Research Topics
Genomes and GenesSpecies | Peter Francis DaviesSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
The convergence of haemodynamics, genomics, and endothelial structure in studies of the focal origin of atherosclerosisPeter F Davies
Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
Biorheology 39:299-306. 2002..Microarrays are a useful and powerful tool for such integration by identifying simultaneous changes in the expression of many genes associated with interconnecting mechanoresponsive cellular pathways...
A spatial approach to transcriptional profiling: mechanotransduction and the focal origin of atherosclerosisP F Davies
Institute for Medicine and Engineering, and the Departments of Pathology and Laboratory Medicine, and Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
Trends Biotechnol 17:347-51. 1999..Improved precision in experimental models of spatially defined flow has recently been combined with regional and single-cell gene-expression profiling to investigate the relationships linking haemodynamics to vessel-wall pathobiology...
Endothelial heterogeneity associated with regional athero-susceptibility and adaptation to disturbed blood flow in vivoPeter F Davies
Institute for Medicine and Engineering, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Semin Thromb Hemost 36:265-75. 2010..The recently identified association of endoplasmic reticulum stress with endothelium in regions of flow disturbance is outlined as an important example of susceptible phenotype linked to proinflammatory and oxidative stress pathways...- Hemodynamic shear stress and the endothelium in cardiovascular pathophysiologyPeter F Davies
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Institute for Medicine and Engineering, 1010 Vagelos Laboratories, 3340 Smith Walk, Philadelphia, PA 19104, USA
Nat Clin Pract Cardiovasc Med 6:16-26. 2009..A single shear stress mechanotransducer is unlikely to exist; rather, mechanotransduction occurs at multiple subcellular locations... - Endothelial transcriptome profiles in vivo in complex arterial flow fieldsPeter Francis Davies
Department of Pathology and Laboratory Medicine, Institute for Medicine and Engineering, University of Pennsylvania, 1010 Vagelos Building, 3340 Smith Walk, Philadelphia, PA 19104, USA
Ann Biomed Eng 36:563-70. 2008..Endothelial phenotype characterization in vivo is complementary to mechanistic studies of flow responses in vitro... - Interdisciplinary BME education: a clinical preceptorship course for undergraduate bioengineering studentsPeter F Davies
Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
Ann Biomed Eng 34:276-81. 2006 - Shear stress biology of the endotheliumPeter F Davies
Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA, 19104, USA
Ann Biomed Eng 33:1714-8. 2005.... - Endoplasmic reticulum stress, redox, and a proinflammatory environment in athero-susceptible endothelium in vivo at sites of complex hemodynamic shear stressPeter F Davies
Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19041, USA
Antioxid Redox Signal 15:1427-32. 2011..The endothelium in such regions is chronically exposed to complex hemodynamic shear stresses that may be considered as a risk factor for atherosclerosis via these mechanisms... - Spatial microstimuli in endothelial mechanosignalingPeter F Davies
Institute for Medicine and Engineering, University of Pennsylvania, 1010 Vagelos Laboratories, 3340 Smith Walk, Philadelphia, PA 19104 USA
Circ Res 92:359-70. 2003..Live cell imaging and computational analyses of structural dynamics, two important approaches to microstimulation at this scale, are briefly reviewed... - Hemodynamics and the focal origin of atherosclerosis: a spatial approach to endothelial structure, gene expression, and functionP F Davies
Institute for Medicine and Engineeering, University of Pennsylvania, Philadelphia 19104, USA
Ann N Y Acad Sci 947:7-16; discussion 16-7. 2001..Length scales ranging from centimeters to nanometers are useful in describing regional, single cell, and intracellular mechanotransduction mechanisms... - Prelesional arterial endothelial phenotypes in hypercholesterolemia: universal ABCA1 upregulation contrasts with region-specific gene expression in vivoMete Civelek
Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
Am J Physiol Heart Circ Physiol 298:H163-70. 2010..Both region-specific and ubiquitous (ABCA1) phenotype changes were identified as early prelesional responses of the endothelium to hypercholesterolemia... - The cytoskeleton under external fluid mechanical forces: hemodynamic forces acting on the endotheliumBrian P Helmke
Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia 19104 6383, USA
Ann Biomed Eng 30:284-96. 2002..These quantitative studies strongly support the decentralized distribution of luminally imposed forces throughout the endothelial cell... - MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitroYun Fang
Institute for Medicine and Engineering, Center for Bioinformatics, and Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 107:13450-5. 2010.... - Chronic endoplasmic reticulum stress activates unfolded protein response in arterial endothelium in regions of susceptibility to atherosclerosisMete Civelek
Institute for Medicine and Engineering, University of Pennsylvania, 1010 Vagelos Laboratories, 3340 Smith Walk, Philadelphia, PA 19104, USA
Circ Res 105:453-61. 2009.... - Spatial heterogeneity of endothelial phenotypes correlates with side-specific vulnerability to calcification in normal porcine aortic valvesCraig A Simmons
Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia PA 19104, USA
Circ Res 96:792-9. 2005..These data implicate the endothelium in regulating valvular calcification and suggest that spatial heterogeneity of valvular endothelial phenotypes may contribute to the focal susceptibility for lesion development... - Hypercholesterolemia induces side-specific phenotypic changes and peroxisome proliferator-activated receptor-gamma pathway activation in swine aortic valve endotheliumMARIE A GUERRATY
Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia 19104, USA
Arterioscler Thromb Vasc Biol 30:225-31. 2010..Transcript profiles indicative of a protective phenotype were induced and persisted on the side prone to aortic valve sclerosis... - Endothelial protein kinase C isoform identity and differential activity of PKCzeta in an athero-susceptible region of porcine aortaRichard Magid
Institute for Medicine and Engineering, Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104 6383, USA
Circ Res 97:443-9. 2005..Steady-state regional heterogeneity of an important family of regulatory proteins in intact arterial endothelium in vivo may link localized athero-susceptibility and the associated hemodynamic environment... - Regional determinants of arterial endothelial phenotype dominate the impact of gender or short-term exposure to a high-fat dietAnthony G Passerini
Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA, USA
Biochem Biophys Res Commun 332:142-8. 2005..The results implicate regional hemodynamics as a predominant epigenetic determinant of endothelial phenotypic heterogeneity underlying atherosusceptibility in vivo... - A rapid, reliable method to isolate high quality endothelial RNA from small spatially-defined locationsCraig A Simmons
Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104 6383, USA
Ann Biomed Eng 32:1453-9. 2004.... - Hemodynamically driven stent strut designJuan M Jiménez
Institute for Medicine and Engineering, University of Pennsylvania, 1010 Vagelos Laboratories, 3340 Smith Walk, Philadelphia, PA 19104 6383, USA
Ann Biomed Eng 37:1483-94. 2009.... - Coexisting proinflammatory and antioxidative endothelial transcription profiles in a disturbed flow region of the adult porcine aortaAnthony G Passerini
Institute for Medicine and Engineering, Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 101:2482-7. 2004..The introduction of additional risk factors may shift this balance to favor lesion development... - Role of lateral cell-cell border location and extracellular/transmembrane domains in PECAM/CD31 mechanosensationDavid A Kaufman
Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, USA
Biochem Biophys Res Commun 320:1076-81. 2004..These findings suggest that mechanosensitive PECAM-1 may lie downstream of a primary mechanosensor that activates a tyrosine kinase... - Hypercholesterolemia suppresses inwardly rectifying K+ channels in aortic endothelium in vitro and in vivoYun Fang
Institute for Medicine and Engineering, Department of Pathology and Laboratory Medicine, University of Pennsylvania, USA
Circ Res 98:1064-71. 2006..Therefore, we suggest that suppression of Kir current is one of the important factors in hypercholesterolemia-induced endothelial dysfunction... - Dual effect of fluid shear stress on volume-regulated anion current in bovine aortic endothelial cellsVictor G Romanenko
Institute for Medicine and Engineering, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Am J Physiol Cell Physiol 282:C708-18. 2002..Our findings suggest that shear stress is an important factor in regulating the ability of vascular endothelial cells to maintain volume homeostasis... - SM22beta encodes a lineage-restricted cytoskeletal protein with a unique developmentally regulated pattern of expressionJanet C L Zhang
Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
Mech Dev 115:161-6. 2002..Taken together, these data demonstrate that SM22beta is a novel actin-associated protein with a unique cell lineage-restricted pattern of expression... - Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2Yun Fang
Institute for Medicine and Engineering, University of Pennsylvania, 1160 Vagelos Research Labs, 3340 Smith Walk, Philadelphia, PA 19104, USA
Am J Physiol Cell Physiol 289:C1134-44. 2005..3 or dnKir2.4. These studies suggest that Kir2.2 and Kir2.1 are primary determinants of endogenous K(+) conductance in HAECs under resting conditions and that Kir2.2 provides the dominant conductance in these cells... - Loss of PECAM-1 function impairs alveolarizationHorace M DeLisser
Pulmonary, Allergy and Critical Care Division, Department of Medicine, Institute for Medicine and Engineering, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
J Biol Chem 281:8724-31. 2006..These data suggest that the loss of PECAM-1 function compromises postnatal lung development and provide evidence that inhibition of EC function, in contrast to a loss of viable EC, inhibits alveolarization...
Research Grants
- MOLECULAR MECHANISMS CELL COMMUNICATIONS/ATHEROGENESISPeter Davies; Fiscal Year: 2002..These studies will address a poorly understood mechanism of vascular cell communication at the tissue, cell and molecular level as a function of atherogenesis. ..
- Cell and molecular studies in cardiovascular engineeringPeter Davies; Fiscal Year: 2005....
- Multidisciplinary training in cardiovascular biologyPeter Davies; Fiscal Year: 2007..Women (6 trainees; 13 of 42 papers) and Minority (1 trainee; 9 of 42 publications) representation is strongly addressed. Novel strategies to attract new minority trainees have been implemented. (END OF ABSTRACT) ..