Peter Francis Davies

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc The convergence of haemodynamics, genomics, and endothelial structure in studies of the focal origin of atherosclerosis
    Peter F Davies
    Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Biorheology 39:299-306. 2002
  2. ncbi request reprint A spatial approach to transcriptional profiling: mechanotransduction and the focal origin of atherosclerosis
    P F Davies
    Institute for Medicine and Engineering, and the Departments of Pathology and Laboratory Medicine, and Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Trends Biotechnol 17:347-51. 1999
  3. pmc Endothelial heterogeneity associated with regional athero-susceptibility and adaptation to disturbed blood flow in vivo
    Peter F Davies
    Institute for Medicine and Engineering, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Semin Thromb Hemost 36:265-75. 2010
  4. pmc Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology
    Peter F Davies
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Institute for Medicine and Engineering, 1010 Vagelos Laboratories, 3340 Smith Walk, Philadelphia, PA 19104, USA
    Nat Clin Pract Cardiovasc Med 6:16-26. 2009
  5. ncbi request reprint Endothelial transcriptome profiles in vivo in complex arterial flow fields
    Peter Francis Davies
    Department of Pathology and Laboratory Medicine, Institute for Medicine and Engineering, University of Pennsylvania, 1010 Vagelos Building, 3340 Smith Walk, Philadelphia, PA 19104, USA
    Ann Biomed Eng 36:563-70. 2008
  6. ncbi request reprint Interdisciplinary BME education: a clinical preceptorship course for undergraduate bioengineering students
    Peter F Davies
    Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Biomed Eng 34:276-81. 2006
  7. ncbi request reprint Shear stress biology of the endothelium
    Peter F Davies
    Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA, 19104, USA
    Ann Biomed Eng 33:1714-8. 2005
  8. pmc Endoplasmic reticulum stress, redox, and a proinflammatory environment in athero-susceptible endothelium in vivo at sites of complex hemodynamic shear stress
    Peter F Davies
    Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19041, USA
    Antioxid Redox Signal 15:1427-32. 2011
  9. ncbi request reprint Spatial microstimuli in endothelial mechanosignaling
    Peter F Davies
    Institute for Medicine and Engineering, University of Pennsylvania, 1010 Vagelos Laboratories, 3340 Smith Walk, Philadelphia, PA 19104 USA
    Circ Res 92:359-70. 2003
  10. ncbi request reprint Hemodynamics and the focal origin of atherosclerosis: a spatial approach to endothelial structure, gene expression, and function
    P F Davies
    Institute for Medicine and Engineeering, University of Pennsylvania, Philadelphia 19104, USA
    Ann N Y Acad Sci 947:7-16; discussion 16-7. 2001

Research Grants

Collaborators

Detail Information

Publications27

  1. pmc The convergence of haemodynamics, genomics, and endothelial structure in studies of the focal origin of atherosclerosis
    Peter F Davies
    Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Biorheology 39:299-306. 2002
    ..Microarrays are a useful and powerful tool for such integration by identifying simultaneous changes in the expression of many genes associated with interconnecting mechanoresponsive cellular pathways...
  2. ncbi request reprint A spatial approach to transcriptional profiling: mechanotransduction and the focal origin of atherosclerosis
    P F Davies
    Institute for Medicine and Engineering, and the Departments of Pathology and Laboratory Medicine, and Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Trends Biotechnol 17:347-51. 1999
    ..Improved precision in experimental models of spatially defined flow has recently been combined with regional and single-cell gene-expression profiling to investigate the relationships linking haemodynamics to vessel-wall pathobiology...
  3. pmc Endothelial heterogeneity associated with regional athero-susceptibility and adaptation to disturbed blood flow in vivo
    Peter F Davies
    Institute for Medicine and Engineering, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Semin Thromb Hemost 36:265-75. 2010
    ..The recently identified association of endoplasmic reticulum stress with endothelium in regions of flow disturbance is outlined as an important example of susceptible phenotype linked to proinflammatory and oxidative stress pathways...
  4. pmc Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology
    Peter F Davies
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Institute for Medicine and Engineering, 1010 Vagelos Laboratories, 3340 Smith Walk, Philadelphia, PA 19104, USA
    Nat Clin Pract Cardiovasc Med 6:16-26. 2009
    ..A single shear stress mechanotransducer is unlikely to exist; rather, mechanotransduction occurs at multiple subcellular locations...
  5. ncbi request reprint Endothelial transcriptome profiles in vivo in complex arterial flow fields
    Peter Francis Davies
    Department of Pathology and Laboratory Medicine, Institute for Medicine and Engineering, University of Pennsylvania, 1010 Vagelos Building, 3340 Smith Walk, Philadelphia, PA 19104, USA
    Ann Biomed Eng 36:563-70. 2008
    ..Endothelial phenotype characterization in vivo is complementary to mechanistic studies of flow responses in vitro...
  6. ncbi request reprint Interdisciplinary BME education: a clinical preceptorship course for undergraduate bioengineering students
    Peter F Davies
    Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Biomed Eng 34:276-81. 2006
  7. ncbi request reprint Shear stress biology of the endothelium
    Peter F Davies
    Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA, 19104, USA
    Ann Biomed Eng 33:1714-8. 2005
    ....
  8. pmc Endoplasmic reticulum stress, redox, and a proinflammatory environment in athero-susceptible endothelium in vivo at sites of complex hemodynamic shear stress
    Peter F Davies
    Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19041, USA
    Antioxid Redox Signal 15:1427-32. 2011
    ..The endothelium in such regions is chronically exposed to complex hemodynamic shear stresses that may be considered as a risk factor for atherosclerosis via these mechanisms...
  9. ncbi request reprint Spatial microstimuli in endothelial mechanosignaling
    Peter F Davies
    Institute for Medicine and Engineering, University of Pennsylvania, 1010 Vagelos Laboratories, 3340 Smith Walk, Philadelphia, PA 19104 USA
    Circ Res 92:359-70. 2003
    ..Live cell imaging and computational analyses of structural dynamics, two important approaches to microstimulation at this scale, are briefly reviewed...
  10. ncbi request reprint Hemodynamics and the focal origin of atherosclerosis: a spatial approach to endothelial structure, gene expression, and function
    P F Davies
    Institute for Medicine and Engineeering, University of Pennsylvania, Philadelphia 19104, USA
    Ann N Y Acad Sci 947:7-16; discussion 16-7. 2001
    ..Length scales ranging from centimeters to nanometers are useful in describing regional, single cell, and intracellular mechanotransduction mechanisms...
  11. pmc Prelesional arterial endothelial phenotypes in hypercholesterolemia: universal ABCA1 upregulation contrasts with region-specific gene expression in vivo
    Mete Civelek
    Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Physiol Heart Circ Physiol 298:H163-70. 2010
    ..Both region-specific and ubiquitous (ABCA1) phenotype changes were identified as early prelesional responses of the endothelium to hypercholesterolemia...
  12. ncbi request reprint The cytoskeleton under external fluid mechanical forces: hemodynamic forces acting on the endothelium
    Brian P Helmke
    Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia 19104 6383, USA
    Ann Biomed Eng 30:284-96. 2002
    ..These quantitative studies strongly support the decentralized distribution of luminally imposed forces throughout the endothelial cell...
  13. pmc MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro
    Yun Fang
    Institute for Medicine and Engineering, Center for Bioinformatics, and Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:13450-5. 2010
    ....
  14. pmc Chronic endoplasmic reticulum stress activates unfolded protein response in arterial endothelium in regions of susceptibility to atherosclerosis
    Mete Civelek
    Institute for Medicine and Engineering, University of Pennsylvania, 1010 Vagelos Laboratories, 3340 Smith Walk, Philadelphia, PA 19104, USA
    Circ Res 105:453-61. 2009
    ....
  15. pmc Spatial heterogeneity of endothelial phenotypes correlates with side-specific vulnerability to calcification in normal porcine aortic valves
    Craig A Simmons
    Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia PA 19104, USA
    Circ Res 96:792-9. 2005
    ..These data implicate the endothelium in regulating valvular calcification and suggest that spatial heterogeneity of valvular endothelial phenotypes may contribute to the focal susceptibility for lesion development...
  16. pmc Hypercholesterolemia induces side-specific phenotypic changes and peroxisome proliferator-activated receptor-gamma pathway activation in swine aortic valve endothelium
    MARIE A GUERRATY
    Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia 19104, USA
    Arterioscler Thromb Vasc Biol 30:225-31. 2010
    ..Side-specific global gene expression can address endothelial phenotype balance in early aortic valve sclerosis...
  17. pmc Endothelial protein kinase C isoform identity and differential activity of PKCzeta in an athero-susceptible region of porcine aorta
    Richard Magid
    Institute for Medicine and Engineering, Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104 6383, USA
    Circ Res 97:443-9. 2005
    ..Steady-state regional heterogeneity of an important family of regulatory proteins in intact arterial endothelium in vivo may link localized athero-susceptibility and the associated hemodynamic environment...
  18. ncbi request reprint Regional determinants of arterial endothelial phenotype dominate the impact of gender or short-term exposure to a high-fat diet
    Anthony G Passerini
    Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA, USA
    Biochem Biophys Res Commun 332:142-8. 2005
    ..The results implicate regional hemodynamics as a predominant epigenetic determinant of endothelial phenotypic heterogeneity underlying atherosusceptibility in vivo...
  19. ncbi request reprint A rapid, reliable method to isolate high quality endothelial RNA from small spatially-defined locations
    Craig A Simmons
    Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104 6383, USA
    Ann Biomed Eng 32:1453-9. 2004
    ....
  20. pmc Hemodynamically driven stent strut design
    Juan M Jiménez
    Institute for Medicine and Engineering, University of Pennsylvania, 1010 Vagelos Laboratories, 3340 Smith Walk, Philadelphia, PA 19104 6383, USA
    Ann Biomed Eng 37:1483-94. 2009
    ....
  21. pmc Coexisting proinflammatory and antioxidative endothelial transcription profiles in a disturbed flow region of the adult porcine aorta
    Anthony G Passerini
    Institute for Medicine and Engineering, Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 101:2482-7. 2004
    ..The introduction of additional risk factors may shift this balance to favor lesion development...
  22. ncbi request reprint Role of lateral cell-cell border location and extracellular/transmembrane domains in PECAM/CD31 mechanosensation
    David A Kaufman
    Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, USA
    Biochem Biophys Res Commun 320:1076-81. 2004
    ..These findings suggest that mechanosensitive PECAM-1 may lie downstream of a primary mechanosensor that activates a tyrosine kinase...
  23. ncbi request reprint Hypercholesterolemia suppresses inwardly rectifying K+ channels in aortic endothelium in vitro and in vivo
    Yun Fang
    Institute for Medicine and Engineering, Department of Pathology and Laboratory Medicine, University of Pennsylvania, USA
    Circ Res 98:1064-71. 2006
    ..Therefore, we suggest that suppression of Kir current is one of the important factors in hypercholesterolemia-induced endothelial dysfunction...
  24. ncbi request reprint Dual effect of fluid shear stress on volume-regulated anion current in bovine aortic endothelial cells
    Victor G Romanenko
    Institute for Medicine and Engineering, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Physiol Cell Physiol 282:C708-18. 2002
    ..Our findings suggest that shear stress is an important factor in regulating the ability of vascular endothelial cells to maintain volume homeostasis...
  25. ncbi request reprint SM22beta encodes a lineage-restricted cytoskeletal protein with a unique developmentally regulated pattern of expression
    Janet C L Zhang
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Mech Dev 115:161-6. 2002
    ..Taken together, these data demonstrate that SM22beta is a novel actin-associated protein with a unique cell lineage-restricted pattern of expression...
  26. ncbi request reprint Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2
    Yun Fang
    Institute for Medicine and Engineering, University of Pennsylvania, 1160 Vagelos Research Labs, 3340 Smith Walk, Philadelphia, PA 19104, USA
    Am J Physiol Cell Physiol 289:C1134-44. 2005
    ..3 or dnKir2.4. These studies suggest that Kir2.2 and Kir2.1 are primary determinants of endogenous K(+) conductance in HAECs under resting conditions and that Kir2.2 provides the dominant conductance in these cells...
  27. ncbi request reprint Loss of PECAM-1 function impairs alveolarization
    Horace M DeLisser
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, Institute for Medicine and Engineering, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    J Biol Chem 281:8724-31. 2006
    ..These data suggest that the loss of PECAM-1 function compromises postnatal lung development and provide evidence that inhibition of EC function, in contrast to a loss of viable EC, inhibits alveolarization...

Research Grants9

  1. MOLECULAR MECHANISMS CELL COMMUNICATIONS/ATHEROGENESIS
    Peter Davies; Fiscal Year: 2002
    ..These studies will address a poorly understood mechanism of vascular cell communication at the tissue, cell and molecular level as a function of atherogenesis. ..
  2. Cell and molecular studies in cardiovascular engineering
    Peter Davies; Fiscal Year: 2005
    ....
  3. Multidisciplinary training in cardiovascular biology
    Peter Davies; Fiscal Year: 2007
    ..Women (6 trainees; 13 of 42 papers) and Minority (1 trainee; 9 of 42 publications) representation is strongly addressed. Novel strategies to attract new minority trainees have been implemented. (END OF ABSTRACT) ..