L C Daws

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. pmc Revisiting serotonin reuptake inhibitors and the therapeutic potential of "uptake-2" in psychiatric disorders
    Lynette C Daws
    Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States
    ACS Chem Neurosci 4:16-21. 2013
  2. ncbi request reprint Ethanol inhibits clearance of brain serotonin by a serotonin transporter-independent mechanism
    Lynette C Daws
    Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Neurosci 26:6431-8. 2006
  3. pmc Unfaithful neurotransmitter transporters: focus on serotonin uptake and implications for antidepressant efficacy
    Lynette C Daws
    University of Texas Health Science Center at San Antonio, Department of Physiology and Pharmacology, 7703 Floyd Curl Drive, MC 7756, San Antonio, Texas 78229 3900, USA
    Pharmacol Ther 121:89-99. 2009
  4. ncbi request reprint Differential behavioural and neurochemical effects of para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine in the rat
    L C Daws
    Department of Clinical and Experimental Pharmacology, University of Adelaide, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 24:955-77. 2000
  5. ncbi request reprint 5-HT(1B) receptor-mediated regulation of serotonin clearance in rat hippocampus in vivo
    L C Daws
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Neurochem 75:2113-22. 2000
  6. ncbi request reprint 5-HT1B antagonists modulate clearance of extracellular serotonin in rat hippocampus
    L C Daws
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, 78284 7764, USA
    Neurosci Lett 266:165-8. 1999
  7. pmc Ontogeny and regulation of the serotonin transporter: providing insights into human disorders
    Lynette C Daws
    Department of Physiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC 7756, San Antonio, TX 78229 3900, USA
    Pharmacol Ther 131:61-79. 2011
  8. ncbi request reprint In vivo chronoamperometric measures of extracellular serotonin clearance in rat dorsal hippocampus: contribution of serotonin and norepinephrine transporters
    L C Daws
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284 7764, USA
    J Pharmacol Exp Ther 286:967-76. 1998
  9. ncbi request reprint Transport mechanisms governing serotonin clearance in vivo revealed by high-speed chronoamperometry
    Lynette C Daws
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Neurosci Methods 143:49-62. 2005
  10. ncbi request reprint Exaggerated effect of fluvoxamine in heterozygote serotonin transporter knockout mice
    Sylvia Montañez
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, USA
    J Neurochem 86:210-9. 2003

Collaborators

Detail Information

Publications33

  1. pmc Revisiting serotonin reuptake inhibitors and the therapeutic potential of "uptake-2" in psychiatric disorders
    Lynette C Daws
    Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States
    ACS Chem Neurosci 4:16-21. 2013
    ..We describe how "uptake-2" transporters may explain the relative lack of therapeutic efficacy of SSRIs, as well as why "uptake-2" transporters might be useful therapeutic targets...
  2. ncbi request reprint Ethanol inhibits clearance of brain serotonin by a serotonin transporter-independent mechanism
    Lynette C Daws
    Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Neurosci 26:6431-8. 2006
    ..The present findings provide new insights into the actions of ethanol on brain function and behavior...
  3. pmc Unfaithful neurotransmitter transporters: focus on serotonin uptake and implications for antidepressant efficacy
    Lynette C Daws
    University of Texas Health Science Center at San Antonio, Department of Physiology and Pharmacology, 7703 Floyd Curl Drive, MC 7756, San Antonio, Texas 78229 3900, USA
    Pharmacol Ther 121:89-99. 2009
    ..This review synthesizes the existing literature, focusing on serotonin to illustrate and revive a model for the rationale design of improved antidepressants...
  4. ncbi request reprint Differential behavioural and neurochemical effects of para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine in the rat
    L C Daws
    Department of Clinical and Experimental Pharmacology, University of Adelaide, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 24:955-77. 2000
    ..However, PMA potently inhibited uptake of 5-HT. 5. Taken together these data suggest that the acute adverse effects of PMA are more likely to be associated with alterations in serotonergic rather than dopaminergic neurotransmission...
  5. ncbi request reprint 5-HT(1B) receptor-mediated regulation of serotonin clearance in rat hippocampus in vivo
    L C Daws
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Neurochem 75:2113-22. 2000
    ..These data are consistent with the hypothesis that activation of terminal 5-HT(1B) autoreceptors increases 5-HTT activity...
  6. ncbi request reprint 5-HT1B antagonists modulate clearance of extracellular serotonin in rat hippocampus
    L C Daws
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, 78284 7764, USA
    Neurosci Lett 266:165-8. 1999
    ..By contrast, in the corpus callosum, none of the drugs altered the 5-HT signal. One interpretation of these data is that 5-HT1B receptors can modulate the activity of the 5-HT transporter...
  7. pmc Ontogeny and regulation of the serotonin transporter: providing insights into human disorders
    Lynette C Daws
    Department of Physiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC 7756, San Antonio, TX 78229 3900, USA
    Pharmacol Ther 131:61-79. 2011
    ..We integrate this knowledge to emphasize how inappropriate SERT expression or its dysregulation may be linked to the pathophysiology of psychiatric, cardiovascular and gastrointestinal diseases...
  8. ncbi request reprint In vivo chronoamperometric measures of extracellular serotonin clearance in rat dorsal hippocampus: contribution of serotonin and norepinephrine transporters
    L C Daws
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284 7764, USA
    J Pharmacol Exp Ther 286:967-76. 1998
    ..Only 5,7-DHT treatment caused this effect in the CA3 region. From these data, it is inferred that in certain regions of brain (dentate gyrus), both the SERT and NET contribute to the active clearance of exogenously applied 5-HT...
  9. ncbi request reprint Transport mechanisms governing serotonin clearance in vivo revealed by high-speed chronoamperometry
    Lynette C Daws
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Neurosci Methods 143:49-62. 2005
    ..e. the 5-HTT) and the other with low affinity but a high capacity (i.e. the NET). These data show for the first time in the whole animal that 5-HT clearance in brain is regionally distinct with regard to rate and affinity...
  10. ncbi request reprint Exaggerated effect of fluvoxamine in heterozygote serotonin transporter knockout mice
    Sylvia Montañez
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, USA
    J Neurochem 86:210-9. 2003
    ..These data highlight the potential of the heterozygote 5-HTT mutant mice to model the dynamic in vivo consequences of the human 5-HTT polymorphism...
  11. ncbi request reprint In vivo chronoamperometric measurements of the clearance of exogenously applied serotonin in the rat dentate gyrus
    L C Daws
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, 78284 7564, USA
    J Neurosci Methods 78:139-50. 1997
    ....
  12. ncbi request reprint Serotonin transporter function in vivo: assessment by chronoamperometry
    A Frazer
    Department of Pharmacology, University of Texas Health Science Center at San Antonio 78250, USA
    Ann N Y Acad Sci 861:217-29. 1998
    ..These and other data have generated a working hypothesis that activation of the terminal serotonin autoreceptor enhances the kinetics of 5-HT uptake through an effect on the serotonin transporter...
  13. ncbi request reprint Serotonin transporter function, but not expression, is dependent on brain-derived neurotrophic factor (BDNF): in vivo studies in BDNF-deficient mice
    L C Daws
    Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Neurochem 101:641-51. 2007
    ..g., in the machinery/signaling required for insertion of 5-HTTs into the plasma membrane and/or activation of the 5-HTT once it is positioned to take up 5-HT from extracellular fluid...
  14. ncbi request reprint Calcium-dependent inhibition of synaptosomal serotonin transport by the alpha 2-adrenoceptor agonist 5-bromo-N-[4,5-dihydro-1H-imidazol-2-yl]-6-quinoxalinamine (UK14304)
    Twum Ampofo Ansah
    Department of Pharmacology, Meharry Medical College, 1005 D B Todd Blvd, Nashville, TN 37208, USA
    J Pharmacol Exp Ther 305:956-65. 2003
    ..Our findings suggest that UK14304 modulates SERT function in vitro and in vivo via signaling pathways, possibly supported by an influx of Ca2+ through voltage-sensitive Ca2+ channels...
  15. pmc Organic cation transporter 3: Keeping the brake on extracellular serotonin in serotonin-transporter-deficient mice
    Nicole L Baganz
    Department of Physiology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Proc Natl Acad Sci U S A 105:18976-81. 2008
    ..OCT3 may be an important transporter mediating serotonergic signaling when 5-HTT expression or function is compromised...
  16. pmc Density and function of central serotonin (5-HT) transporters, 5-HT1A and 5-HT2A receptors, and effects of their targeting on BTBR T+tf/J mouse social behavior
    Georgianna G Gould
    Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Neurochem 116:291-303. 2011
    ..1 mg/kg) reduced marble burying, but failed to improve sociability. Overall, altered SERT and/or 5-HT(1A) functionality in hippocampus could contribute to the relatively low sociability of BTBR mice...
  17. pmc Repeated swim impairs serotonin clearance via a corticosterone-sensitive mechanism: organic cation transporter 3, the smoking gun
    Nicole Baganz
    Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    J Neurosci 30:15185-95. 2010
    ....
  18. pmc Reduced effectiveness of escitalopram in the forced swimming test is associated with increased serotonin clearance rate in food-restricted rats
    Charles P France
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Int J Neuropsychopharmacol 12:731-6. 2009
    ..These results suggest that diet plays an integral role in determining efficacy of antidepressant drugs, and might well generalize to other psychoactive drugs that impinge upon the 5-HT transporter...
  19. ncbi request reprint Serotonin (5-HT) transporter (SERT) function after graded destruction of serotonergic neurons
    Sylvia Montañez
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Neurochem 87:861-7. 2003
    ..Functional loss of SERT activity occurs when destruction of serotonergic innervation is greater than 90% but serotonin clearance and efficacy of fluvoxamine is maintained with as few as one fifth of a full complement of SERTs...
  20. ncbi request reprint Differential in vivo clearance of serotonin in rat dorsal raphe nucleus and CA3 region
    Sylvia Montañez
    Department of Psychiatry, MS 7792, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Brain Res 955:236-44. 2002
    ....
  21. ncbi request reprint In vivo analysis of serotonin clearance in rat hippocampus reveals that repeated administration of p-methoxyamphetamine (PMA), but not 3,4-methylenedioxymethamphetamine (MDMA), leads to long-lasting deficits in serotonin transporter function
    Paul D Callaghan
    Department of Physiology, The University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
    J Neurochem 100:617-27. 2007
    ....
  22. ncbi request reprint Differences in the in vivo dynamics of neurotransmitter release and serotonin uptake after acute para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine revealed by chronoamperometry
    Paul D Callaghan
    Department of Physiology, The University of Texas Health Science Center at San Antonio, San Antonio, 78229 3900, USA
    Neurochem Int 47:350-61. 2005
    ..These fundamental differences may account for the more severe adverse reactions seen clinically after PMA, compared to MDMA...
  23. ncbi request reprint Cocaine increases dopamine uptake and cell surface expression of dopamine transporters
    Lynette C Daws
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC 7764, San Antonio, Texas 78229 3900, USA
    Biochem Biophys Res Commun 290:1545-50. 2002
    ..Cocaine-induced increases in cell surface expression of DAT and associated changes in DA clearance represent a novel mechanism that may play a role in its addictive properties...
  24. ncbi request reprint Rapid stimulation of presynaptic serotonin transport by A(3) adenosine receptors
    Chong Bin Zhu
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Pharmacol Exp Ther 322:332-40. 2007
    ..Together, these results identify a novel, region-specific action of CNS A(3)ARs in the modulation of SERT-mediated 5-HT transport that may be relevant for the etiology and/or therapy of 5-HT-linked brain disorders...
  25. ncbi request reprint Deficits in dopamine clearance and locomotion in hypoinsulinemic rats unmask novel modulation of dopamine transporters by amphetamine
    W Anthony Owens
    Department of Physiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Neurochem 94:1402-10. 2005
    ..These results provide exciting new evidence that actions of amphetamine on DA neurotransmission are insulin-dependent and further suggest that exposure to amphetamine may cause long-lasting changes in DAT function...
  26. ncbi request reprint CB1-independent inhibition of dopamine transporter activity by cannabinoids in mouse dorsal striatum
    David A Price
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Neurochem 101:389-96. 2007
    ..These results indicate that both cannabinoid agonists and antagonists inhibit dopamine transporter activity via molecular targets other than CB(1) receptors...
  27. pmc Juxtacellular labeling and chemical phenotyping of extracellularly recorded neurons in vivo
    Glenn M Toney
    Department of Physiology, University of Texas Health Science Center, San Antonio, USA
    Methods Mol Biol 337:127-37. 2006
    ....
  28. pmc Feeding conditions differentially affect the neurochemical and behavioral effects of dopaminergic drugs in male rats
    Rajkumar J Sevak
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, United States
    Eur J Pharmacol 592:109-15. 2008
    ..g., glucose and insulin) in modulating dopamine neurotransmission and in so doing they begin to establish a neurochemical link between the high co-morbidity of eating disorders and drug abuse...
  29. ncbi request reprint Evidence for D2 receptor mediation of amphetamine-induced normalization of locomotion and dopamine transporter function in hypoinsulinemic rats
    Rajkumar J Sevak
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Neurochem 101:151-9. 2007
    ..These results support a role for D2 receptors in regulating DA transporter activity, and further demonstrate that D2 receptors contribute to changes in sensitivity to amphetamine in hypoinsulinemic rats...
  30. ncbi request reprint Ethanol-related behaviors in serotonin transporter knockout mice
    Janel M Boyce-Rustay
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland, USA
    Alcohol Clin Exp Res 30:1957-65. 2006
    ..Increasing evidence supports a role for 5-hydroxytryptamine (5-HT) and the 5-HT transporter (5-HTT) in modulating the neural and behavioral actions of ethanol (EtOH) and other drugs of abuse...
  31. ncbi request reprint Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport
    Jacob U Fog
    Molecular Neuropharmacology Group and Center for Pharmacogenomics, Department of Pharmacology, The Panum Institute, University of Copenhagen, DK 2200 Copenhagen, Denmark
    Neuron 51:417-29. 2006
    ..Our data suggest that CaMKIIalpha binding to the DAT C terminus facilitates phosphorylation of the DAT N terminus and mediates amphetamine-induced dopamine efflux...
  32. ncbi request reprint Repeated administration of the substituted amphetamine p-methoxyamphetamine produces reductions in cortical 5-HT transporter binding but not 5-HT content, unlike 3,4-methylenedioxyamethamphetamine
    Paul D Callaghan
    Discipline of Pharmacology, School of Medical Sciences, Medical School North, The University of Adelaide, Adelaide, South Australia, 5005, Australia
    Eur J Pharmacol 546:74-81. 2006
    ..These data suggest PMA has severe long-term implications clinically for alteration of 5-HT neurotransmission that may differ from MDMA, but may not necessarily be interpreted as a degeneration of 5-HT fibres...
  33. pmc Hypoinsulinemia regulates amphetamine-induced reverse transport of dopamine
    Jason M Williams
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    PLoS Biol 5:e274. 2007
    ..These data suggest that insulin signaling pathways may represent a novel mechanism for regulating DA transmission, one which may be targeted for the treatment of AMPH abuse and potentially other dopaminergic disorders...

Research Grants10

  1. Mechanisms Regulating Serotonin Clearance In Vivo: Studies Using KO Mice
    Lynette Daws; Fiscal Year: 2007
    ..That is, drugs targeted at OCTs or PROT may represent first line or adjunctive therapies for individuals who do not respond well to treatment with SSRIs. ..
  2. 5-HT Transporter Function In Vivo: Studies Using KO Mice
    Lynette Daws; Fiscal Year: 2006
    ..abstract_text> ..
  3. AMPHETAMINE, INSULIN AND THE DA TRANSPORTER IN VIVO
    Lynette Daws; Fiscal Year: 2005
    ..In turn, these studies may help to illuminate the neural mechanisms underlying the high co-morbidity of eating disorders and drug abuse. ..
  4. Mechanisms Regulating Serotonin Clearance In Vivo: Studies Using KO Mice
    Lynette C Daws; Fiscal Year: 2010
    ..That is, drugs targeted at OCTs or PROT may represent first line or adjunctive therapies for individuals who do not respond well to treatment with SSRIs. ..