R L Davisson

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi request reprint Physiological genomic analysis of the brain renin-angiotensin system
    Robin L Davisson
    Dept of Anatomy and Cell Biology, 1 251 Bowen Science Bldg, The Univ of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
    Am J Physiol Regul Integr Comp Physiol 285:R498-511. 2003
  2. ncbi request reprint Discovery of a spontaneous genetic mouse model of preeclampsia
    Robin L Davisson
    Department of Anatomy, University of Iowa College of Medicine, Iowa City 52242, USA
    Hypertension 39:337-42. 2002
  3. pmc Divergent functions of angiotensin II receptor isoforms in the brain
    R L Davisson
    Department of Internal Medicine The University of Iowa, Iowa City, Iowa, USA
    J Clin Invest 106:103-6. 2000
  4. ncbi request reprint Elevated blood pressure in transgenic mice with brain-specific expression of human angiotensinogen driven by the glial fibrillary acidic protein promoter
    S Morimoto
    Department of Internal Medicine and Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242, USA
    Circ Res 89:365-72. 2001
  5. doi request reprint Chronic tempol prevents hypertension, proteinuria, and poor feto-placental outcomes in BPH/5 mouse model of preeclampsia
    Darren S Hoffmann
    Department of Anatomy and Cell Biology, The University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City, USA
    Hypertension 51:1058-65. 2008
  6. ncbi request reprint Hypertension caused by angiotensin II infusion involves increased superoxide production in the central nervous system
    Matthew C Zimmerman
    Department of Anatomy and Cell Biology, The University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City 52242, USA
    Circ Res 95:210-6. 2004
  7. ncbi request reprint Long-term telemetric measurement of cardiovascular parameters in awake mice: a physiological genomics tool
    G M Butz
    Department of Anatomy and Cell Biology, College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Physiol Genomics 5:89-97. 2001
  8. ncbi request reprint Reactive oxygen species in the neuropathogenesis of hypertension
    Jeffrey R Peterson
    Anatomy and Cell Biology, 1 251 Bowen Science Building, The Roy J and Lucille A Carver College of Medicine, The University of Iowa, Iowa City, IA 52245, USA
    Curr Hypertens Rep 8:232-41. 2006
  9. ncbi request reprint NAD(P)H oxidase-induced oxidative stress in sympathetic ganglia of apolipoprotein E deficient mice
    Xiuying Ma
    The Cardiovascular Center and Department of Internal Medicine, The University of Iowa, and the Veterans Affairs Medical Center, Iowa City, IA 52246, USA
    Auton Neurosci 126:285-91. 2006
  10. pmc A differential role for endocytosis in receptor-mediated activation of Nox1
    Francis J Miller
    Department of Medicine, University of Iowa, Iowa City, USA
    Antioxid Redox Signal 12:583-93. 2010

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Physiological genomic analysis of the brain renin-angiotensin system
    Robin L Davisson
    Dept of Anatomy and Cell Biology, 1 251 Bowen Science Bldg, The Univ of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
    Am J Physiol Regul Integr Comp Physiol 285:R498-511. 2003
    ..It also summarizes the principles, progress, and prospects for a better understanding of the brain RAS in health and disease...
  2. ncbi request reprint Discovery of a spontaneous genetic mouse model of preeclampsia
    Robin L Davisson
    Department of Anatomy, University of Iowa College of Medicine, Iowa City 52242, USA
    Hypertension 39:337-42. 2002
    ..This is the first report of an animal model that spontaneously develops a syndrome that bears close resemblance to preeclampsia, and it should have an impact on our understanding of the pathophysiology of this disorder...
  3. pmc Divergent functions of angiotensin II receptor isoforms in the brain
    R L Davisson
    Department of Internal Medicine The University of Iowa, Iowa City, Iowa, USA
    J Clin Invest 106:103-6. 2000
    ..However, the drinking response requires the presence of AT(1B) receptors. To our knowledge, this is the first demonstration of a primary and nonredundant physiological function for AT(1B) receptors...
  4. ncbi request reprint Elevated blood pressure in transgenic mice with brain-specific expression of human angiotensinogen driven by the glial fibrillary acidic protein promoter
    S Morimoto
    Department of Internal Medicine and Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242, USA
    Circ Res 89:365-72. 2001
    ..Blood pressure in the hREN/GFAP-hAGT mice was lowered after ICV, but not intravenous losartan. These studies suggest that AGT synthesis in the brain has an important role in the regulation of blood pressure and electrolyte balance...
  5. doi request reprint Chronic tempol prevents hypertension, proteinuria, and poor feto-placental outcomes in BPH/5 mouse model of preeclampsia
    Darren S Hoffmann
    Department of Anatomy and Cell Biology, The University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City, USA
    Hypertension 51:1058-65. 2008
    ..The results also strongly suggest the potential utility of antioxidant therapy in treating preeclampsia...
  6. ncbi request reprint Hypertension caused by angiotensin II infusion involves increased superoxide production in the central nervous system
    Matthew C Zimmerman
    Department of Anatomy and Cell Biology, The University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City 52242, USA
    Circ Res 95:210-6. 2004
    ..These data suggest that increased intracellular O2*- production in the SFO is critical in the development of Ang II-induced hypertension...
  7. ncbi request reprint Long-term telemetric measurement of cardiovascular parameters in awake mice: a physiological genomics tool
    G M Butz
    Department of Anatomy and Cell Biology, College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Physiol Genomics 5:89-97. 2001
    ..These results demonstrate the feasibility of stress-free, long-term monitoring of CV parameters in pregnant or nonpregnant mice of typical size and offer exciting possibilities for application in CV functional genomic research...
  8. ncbi request reprint Reactive oxygen species in the neuropathogenesis of hypertension
    Jeffrey R Peterson
    Anatomy and Cell Biology, 1 251 Bowen Science Building, The Roy J and Lucille A Carver College of Medicine, The University of Iowa, Iowa City, IA 52245, USA
    Curr Hypertens Rep 8:232-41. 2006
    ....
  9. ncbi request reprint NAD(P)H oxidase-induced oxidative stress in sympathetic ganglia of apolipoprotein E deficient mice
    Xiuying Ma
    The Cardiovascular Center and Department of Internal Medicine, The University of Iowa, and the Veterans Affairs Medical Center, Iowa City, IA 52246, USA
    Auton Neurosci 126:285-91. 2006
    ..We speculate that oxidative stress in sympathetic ganglia may contribute to impaired baroreflex control of sympathetic nerve activity...
  10. pmc A differential role for endocytosis in receptor-mediated activation of Nox1
    Francis J Miller
    Department of Medicine, University of Iowa, Iowa City, USA
    Antioxid Redox Signal 12:583-93. 2010
    ..These findings provide novel insights into the role of compartmentalization for integrating redox-dependent cell signaling...
  11. pmc Complementation of reduced survival, hypotension, and renal abnormalities in angiotensinogen-deficient mice by the human renin and human angiotensinogen genes
    R L Davisson
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA
    J Clin Invest 99:1258-64. 1997
    ....
  12. pmc Scavenging superoxide selectively in mouse forebrain is associated with improved cardiac function and survival following myocardial infarction
    Timothy E Lindley
    Department of Anatomy, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1-8. 2009
    ..This suggests that oxidative stress in the SFO plays a critical role in the deterioration of cardiac function following MI and underscores the promise of CNS-targeted antioxidant therapy for the treatment of MI-induced HF...
  13. ncbi request reprint Ganglionic action of angiotensin contributes to sympathetic activity in renin-angiotensinogen transgenic mice
    Xiuying Ma
    Cardiovascular Center and Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Hypertension 43:312-6. 2004
    ..The significant contribution of the direct ganglionic action of Ang II in R+A+ mice likely reflects both increased levels of Ang II and upregulation of AT1 receptors in sympathetic ganglia...
  14. ncbi request reprint Severe feto-placental abnormalities precede the onset of hypertension and proteinuria in a mouse model of preeclampsia
    Anuja Dokras
    Department of Obstetrics and Gynecology, Roy J and Lucille A Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
    Biol Reprod 75:899-907. 2006
    ....
  15. ncbi request reprint Requirement for Rac1-dependent NADPH oxidase in the cardiovascular and dipsogenic actions of angiotensin II in the brain
    Matthew C Zimmerman
    Department of Anatomy and Cell Biology, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City 52242, USA
    Circ Res 95:532-9. 2004
    ....
  16. ncbi request reprint Cardiac hypertrophy is not a required compensatory response to short-term pressure overload
    J A Hill
    Division of Cardiovascular Diseases, Department of Internal Medicine, Department of Veterans Affairs, University of Iowa College of Medicine, Iowa City 52242 1081, USA
    Circulation 101:2863-9. 2000
    ..Cardiac hypertrophy is considered a necessary compensatory response to sustained elevations of left ventricular (LV) wall stress...
  17. ncbi request reprint Nox2-containing NADPH oxidase and Akt activation play a key role in angiotensin II-induced cardiomyocyte hypertrophy
    Shawn D Hingtgen
    Department of Anatomy and Cell Biology, The Free Radical and Radiation Biology Program, Roy J and Lucille A Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
    Physiol Genomics 26:180-91. 2006
    ....
  18. pmc Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angiotensin system
    Marc F Doobay
    Department of Anatomy and Cell Biology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA
    Am J Physiol Regul Integr Comp Physiol 292:R373-81. 2007
    ....
  19. ncbi request reprint Superoxide mediates the actions of angiotensin II in the central nervous system
    Matthew C Zimmerman
    Department of Anatomy and Cell Biology, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City 52242, USA
    Circ Res 91:1038-45. 2002
    ..These results identify a novel signaling mechanism mediating the actions of Ang II in the CNS. Dysregulation of this signaling cascade may be important in hypertension and heart failure triggered by Ang II acting in the CNS...
  20. ncbi request reprint Superoxide is involved in the central nervous system activation and sympathoexcitation of myocardial infarction-induced heart failure
    Timothy E Lindley
    Department of Anatomy and Cell Biology, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242, USA
    Circ Res 94:402-9. 2004
    ....
  21. ncbi request reprint Genetic ablation of angiotensinogen in the subfornical organ of the brain prevents the central angiotensinergic pressor response
    Puspha Sinnayah
    Department of Anatomy and Cell Biology, Roy J and Lucille A Carver College of Medicine, The University of Iowa, Iowa City, USA
    Circ Res 99:1125-31. 2006
    ....
  22. ncbi request reprint Pleiotropic functions of TNF-alpha determine distinct IKKbeta-dependent hepatocellular fates in response to LPS
    Rana Dajani
    Department of Anatomy and Cell Biology, University of Iowa, College of Medicine, 51 Newton Rd, Rm 1 111 BSB, Iowa City, IA 52242, USA
    Am J Physiol Gastrointest Liver Physiol 292:G242-52. 2007
    ..In conclusion, our studies demonstrate that induction of NF-kappaB and TNF-alpha balances protective (antiapoptotic) and detrimental (proinflammatory) pathways to determine hepatocellular fates during endotoxemia...
  23. ncbi request reprint Genetic redox preconditioning differentially modulates AP-1 and NF kappa B responses following cardiac ischemia/reperfusion injury and protects against necrosis and apoptosis
    Jusan Yang
    Department of Anatomy and Cell Biology, The Center for Gene Therapy of Cystic Fibrosis and Other Genetic Disorders, University of Iowa College of Medicine, Iowa City, Iowa 52242 USA
    Mol Ther 7:341-53. 2003
    ....
  24. ncbi request reprint Gene therapeutic approaches to oxidative stress-induced cardiac disease: principles, progress, and prospects
    S D Hingtgen
    Department of Anatomy and Cell Biology, College of Medicine, The University of Iowa, Iowa City 52242, USA
    Antioxid Redox Signal 3:433-49. 2001
    ..Improved understanding of pathophysiology, better gene delivery systems, and specific gene therapeutic strategies will be needed before gene therapy of oxyradical-mediated myocardial damage becomes a clinical reality...
  25. pmc Enhanced water and salt intake in transgenic mice with brain-restricted overexpression of angiotensin (AT1) receptors
    Eric Lazartigues
    Department of Anatomy and Cell Biology, The University of Iowa, Iowa City, Iowa, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1539-45. 2008
    ..This model provides a new tool for studying the mechanisms of brain AT(1A)-dependent water and salt consumption...
  26. ncbi request reprint Targeted viral delivery of Cre recombinase induces conditional gene deletion in cardiovascular circuits of the mouse brain
    Puspha Sinnayah
    Department of Anatomy and Cell Biology, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242, USA
    Physiol Genomics 18:25-32. 2004
    ....
  27. ncbi request reprint NADPH oxidases of the brain: distribution, regulation, and function
    David W Infanger
    Department of Anatomy and Cell Biology, Free Radical and Radiation Biology Program, The University of Iowa, Iowa City, 52245, USA
    Antioxid Redox Signal 8:1583-96. 2006
    ..In addition, perspectives for future research and novel therapeutic targets are offered...
  28. ncbi request reprint Renovascular hypertension in mice with brain-selective overexpression of AT1a receptors is buffered by increased nitric oxide production in the periphery
    Eric Lazartigues
    Department of Anatomy and Cell Biology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City 52242, USA
    Circ Res 95:523-31. 2004
    ....
  29. ncbi request reprint Brain-selective overexpression of angiotensin (AT1) receptors causes enhanced cardiovascular sensitivity in transgenic mice
    Eric Lazartigues
    Department of Anatomy and Cell Biology, The University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Circ Res 90:617-24. 2002
    ....
  30. ncbi request reprint Superoxide mediates angiotensin II-induced influx of extracellular calcium in neural cells
    Matthew C Zimmerman
    Department of Anatomy and Cell Biology, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City 52242, USA
    Hypertension 45:717-23. 2005
    ....
  31. ncbi request reprint Selective gene transfer to key cardiovascular regions of the brain: comparison of two viral vector systems
    Puspha Sinnayah
    Department of Anatomy, The University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Hypertension 39:603-8. 2002
    ....
  32. ncbi request reprint Redox signaling in central neural regulation of cardiovascular function
    Matthew C Zimmerman
    Department of Anatomy and Cell Biology, Roy J and Lucille A Carver College of Medicine, The University of Iowa, Iowa City 52245, USA
    Prog Biophys Mol Biol 84:125-49. 2004
    ..The main objective of this review is to discuss the recent progress and prospects for this new field of central redox signaling in cardiovascular regulation, while also addressing the molecular tools that have spurred it forward...
  33. pmc Microdystrophin gene therapy of cardiomyopathy restores dystrophin-glycoprotein complex and improves sarcolemma integrity in the mdx mouse heart
    Yongping Yue
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212, USA
    Circulation 108:1626-32. 2003
    ..Here, we tested the therapeutic potential of adeno-associated virus (AAV)-mediated microdystrophin gene therapy in the mdx mouse heart...
  34. pmc Hypertension and cerebrovascular dysfunction
    Costantino Iadecola
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY 10021, USA
    Cell Metab 7:476-84. 2008
    ..This review focuses on the mechanisms by which hypertension disrupts cerebral blood vessels, highlighting recent advances and outstanding issues...
  35. doi request reprint Longitudinal noninvasive monitoring of transcription factor activation in cardiovascular regulatory nuclei using bioluminescence imaging
    Jeffrey R Peterson
    Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 6401, USA
    Physiol Genomics 33:292-9. 2008
    ..These results demonstrate that BLI, in combination with virally mediated gene transfer, is a powerful method for longitudinal monitoring and quantification of TF activity in targeted CNS nuclei in vivo...
  36. ncbi request reprint Does angiotensin interact with dopaminergic mechanisms in the brain to modulate prepulse inhibition in mice?
    Sally Martin
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville Melbourne, Victoria 3052, Australia
    Neuropharmacology 54:399-404. 2008
    ..Our previous results on the effects of reduced ACE activity could be explained by mechanisms other than angiotensin, such as effects on enkephalin or bradykinin metabolism...
  37. pmc Local production of angiotensin II in the subfornical organ causes elevated drinking
    Koji Sakai
    Department of Internal Medicine, Department of Anatomy and Cell Biology, and Center on Functional Genomics of Hypertension, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Clin Invest 117:1088-95. 2007
    ..These data provide strong genetic evidence implicating de novo synthesis of Ang II in the SFO as an integral player in fluid homeostasis...
  38. ncbi request reprint Recommendations for blood pressure measurement in animals: summary of an AHA scientific statement from the Council on High Blood Pressure Research, Professional and Public Education Subcommittee
    Theodore W Kurtz
    Arterioscler Thromb Vasc Biol 25:478-9. 2005
  39. ncbi request reprint Recommendations for blood pressure measurement in humans and experimental animals: part 2: blood pressure measurement in experimental animals: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart A
    Theodore W Kurtz
    Arterioscler Thromb Vasc Biol 25:e22-33. 2005
    ..Selection of the methods to be used should ultimately be guided by the study objectives to insure that the techniques chosen are appropriate for the experimental questions being explored...
  40. ncbi request reprint Recommendations for blood pressure measurement in humans and experimental animals. Part 2: Blood pressure measurement in experimental animals: a statement for professionals from the subcommittee of professional and public education of the American Heart A
    Theodore W Kurtz
    Hypertension 45:299-310. 2005
    ..Selection of the methods to be used should ultimately be guided by the study objectives to insure that the techniques chosen are appropriate for the experimental questions being explored...