Research Topics
| J M DavisSummaryAffiliation: University of Illinois at Chicago Country: USA Publications
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Publications
Old versus new: weighing the evidence between the first- and second-generation antipsychoticsJohn M Davis
Department of Psychiatry M C 912, University of Illinois at Chicago, University of Maryland Psychiatric Research Center, 1601 W Taylor Street, Chicago, IL, USA
Eur Psychiatry 20:7-14. 2005..Choice of antipsychotic, in our opinion, is probably the most important decision that the clinician makes for the psychotic patient. This involves the choice of drug, its dose, balancing efficacy, side-effects and cost...
American College of Neuropsychopharmacology--43rd annual meeting. 12-16 December 2004, San Juan, Puerto RicoJohn M Davis
Illinois State Psychiatric Institute, Room 309, 1601 West Taylor Street, West Chicago, IL 60612-4397, USA
IDrugs 8:100-3. 2005
Commentary on strategies for switching antipsychoticsJohn M Davis
Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA
BMC Med 6:18. 2008..In this issue, Ganguli et al. have carried out a randomized switching study, the data from which indicates the tactics that might be optimal. We put this paper into context, provide a critique and describe indications for switching...
Clinical profile of an atypical antipsychotic: risperidoneJohn M Davis
The Psychiatric Institute, University of Illinois at Chicago, 60612, USA
Schizophr Bull 28:43-61. 2002..Second, we performed a meta-analysis of 18 controlled risperidone trials: risperidone was consistently more effective than conventional antipsychotics in treating positive and negative symptoms...
Should we treat depression with drugs or psychological interventions? A reply to IoannidisJohn M Davis
Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA
Philos Ethics Humanit Med 6:8. 2011....
Choice of maintenance medication for schizophreniaJohn M Davis
Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
J Clin Psychiatry 64:24-33. 2003....
The effects of olanzapine on the 5 dimensions of schizophrenia derived by factor analysis: combined results of the North American and international trialsJ M Davis
Department of Psychiatry and the Psychiatric Institute, University of Illinois at Chicago, USA
J Clin Psychiatry 62:757-71. 2001..The choice of drug to treat a patient with schizophrenia is one of the most critical clinical decisions. Controversy exists on the differential efficacy of olanzapine...
Dose response and dose equivalence of antipsychoticsJohn M Davis
Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, Chicago, IL 60612, USA
J Clin Psychopharmacol 24:192-208. 2004..3 to 10 mg). While high-dose FGAs are not less effective, we feel it is important not to avoid using high dose to avoid excessive toxicity...
A meta-analysis of the efficacy of second-generation antipsychoticsJohn M Davis
Psychiatric Institute, University of Illinois at Chicago, 60612, USA
Arch Gen Psychiatry 60:553-64. 2003....
In psychosis, cortical interneurons overexpress DNA-methyltransferase 1Marin Veldic
Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, 1601 West Taylor Street, Chicago, IL 60612, USA
Proc Natl Acad Sci U S A 102:2152-7. 2005..Interestingly, the DNMT1 increase failed to occur when patients with psychosis received a combination of valproate and APS treatment but not APS monotherapy...
S-adenosyl methionine and DNA methyltransferase-1 mRNA overexpression in psychosisAlessandro Guidotti
Department of Psychiatry, Psychiatric Institute, University of Illinois, Chicago, Illinois, USA
Neuroreport 18:57-60. 2007....
GABAergic dysfunction in schizophrenia: new treatment strategies on the horizonAlessandro Guidotti
Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 Taylor St, Chicago, IL 60612, USA
Psychopharmacology (Berl) 180:191-205. 2005....
Epigenetic GABAergic targets in schizophrenia and bipolar disorderA Guidotti
Department of Psychiatry, University of Illinois at Chicago, College of Medicine, Psychiatric Institute, 1601 Taylor, Chicago, IL 60612, USA
Neuropharmacology 60:1007-16. 2011..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'...
A double-blind, randomized, prospective evaluation of the efficacy and safety of risperidone versus haloperidol in the treatment of schizoaffective disorderP G Janicak
The Psychiatric Clinical Research Center and Department of Psychiatry, College of Medicine, University of Illinois at Chicago, 60612, USA
J Clin Psychopharmacol 21:360-8. 2001..In those subjects with higher baseline HAM-D scores (i.e., >20), risperidone produced a greater improvement in depressive symptoms than haloperidol...
Lower number of cerebellar Purkinje neurons in psychosis is associated with reduced reelin expressionEkrem Maloku
Department of Psychiatry, Psychiatric Institute, University of Illinois, Chicago, IL 60612, USA
Proc Natl Acad Sci U S A 107:4407-11. 2010..This finding suggests that lack of reelin impairs GABAergic Purkinje neuron expression and/or positioning during cerebellar development...
A multidose study of haloperidol decanoate in the maintenance treatment of schizophreniaJohn M Kane
Department of Psychiatry, Hillside Hospital, Glen Oaks, NY 11004, USA
Am J Psychiatry 159:554-60. 2002..Maintenance medication is critical in the prevention of psychotic relapse and rehospitalization among patients with schizophrenia. Given potential adverse effects, identification of the minimum effective dose is clinically important...
A comparison of thiothixene with chlorpromazine in the treatment of maniaP G Janicak
Illinois State Psychiatric Institute, Chicago
J Clin Psychopharmacol 8:33-7. 1988..The implications for less aggressive use of neuroleptics to treat mania are discussed...
A decrease of reelin expression as a putative vulnerability factor in schizophreniaF Impagnatiello
Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, Chicago, IL 60612, USA
Proc Natl Acad Sci U S A 95:15718-23. 1998..These findings are interpreted within a neurodevelopmental/vulnerability "two-hit" model for the etiology of schizophrenia...
An upregulation of DNA-methyltransferase 1 and 3a expressed in telencephalic GABAergic neurons of schizophrenia patients is also detected in peripheral blood lymphocytesA Zhubi
Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, IL, USA
Schizophr Res 111:115-22. 2009..Hence, PBL studies may become useful to investigate a diagnostic epigenetic marker of SZ morbidity...
Imidazenil: an antagonist of the sedative but not the anticonvulsant action of diazepamJames Auta
Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor St, Chicago, IL 60612, USA
Neuropharmacology 49:425-9. 2005..Thus, we suggest that imidazenil might be more effective than FLU at alleviating the withdrawal syndrome associated with long-term BZ administration...
Epigenetic mechanisms expressed in basal ganglia GABAergic neurons differentiate schizophrenia from bipolar disorderMarin Veldic
Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, 1601 West Taylor Street, Chicago, IL 60612, United States
Schizophr Res 91:51-61. 2007..This suggests that different epigenetic mechanisms must exist in the pathogenesis underlying SZ and BDP and implies that these disorders might involve two separate entities that are characterized by a well-defined neuropathology...
Reelin down-regulation in mice and psychosis endophenotypesPatricia Tueting
Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street Chicago, IL 60612, USA
Neurosci Biobehav Rev 30:1065-77. 2006..Thus, an animal model that combines genetic heterozygocity with epigenesis holds promise for understanding the role of Reelin down-regulation in psychosis...
Issues that may determine the outcome of antipsychotic trials: industry sponsorship and extrapyramidal side effectJohn M Davis
Department of Psychiatry, University of Illinois at Chicago, 1601 W Taylor Street, Chicago, IL 60612, USA
Neuropsychopharmacology 33:971-5. 2008..We were unable to confirm that the drug's EPS properties or antiparkinsonian management altered actual efficacy...
Effects of olanzapine and risperidone on lipid metabolism in chronic schizophrenic patients with long-term antipsychotic treatment: a randomized five month studyRobert C Smith
Department of Psychiatry, New York University Medical School, Hewlett, NY 11557, USA
Schizophr Res 120:204-9. 2010..We present results of a randomized prospective study of lipid metabolism and metabolic syndrome in chronic schizophrenic patients using both fasting and post-prandial lipid measures...
Methodological factors influencing measurement and processing of plasma reelin in humansGiovanni Lugli
Department of Psychiatry and Psychiatric Institute, University of Illinois at Chicago, MC 912, 1601 W, Taylor Street, Chicago, IL 60612, USA
BMC Biochem 4:9. 2003..Here we describe the methodological and biological foundation for carrying out and interpreting clinical studies of plasma reelin...
L-methionine decreases dendritic spine density in mouse frontal cortexPatricia Tueting
Department of Psychiatry, Psychiatric Institute, College of Medicine, University of Illinois at Chicago, USA
Neuroreport 21:543-8. 2010....
Olfactory discrimination training up-regulates and reorganizes expression of microRNAs in adult mouse hippocampusNeil R Smalheiser
Department of Psychiatry and UIC Psychiatric Institute MC912, University of Illinois at Chicago, 1601 W Taylor Street, Chicago, IL 60612, USA
ASN Neuro 2:e00028. 2010..These in vivo results indicate that significant, dynamic and co-ordinated changes in miRNA expression accompany early stages of learning...
Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain studyA Guidotti
Psychiatric Institute, University of Illinois at Chicago, 1601 W Taylor St, Room 256, Chicago, IL 60612, USA
Arch Gen Psychiatry 57:1061-9. 2000....
Feasibility of reducing the duration of placebo-controlled trials in schizophrenia researchRobert P McMahon
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland Baltimore Medical School, Baltimore, MD, USA
Schizophr Bull 34:292-301. 2008..Shortening placebo-controlled trials would reduce patient burden and ethical objections to prolonged administration of placebo and reduce potential bias due to high dropout rates in longer clinical trials...
Effects of olanzapine and risperidone on glucose metabolism and insulin sensitivity in chronic schizophrenic patients with long-term antipsychotic treatment: a randomized 5-month studyRobert C Smith
Department of Psychiatry, NYU Medical School, Hewlett, NY 11557, USA
J Clin Psychiatry 70:1501-13. 2009..Randomized prospective studies of metabolic effects during treatment with these drugs may provide results that are more informative...
Structure of mania: depressive, irritable, and psychotic clusters with different retrospectively-assessed course patterns of illness in randomized clinical trial participantsA C Swann
Department of Psychiatry, University of Texas Houston Health Science Center, 1300 Moursund Street, Room 270, Houston, TX 77030, USA
J Affect Disord 67:123-32. 2001..We investigated the structure of manic episodes by determining whether there was evidence for distinct groups of patients differing in clinical characteristics and course of illness...
Relapse of aggressive and disruptive behavior in mentally retarded adults following antipsychotic drug withdrawal predicts psychotropic drug use a decade laterDavid S Janowsky
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7175, USA
J Clin Psychiatry 67:1272-7. 2006..The purpose of this study was to determine if relapse during or after antipsychotic drug withdrawal in mentally retarded adults predicts continuing antipsychotic drug use an average of a decade later...
Antipsychotic withdrawal-induced relapse predicts future relapses in institutionalized adults with severe intellectual disabilityDavid S Janowsky
Department of Psychiatry, CB 7175, Medical Research Building A, University of North Carolina, Chapel Hill, NC 27599 7175, USA
J Clin Psychopharmacol 28:401-5. 2008..Thus, if relapse occurs after an antipsychotic drug withdrawal attempt, subsequent attempts at withdrawal are also very likely to lead to further relapses...
Antagonism of anticholinesterase (DFP) toxicity by donepezil plus scopolamine: a preliminary studyDavid S Janowsky
Department of Psychiatry, University of North Carolina, CB 7175, Medical Research Building A, Chapel Hill, NC 27599 7175, USA
Pharmacol Biochem Behav 77:337-43. 2004..Therefore, these preliminary findings are encouraging, but many additional studies are needed to establish the effectiveness of donepezil as a prophylactic agent against irreversible cholinesterase inhibition by DFP...
Olanzapine for self-injurious, aggressive, and disruptive behaviors in intellectually disabled adults: a retrospective, open-label, naturalistic trialDavid S Janowsky
Department of Psychiatry, CB 7175, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7175, USA
J Clin Psychiatry 64:1258-65. 2003..The effectiveness of olanzapine in treating challenging behaviors in the intellectually disabled and its ability to substitute for conventional antipsychotic drugs were evaluated...
A GABAergic cortical deficit dominates schizophrenia pathophysiologyE Costa
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 W Taylor St, Chicago IL 60612, USA
Crit Rev Neurobiol 16:1-23. 2004..Hence, imidazenil should be appropriately studied as a prospective candidate for a pharmacological intervention in schizophrenia...
The neuropharmacology of psychosisCarol A Tamminga
Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, NE5 110F, Dallas, TX 75390 9127, USA
Schizophr Bull 33:937-46. 2007..We discuss the kinds of data necessary to further support the dimensional aspects of psychosis...
Minimally effective doses of conventional antipsychotic medications used to treat aggression, self-injurious and destructive behaviors in mentally retarded adultsDavid S Janowsky
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7175, USA
J Clin Psychopharmacol 25:19-25. 2005..3 mg/d and relapse occurred at a mean dose of 93.6 mg/d. The mean lowest effective dose of haloperidol or related high potency drugs (expressed as haloperidol equivalents) was 5.9 mg/d, and relapse occurred at a mean dose of 3.8 mg/d...
Serotonergic antidepressant effects on aggressive, self-injurious and destructive/disruptive behaviours in intellectually disabled adults: a retrospective, open-label, naturalistic trialDavid S Janowsky
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7175, USA
Int J Neuropsychopharmacol 8:37-48. 2005..The results suggest that serotonergic antidepressants are useful in the treatment of challenging/maladaptive behaviours in the intellectually disabled...
Anticholinesterase (DFP) toxicity antagonism by chronic donepezil: a potential nerve agent treatmentDavid S Janowsky
Department of Psychiatry, CB 7175, Medical Research Building A, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7175, USA
Pharmacol Biochem Behav 81:917-22. 2005..Although these phenomena are not the same as lethality, they may be parallel phenomena, and our results may have therapeutic implications for the treatment of nerve agent toxicity...
A comparative evaluation of three self-rating scales for acute maniaE Altman
Psychiatric Institute, University of Illinois at Chicago, 1601 W. Taylor Street, Chicago, IL 60612, USA
Biol Psychiatry 50:468-71. 2001..All three measures were sensitive to treatment effects; however, the item content of the SRMI and the poor sensitivity of the ISS may limit their utility in inpatient settings...
Omega-3 fatty acids: evidence basis for treatment and future research in psychiatryMarlene P Freeman
Women s Mental Health Program, Department of Psychiatry, University of Arizona College of Medicine, Tucson 85724 5002, USA
J Clin Psychiatry 67:1954-67. 2006..To determine if the available data support the use of omega-3 essential fatty acids (EFA) for clinical use in the prevention and/or treatment of psychiatric disorders...
Diagnosis and treatment of depression in patients with mental retardationDavid S Janowsky
Department of Psychiatry, CB 7175, Medical Research Building A, University of North Carolina, Chapel Hill, NC 27599, USA
Curr Psychiatry Rep 7:421-8. 2005..This article reviews numerous studies elaborating on the diagnosis, phenomenology, and treatment of depression in mentally retarded individuals...
Physical health monitoring of patients with schizophreniaStephen R Marder
Department of Veterans Affairs Greater Los Angeles Healthcare System, CA, USA
Am J Psychiatry 161:1334-49. 2004..The authors discuss a consensus panel's recommendations for improving the physical health monitoring of patients with schizophrenia who are treated in outpatient settings...
The Mount Sinai conference on the pharmacotherapy of schizophreniaStephen R Marder
VA Desert Pacific Mental Illness Research Education and Clinical Center, West Los Angeles VA Health Care Center, CA 90073, USA
Schizophr Bull 28:5-16. 2002....
First- and second-generation antipsychotics: learning from CUtLASS and CATIERajiv Tandon
Arch Gen Psychiatry 64:977-8; author reply 979-80. 2007
The choice of drugs for schizophreniaJohn M Davis
N Engl J Med 354:518-20. 2006
All-cause treatment discontinuation in schizophrenia during treatment with olanzapine relative to other antipsychotics: an integrated analysisCharles M Beasley
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
J Clin Psychopharmacol 27:252-8. 2007..This integrated analysis compared the likelihood of discontinuation from olanzapine treatment versus other antipsychotics among patients with schizophrenia...
Is the superior efficacy of new generation antipsychotics an artifact of LOCF?Stefan Leucht
Klinik für Psychiatrie und Psychotherapie der TU München, Klinikum rechts der Isar, Ismaningerstr 22, 81675 Munchen, Germany
Schizophr Bull 33:183-91. 2007..Ultimately, strategies to reduce dropout rates are needed...
Concomitant medications may not improve outcome of antipsychotic monotherapy for stabilized patients with nonacute schizophreniaIra D Glick
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
J Clin Psychiatry 67:1261-5. 2006..To our knowledge, there have been no published reports of prospective systematic investigations of the efficacy of unrestricted CPM use in nonacute schizophrenia...
The costs of drugs for schizophreniaRobert Freedman
Am J Psychiatry 163:2029-31. 2006
Switch or stay?John M Davis
Am J Psychiatry 163:2032-3. 2006
Omega-3 fatty acid supplementation in patients with recurrent self-harm. Single-centre double-blind randomised controlled trialBrian Hallahan
Department of Psychiatry, Beaumont Hospital and The Royal College of Surgeons in Ireland, Ireland
Br J Psychiatry 190:118-22. 2007..Trials have demonstrated benefits of long-chain omega-3 essential fatty acid (n-3 EFA) supplementation in a variety of psychiatric disorders...
Defining 'response' in antipsychotic drug trials: recommendations for the use of scale-derived cutoffsStefan Leucht
Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaningerstrasse 22, 81675 Munich, Germany
Neuropsychopharmacology 32:1903-10. 2007..We suggest a table presenting responder rates in 25 percent steps covering the whole range up to 100% reduction from baseline, which could be displayed together with recently presented criteria for remission...
Clinical features of 39 patients with antibodies to extractable nuclear antigens despite negative antinuclear antibodies: evidence for autoimmunity including neurologic and connective tissue diseasesJohn M Davis
Division of Rheumatology, Department of Medicine, Mayo Clinic College of Medicine and Mayo Clinic, Rochester, Minnesota 55905, USA
Medicine (Baltimore) 84:208-17. 2005..This may represent test bias or false-positive anti-ENA assays or false-negative ANA assays, or may imply immune-related mechanisms not previously described...
Glucocorticoids and cardiovascular and cerebrovascular events in polymyalgia rheumaticaHilal Maradit Kremers
Mayo Clinic, Rochester, Minnesota 55905, USA
Arthritis Rheum 57:279-86. 2007..To examine the effect of glucocorticoid use on the risk of various cardiovascular diseases in patients with polymyalgia rheumatica (PMR)...
Does the gerbil model mimic human iron overload?Lana Kaiser
J Lab Clin Med 141:419-20; author reply 420-2. 2003
Thrombostatin, a bradykinin metabolite, reduces platelet activation in a model of arterial wall injuryAlejandro R Prieto
Department of Internal Medicine, Division of Cardiology, Michigan State University, East Lansing, MI 48824, USA
Cardiovasc Res 53:984-92. 2002..5x (P<0.03) using laser-light scattering and platelet adhesion by 1.8x (P<0.02). CONCLUSION: Thrombostatin or aspirin independently decreases evidence of platelet activation in the canine carotid artery model of BA injury...
Glucocorticoids and cardiovascular events in rheumatoid arthritis: a population-based cohort studyJohn M Davis
Mayo Clinic, Rochester, Minnesota 55905, USA
Arthritis Rheum 56:820-30. 2007..To determine the relationship between glucocorticoid exposure and cardiovascular (CV) events in patients with rheumatoid arthritis (RA)...
Are there problems with the "time compressed model" of iron overload?Lana Kaiser
J Lab Clin Med 143:130-2; author reply 133-4. 2004
Has research informed us on the practical drug treatment of schizophrenia?John M Davis
Schizophr Bull 34:403-5. 2008
Treating schizophrenia with comorbid depressive or demoralization symptomsIra D Glick
J Clin Psychiatry 69:501. 2008
Genetic dissection of fusiform rust and pitch canker disease traits in loblolly pineGogce C Kayihan
School of Forest Resources and Conservation, University of Florida, PO Box 110410, Gainesville, FL 32611, USA
Theor Appl Genet 110:948-58. 2005..The disease phenotyping described here is a critical step towards identifying specific loci and alleles associated with fusiform rust and pitch canker resistance...
