C William Davis

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Regulation of mucin secretion from human bronchial epithelial cells grown in murine hosted xenografts
    Jason D Conway
    Cystic Fibrosis Pulmonary Research and Treatment Center and Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, North Carolina 27599 7248, USA
    Am J Physiol Lung Cell Mol Physiol 284:L945-54. 2003
  2. pmc Coupling of airway ciliary activity and mucin secretion to mechanical stresses by purinergic signaling
    C William Davis
    Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, NC 27599 7248, United States
    Respir Physiol Neurobiol 163:208-13. 2008
  3. ncbi request reprint Regulated airway goblet cell mucin secretion
    C William Davis
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, NC 27599 7248, USA
    Annu Rev Physiol 70:487-512. 2008
  4. pmc Munc13-2-/- baseline secretion defect reveals source of oligomeric mucins in mouse airways
    Yunxiang Zhu
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, NC 27599 7248, USA
    J Physiol 586:1977-92. 2008
  5. ncbi request reprint Barrier role of actin filaments in regulated mucin secretion from airway goblet cells
    Camille Ehre
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina 27599 7248, USA
    Am J Physiol Cell Physiol 288:C46-56. 2005
  6. pmc Coupled nucleotide and mucin hypersecretion from goblet-cell metaplastic human airway epithelium
    Seiko F Okada
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, 27599, USA
    Am J Respir Cell Mol Biol 45:253-60. 2011
  7. ncbi request reprint nPKCepsilon, a P2Y2-R downstream effector in regulated mucin secretion from airway goblet cells
    Camille Ehre
    CCystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina 27599 7248, USA
    Am J Physiol Cell Physiol 293:C1445-54. 2007
  8. ncbi request reprint Regulation of mucin secretion from in vitro cellular models
    C William Davis
    Department of Cell and Molecular Physiology, and Cystic Fibrosis Pulmonary Research and Treatment Center, 6009 Thurston Bowles, University of North Carolina, Chapel Hill, NC 27599 7248, USA
    Novartis Found Symp 248:113-25; discussion 125-31, 277-82. 2002
  9. pmc Human airway ciliary dynamics
    Patrick R Sears
    Cystic Fibrosis Center, University of North Carolina, 6026 Thurston Bowles Bldg, CB7248, Chapel Hill, NC 27599, USA
    Am J Physiol Lung Cell Mol Physiol 304:L170-83. 2013
  10. pmc Mucociliary interactions and mucus dynamics in ciliated human bronchial epithelial cell cultures
    Patrick R Sears
    Cystic Fibrosis Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Physiol Lung Cell Mol Physiol 301:L181-6. 2011

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Regulation of mucin secretion from human bronchial epithelial cells grown in murine hosted xenografts
    Jason D Conway
    Cystic Fibrosis Pulmonary Research and Treatment Center and Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, North Carolina 27599 7248, USA
    Am J Physiol Lung Cell Mol Physiol 284:L945-54. 2003
    ..Hence, human airway goblet cells, like those of other species, appear to be regulated primarily via phospholipase C pathways, activated particularly by apical membrane P2Y(2)-R agonists...
  2. pmc Coupling of airway ciliary activity and mucin secretion to mechanical stresses by purinergic signaling
    C William Davis
    Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, NC 27599 7248, United States
    Respir Physiol Neurobiol 163:208-13. 2008
    ..Of these, ATP, adenosine, UTP, and UDP act as agonists at apical P2Y2 (ATP, UTP), P2Y6 (UDP), and A2B (adenosine) receptors on ciliated and/or goblet cells to regulate mucociliary clearance...
  3. ncbi request reprint Regulated airway goblet cell mucin secretion
    C William Davis
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, NC 27599 7248, USA
    Annu Rev Physiol 70:487-512. 2008
    ..In contrast, synaptotagmin 2, a fast Ca2+ sensor for the SNARE complex, is essential for regulated secretion. Interestingly, these early results suggest that there are two pathways for excocytic mucin release from goblet cells...
  4. pmc Munc13-2-/- baseline secretion defect reveals source of oligomeric mucins in mouse airways
    Yunxiang Zhu
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, NC 27599 7248, USA
    J Physiol 586:1977-92. 2008
    ....
  5. ncbi request reprint Barrier role of actin filaments in regulated mucin secretion from airway goblet cells
    Camille Ehre
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina 27599 7248, USA
    Am J Physiol Cell Physiol 288:C46-56. 2005
    ..We conclude that actin filaments negatively regulate mucin secretion basally in airway goblet cells and are dynamically remodeled in agonist-stimulated cells to promote exocytosis...
  6. pmc Coupled nucleotide and mucin hypersecretion from goblet-cell metaplastic human airway epithelium
    Seiko F Okada
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, 27599, USA
    Am J Respir Cell Mol Biol 45:253-60. 2011
    ....
  7. ncbi request reprint nPKCepsilon, a P2Y2-R downstream effector in regulated mucin secretion from airway goblet cells
    Camille Ehre
    CCystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina 27599 7248, USA
    Am J Physiol Cell Physiol 293:C1445-54. 2007
    ..The translocation of nPKCdelta observed in activated cells is likely not related to mucin secretion but to some other aspect of goblet cell biology...
  8. ncbi request reprint Regulation of mucin secretion from in vitro cellular models
    C William Davis
    Department of Cell and Molecular Physiology, and Cystic Fibrosis Pulmonary Research and Treatment Center, 6009 Thurston Bowles, University of North Carolina, Chapel Hill, NC 27599 7248, USA
    Novartis Found Symp 248:113-25; discussion 125-31, 277-82. 2002
    ....
  9. pmc Human airway ciliary dynamics
    Patrick R Sears
    Cystic Fibrosis Center, University of North Carolina, 6026 Thurston Bowles Bldg, CB7248, Chapel Hill, NC 27599, USA
    Am J Physiol Lung Cell Mol Physiol 304:L170-83. 2013
    ..31(0.04), 0.25(0.06), 0.50(0.12), 0.50(0.10), μm, respectively. In contrast, the same measures for three different PCD waveforms had values far outside this range...
  10. pmc Mucociliary interactions and mucus dynamics in ciliated human bronchial epithelial cell cultures
    Patrick R Sears
    Cystic Fibrosis Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Physiol Lung Cell Mol Physiol 301:L181-6. 2011
    ..The significance of these findings is that aberrant modulation of such an intrinsic property may explain the initiation of highly adherent mucus in cystic fibrosis lung disease...
  11. ncbi request reprint Regulation of airway goblet cell mucin secretion by tyrosine phosphorylation signaling pathways
    Lubna H Abdullah
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Am J Physiol Lung Cell Mol Physiol 293:L591-9. 2007
    ..Hence, PLC signaling may play a key role in regulated mucin secretion, whether the event is initiated by mediators interacting with GPCRs or RYKs...
  12. ncbi request reprint Calcium signaling in human airway goblet cells following purinergic activation
    Andrea H Rossi
    CF Pulmonary Research and Treatment Center, Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, NC 27599 7248, USA
    Am J Physiol Lung Cell Mol Physiol 292:L92-8. 2007
    ..1 +/- 7% of the ATPgammaS control peak), brief rise in Ca(i)(2+). This diminutive signal likely denotes a local Ca(2+) gradient, which may be associated with the mucin granule exocytotic process...
  13. ncbi request reprint Mucin secretion and PKC isoforms in SPOC1 goblet cells: differential activation by purinergic agonist and PMA
    Lubna H Abdullah
    Cystic Fibrosis Pulmonary Treatment and Research Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599 7248, USA
    Am J Physiol Lung Cell Mol Physiol 285:L149-60. 2003
    ..Hence, P2Y2 agonists activate nPKCdelta in SPOC1 cells. PMA activates cPKCalpha and nPKCdelta at high affinity and stimulates a lower affinity PKC-independent pathway that leads to mucin secretion...
  14. pmc Coordinated release of nucleotides and mucin from human airway epithelial Calu-3 cells
    Silvia M Kreda
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, 7017 Thurston Bowles Building, Chapel Hill, NC 27599 7248, USA
    J Physiol 584:245-59. 2007
    ..Our data suggest that nucleotide release is a mechanism by which mucin-secreting goblet cells produce paracrine signals for mucin hydration within the ASL...
  15. ncbi request reprint Mechanosensitivity of mouse tracheal ciliary beat frequency: roles for Ca2+, purinergic signaling, tonicity, and viscosity
    Scot L Winters
    Department of Medicine, Cystic Fibrosis Pulmonary Research and Tteatment Center, University of North Carolina, Chapel Hill, NC 27599 7248, USA
    Am J Physiol Lung Cell Mol Physiol 292:L614-24. 2007
    ....
  16. doi request reprint Studying mucin secretion from human bronchial epithelial cell primary cultures
    Lubna H Abdullah
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, NC, USA
    Methods Mol Biol 842:259-77. 2012
    ..These results indicate that the more nonspecific assays are suitable to assess overall secretory responses by goblet cells, but are likely unsuited for specific measurements of polymeric mucins, per se...
  17. pmc CFTR, mucins, and mucus obstruction in cystic fibrosis
    Silvia M Kreda
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, NC 27517 7248, USA
    Cold Spring Harb Perspect Med 2:a009589. 2012
    ..In any event, the path between CFTR dysfunction and mucus hyperproduction has proven tortuous, and its unraveling continues to offer its own twists and turns, along with fascinating glimpses into biology...
  18. pmc Ca2+ dependency of 'Ca2+-independent' exocytosis in SPOC1 airway goblet cells
    Andrea H Rossi
    6009 Thurston Bowles, University of North Carolina, Chapel Hill, NC 27599 7248, USA
    J Physiol 559:555-65. 2004
    ..PMA-induced secretion in EGTA was insensitive to heparin. These results suggest that Ca2+ is released locally during PMA-induced exocytosis, by an IP3-independent mechanism...
  19. pmc Force generation and dynamics of individual cilia under external loading
    David B Hill
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Biophys J 98:57-66. 2010
    ..By applying a quasistatic force model, we deduce that axoneme stiffness is dominated by the rigidity of the microtubules, and that cilia can exert 62 +/- 18 pN of force at the tip via the generation of 5.6 +/- 1.6 pN/dynein head...
  20. ncbi request reprint Mucins and their O-Glycans from human bronchial epithelial cell cultures
    Jessica M Holmén
    Department of Medical Biochemistry, Göteborgs Universitet, 405 30 Gothenburg, Sweden
    Am J Physiol Lung Cell Mol Physiol 287:L824-34. 2004
    ..We conclude that the differences observed in the mucins sampled directly from patients are most likely due to environmental factors relating to infection and/or inflammation...
  21. ncbi request reprint Airway epithelium, inflammation, and mechanisms of disease: A tribute to Carol B. Basbaum
    Kenneth B Adler
    Am J Respir Cell Mol Biol 34:523-6. 2006

Research Grants9

  1. INTRACELLULAR PATHWAYS MEDIATING AIRWAY MUCIN SECRETION
    C Davis; Fiscal Year: 2003
    ..Lastly, we will exploit the different binding kinetics of BAPTA and EGTRA to test the degree of independence between PKC and Ca2+ in the final steps of exocytosis. ..
  2. Regulation of Airway Goblet Cell Mucin Secretion
    C Davis; Fiscal Year: 2007
    ..abstract_text> ..
  3. Molecular Pathways Regulating Airway Goblet Cell Mucin Secretion
    Burton F Dickey; Fiscal Year: 2010
    ....