Research Topics
| L C DawsSummaryAffiliation: University of Texas Health Science Center Country: USA Publications
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Publications
Revisiting serotonin reuptake inhibitors and the therapeutic potential of "uptake-2" in psychiatric disordersLynette C Daws
Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States
ACS Chem Neurosci 4:16-21. 2013..We describe how "uptake-2" transporters may explain the relative lack of therapeutic efficacy of SSRIs, as well as why "uptake-2" transporters might be useful therapeutic targets...
Ethanol inhibits clearance of brain serotonin by a serotonin transporter-independent mechanismLynette C Daws
Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
J Neurosci 26:6431-8. 2006..The present findings provide new insights into the actions of ethanol on brain function and behavior...- Unfaithful neurotransmitter transporters: focus on serotonin uptake and implications for antidepressant efficacyLynette C Daws
University of Texas Health Science Center at San Antonio, Department of Physiology and Pharmacology, 7703 Floyd Curl Drive, MC 7756, San Antonio, Texas 78229 3900, USA
Pharmacol Ther 121:89-99. 2009..This review synthesizes the existing literature, focusing on serotonin to illustrate and revive a model for the rationale design of improved antidepressants... - Differential behavioural and neurochemical effects of para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine in the ratL C Daws
Department of Clinical and Experimental Pharmacology, University of Adelaide, Australia
Prog Neuropsychopharmacol Biol Psychiatry 24:955-77. 2000..However, PMA potently inhibited uptake of 5-HT. 5. Taken together these data suggest that the acute adverse effects of PMA are more likely to be associated with alterations in serotonergic rather than dopaminergic neurotransmission... - 5-HT(1B) receptor-mediated regulation of serotonin clearance in rat hippocampus in vivoL C Daws
Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
J Neurochem 75:2113-22. 2000..These data are consistent with the hypothesis that activation of terminal 5-HT(1B) autoreceptors increases 5-HTT activity... - 5-HT1B antagonists modulate clearance of extracellular serotonin in rat hippocampusL C Daws
Department of Pharmacology, University of Texas Health Science Center at San Antonio, 78284 7764, USA
Neurosci Lett 266:165-8. 1999..By contrast, in the corpus callosum, none of the drugs altered the 5-HT signal. One interpretation of these data is that 5-HT1B receptors can modulate the activity of the 5-HT transporter... - Ontogeny and regulation of the serotonin transporter: providing insights into human disordersLynette C Daws
Department of Physiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC 7756, San Antonio, TX 78229 3900, USA
Pharmacol Ther 131:61-79. 2011..We integrate this knowledge to emphasize how inappropriate SERT expression or its dysregulation may be linked to the pathophysiology of psychiatric, cardiovascular and gastrointestinal diseases... - In vivo chronoamperometric measures of extracellular serotonin clearance in rat dorsal hippocampus: contribution of serotonin and norepinephrine transportersL C Daws
Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284 7764, USA
J Pharmacol Exp Ther 286:967-76. 1998..Only 5,7-DHT treatment caused this effect in the CA3 region. From these data, it is inferred that in certain regions of brain (dentate gyrus), both the SERT and NET contribute to the active clearance of exogenously applied 5-HT... - Transport mechanisms governing serotonin clearance in vivo revealed by high-speed chronoamperometryLynette C Daws
Department of Psychiatry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
J Neurosci Methods 143:49-62. 2005..e. the 5-HTT) and the other with low affinity but a high capacity (i.e. the NET). These data show for the first time in the whole animal that 5-HT clearance in brain is regionally distinct with regard to rate and affinity... - Exaggerated effect of fluvoxamine in heterozygote serotonin transporter knockout miceSylvia Montañez
Department of Psychiatry, University of Texas Health Science Center at San Antonio, USA
J Neurochem 86:210-9. 2003..These data highlight the potential of the heterozygote 5-HTT mutant mice to model the dynamic in vivo consequences of the human 5-HTT polymorphism... - In vivo chronoamperometric measurements of the clearance of exogenously applied serotonin in the rat dentate gyrusL C Daws
Department of Pharmacology, University of Texas Health Science Center at San Antonio, 78284 7564, USA
J Neurosci Methods 78:139-50. 1997.... - Serotonin transporter function in vivo: assessment by chronoamperometryA Frazer
Department of Pharmacology, University of Texas Health Science Center at San Antonio 78250, USA
Ann N Y Acad Sci 861:217-29. 1998..These and other data have generated a working hypothesis that activation of the terminal serotonin autoreceptor enhances the kinetics of 5-HT uptake through an effect on the serotonin transporter... - Serotonin transporter function, but not expression, is dependent on brain-derived neurotrophic factor (BDNF): in vivo studies in BDNF-deficient miceL C Daws
Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
J Neurochem 101:641-51. 2007..g., in the machinery/signaling required for insertion of 5-HTTs into the plasma membrane and/or activation of the 5-HTT once it is positioned to take up 5-HT from extracellular fluid... - Calcium-dependent inhibition of synaptosomal serotonin transport by the alpha 2-adrenoceptor agonist 5-bromo-N-[4,5-dihydro-1H-imidazol-2-yl]-6-quinoxalinamine (UK14304)Twum Ampofo Ansah
Department of Pharmacology, Meharry Medical College, 1005 D B Todd Blvd, Nashville, TN 37208, USA
J Pharmacol Exp Ther 305:956-65. 2003..Our findings suggest that UK14304 modulates SERT function in vitro and in vivo via signaling pathways, possibly supported by an influx of Ca2+ through voltage-sensitive Ca2+ channels... - Organic cation transporter 3: Keeping the brake on extracellular serotonin in serotonin-transporter-deficient miceNicole L Baganz
Department of Physiology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
Proc Natl Acad Sci U S A 105:18976-81. 2008..OCT3 may be an important transporter mediating serotonergic signaling when 5-HTT expression or function is compromised... - Density and function of central serotonin (5-HT) transporters, 5-HT1A and 5-HT2A receptors, and effects of their targeting on BTBR T+tf/J mouse social behaviorGeorgianna G Gould
Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
J Neurochem 116:291-303. 2011..1 mg/kg) reduced marble burying, but failed to improve sociability. Overall, altered SERT and/or 5-HT(1A) functionality in hippocampus could contribute to the relatively low sociability of BTBR mice... - Repeated swim impairs serotonin clearance via a corticosterone-sensitive mechanism: organic cation transporter 3, the smoking gunNicole Baganz
Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
J Neurosci 30:15185-95. 2010.... - Reduced effectiveness of escitalopram in the forced swimming test is associated with increased serotonin clearance rate in food-restricted ratsCharles P France
Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229, USA
Int J Neuropsychopharmacol 12:731-6. 2009..These results suggest that diet plays an integral role in determining efficacy of antidepressant drugs, and might well generalize to other psychoactive drugs that impinge upon the 5-HT transporter... - Serotonin (5-HT) transporter (SERT) function after graded destruction of serotonergic neuronsSylvia Montañez
Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
J Neurochem 87:861-7. 2003..Functional loss of SERT activity occurs when destruction of serotonergic innervation is greater than 90% but serotonin clearance and efficacy of fluvoxamine is maintained with as few as one fifth of a full complement of SERTs... - Differential in vivo clearance of serotonin in rat dorsal raphe nucleus and CA3 regionSylvia Montañez
Department of Psychiatry, MS 7792, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
Brain Res 955:236-44. 2002.... - In vivo analysis of serotonin clearance in rat hippocampus reveals that repeated administration of p-methoxyamphetamine (PMA), but not 3,4-methylenedioxymethamphetamine (MDMA), leads to long-lasting deficits in serotonin transporter functionPaul D Callaghan
Department of Physiology, The University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
J Neurochem 100:617-27. 2007.... - Differences in the in vivo dynamics of neurotransmitter release and serotonin uptake after acute para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine revealed by chronoamperometryPaul D Callaghan
Department of Physiology, The University of Texas Health Science Center at San Antonio, San Antonio, 78229 3900, USA
Neurochem Int 47:350-61. 2005..These fundamental differences may account for the more severe adverse reactions seen clinically after PMA, compared to MDMA... - Cocaine increases dopamine uptake and cell surface expression of dopamine transportersLynette C Daws
Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC 7764, San Antonio, Texas 78229 3900, USA
Biochem Biophys Res Commun 290:1545-50. 2002..Cocaine-induced increases in cell surface expression of DAT and associated changes in DA clearance represent a novel mechanism that may play a role in its addictive properties... - Rapid stimulation of presynaptic serotonin transport by A(3) adenosine receptorsChong Bin Zhu
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
J Pharmacol Exp Ther 322:332-40. 2007..Together, these results identify a novel, region-specific action of CNS A(3)ARs in the modulation of SERT-mediated 5-HT transport that may be relevant for the etiology and/or therapy of 5-HT-linked brain disorders... - Deficits in dopamine clearance and locomotion in hypoinsulinemic rats unmask novel modulation of dopamine transporters by amphetamineW Anthony Owens
Department of Physiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
J Neurochem 94:1402-10. 2005..These results provide exciting new evidence that actions of amphetamine on DA neurotransmission are insulin-dependent and further suggest that exposure to amphetamine may cause long-lasting changes in DAT function... - CB1-independent inhibition of dopamine transporter activity by cannabinoids in mouse dorsal striatumDavid A Price
Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
J Neurochem 101:389-96. 2007..These results indicate that both cannabinoid agonists and antagonists inhibit dopamine transporter activity via molecular targets other than CB(1) receptors... - Juxtacellular labeling and chemical phenotyping of extracellularly recorded neurons in vivoGlenn M Toney
Department of Physiology, University of Texas Health Science Center, San Antonio, USA
Methods Mol Biol 337:127-37. 2006.... - Feeding conditions differentially affect the neurochemical and behavioral effects of dopaminergic drugs in male ratsRajkumar J Sevak
Department of Pharmacology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, United States
Eur J Pharmacol 592:109-15. 2008..g., glucose and insulin) in modulating dopamine neurotransmission and in so doing they begin to establish a neurochemical link between the high co-morbidity of eating disorders and drug abuse... - Evidence for D2 receptor mediation of amphetamine-induced normalization of locomotion and dopamine transporter function in hypoinsulinemic ratsRajkumar J Sevak
Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
J Neurochem 101:151-9. 2007..These results support a role for D2 receptors in regulating DA transporter activity, and further demonstrate that D2 receptors contribute to changes in sensitivity to amphetamine in hypoinsulinemic rats... - Ethanol-related behaviors in serotonin transporter knockout miceJanel M Boyce-Rustay
Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland, USA
Alcohol Clin Exp Res 30:1957-65. 2006..Increasing evidence supports a role for 5-hydroxytryptamine (5-HT) and the 5-HT transporter (5-HTT) in modulating the neural and behavioral actions of ethanol (EtOH) and other drugs of abuse... - Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transportJacob U Fog
Molecular Neuropharmacology Group and Center for Pharmacogenomics, Department of Pharmacology, The Panum Institute, University of Copenhagen, DK-2200 Copenhagen, Denmark
Neuron 51:417-29. 2006..Our data suggest that CaMKIIalpha binding to the DAT C terminus facilitates phosphorylation of the DAT N terminus and mediates amphetamine-induced dopamine efflux... - Repeated administration of the substituted amphetamine p-methoxyamphetamine produces reductions in cortical 5-HT transporter binding but not 5-HT content, unlike 3,4-methylenedioxyamethamphetaminePaul D Callaghan
Discipline of Pharmacology, School of Medical Sciences, Medical School North, The University of Adelaide, Adelaide, South Australia, 5005, Australia
Eur J Pharmacol 546:74-81. 2006..These data suggest PMA has severe long-term implications clinically for alteration of 5-HT neurotransmission that may differ from MDMA, but may not necessarily be interpreted as a degeneration of 5-HT fibres... 
Hypoinsulinemia regulates amphetamine-induced reverse transport of dopamineJason M Williams
Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
PLoS Biol 5:e274. 2007..These data suggest that insulin signaling pathways may represent a novel mechanism for regulating DA transmission, one which may be targeted for the treatment of AMPH abuse and potentially other dopaminergic disorders...
Research Grants
- Mechanisms Regulating Serotonin Clearance In Vivo: Studies Using KO MiceLynette Daws; Fiscal Year: 2007..That is, drugs targeted at OCTs or PROT may represent first line or adjunctive therapies for individuals who do not respond well to treatment with SSRIs. ..
- 5-HT Transporter Function In Vivo: Studies Using KO MiceLynette Daws; Fiscal Year: 2006..abstract_text> ..
- AMPHETAMINE, INSULIN AND THE DA TRANSPORTER IN VIVOLynette Daws; Fiscal Year: 2005..In turn, these studies may help to illuminate the neural mechanisms underlying the high co-morbidity of eating disorders and drug abuse. ..
- Mechanisms Regulating Serotonin Clearance In Vivo: Studies Using KO MiceLynette C Daws; Fiscal Year: 2010..That is, drugs targeted at OCTs or PROT may represent first line or adjunctive therapies for individuals who do not respond well to treatment with SSRIs. ..