    Geraldine Dawson
    Center on Human Development and Disability, University of Washington, Seattle 98195, USA
    Child Dev 73:700-17. 2002
    ..These data suggest that autism is associated with face recognition impairment that is manifest early in life...
  11. pmc Rate of head growth decelerates and symptoms worsen in the second year of life in autism
    Geraldine Dawson
    Autism Center, University of Washington, Seattle, Washington, USA
    Biol Psychiatry 61:458-64. 2007
    ..Longitudinal studies of head circumference growth in infants later diagnosed with autism are needed to understand the accelerated head growth in this disorder...
  12. ncbi request reprint Infants of depressed mothers exhibit atypical frontal electrical brain activity during interactions with mother and with a familiar, nondepressed adult
    G Dawson
    Department of Psychology, University of Washington, Seattle 98195, USA
    Child Dev 70:1058-66. 1999
    ..The present results suggest that the atypical pattern of electrical brain activity found in infants of depressed mothers generalizes to a variety of situations, including positive interactions with nondepressed adults...
  13. pmc Early social, imitation, play, and language abilities of young non-autistic siblings of children with autism
    Karen Toth
    UW Autism Center and Center on Human Development and Disability, University of Washington, Seattle, USA
    J Autism Dev Disord 37:145-57. 2007
    ..These results suggest that the development of young non-autistic siblings is affected at an early age and, thus, should be closely monitored, with appropriate interventions implemented as needed...
  14. ncbi request reprint Amygdalar volume and behavioral development in autism
    Jeffrey Munson
    University of Washington Autism Center, University of Washington, Seattle, USA
    Arch Gen Psychiatry 63:686-93. 2006
    ..The amygdala is associated with socioemotional function and has been implicated in the pathophysiology of autism...
  15. ncbi request reprint Head circumference and height in autism: a study by the Collaborative Program of Excellence in Autism
    Janet E Lainhart
    Department of Psychiatry, The Brain Institute at the University of Utah, Salt Lake City, Utah 84108, USA
    Am J Med Genet A 140:2257-74. 2006
    ..The wide distribution of head circumference in autism has major implications for genetic, neuroimaging, and other neurobiological research...
  16. ncbi request reprint Variation in early developmental course in autism and its relation with behavioral outcome at 3-4 years of age
    Emily Werner
    Department of Psychology and UW Autism Center, University of Washington, Seattle, WA 98195, USA
    J Autism Dev Disord 35:337-50. 2005
    ..late onset of symptoms, and with vs. without a history of loss of skills (regression) were not found to differ on standardized tests of verbal and nonverbal IQ and observational measures of autism symptom severity...
  17. ncbi request reprint Stress hormone levels of children of depressed mothers
    Sharon B Ashman
    Department of Psychology, University of Washington, Seattle 98195, USA
    Dev Psychopathol 14:333-49. 2002
    ..The results also provide preliminary evidence that exposure to maternal depression in the first 2 years of life may be related to children's cortisol levels later in life...
  18. ncbi request reprint Fluorine magnetic resonance spectroscopy measurement of brain fluvoxamine and fluoxetine in pediatric patients treated for pervasive developmental disorders
    Wayne L Strauss
    Center on Human Development and Disability, University of Washington, Seattle, 98105 6099, USA
    Am J Psychiatry 159:755-60. 2002
    ..The authors used fluorine magnetic resonance spectroscopy ((19)F MRS) to evaluate age effects on whole-brain concentrations of fluvoxamine and fluoxetine in children taking SSRIs...
  19. pmc Age-related differences in neural correlates of face recognition during the toddler and preschool years
    Leslie J Carver
    Psychology Department, University of California, San Diego, La Jolla, CA 92093 0109, USA
    Dev Psychobiol 42:148-59. 2003
    ..We propose that these changes are based on age-related differences in the perceived salience of the face of the primary caregiver versus strangers...
  20. pmc Rule learning in autism: the role of reward type and social context
    E J H Jones
    Center on Child Health, Behavior and Development, Seattle Children s Hospital, Seattle, Washington, USA
    Dev Neuropsychol 38:58-77. 2013
    ..Learning abstract rules about social stimuli remained challenging through late childhood, indicating the importance of testing executive functions in both social and non-social contexts...
  21. ncbi request reprint Prototype formation in autism
    L G Klinger
    Department of Psychology, University of Alabama, Tuscaloosa 35487, USA
    Dev Psychopathol 13:111-24. 2001
    ..These data suggest that persons with autism and Down syndrome have difficulty categorizing new information by forming prototypes and, instead, tend to rely on a rule-based approach to learning...
  22. pmc Mutations in the TSGA14 gene in families with autism spectrum disorders
    O Korvatska
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, 98195, USA
    Am J Med Genet B Neuropsychiatr Genet 156:303-11. 2011
    ..022). This is the first report of a possible link of a gene with a centrosomal function with familial autism...
  23. ncbi request reprint Corpus callosum morphometrics in young children with autism spectrum disorder
    Inbal Boger-Megiddo
    Department of Radiology, 5C 1, Children s Hospital and Regional Medical Center, 4800 Sand Point Way NE, Seattle, WA, 98105, USA
    J Autism Dev Disord 36:733-9. 2006
    ..Results could reflect decreased inter-hemispheric connectivity or cerebral enlargement due to increase in tissues less represented in the corpus callosum in ASD...
  24. doi request reprint Becoming a face expert: a computerized face-training program for high-functioning individuals with autism spectrum disorders
    Susan Faja
    Department of Psychology, University of Washington, USA
    Dev Neuropsychol 33:1-24. 2008
    ..These findings suggest that face processing ability and strategies in autism can be significantly improved through training...
  25. ncbi request reprint Neurocognitive function and joint attention ability in young children with autism spectrum disorder versus developmental delay
    Geraldine Dawson
    Center on Human Development and Disability, University of Washington, Seattle 98195, USA
    Child Dev 73:345-58. 2002
    ..The ventromedial prefrontal cortex is hypothesized to play a role in the development of joint attention and possibly some aspects of the autistic syndrome...
  26. ncbi request reprint Event-related brain potentials reveal anomalies in temporal processing of faces in autism spectrum disorder
    James McPartland
    UW Autism Center, University of Washington, Seattle, USA
    J Child Psychol Psychiatry 45:1235-45. 2004
    ..The current study examined the temporal characteristics of face processing in autism and their relation to behavior...
  27. ncbi request reprint Performance on Cambridge Neuropsychological Test Automated Battery subtests sensitive to frontal lobe function in people with autistic disorder: evidence from the Collaborative Programs of Excellence in Autism network
    Sally Ozonoff
    Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah, USA
    J Autism Dev Disord 34:139-50. 2004
    ....
  28. pmc A replication of the Autism Diagnostic Observation Schedule (ADOS) revised algorithms
    Katherine Gotham
    University of Michigan Autism and Communication Disorders Center, 1111 East Catherine Street, Ann Arbor, MI 48109 2054, USA
    J Am Acad Child Adolesc Psychiatry 47:642-51. 2008
    ..To replicate the factor structure and predictive validity of revised Autism Diagnostic Observation Schedule algorithms in an independent dataset (N = 1,282)...
  29. pmc Evidence for latent classes of IQ in young children with autism spectrum disorder
    Jeffrey Munson
    University of Washington, Psychiatry and Behavioral Sciences, Seattle, WA 98195, USA
    Am J Ment Retard 113:439-52. 2008
    ..Results support the notion of distinct subtypes of autism that differ in severity of intellectual ability, patterns of cognitive strengths and weaknesses, and severity of autism symptoms...
  30. pmc Head circumference as an early predictor of autism symptoms in younger siblings of children with autism spectrum disorder
    Lauren M Elder
    Department of Psychology, Autism Center, University of Washington, Box 357920, Seattle, WA, USA
    J Autism Dev Disord 38:1104-11. 2008
    ..Among infant siblings of children with autism, atypical HC growth might alert pediatricians to provide screening and/or referral for further evaluation...
  31. ncbi request reprint Characteristics associated with presence of depressive symptoms in adults with autism spectrum disorder
    Lindsey Sterling
    UW Autism Center, Department of Psychology, University of Washington, Seattle, WA, USA
    J Autism Dev Disord 38:1011-8. 2008
    ..These characteristics may be vulnerability factors for the development of depression, and should be considered when screening and treating adults with ASD...
  32. pmc Association between amygdala response to emotional faces and social anxiety in autism spectrum disorders
    Natalia M Kleinhans
    Department of Radiology, University of Washington, Seattle, WA 98195, USA
    Neuropsychologia 48:3665-70. 2010
    ..These results indicate that level of social anxiety mediates the neural response to emotional face perception in ASD...
  33. ncbi request reprint Level of intellectual functioning predicts patterns of associated symptoms in school-age children with autism spectrum disorder
    Annette Mercer Estes
    Autism Center, University of Washington, Seattle 98195, USA
    Am J Ment Retard 112:439-49. 2007
    ..Results suggest that level of intellectual functioning may be a risk factor for different patterns of associated symptoms by later childhood...
  34. pmc Rate of head circumference growth as a function of autism diagnosis and history of autistic regression
    Sara Jane Webb
    Department of Psychiatry and Behavioral Sciences, University of Washington Autism Center, University of Washington, Seattle, WA 98195, USA
    J Child Neurol 22:1182-90. 2007
    ..Findings from this study suggest that the aberrant growth is present in the first year of life and precedes the onset and diagnosis in children with autism spectrum disorder with and without a history of autistic regression...
  35. ncbi request reprint Increased amygdala activation to neutral faces is associated with better face memory performance
    Natalia M Kleinhans
    Department of Radiology, University of Washington, Seattle, Washington 98195, USA
    Neuroreport 18:987-91. 2007
    ..These findings indicate that the role of the amygdala may include processing neutral yet socially relevant stimuli. Further, amygdala activation, independent of emotional valence, appears to be associated with memory enhancement...
  36. pmc fMRI evidence of neural abnormalities in the subcortical face processing system in ASD
    Natalia M Kleinhans
    Department of Radiology, University of Washington, Seattle, WA 98195, USA
    Neuroimage 54:697-704. 2011
    ..Neural abnormalities in this system may contribute to early-emerging deficits in social orienting and attention, the putative precursors to abnormalities in social cognition and cortical face processing specialization...
  37. doi request reprint Abnormal functional connectivity in autism spectrum disorders during face processing
    Natalia M Kleinhans
    Department of Radiology, University of Washington, Box 357115, Seattle, WA 98195, USA
    Brain 131:1000-12. 2008
    ..These results suggest that abnormal neural connections within the limbic system may contribute to the social impairments observed in ASD...
  38. pmc Response to familiar faces, newly familiar faces, and novel faces as assessed by ERPs is intact in adults with autism spectrum disorders
    Sara J Webb
    University of Washington Department of Psychiatry and Behavioral Sciences, Seattle, WA, USA
    Int J Psychophysiol 77:106-17. 2010
    ..This study found no evidence that early-stage facial identity processing is a primary contributor to the face recognition deficit in high-functioning ASD...
  39. doi request reprint Trajectories of maternal depression over 7 years: relations with child psychophysiology and behavior and role of contextual risks
    Sharon B Ashman
    University of Washington, USA
    Dev Psychopathol 20:55-77. 2008
    ..Contextual risk factors were found to mediate the relation between maternal depression and child behavioral outcomes...
  40. doi request reprint Reduced neural habituation in the amygdala and social impairments in autism spectrum disorders
    Natalia M Kleinhans
    Department of Radiology, University of Washington, Box 357115, Seattle, WA 98195, USA
    Am J Psychiatry 166:467-75. 2009
    ..This study was designed to investigate whether abnormal habituation characterizes amygdala dysfunction in autism spectrum disorders and whether the rate of amygdala habituation is related to social impairment...
  41. pmc Neurocognitive predictors of social and communicative developmental trajectories in preschoolers with autism spectrum disorders
    Jeffrey Munson
    University of Washington Autism Center and Center on Human Development and Disability, Seattle, Washington 98195, USA
    J Int Neuropsychol Soc 14:956-66. 2008
    ..The benefits and challenges of assessing specific neurocognitive functions in children with autism is discussed with regard to general cognitive/developmental ability and the behavioral requirements of most assessment settings...
  42. pmc Brief report: face configuration accuracy and processing speed among adults with high-functioning autism spectrum disorders
    Susan Faja
    Department of Psychology, Center on Human Development and Disability, University of Washington Autism Center, Seattle, WA, USA
    J Autism Dev Disord 39:532-8. 2009
    ....
  43. ncbi request reprint Brief report: biochemical correlates of clinical impairment in high functioning autism and Asperger's disorder
    Natalia M Kleinhans
    Department of Radiology, University of Washington, Box 357115, Seattle, WA 98195, USA
    J Autism Dev Disord 39:1079-86. 2009
    ..This suggests that altered metabolite levels in the amygdala may be associated with a more severe early developmental course in ASD...
  44. pmc Cerebellar vermal volumes and behavioral correlates in children with autism spectrum disorder
    Sara Jane Webb
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 38195, United States
    Psychiatry Res 172:61-7. 2009
    ..Within the DD group, larger cerebellar measurements were correlated with fewer impairments. The specific relation between altered cerebellar structure and symptom expression in autism remains unclear...
  45. ncbi request reprint An investigation of the relationship between fMRI and ERP source localized measurements of brain activity during face processing
    Neva M Corrigan
    Department of Radiology, University of Washington, 1100 NE 45th Street, Suite 555, Seattle, WA, 98195, USA
    Brain Topogr 22:83-96. 2009
    ..The combination of data from these techniques suggested that electrical brain activity at the latency of the N170 is highly represented in fMRI statistical maps...
  46. pmc The role of face familiarity in eye tracking of faces by individuals with autism spectrum disorders
    Lindsey Sterling
    Department of Psychology, University of Washington Autism Center, University of Washington, Box 357920, Seattle, WA 98195, USA
    J Autism Dev Disord 38:1666-75. 2008
    ..A second task assessed facial recognition accuracy and response time for familiar and novel faces. The groups did not differ on accuracy or reaction times...
  47. pmc Parenting stress and psychological functioning among mothers of preschool children with autism and developmental delay
    Annette Estes
    University of Washington, Seattle WA 98195 7920, USA
    Autism 13:375-87. 2009
    ..Results suggest clinical services aiming to support parents should include a focus on reducing problem behaviors in children with developmental disabilities...
  48. pmc Toddlers with elevated autism symptoms show slowed habituation to faces
    Sara Jane Webb
    Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA
    Child Neuropsychol 16:255-78. 2010
    ..We conclude that slower rates of face learning may be an endophenotype of ASD and is associated with more severe symptoms among affected individuals...
  49. pmc Resting state cortical connectivity reflected in EEG coherence in individuals with autism
    Michael Murias
    University of Washington Autism Center, Seattle, Washington 98195, USA
    Biol Psychiatry 62:270-3. 2007
    ..Theoretical conceptions of autism spectrum disorder (ASD) and experimental studies of cerebral blood flow suggest abnormalities in connections among distributed neural systems in ASD...
  50. ncbi request reprint Early recognition of 1-year-old infants with autism spectrum disorder versus mental retardation
    Julie A Osterling
    Center on Human Development and Disability, University of Washington, Seattle 98195, USA
    Dev Psychopathol 14:239-51. 2002
    ..These results indicate that autism can be distinguished from mental retardation and typical development by 1 year of age...
  51. ncbi request reprint Defining the broader phenotype of autism: genetic, brain, and behavioral perspectives
    Geraldine Dawson
    Center of Human Development and Disability, University of Washington, Seattle 98195, USA
    Dev Psychopathol 14:581-611. 2002
    ....
  52. ncbi request reprint Single-suture craniosynostosis: a review of neurobehavioral research and theory
    Matthew L Speltz
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, USA
    J Pediatr Psychol 29:651-68. 2004
    ..To review research and theory regarding the neurobehavioral correlates and outcomes of single-suture, or isolated, craniosynostosis in children...
  53. ncbi request reprint Links between social and linguistic processing of speech in preschool children with autism: behavioral and electrophysiological measures
    Patricia K Kuhl
    Center on Human Development and Disabilities and Department of Speech and Hearing Sciences, University of Washington, Seattle, WA 98195, USA
    Dev Sci 8:F1-F12. 2005
    ..The data support the hypothesis of an association between social and linguistic processing in children with ASD...
  54. ncbi request reprint Individuals with autism spectrum disorder show normal responses to a fear potential startle paradigm
    Raphael Bernier
    Center on Human Development and Disability, University of Washington, Seattle 98195, USA
    J Autism Dev Disord 35:575-83. 2005
    ..These results suggest that this aspect of amygdala function, namely fear conditioning and potentiation of the startle response, is intact in individuals with autism...
  55. pmc Event-related potential (ERP) indices of infants' recognition of familiar and unfamiliar objects in two and three dimensions
    Leslie J Carver
    Center on Human Development and Disability, University of Washington, USA
    Dev Sci 9:51-62. 2006
    ..This is the first study using 3-D objects in conjunction with ERPs in infants, and it introduces an interesting new methodology for assessing infants' electrophysiological responses to real objects...
  56. ncbi request reprint Gray and white matter brain chemistry in young children with autism
    Seth D Friedman
    Department of Radiology, University of Washington School of Medicine, Seattle, WA 98105 6099, USA
    Arch Gen Psychiatry 63:786-94. 2006
    ..The brain pathophysiological abnormalities underlying autism remain unclear. Neuroimaging and histological studies suggest cellular abnormalities early in the course of the disease...
  57. pmc Early predictors of communication development in young children with autism spectrum disorder: joint attention, imitation, and toy play
    Karen Toth
    Department of Psychology, UW Autism Center, CHDD, University of Washington 357920, Seattle, WA 98195, USA
    J Autism Dev Disord 36:993-1005. 2006
    ..5 years. The implications of these results for understanding the nature and course of language development in autism and for the development of targeted early interventions are discussed...
  58. pmc ERP evidence of atypical face processing in young children with autism
    Sara J Webb
    Psychiatry and Behavioral Sciences, Box 357920 CHDD, Seattle, WA 98195, USA
    J Autism Dev Disord 36:881-90. 2006
    ..These findings indicate that children with ASD have a disordered pattern of brain responses to faces and objects at an early age...
  59. ncbi request reprint Is there a 'regressive phenotype' of Autism Spectrum Disorder associated with the measles-mumps-rubella vaccine? A CPEA Study
    Jennifer Richler
    University of Michigan, Ann Arbor, 48109 2054, USA
    J Autism Dev Disord 36:299-316. 2006
    ..There was no evidence that onset of autistic symptoms or of regression was related to measles-mumps-rubella vaccination. The implications of these findings for the existence of a 'regressive phenotype' of ASD are discussed...
  60. ncbi request reprint Early regression in social communication in autism spectrum disorders: a CPEA Study
    Rhiannon Luyster
    Autism and Communication Disorders Center, University of Michigan, Ann Arbor 48109 2054, USA
    Dev Neuropsychol 27:311-36. 2005
    ..A significant minority of children with autism without word loss showed a very similar pattern of loss of social-communication skills, a pattern not observed in the children with developmental delays or typical development...
  61. ncbi request reprint Cerebral cortical gray matter overgrowth and functional variation of the serotonin transporter gene in autism
    Thomas H Wassink
    Department of Psychiatry, The University of Iowa, USA
    Arch Gen Psychiatry 64:709-17. 2007
    ..Autism is a heritable neurodevelopmental disorder characterized biologically by enlargement of the head and brain and abnormalities of serotonin neurotransmission...
  62. doi request reprint Early behavioral intervention, brain plasticity, and the prevention of autism spectrum disorder
    Geraldine Dawson
    Autism Speaks, Hillsborough, NC 27278, USA
    Dev Psychopathol 20:775-803. 2008
    ..This article describes a developmental model of risk, risk processes, symptom emergence, and adaptation in ASD that offers a framework for understanding early brain plasticity in ASD and its role in prevention of the disorder...
  63. ncbi request reprint Evidence for multiple loci from a genome scan of autism kindreds
    G D Schellenberg
    Geriatrics Research Education and Clinical Center, Puget Sound Veterans Affairs Medical Center, Seattle, WA 98108, USA
    Mol Psychiatry 11:1049-60, 979. 2006
    ..Diagnostic specificity and detailed analysis of the autism phenotype is critical for identifying autism loci...
  64. ncbi request reprint Development and neural bases of face recognition in autism
    L J Carver
    Dept of Psychology, University of Washington, Seattle, WA 98195, USA
    Mol Psychiatry 7:S18-20. 2002
  65. ncbi request reprint Shape mapping of the hippocampus in young children with autism spectrum disorder
    S R Dager
    Department of Radiology, University of Washington, Seattle, WA 98105, USA
    AJNR Am J Neuroradiol 28:672-7. 2007
    ..We hypothesized the occurrence of characteristic hippocampal-shape alterations in young children with autistic spectrum disorder (ASD) who also exhibit deficits on neuropsychologic tests of medial temporal lobe (MTL) function...
  66. pmc EEG mu rhythm and imitation impairments in individuals with autism spectrum disorder
    R Bernier
    Department of Psychology, University of Washington, Seattle, WA 98185, USA
    Brain Cogn 64:228-37. 2007
    ..These findings suggest that there is execution/observation matching system dysfunction in individuals with autism and that this matching system is related to degree of impairment in imitation abilities...
  67. ncbi request reprint Heterogeneous association between engrailed-2 and autism in the CPEA network
    Camille W Brune
    Department of Psychiatry, Institute for Juvenile Research, University of Illinois Chicago, Chicago, Illinois, USA
    Am J Med Genet B Neuropsychiatr Genet 147:187-93. 2008
    ..Future studies investigating EN2 should consider how the association of variants in this gene with autism could be influenced by differences in phenotype and possible interactions with genotypes at other autism candidate genes...
  68. ncbi request reprint No evidence for linkage of liability to autism to HOXA1 in a sample from the CPEA network
    Bernie Devlin
    Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Med Genet 114:667-72. 2002
    ..Therefore, although we cannot exclude the possibility that the samples in the two studies are intrinsically different, our data from our sample argue against a major role for HOXA1 (His)73(Arg) in liability to autism...
  69. ncbi request reprint Brain structural abnormalities in young children with autism spectrum disorder
    B F Sparks
    Department of Radiology, University of Washington School of Medicine, Seattle, WA 98105, USA
    Neurology 59:184-92. 2002
    ....
  70. pmc Presence of large deletions in kindreds with autism
    Chang En Yu
    Geriatrics Research Education and Clinical Center, Puget Sound Veterans Affairs Medical Center, University of Washington, Seattle 98108, USA
    Am J Hum Genet 71:100-15. 2002
    ..An alternative hypothesis is that autism-susceptibility alleles elsewhere cause the deletions detected here, possibly by inducing errors during meiosis...
  71. ncbi request reprint Early intervention and brain plasticity in autism
    Geraldine Dawson
    Autism Center, University of Washington, Seattle, WA 98195, USA
    Novartis Found Symp 251:266-74; discussion 274-80, 281-97. 2003
    ..Early interventions that enhance social attention should result in changes in brain activity, as reflected in ERPs to face stimuli, with those children showing the greatest social improvement exhibiting more normal brain activity...
  72. ncbi request reprint Alleles of a reelin CGG repeat do not convey liability to autism in a sample from the CPEA network
    Bernie Devlin
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 126:46-50. 2004
    ..Neither is significantly associated with Reelin alleles. Our results are not consistent with a major role for Reelin alleles in liability to autism...
  73. ncbi request reprint A randomized, double-blind, placebo-controlled trial of porcine versus synthetic secretin for reducing symptoms of autism
    Alan S Unis
    Department of Psychiatry and Behavioral Science, University of Washington, Seattle, WA 98195, USA
    J Am Acad Child Adolesc Psychiatry 41:1315-21. 2002
    ..To compare the effects of a single dose of biologic and synthetic porcine secretin to placebo on a variety of autism symptoms...
  74. ncbi request reprint Identification of a novel gene on chromosome 7q11.2 interrupted by a translocation breakpoint in a pair of autistic twins
    Razia Sultana
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 98195, USA
    Genomics 80:129-34. 2002
    ..Thus, although it is unlikely that AUTS2 is an autism susceptibility gene for idiopathic autism, it may be the gene responsible for the disorder in the twins studied here...
  75. ncbi request reprint Despite major challenges, autism research continues to offer hope
    Geraldine Dawson
    Arch Pediatr Adolesc Med 161:411-2. 2007
  76. ncbi request reprint Challenges in evaluating psychosocial interventions for Autistic Spectrum Disorders
    Catherine Lord
    University of Michigan, Austim and Communication Disorders Center 1111, Ann Arbor 48109, USA
    J Autism Dev Disord 35:695-708; discussion 709-11. 2005
    ....
  77. ncbi request reprint Designing research studies on psychosocial interventions in autism
    Tristram Smith
    Department of Pediatrics, Strong Center for Developmental Disabilities, University of Rochester Medical Center, 601 Elmwood, Box 671, Rochester, NY 14642, USA
    J Autism Dev Disord 37:354-66. 2007
    ....
  78. ncbi request reprint Familial autoimmune thyroid disease as a risk factor for regression in children with Autism Spectrum Disorder: a CPEA Study
    Cynthia A Molloy
    Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Ohio 45229 3039, USA
    J Autism Dev Disord 36:317-24. 2006
    ..89; 95% CI: 1.17, 3.10). The only specific autoimmune disorder found to be associated with regression was autoimmune thyroid disease (adjusted OR=2.09; 95% CI: 1.28, 3.41)...
  79. ncbi request reprint Mapping autism risk loci using genetic linkage and chromosomal rearrangements
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Nat Genet 39:319-28. 2007
    ..Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs...

Research Grants4

  1. NEUROBIOLOGY AND GENETICS OF AUTISM
    Geraldine Dawson; Fiscal Year: 2003
    ..Thus, findings from all five research projects are being integrated in a synergistic way to offer a deeper understanding of the neurobiological and genetic basis of autism. ..
  2. NEUROBIOLOGY AND GENETICS OF AUTISM
    Geraldine Dawson; Fiscal Year: 2006
    ..Thus, findings from all five research projects are being integrated in a synergistic way to offer a deeper understanding of the neurobiological and genetic basis of autism. ..
  3. UW Autism Research Center of Excellence
    Elizabeth Aylward; Fiscal Year: 2007
    ..5) To conduct molecular biology studies aimed at gene discovery in autism. Identification of susceptibility genes in autism is important for early identification, prevention, and medical treatment (Project V). ..