Stephen N Davis

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi Clinical impact of initiating insulin glargine therapy with disposable pen versus vial in patients with type 2 diabetes mellitus in a managed care setting
    Stephen N Davis
    University of Maryland Medical Center, Baltimore, Maryland 21201, USA
    Endocr Pract 17:845-52. 2011
  2. ncbi Effects of acute hypoglycemia on inflammatory and pro-atherothrombotic biomarkers in individuals with type 1 diabetes and healthy individuals
    Nino Gogitidze Joy
    University of Maryland School of Medicine, Baltimore, Maryland, USA
    Diabetes Care 33:1529-35. 2010
  3. ncbi Dose-response effects of insulin glargine in type 2 diabetes
    Zhihui Wang
    Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    Diabetes Care 33:1555-60. 2010
  4. ncbi Effects of oral carbohydrate on autonomic nervous system counterregulatory responses during hyperinsulinemic hypoglycemia and euglycemia
    Andrew C Ertl
    Division of Diabetes, Endocrinology and Metabolism, Dept of Medicine, 7465 MRB IV, Nashville, TN 37232 0475, USA
    Am J Physiol Endocrinol Metab 295:E618-25. 2008
  5. ncbi Effect of sex on counterregulatory responses to exercise after antecedent hypoglycemia in type 1 diabetes
    Pietro Galassetti
    715 PRB, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt Univ. School of Medicine, Nashville, TN 37232-6303, USA
    Am J Physiol Endocrinol Metab 287:E16-24. 2004
  6. ncbi Effects of intensive therapy and antecedent hypoglycemia on counterregulatory responses to hypoglycemia in type 2 diabetes
    Stephen N Davis
    Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    Diabetes 58:701-9. 2009
  7. ncbi Differing physiological effects of epinephrine in type 1 diabetes and nondiabetic humans
    Deanna Aftab Guy
    Division of Pediatric Endocrinology, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232-6303, USA
    Am J Physiol Endocrinol Metab 288:E178-86. 2005
  8. ncbi Effect of antecedent hypoglycemia on counterregulatory responses to subsequent euglycemic exercise in type 1 diabetes
    Pietro Galassetti
    Departments of Medicine and Molecular Physiology and Biophysics, Vanderbilt University School of Medicine and Nashville Veteran Affairs Medical Center, Nashville, Tennessee 37232-6303, USA
    Diabetes 52:1761-9. 2003
  9. ncbi Effects of a selective serotonin reuptake inhibitor, fluoxetine, on counterregulatory responses to hypoglycemia in healthy individuals
    Vanessa J Briscoe
    Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    Diabetes 57:2453-60. 2008
  10. ncbi Effects of glycemic control on target organ responses to epinephrine in type 1 diabetes
    Deanna Aftab Guy
    715 PRB, Div. of Diabetes, Endocrinology and Metabolism, Vanderbilt Univ. School of Medicine, Nashville, TN 37232-6303, USA
    Am J Physiol Endocrinol Metab 289:E258-65. 2005

Collaborators

Detail Information

Publications48

  1. ncbi Clinical impact of initiating insulin glargine therapy with disposable pen versus vial in patients with type 2 diabetes mellitus in a managed care setting
    Stephen N Davis
    University of Maryland Medical Center, Baltimore, Maryland 21201, USA
    Endocr Pract 17:845-52. 2011
    ....
  2. ncbi Effects of acute hypoglycemia on inflammatory and pro-atherothrombotic biomarkers in individuals with type 1 diabetes and healthy individuals
    Nino Gogitidze Joy
    University of Maryland School of Medicine, Baltimore, Maryland, USA
    Diabetes Care 33:1529-35. 2010
    ..Therefore, the aim of this study was to determine whether 2 h of moderate clamped hypoglycemia could decrease fibrinolytic balance and activate pro-atherothrombotic mechanisms in individuals with type 1 diabetes and healthy individuals...
  3. ncbi Dose-response effects of insulin glargine in type 2 diabetes
    Zhihui Wang
    Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    Diabetes Care 33:1555-60. 2010
    ..To determine the pharmacokinetic and pharmacodynamic dose-response effects of insulin glargine administered subcutaneously in individuals with type 2 diabetes...
  4. ncbi Effects of oral carbohydrate on autonomic nervous system counterregulatory responses during hyperinsulinemic hypoglycemia and euglycemia
    Andrew C Ertl
    Division of Diabetes, Endocrinology and Metabolism, Dept of Medicine, 7465 MRB IV, Nashville, TN 37232 0475, USA
    Am J Physiol Endocrinol Metab 295:E618-25. 2008
    ....
  5. ncbi Effect of sex on counterregulatory responses to exercise after antecedent hypoglycemia in type 1 diabetes
    Pietro Galassetti
    715 PRB, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt Univ. School of Medicine, Nashville, TN 37232-6303, USA
    Am J Physiol Endocrinol Metab 287:E16-24. 2004
    ..Preserved counterregulatory responses during exercise in T1DM women may confer greater protection against hypoglycemia than in men with T1DM...
  6. ncbi Effects of intensive therapy and antecedent hypoglycemia on counterregulatory responses to hypoglycemia in type 2 diabetes
    Stephen N Davis
    Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    Diabetes 58:701-9. 2009
    ..0% would blunt autonomic nervous system (ANS) responses to hypoglycemia, and 2) antecedent hypoglycemia will result in counterregulatory failure during subsequent hypoglycemia in patients with suboptimal and good glycemic control...
  7. ncbi Differing physiological effects of epinephrine in type 1 diabetes and nondiabetic humans
    Deanna Aftab Guy
    Division of Pediatric Endocrinology, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232-6303, USA
    Am J Physiol Endocrinol Metab 288:E178-86. 2005
    ..Thus we conclude that there is a spectrum of significant in vivo physiological differences of epinephrine action at the liver, muscle, adipose tissue, pancreas, and cardiovascular system between T1DM and healthy subjects...
  8. ncbi Effect of antecedent hypoglycemia on counterregulatory responses to subsequent euglycemic exercise in type 1 diabetes
    Pietro Galassetti
    Departments of Medicine and Molecular Physiology and Biophysics, Vanderbilt University School of Medicine and Nashville Veteran Affairs Medical Center, Nashville, Tennessee 37232-6303, USA
    Diabetes 52:1761-9. 2003
    ..These data indicate that counterregulatory failure may be a significant in vivo mechanism responsible for exercise-associated hypoglycemia in type 1 diabetes...
  9. ncbi Effects of a selective serotonin reuptake inhibitor, fluoxetine, on counterregulatory responses to hypoglycemia in healthy individuals
    Vanessa J Briscoe
    Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    Diabetes 57:2453-60. 2008
    ....
  10. ncbi Effects of glycemic control on target organ responses to epinephrine in type 1 diabetes
    Deanna Aftab Guy
    715 PRB, Div. of Diabetes, Endocrinology and Metabolism, Vanderbilt Univ. School of Medicine, Nashville, TN 37232-6303, USA
    Am J Physiol Endocrinol Metab 289:E258-65. 2005
    ....
  11. ncbi Estrogen blunts neuroendocrine and metabolic responses to hypoglycemia
    Darleen A Sandoval
    Department of Medicine, Vanderbilt University School of Medicine and Nashville Veterans Affairs Medical Center, Nashville, Tennessee, USA
    Diabetes 52:1749-55. 2003
    ..05) responses to hypoglycemia were all significantly lower in E2 vs. NO E2 subjects. We conclude that estrogen appears to play a major role in the sexual dimorphism present in counterregulatory responses to hypoglycemia in healthy humans...
  12. ncbi Effects of differing antecedent increases of plasma cortisol on counterregulatory responses during subsequent exercise in type 1 diabetes
    Shichun Bao
    Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Diabetes 58:2100-8. 2009
    ..The aim of this study was to determine whether antecedent increase of plasma cortisol is a mechanism responsible for this finding...
  13. ncbi Effects of antecedent GABAA activation with alprazolam on counterregulatory responses to hypoglycemia in healthy humans
    Maka S Hedrington
    Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    Diabetes 59:1074-81. 2010
    ....
  14. ncbi Acute, same-day effects of antecedent exercise on counterregulatory responses to subsequent hypoglycemia in type 1 diabetes mellitus
    Darleen A Sandoval
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Am J Physiol Endocrinol Metab 290:E1331-8. 2006
    ..These data suggest that exercise-induced counterregulatory failure can occur very rapidly, increasing the risk for hypoglycemia in T1DM within hours...
  15. ncbi Effect of differing antecedent hypoglycemia on counterregulatory responses to exercise in type 1 diabetes
    Pietro Galassetti
    Division of Diabetes, Endocrinology and Metabolism, Vanderbilt Univ. School of Medicine, Nashville, TN 37232-6303, USA
    Am J Physiol Endocrinol Metab 290:E1109-17. 2006
    ..9 mmol/l in patients with T1DM...
  16. ncbi The effects of dehydroepiandrosterone sulfate on counterregulatory responses during repeated hypoglycemia in conscious normal rats
    Darleen A Sandoval
    Department of Medicine, Vanderbilt University School of Medicine, and Nashville Veterans Affairs Medical Center, Nashville, Tennessee, USA
    Diabetes 53:679-86. 2004
    ..However, simultaneous DHEA-S infusion during antecedent hypoglycemia preserved neuroendocrine and metabolic counterregulatory responses during subsequent hypoglycemia in conscious rats...
  17. ncbi Effects of low and moderate antecedent exercise on counterregulatory responses to subsequent hypoglycemia in type 1 diabetes
    Darleen A Sandoval
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6303, USA
    Diabetes 53:1798-806. 2004
    ....
  18. ncbi Effect of gender on counterregulatory responses to euglycemic exercise in type 1 diabetes
    Pietro Galassetti
    Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University School of Medicine, Nashville, TN 37232-6303, USA
    J Clin Endocrinol Metab 87:5144-50. 2002
    ..Other responses, including glucagon and EGP, were similar between genders, suggesting that the glucagon to insulin ratio may be the primary determinant of EGP during moderate intensity exercise in T1DM...
  19. ncbi Stimulation of both type I and type II corticosteroid receptors blunts counterregulatory responses to subsequent hypoglycemia in healthy man
    Stephanie M Gustavson
    Department of Medicine, Div of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center 7465 MRB IV, Nashville, TN 37232 0475, USA
    Am J Physiol Endocrinol Metab 294:E506-12. 2008
    ..Both type I and type II corticosteroid receptors may be involved in the multiple mechanisms controlling counterregulatory responses to hypoglycemia in healthy man...
  20. ncbi Leptin responses to antecedent exercise and hypoglycemia in healthy and type 1 diabetes mellitus men and women
    Darleen A Sandoval
    Department of Medicine, Vanderbilt University School of Medicine and Nashville Veterans Affairs Medical Center, Nashville, TN 37232, USA
    J Diabetes Complications 17:301-6. 2003
    ..However, T1DM patients do have increased basal leptin levels compared to healthy man. Lastly, there is a marked sexual dimorphism in plasma leptin responses to repeated episodes of exercise...
  21. ncbi Forebrain and hindbrain effects of ethanol on counterregulatory responses to hypoglycemia in conscious rats
    Darleen A Sandoval
    Department of Medicine, Vanderbilt University School of Medicine and, Nashville Veterans Affairs Medical Center, Nashville, TN 37232, USA
    Metabolism 56:1623-8. 2007
    ..The greater impact of 4VOH compared with LVOH administration suggests that OH exerts its effects to blunt autonomic nervous system counterregulatory responses during hypoglycemia primarily by actions on the hindbrain...
  22. ncbi Effects of the selective serotonin reuptake inhibitor fluoxetine on counterregulatory responses to hypoglycemia in individuals with type 1 diabetes
    Vanessa J Briscoe
    Department of Medicine, Vanderbilt University, Nashville, TN, USA
    Diabetes 57:3315-22. 2008
    ..Therefore, the specific aim of this study was to test the hypothesis that 6-week use of the SSRI fluoxetine would amplify autonomic nervous system (ANS) counterregulatory responses to hypoglycemia in individuals with type 1 diabetes...
  23. ncbi Brain region-dependent effects of dexamethasone on counterregulatory responses to hypoglycemia in conscious rats
    Darleen A Sandoval
    Department of Medicine, Vanderbilt University School of Medicine, Nashville Veterans Affairs Medical Center, Nashville, TN 37232-6303, USA
    Am J Physiol Regul Integr Comp Physiol 288:R413-9. 2005
    ..These data suggest that prior activation of type II glucocorticoid receptors within the hindbrain plays a major role in blunting autonomic nervous system counterregulatory responses to subsequent hypoglycemia in the conscious rat...
  24. ncbi Glucoregulation during and after exercise in health and insulin-dependent diabetes
    Raul C Camacho
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232-0615, USA
    Exerc Sport Sci Rev 33:17-23. 2005
    ..These mechanisms of glucoregulatory failure may cause hypoglycemia in insulin-dependent diabetics during and after exercise...
  25. ncbi Exploring the substitution of exenatide for insulin in patients with type 2 diabetes treated with insulin in combination with oral antidiabetes agents
    Stephen N Davis
    Endocrinology and Metabolism, Vanderbilt University, 715 PRB, 2220 Pierce Ave, Nashville, TN 37232 6303, USA
    Diabetes Care 30:2767-72. 2007
    ..This 16-week study explored the safety of substituting exenatide for insulin in patients with type 2 diabetes using insulin in combination with oral antidiabetes agents...
  26. ncbi Cortisol acts through central mechanisms to blunt counterregulatory responses to hypoglycemia in conscious rats
    Darleen A Sandoval
    Department of Medicine, Vanderbilt University School of Medicine and Nashville Veterans Affairs Medical Center, Nashville, Tennessee 37232 6303, USA
    Diabetes 52:2198-204. 2003
    ..We conclude that cortisol can act directly on the central nervous system to blunt counterregulatory responses to subsequent hypoglycemia in the conscious rat...
  27. ncbi The renin-angiotensin-aldosterone system: a pivotal role in insulin sensitivity and glycemic control
    Jennifer M Perkins
    Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University, Nashville, Tennesse 37232 0475, USA
    Curr Opin Endocrinol Diabetes Obes 15:147-52. 2008
    ....
  28. ncbi Endocannabinoid system overactivity and the metabolic syndrome: prospects for treatment
    Jennifer M Perkins
    Division of Diabetes, Endocrinology and Metabolism, Mark Collie Professor of Medicine, Molecular Physiology and Biophysics, Vanderbilt University, 7465 MRB IV, Nashville, TN 37232 0475, USA
    Curr Diab Rep 8:12-9. 2008
    ....
  29. ncbi Evaluation of colesevelam hydrochloride for the treatment of type 2 diabetes
    Lisa M Younk
    University of Maryland School of Medicine, Department of Medicine, 10 055 Bressler Research Building, 655 W Baltimore St, Baltimore, MD 21201, USA
    Expert Opin Drug Metab Toxicol 8:515-25. 2012
    ..The mechanism(s) by which colesevelam improves glycemia are not yet understood but might involve enhanced meal-induced incretin secretion and altered farnesoid X receptor signaling...
  30. ncbi Pharmacokinetics, efficacy and safety of aleglitazar for the treatment of type 2 diabetes with high cardiovascular risk
    Lisa M Younk
    University of Maryland School of Medicine, Department of Medicine, Baltimore, MD 21201, USA
    Expert Opin Drug Metab Toxicol 7:753-63. 2011
    ..However, PPAR-α- and -γ-associated side effects have been observed and additional large-scale, long-term clinical studies are necessary to better understand the clinical implications of these effects...
  31. ncbi Autonomic contribution to blood pressure and metabolism in obesity
    Cyndya Shibao
    Division of Clinical Pharmacology and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Hypertension 49:27-33. 2007
    ..These results suggest that the sympathetic nervous system could be targeted in the treatment of obesity-associated hypertension...
  32. ncbi Psychological insulin resistance: overcoming barriers to starting insulin therapy
    Stephen N Davis
    Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical School, Nashville, Tennessee 37232-6303, USA
    Diabetes Educ 32:146S-152S. 2006
  33. ncbi Prior exercise and the response to insulin-induced hypoglycemia in the dog
    Yoshiharu Koyama
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0615, USA
    Am J Physiol Endocrinol Metab 282:E1128-38. 2002
    ..The primary site of this reduction is the liver...
  34. ncbi Hypoglycemia associated autonomic failure
    Laura Diedrich
    715 PRB II, Division of Diabetes and Endocrinology, Vanderbilt University Medical School, Nashville, TN 37232-6303, USA
    Clin Auton Res 12:358-65. 2002
    ..This article will review our current understanding of the mechanisms responsible for hypoglycemia associated autonomic failure...
  35. ncbi Basal insulin treatment in type 2 diabetes
    Maka S Hedrington
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Diabetes Technol Ther 13:S33-42. 2011
    ..Insulin glargine is well tolerated, has low immunogenicity, reduced risks for acute myocardial infarction, and a lower risk of hypoglycemia compared with NPH insulin in individuals with type 2 diabetes...
  36. ncbi The role of inhaled insulin in the treatment of type 2 diabetes
    Stephen N Davis
    Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical School, Nashville, TN, USA
    J Diabetes Complications 22:420-9. 2008
    ..Greater acceptance of new insulin delivery systems may lead to earlier introduction of insulin therapy, which should help more patients with diabetes achieve glycemic control sooner after diagnosis...
  37. ncbi The role of glimepiride in the treatment of type 2 diabetes mellitus
    Vanessa J Briscoe
    Vanderbilt University, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, 7465 MRB IV, 2213 Garland Avenue, Nashville, TN 37232 0475, USA
    Expert Opin Drug Metab Toxicol 6:225-35. 2010
    ..Sulfonylureas have been used in the treatment of type 2 diabetes for many years...
  38. ncbi Role of the endocannabinoid system in management of patients with type 2 diabetes mellitus and cardiovascular risk factors
    Stephen N Davis
    Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Endocr Pract 13:790-804. 2007
    ....
  39. ncbi STAR 3 randomized controlled trial to compare sensor-augmented insulin pump therapy with multiple daily injections in the treatment of type 1 diabetes: research design, methods, and baseline characteristics of enrolled subjects
    Stephen N Davis
    Diabetes Endocrinology, Department of Medicine, Vanderbilt University, 2213 Garland Avenue, Nashville, TN 37232 0475, USA
    Diabetes Technol Ther 12:249-55. 2010
    ..Sensor-Augmented Pump Therapy for A1c Reduction (STAR) 3 is a multicenter randomized controlled trial comparing the efficacy of SAPT to that of MDI in subjects with type 1 diabetes...
  40. ncbi The role of glimepiride in the effective management of Type 2 diabetes
    Stephen N Davis
    Division of Diabetes Endocrinology and Metabolism, Vanderbilt University Medical School, 715 Preston Research Building, Nashville, TN 37232 6303, USA
    J Diabetes Complications 18:367-76. 2004
    ..The unique properties of glimepiride may provide advantages over other currently available insulin secretagogues...
  41. ncbi Contemporary strategies for managing cardiometabolic risk factors
    Stephen N Davis
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Manag Care Pharm 12:S4-9. 2006
    ..It has led to significant weight loss, reduced central fat, and improved glycemic and lipid profiles...
  42. ncbi Treating to target in type 2 diabetes: a case presentation
    Stephen N Davis
    Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical School, Nashville, Tennessee 37232-6303, USA
    Diabetes Educ 32:137S-145S. 2006
  43. ncbi A review of the efficacy and safety of oral antidiabetic drugs
    Stephanie Aleskow Stein
    University of Maryland Medical Center, Endocrinology, Diabetes and Metabolism, 22 South Greene St N3W157, Baltimore, MD 21201, USA
    Expert Opin Drug Saf 12:153-75. 2013
    ..BAS and bromocriptine have the lowest efficacy with regard to HbA(1c) reduction, also are plagued by GI adverse reactions, but have a low risk of hypoglycemia...
  44. ncbi Optimizing combination therapy for type 2 diabetes in adolescents and adults: a case-based approach
    Tom A Elasy
    Division of General Internal Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    J Fam Pract 53:815-22. 2004
    ..If a patient is unable to achieve glycemic control on 2 oral agents, insulin therapy is an appropriate consideration and should be added to oral agents (rather than substituted) (SOR: B)...
  45. ncbi Combination of glibenclamide-metformin HCl for the treatment of type 2 diabetes mellitus
    Elizabeth Mary Lamos
    University of Maryland Medical Center, Endocrinology, Diabetes and Metabolism, Baltimore, Maryland 21201, USA
    Expert Opin Pharmacother 13:2545-54. 2012
    ..Alternatively, practitioners may want to weigh the efficacy and safety of available dipeptidyl-peptidase-4 inhibitor-metformin combinations to those of glibenclamide-metformin when considering combination therapy...
  46. ncbi Leptin: metabolic control and regulation
    Darleen A Sandoval
    Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University, Nashville, TN, USA
    J Diabetes Complications 17:108-13. 2003
    ..The purpose of this review to is critically analyze the literature regarding the impact of different types of stress on leptin secretion, the function of leptin during stress, and the role of leptin in the pathophysiology of diabetes...
  47. ncbi Pramlintide and the treatment of diabetes: a review of the data since its introduction
    Lisa M Younk
    University of Maryland School of Medicine, Department of Medicine, Baltimore, MD 21201 USA
    Expert Opin Pharmacother 12:1439-51. 2011
    ..Newer research is focusing on weight loss effects of pramlintide and pramlintide plus metreleptin in nondiabetic obese individuals. Preliminary results of these studies are discussed...
  48. ncbi Diabetic ketoacidosis in type 2 diabetes mellitus--pathophysiology and clinical presentation
    Stephen N Davis
    Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University School of Medicine, Nashville, TN 37232-6303, USA
    Nat Clin Pract Endocrinol Metab 3:730-1. 2007