Research Topics
| Roger DavisSummaryAffiliation: University of Massachusetts Medical School Country: USA Publications
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Publications
Signal transduction by the JNK group of MAP kinasesR J Davis
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605, USA
Cell 103:239-52. 2000- Signal transduction by MAP kinases: regulation by phosphorylation-dependent switchesA J Whitmarsh
Howard Hughes Medical Institute, Program in Molecular Medicine, Department of Biochemistry, University of Massachusetts Medical School, Worcester, MA 01605 USA
Sci STKE 1999:PE1. 1999.... 
c-Jun NH2-terminal kinase is required for lineage-specific differentiation but not stem cell self-renewalPing Xu
Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA
Mol Cell Biol 30:1329-40. 2010..Together, these data demonstrate that JNK is not required for proliferation or self-renewal of ES cells, but JNK plays a key role in the differentiation of ES cells...- Requirement of c-Jun NH(2)-terminal kinase for Ras-initiated tumor formationCristina Cellurale
Howard Hughes Medical Institute, Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
Mol Cell Biol 31:1565-76. 2011..Moreover, JNK is required for lung tumor development caused by mutational activation of the endogenous KRas gene in vivo. Together, these data establish that JNK plays a key role in Ras-induced tumorigenesis... - The c-Jun NH2-terminal kinase is essential for epidermal growth factor expression during epidermal morphogenesisClaire R Weston
Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Proc Natl Acad Sci U S A 101:14114-9. 2004..We conclude that JNK is necessary for epithelial morphogenesis and is an essential regulator of signal transduction by the EGF receptor in the epidermis... - Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3)Nyaya Kelkar
Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
Proc Natl Acad Sci U S A 100:9843-8. 2003..The central nervous system abnormalities of Jip3-/- mice may be accounted for in part by a reduction in signal transduction by RhoA and its effector ROCK... - Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascadesDeborah Brancho
Howard Hughes Medical Institute, Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation St, Worcester, MA 01605, USA
Mol Cell Biol 25:3670-81. 2005..However, we did find that MLK3 deficiency caused a selective reduction in tumor necrosis factor (TNF)-stimulated JNK activation. Together, these data demonstrate that MLK3 contributes to the TNF signaling pathway that activates JNK... - Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosisCaroline Morel
Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Mol Cell Biol 29:3845-52. 2009..Together, these data establish that Mcl-1 functions as a site of signal integration between the proapoptotic activity of JNK and the prosurvival activity of the AKT pathway that inhibits GSK3... - c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascadeYong Hee Lee
Howard Hughes Medical Institute, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Biol Chem 278:2896-902. 2003..These results support the hypothesis that JNK is a negative feedback regulator of insulin action by phosphorylating Ser(307) in Irs1... - Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathwaysNyaya Kelkar
Howard Hughes Medical Institute, Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation St, Worcester, MA 01605, USA
Mol Cell Biol 25:2733-43. 2005..The JIP4 scaffold protein therefore appears to be a new component of the p38 MAP kinase signaling pathway... - JNK2 is a positive regulator of the cJun transcription factorAnja Jaeschke
Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Mol Cell 23:899-911. 2006.... - JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissureClaire R Weston
Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Genes Dev 17:1271-80. 2003.... - Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetesAnja Jaeschke
Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Proc Natl Acad Sci U S A 102:6931-5. 2005..We conclude that JNK protein kinases may have important roles in diabetes, including functions of JNK1 in type 2 diabetes and JNK2 in type 1 diabetes... - Multisite phosphorylation regulates Bim stability and apoptotic activityAnette Hübner
Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA
Mol Cell 30:415-25. 2008..Together, these data indicate that phosphorylation can regulate Bim by multiple mechanisms and that the phosphorylation of Bim on different sites can contribute to the sensitivity of cellular apoptotic responses... - Suppression of p53-dependent senescence by the JNK signal transduction pathwayMadhumita Das
Program in Molecular Medicine, Department of Cancer Cell Biology, and Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA
Proc Natl Acad Sci U S A 104:15759-64. 2007..These data demonstrate that JNK can act as a negative regulator of the p53 tumor suppressor... - JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen speciesJuan Jose Ventura
Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Genes Dev 18:2905-15. 2004..Together, these data indicate that JNK can shift the balance of TNF-stimulated cell death from apoptosis to necrosis. Increased necrosis may represent a contributing factor in stress-induced inflammatory responses mediated by JNK... - JNK regulates autocrine expression of TGF-beta1Juan Jose Ventura
Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester 01605, USA
Mol Cell 15:269-78. 2004..Together, these data demonstrate that the JNK pathway may contribute to the regulation of autocrine TGF-beta1-mediated biological responses in vivo... - Chemical genetic analysis of the time course of signal transduction by JNKJuan Jose Ventura
Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, 01605, USA
Mol Cell 21:701-10. 2006..These data indicate that the time course of JNK signaling can influence the biological response to JNK activation... - Suppression of Ras-stimulated transformation by the JNK signal transduction pathwayNorman J Kennedy
Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Genes Dev 17:629-37. 2003..This conclusion is consistent with the presence in human tumors of loss-of-function mutations in the JNK pathway... - Induction of hepatitis by JNK-mediated expression of TNF-alphaMadhumita Das
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Cell 136:249-60. 2009..These observations confirm a role for JNK in the development of hepatitis but identify hematopoietic cells as the site of the essential function of JNK... - Prevention of steatosis by hepatic JNK1Guadalupe Sabio
Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA
Cell Metab 10:491-8. 2009..JNK1 therefore serves opposing actions in liver and adipose tissue to both promote and prevent hepatic steatosis. This finding has potential implications for the design of JNK1-selective drugs for the treatment of metabolic syndrome... - An essential role of the JIP1 scaffold protein for JNK activation in adipose tissueAnja Jaeschke
Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester 01605, USA
Genes Dev 18:1976-80. 2004..These data identify JIP1 as a novel molecular target for therapeutic intervention in the development of obesity... - Inhibition of the p38 pathway upregulates macrophage JNK and ERK activities, and the ERK, JNK, and p38 MAP kinase pathways are reprogrammed during differentiation of the murine myeloid M1 cell lineJ Perry Hall
Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
J Cell Biochem 86:1-11. 2002..Thus, we speculate that during inflammatory conditions in vivo macrophage p38 may regulate JNK and ERK activity and inhibit IL-10 expression. These data highlight the importance of p38 in the molecular mechanisms of macrophage function... - Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblastsPatricia Hess
Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, Massachusetts 01605, USA
Nat Genet 32:201-5. 2002..Our results show that Jnk1 signals cell survival in transformed B lymphoblasts and suggest that it may contribute to the pathogenesis of some proliferative diseases... - Role of JNK in tumor developmentNorman J Kennedy
Howard Hughes Medical Institute and Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
Cell Cycle 2:199-201. 2003..Indeed, an understanding of this question will be required for the rational use of small molecule inhibitors of JNK for tumor therapy... - Analysis of c-Jun N-terminal kinase regulation and functionJ Perry Hall
Howard Hughes Medical Institute, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Methods Enzymol 345:413-25. 2002 - The JNK signal transduction pathwayClaire R Weston
Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Curr Opin Genet Dev 12:14-21. 2002..In addition, a small molecule pharmacological inhibitor of JNK has been described and it is likely that this drug will facilitate future studies of JNK function... - The JNK signal transduction pathwayClaire R Weston
Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Curr Opin Cell Biol 19:142-9. 2007..Roles of novel molecules that participate in the JNK pathway have been defined and new insight into the role of JNK in survival signaling, cell death, cancer and diabetes has been achieved... - Requirement of JIP1-mediated c-Jun N-terminal kinase activation for obesity-induced insulin resistanceCaroline Morel
Howard Hughes Medical Institute, Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
Mol Cell Biol 30:4616-25. 2010..We conclude that JIP1-mediated JNK activation plays a critical role in metabolic stress regulation of the JNK signaling pathway... - Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1Guadalupe Sabio
Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Genes Dev 24:256-64. 2010..These data demonstrate that the hypothalamic-pituitary-thyroid axis represents an important target of metabolic signaling by JNK1... - The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinaseKui Lei
Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Mol Cell Biol 22:4929-42. 2002..These data demonstrate that proapoptotic members of the Bax protein subfamily are essential for JNK-dependent apoptosis... - Deficiency of the zinc finger protein ZPR1 causes neurodegenerationBeth Doran
Program in Molecular Medicine, Department of Cell Biology, and Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA
Proc Natl Acad Sci U S A 103:7471-5. 2006..We report that ZPR1-deficient mice exhibit axonal pathology and neurodegeneration. These data identify ZPR1 deficiency as a contributing factor in neurodegenerative disorders... - Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexesClaire L Standen
Howard Hughes Medical Institute, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Mol Cell Biol 29:4831-40. 2009..Together, these observations demonstrate that JIP proteins can influence insulin-stimulated signal transduction mediated by IRS proteins... - A stress signaling pathway in adipose tissue regulates hepatic insulin resistanceGuadalupe Sabio
Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA
Science 322:1539-43. 2008..Thus, JNK1 activation in adipose tissue can cause insulin resistance in the liver... - c-Jun NH(2)-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factorJuan Jose Ventura
Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Mol Cell Biol 23:2871-82. 2003..These changes were associated with marked defects in TNF-regulated gene expression. The JNK signal transduction pathway is therefore essential for AP-1 transcription factor regulation in cells exposed to TNF... - Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistanceGuadalupe Sabio
Howard Hughes Medical Institute, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
Mol Cell Biol 30:106-15. 2010..These data demonstrate that JNK1 in muscle contributes to peripheral insulin resistance in response to diet-induced obesity... - Oncogene addiction: role of signal attenuationAnette Hübner
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Dev Cell 11:752-4. 2006..In a recent issue of Cancer Cell, Sharma et al. (2006b) reported that "oncogene addiction" may be mediated by differential rates of signal attenuation of proapoptotic and prosurvival pathways... - Metabolic stress signaling mediated by mixed-lineage kinasesAnja Jaeschke
Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA
Mol Cell 27:498-508. 2007..Loss of PKC, MLK3, MKK4, or MKK7 expression prevents FFA-stimulated JNK activation. Together, these data establish a signaling pathway that mediates effects of metabolic stress on insulin resistance... - Functional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim in vivoAnette Hübner
Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
Mol Cell Biol 30:98-105. 2010..Thus, developmental ablation of interdigital webbing on mouse paws and normal lymphocyte homeostasis require the cooperative activity of Bim and Bmf... - H2AX is a target of the JNK signaling pathway that is required for apoptotic DNA fragmentationHayla K Sluss
Department of Cancer Cell Biology and University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Mol Cell 23:152-3. 2006..In the July 7 issue of Molecular Cell, Lu et al. (2006) report that JNK phosphorylation of H2AX at a noncanonical site is required for caspase-induced DNA fragmentation... - JNK1 is required to preserve cardiac function in the early response to pressure overloadHideo Tachibana
Department of Medicine, Cell Biology and Genetics, Duke University Medical Center, Durham, NC 27710, USA
Biochem Biophys Res Commun 343:1060-6. 2006..These data suggest that JNK1 plays a protective role in response to pressure overload, preventing the early deterioration in cardiac function following an acute increase in afterload... - c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 signaling pathways have divergent roles in CD8(+) T cell-mediated antiviral immunityNathalie Arbour
Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Exp Med 195:801-10. 2002..JNK1 is involved in survival of activated T cells during immune responses, and JNK2 plays a role in control of CD8(+) T cell expansion in vivo... - c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activationDietrich Conze
Section of Immunobiology, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
J Exp Med 195:811-23. 2002..Thus, JNK1 and JNK2 play different roles during CD8(+) T cell activation and these roles differ from those in CD4(+) T cells... - Signalling pathways involved in multisite phosphorylation of the transcription factor ATF-2Simon Morton
MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dundee DD1 5EH, Scotland, UK
FEBS Lett 572:177-83. 2004..In JNK-deficient cells, p38 MAPK substituted for JNK partially in the phosphorylation of Thr69 and p38 MAPK or ERK1/2 in the phosphorylation of Thr71. JNK was the only MAP kinase that phosphorylated Ser90 under the conditions examined... - Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1Danielle Morse
Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Biol Chem 278:36993-8. 2003..For the first time, the effect of CO is shown to be mediated via the JNK signaling pathway and the transcription factor AP-1... - c-Jun N-terminal kinase 3 deficiency protects neurons from axotomy-induced death in vivo through mechanisms independent of c-Jun phosphorylationElizabeth Keramaris
Neuroscience East, Ottawa Health Research Institute, Ontario, Canada
J Biol Chem 280:1132-41. 2005..In a sciatic axotomy model of neuronal injury in the neonate, death of DRG neurons was also reduced by JNK3 deficiency. However, in this case, c-Jun activation was also eliminated... - Analyzing mitogen-activated protein kinase (MAPK) activities in T cellsAlan J Whitmarsh
University of Manchester, School of Biological Sciences, Manchester, United Kingdom
Curr Protoc Immunol . 2004..Also described is a procedure for preparing GSThyphen;cJun/GSH-Sepharose beads needed in the solid-phase JNK protein kinase activity assay... 
MKK3 signalling plays an essential role in leukocyte-mediated pancreatic injury in the multiple low-dose streptozotocin modelKyoichi Fukuda
Department of Nephrology, Monash Medical Centre, Clayton, Vic, Australia
Lab Invest 88:398-407. 2008..In conclusion, MKK3 signalling plays an essential role in the development of islet inflammation leading to destruction of beta-cells and hyperglycaemia in MLD-STZ-induced pancreatic injury...- Targeting dendritic cell signaling to regulate the response to immunizationDavid Escors
Infection and Immunity, University College London, London, United Kingdom
Blood 111:3050-61. 2008.... - c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infectionJoao H F Pedra
Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
Infect Immun 76:308-16. 2008..Collectively, these findings provide strong evidence that JNK2 is an important regulatory protein for IFN-gamma secretion upon challenge with A. phagocytophilum... - Carbon monoxide modulates Fas/Fas ligand, caspases, and Bcl-2 family proteins via the p38alpha mitogen-activated protein kinase pathway during ischemia-reperfusion lung injuryXuchen Zhang
Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
J Biol Chem 278:22061-70. 2003..Taken together, our data are the first to demonstrate that CO has an antiapoptotic effect by inhibiting Fas/Fas ligand, caspases, proapoptotic Bcl-2 proteins, and cytochrome c release via the MKK3/p38alpha MAPK pathway... - MKK3-p38 signaling promotes apoptosis and the early inflammatory response in the obstructed mouse kidneyFrank Y Ma
Department of Nephrology, Monash Medical Centre, 246 Clayton Rd, Clayton, Victoria 3168, Australia
Am J Physiol Renal Physiol 293:F1556-63. 2007..In conclusion, these studies identify discrete roles for MKK3-p38 signaling in renal cell apoptosis and the early inflammatory response in the obstructed kidney... - Deficiency in the c-Jun NH2-terminal kinase signaling pathway confers susceptibility to hyperoxic lung injury in miceDanielle Morse
Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Am J Physiol Lung Cell Mol Physiol 285:L250-7. 2003..These results indicate that JNK pathways participate in adaptive responses to hyperoxia in mice... - Signal transduction. MAP kinase signaling specificityClaire R Weston
Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Science 296:2345-7. 2002 - JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosisKui Lei
Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Proc Natl Acad Sci U S A 100:2432-7. 2003..These proapoptotic BH3-only proteins therefore provide a molecular link between the JNK signal transduction pathway and the Bax/Bak-dependent mitochondrial apoptotic machinery... - The p65/RelA subunit of NF-kappaB suppresses the sustained, antiapoptotic activity of Jun kinase induced by tumor necrosis factorJulie Y Reuther-Madrid
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Mol Cell Biol 22:8175-83. 2002..These data suggest that the activity of JNK in cells blocked for NF-kappaB function provides an antiapoptotic signal and explains, at least partly, why a significant number of NF-kappaB null cells remain viable following TNF treatment... - Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3Xuchen Zhang
Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Biol Chem 278:1248-58. 2003..Taken together, our data are the first to demonstrate in models of A-R that the anti-apoptotic effects of CO are via modulation of p38 MAPK and caspase 3... - Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosisNobuyuki Tanaka
Section of Immunobiology, Yale University School of Medicine, New Haven CT 06520, USA
EMBO Rep 3:785-91. 2002..In peripheral CD4(+)T cells, MKK3 is induced upon stimulation, whereas MKK6 is downregulated. These results suggest a novel mechanism regulating T-cell apoptosis differentially through the p38MAPK pathway by MKK3 and MKK6... - Interaction of the c-Jun/JNK pathway and cyclin-dependent kinases in death of embryonic cortical neurons evoked by DNA damageMohammad H Ghahremani
Neuroscience Research Institute, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
J Biol Chem 277:35586-96. 2002..Finally, c-Jun activation is independent of p53 and Bax. Accordingly, we propose that c-Jun is regulated by the JNK and CDK pathways and that both must be activated for efficient c-Jun activation to occur... - Murine Lyme arthritis development mediated by p38 mitogen-activated protein kinase activityJuan Anguita
Department of Biology, University of North Carolina, Charlotte, NC 28223, USA
J Immunol 168:6352-7. 2002..Overall, these data indicated that the p38 MAP kinase pathway plays an important role in B. burgdorferi-elicited inflammation and point to potential new therapeutic approaches to the treatment of inflammation induced by the spirochete... - Phosphorylation of NFATc4 by p38 mitogen-activated protein kinasesTeddy T C Yang
Department of Molecular Pharmacology, Jack and Pearl Resnick Campus, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Mol Cell Biol 22:3892-904. 2002..Thus, NFAT regulates PPAR gamma gene expression and has a direct role in adipocyte differentiation... - Targeting JNK for therapeutic benefit: from junk to gold?Anthony M Manning
Roche Pharmaceuticals, 3411 Hillview Avenue, Palo Alto, CA 94306, USA
Nat Rev Drug Discov 2:554-65. 2003..Here we discuss the evidence supporting the application of JNK inhibitors in inflammatory, vascular, neurodegenerative, metabolic and oncological diseases in humans, and describe the present status of drug discovery targeting JNK... - c-Jun N-terminal kinase 1 is required for Toll-like receptor 1 gene expression in macrophagesHooman Izadi
Department of Veterinary and Animal Sciences, University of Massachusetts Amherst, MA 01003, USA
Infect Immun 75:5027-34. 2007..These results demonstrate that JNK1 regulates the response to TLR1/2 ligands and suggest a positive feedback loop that may serve to increase the innate immune response to the spirochete... - Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5Yongliang Zhang
Department of Immunology, University of Washington, Seattle, Washington 98195 7650, USA
Nature 430:793-7. 2004..Therefore, MKP5 has a principal function in both innate and adaptive immune responses, and represents a novel target for therapeutic intervention of immune diseases... - JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16Seung Wook Oh
Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA
Proc Natl Acad Sci U S A 102:4494-9. 2005..Our findings define an interaction between two well conserved proteins, JNK-1 and DAF-16, and provide a mechanism by which JNK regulates longevity and stress resistance... - Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosisYankun Li
Department of Medicine, Columbia University, 630 West 168th Street, New York, NY 10032, USA
J Biol Chem 280:21763-72. 2005..Moreover, this model may help explain the relationship between FC accumulation and inflammation in vulnerable plaques... - GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cellsHongbo Chi
Section of Immunobiology, Yale University School of Medicine, New Haven, CT, USA
EMBO J 23:1576-86. 2004..During Th1 differentiation, the GADD45beta/GADD45gamma/MEKK4 pathway appears to integrate upstream signals transduced by both T cell receptor and IL12/STAT4, leading to augmented IFNgamma production in a process independent of STAT4... - A critical role of neural-specific JNK3 for ischemic apoptosisChia Yi Kuan
Department of Pediatrics, Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Proc Natl Acad Sci U S A 100:15184-9. 2003..The downstream mechanism of JNK3-mediated apoptosis may include the induction of Bim and Fas and the mitochondrial release of cytochrome c. These results suggest that JNK3 is a potential target for neuroprotection therapies in stroke... - JNK1 is essential for CD8+ T cell-mediated tumor immune surveillanceYunfei Gao
Section of Rheumatology, Department of Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
J Immunol 175:5783-9. 2005..Taken together, our results demonstrate that JNK1 plays an important role in tumor immune surveillance through regulating the effector functions of CD8+ T cells... - The transcriptional repressor HBP1 is a target of the p38 mitogen-activated protein kinase pathway in cell cycle regulationMei Xiu
Department of Biochemistry, School of Medicine, Tufts University, Boston, Massachusetts 02111, USA
Mol Cell Biol 23:8890-901. 2003..Together, our work supports a molecular framework in which p38 MAP kinase activity contributes to cell cycle inhibition by increasing HBP1 and other G1 inhibitory factors by regulating protein stability... - Mechanism of p38 MAP kinase activation in vivoDeborah Brancho
Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Genes Dev 17:1969-78. 2003..These data indicate that p38 MAPK is regulated by the coordinated and selective actions of three different protein kinases in response to cytokines and exposure to environmental stress... - The death domain kinase RIP1 is essential for tumor necrosis factor alpha signaling to p38 mitogen-activated protein kinaseThomas H Lee
Department of Cancer Biology and Interdisciplinary Graduate Program, University of Massachusetts Medical School, Lazare Research Building, Worcester, MA 01605
Mol Cell Biol 23:8377-85. 2003..Taken together, these studies suggest a mechanism whereby RIP1 may mediate the p38 MAP kinase response to TNF-alpha, by recruiting the MAP3K MEKK3... - Role of the p38 mitogen-activated protein kinase pathway in the generation of arsenic trioxide-dependent cellular responsesNick Giafis
Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Department of Medicine, Northwestern University Medical School, 303 East Superior Street, Chicago, IL 60611, USA
Cancer Res 66:6763-71. 2006..Altogether, our data indicate that the Mkk3/6-p38 signaling cascade is activated in a negative regulatory feedback manner to control induction of As(2)O(3)-mediated antileukemic effects... - Multiple activation mechanisms of p38alpha mitogen-activated protein kinaseYoung Jun Kang
Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
J Biol Chem 281:26225-34. 2006..Therefore, multiple mechanisms of p38alpha activation exist that can influence each other, be simultaneously activated by a given stimulus, and/or be selectively used by different stimuli in a cell type-specific manner... - A reinvestigation of the multisite phosphorylation of the transcription factor c-JunSimon Morton
MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dundee DD1 5EH, UK
EMBO J 22:3876-86. 2003..The agonist-induced dephosphorylation of Thr239 may involve a conformational change that exposes Thr239 to dephosphorylation and/or the activation of a Thr239 phosphatase... - Inactivation of JNK1 enhances innate IL-10 production and dampens autoimmune inflammation in the brainElise H Tran
Section of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 103:13451-6. 2006..Our findings provide further insights into the pivotal MAPK-regulated network of innate and adaptive cytokines in the progression to autoimmunity... - Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemiaMasaya Tanno
Department of Cardiology, Guy s, King s and St Thomas School of Medicine, King s College London, The Rayne Institute, St Thomas Hospital, London, UK
Circ Res 93:254-61. 2003..However, SB203580 (1 micromol/L) did not prevent the phosphorylation of resistant p38alpha-MAPK. These findings suggest the ischemic activation of p38-MAPK contributing to myocardial injury is by TAB1-associated autophosphorylation... - A radical role for p38 MAPK in tumor initiationNorman J Kennedy
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Cancer Cell 11:101-3. 2007..A new study in this issue of Cancer Cell shows that p38 MAP kinase plays a selective role in tumor initiation mediated by oxidative stress... - JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune responseJian Tao
Section of Rheumatology, Department of Medicine, Yale School of Medicine, New Haven, CT 06520 8031, USA
Eur J Immunol 37:818-29. 2007..In summary, our results demonstrate that JNK2 negatively regulates antigen-specific CD8+ T cell expansion and effector function, and thus selectively blocking JNK2 in CD8+ T cells may potentially enhance anti-tumor immune response... - JunD mediates survival signaling by the JNK signal transduction pathwayJennifer A Lamb
Howard Hughes Medical Institute and Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Mol Cell 11:1479-89. 2003..Furthermore, these data illustrate the general principal that signal transduction pathway integration is critical for the ability of cells to mount an appropriate biological response to a specific challenge... - MAP kinases in the immune responseChen Dong
Department of Immunology, University of Washington School of Medicine, Seattle, Washington 98195 7650, USA
Annu Rev Immunol 20:55-72. 2002..In this review, we summarize recent progress in understanding the function and regulation of MAP kinase pathways in these phases of immune responses...
Research Grants
- Mechanisms of NeurodegenerationRoger J Davis; Fiscal Year: 2010..The Specific Aims of this proposal are to examine: 1. The physiological role of JNK in neurons. 2. The mechanism of JNK-induced neurodegeneration. ..
- MECHANISM OF ACTION OF PRO INFLAMMATORY CYTOKINESRoger Davis; Fiscal Year: 2004..The specific aims of this proposal are to examine the effects of the JNK signaling pathway on : 1. Apoptosis and cell survival; 2. Oncogenic transformation and 3. Gene expression. ..
- STRUCTURAL ORGANIZATION OF SIGNALING PATHWAYSRoger Davis; Fiscal Year: 2004..The Specific Aims of this proposal are to examine: 1. The physiological role of JIP scaffold proteins. 2. The structure and dynamics of JIP scaffold complexes. 3. The mechanism of JIP-stimulated JNK activity. ..
- Functional Analysis of the Beta-CellRoger Davis; Fiscal Year: 2006..The Specific Aims of this proposal are to employ mouse models to: Define the role of JNK in beta cells. Define the role of JIP scaffold proteins in beta cells Define the function of diabetes-associated mutations in JIP1 ..
- Mechanisms of Action of Pro-inflammatory CytokinesRoger J Davis; Fiscal Year: 2010..The Specific Aims of thisproposal are to examine: 1. The physiological role of JNK in TNF signal transduction. 2. The mechanism of JNK-induced apoptosis. ..
- Chemical Genetics Analysis Targeted to the Mouse Prostate EpitheliumRoger Davis; Fiscal Year: 2007..Develop a method to selectively disrupt JNK in the murine prostate epithelium.. 2. Develop a general method that can be used to selectively and temporally regulate the function of JNK in the murine prostate epithelium. ..
- Mechanisms of NeurodegenerationRoger Davis; Fiscal Year: 2007..The Specific Aims of this proposal are to examine: 1. The physiological role of JNK in neurons. 2. The mechanism of JNK-induced neurodegeneration. ..
- Mechanisms of Action of Pro-inflammatory CytokinesRoger Davis; Fiscal Year: 2007..The Specific Aims of this proposal are to examine 1) The physiological role of JNK in TNF signal transduction. 2) The mechanism of JNK-induced apoptosis. ..
- MECHANISM OF ACTION OF PRO-INFLAMMATORY CYTOKINESRoger Davis; Fiscal Year: 1999..The Specific Aims of this proposal are to examine: 1. The JNK protein kinase cascade. 2. The activation of the JNK pathway by cytokine receptors. 3. The interaction of JNK with other proteins. ..
- SIGNAL TRANSDUCTION BY THE EGF RECEPTORRoger Davis; Fiscal Year: 1993..We shall test the hypothesis that Ser(1046/7 phosphorylation regulates the association of proteins with the EGF receptor...
- SIGNAL TRANSDUCTION BY THE EGF RECEPTORRoger Davis; Fiscal Year: 2001..In the second aim, the investigator will attempt to identify target molecules that interact with ZPR1. In the third specific aim, the investigator will determine ZPR1 function using genetic analysis in yeast. ..