KELVIN J DAVIES

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint The broad spectrum of responses to oxidants in proliferating cells: a new paradigm for oxidative stress
    K J Davies
    Ethel Percy Andrus Gerontology Center and Division of Molecular Biology, University of Southern California, Los Angeles 90089 0191, USA
    IUBMB Life 48:41-7. 1999
  2. ncbi request reprint Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin
    Kelvin J A Davies
    Ethel Percy Andrus Gerontology Center, and Division of Molecular and Computational Biology, The University of Southern California, Los Angeles, CA 90089 0191, USA
    FASEB J 21:3023-8. 2007
  3. ncbi request reprint RCAN1 (DSCR1 or Adapt78) stimulates expression of GSK-3beta
    Gennady Ermak
    Ethel Percy Andrus Gerontology Center, The University of Southern California, Los Angeles, CA 90089 0191, USA
    FEBS J 273:2100-9. 2006
  4. ncbi request reprint Preferential degradation of oxidized proteins by the 20S proteasome may be inhibited in aging and in inflammatory neuromuscular diseases
    Kelvin J A Davies
    The Ethel Percy Andrus Gerontology Center, Division of Molecular and Computational Biology, University of Southern California, Los Angeles, CA, USA
    Neurology 66:S93-6. 2006
  5. ncbi request reprint Gene expression in Alzheimer's disease
    Gennady Ermak
    Ethel Percy Andrus Gerontology Center and Division of Molecular and Computational Biology, The University of Southern California, Los Angeles 90089 0191, USA
    Drugs Today (Barc) 38:509-16. 2002
  6. ncbi request reprint Oxidative stress, antioxidant defenses, and damage removal, repair, and replacement systems
    K J Davies
    Ethel Percy Andrus Gerontology Center and Division of Molecular Biology, The University of Southern California, Los Angeles 90089 0191, USA
    IUBMB Life 50:279-89. 2000
  7. ncbi request reprint Protein oxidation and 20S proteasome-dependent proteolysis in mammalian cells
    R Shringarpure
    Ethel Percy Andrus Gerontology Center and Division of Molecular Biology, University of Southern California, Los Angeles 90089-0191, USA
    Cell Mol Life Sci 58:1442-50. 2001
  8. ncbi request reprint Degradation of oxidized proteins by the 20S proteasome
    K J Davies
    Ethel Percy Andrus Gerontology Center, and Division of Molecular Biology, University of Southern California, Los Angeles 90089 0191, USA
    Biochimie 83:301-10. 2001
  9. ncbi request reprint Mitochondrial free radical generation, oxidative stress, and aging
    E Cadenas
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy University of Southern California, Los Angeles 90033, USA
    Free Radic Biol Med 29:222-30. 2000
  10. ncbi request reprint Glutathiolation of the proteasome is enhanced by proteolytic inhibitors
    M Demasi
    Ethel Percy Andrus Gerontology Center, Division of Molecular Biology, University of Southern California, 3715 McClintock Avenue, Room 306, Los Angeles, California 90089-0191, USA
    Arch Biochem Biophys 389:254-63. 2001

Research Grants

Detail Information

Publications12

  1. ncbi request reprint The broad spectrum of responses to oxidants in proliferating cells: a new paradigm for oxidative stress
    K J Davies
    Ethel Percy Andrus Gerontology Center and Division of Molecular Biology, University of Southern California, Los Angeles 90089 0191, USA
    IUBMB Life 48:41-7. 1999
    ..This broad spectrum of cellular responses to oxidant stress, depending on the amount of oxidant applied and the concentration of oxygen in the cell culture system, provides for a new paradigm of cellular oxidative stress responses...
  2. ncbi request reprint Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin
    Kelvin J A Davies
    Ethel Percy Andrus Gerontology Center, and Division of Molecular and Computational Biology, The University of Southern California, Los Angeles, CA 90089 0191, USA
    FASEB J 21:3023-8. 2007
  3. ncbi request reprint RCAN1 (DSCR1 or Adapt78) stimulates expression of GSK-3beta
    Gennady Ermak
    Ethel Percy Andrus Gerontology Center, The University of Southern California, Los Angeles, CA 90089 0191, USA
    FEBS J 273:2100-9. 2006
    ..Here we propose a new model (incorporating all these findings) in which cells maintain an equilibrium between RCAN1s, calcineurin, and GSK-3beta...
  4. ncbi request reprint Preferential degradation of oxidized proteins by the 20S proteasome may be inhibited in aging and in inflammatory neuromuscular diseases
    Kelvin J A Davies
    The Ethel Percy Andrus Gerontology Center, Division of Molecular and Computational Biology, University of Southern California, Los Angeles, CA, USA
    Neurology 66:S93-6. 2006
    ....
  5. ncbi request reprint Gene expression in Alzheimer's disease
    Gennady Ermak
    Ethel Percy Andrus Gerontology Center and Division of Molecular and Computational Biology, The University of Southern California, Los Angeles 90089 0191, USA
    Drugs Today (Barc) 38:509-16. 2002
    ..Chronic downregulation of calcineurin can lead to gradual accumulation of hyperphosphorylated tau, the formation of paired helical filaments and Alzheimer's disease-like cytoskeletal changes...
  6. ncbi request reprint Oxidative stress, antioxidant defenses, and damage removal, repair, and replacement systems
    K J Davies
    Ethel Percy Andrus Gerontology Center and Division of Molecular Biology, The University of Southern California, Los Angeles 90089 0191, USA
    IUBMB Life 50:279-89. 2000
    ..This remarkable array of systems for defense; damage removal, replacement, and repair; adaptation; growth modulation; and apoptosis make it possible for us to enjoy life in an oxygen-rich environment...
  7. ncbi request reprint Protein oxidation and 20S proteasome-dependent proteolysis in mammalian cells
    R Shringarpure
    Ethel Percy Andrus Gerontology Center and Division of Molecular Biology, University of Southern California, Los Angeles 90089-0191, USA
    Cell Mol Life Sci 58:1442-50. 2001
    ..Interestingly, it appears that the 20S 'core' proteasome conducts the recognition and elimination of oxidized proteins in an ATP-independent and ubiquitin-independent pathway...
  8. ncbi request reprint Degradation of oxidized proteins by the 20S proteasome
    K J Davies
    Ethel Percy Andrus Gerontology Center, and Division of Molecular Biology, University of Southern California, Los Angeles 90089 0191, USA
    Biochimie 83:301-10. 2001
    ..Since these products of severe oxidative stress inhibit the 20S proteasome, they cause a vicious cycle of progressively worsening accumulation of cytotoxic protein oxidation products...
  9. ncbi request reprint Mitochondrial free radical generation, oxidative stress, and aging
    E Cadenas
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy University of Southern California, Los Angeles 90033, USA
    Free Radic Biol Med 29:222-30. 2000
    ..The possible contributions of mitochondrial oxidative polynucleotide and protein turnover to apoptosis and aging are explored...
  10. ncbi request reprint Glutathiolation of the proteasome is enhanced by proteolytic inhibitors
    M Demasi
    Ethel Percy Andrus Gerontology Center, Division of Molecular Biology, University of Southern California, 3715 McClintock Avenue, Room 306, Los Angeles, California 90089-0191, USA
    Arch Biochem Biophys 389:254-63. 2001
    ..Third, proteasome glutathiolation seems to be a previously unknown mechanism of proteasome regulation in vivo...
  11. pmc Impairment of lon-induced protection against the accumulation of oxidized proteins in senescent wi-38 fibroblasts
    Jenny K Ngo
    Ethel Percy Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089 0191, USA
    J Gerontol A Biol Sci Med Sci 66:1178-85. 2011
    ..These senescent changes are similar to the effects of Lon silencing in young cells. We suggest that loss of Lon stress inducibility is part of a pattern of diminishing stress adaptability that predisposes cells to senescence...
  12. doi request reprint Do RCAN1 proteins link chronic stress with neurodegeneration?
    Gennady Ermak
    Ethel Percy Andrus Gerontology Center, Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA 90089 0191, USA
    FASEB J 25:3306-11. 2011
    ..Both inhibition of calcineurin and induction of GSK-3β contribute to accumulation of phosphorylated tau, formation of neurofibrillary tangles, and eventual neurodegeneration...

Research Grants23

  1. ADAPT 78 IN OXIDANT STRESS, AGING AND NEURODEGENERATION
    Kelvin Davies; Fiscal Year: 2004
    ..abstract_text> ..
  2. OXYGEN RADICAL TOXICITY AND PROTEIN DEGRADATION
    Kelvin Davies; Fiscal Year: 2005
    ..Antibody inhibition and immunoprecipitation of I 9S and 1lS regulators will be studied in cell extracts and with purified 26S and 'immunoproteasomes. ..
  3. OXYGEN RADICAL TOXICITY AND PROTEIN DEGRADATION
    Kelvin Davies; Fiscal Year: 2009
    ..Our studies will contribute to public health through improved understanding of mechanisms of toxicity, especially acute exposure versus chronic or repeated insults. ..
  4. OXYGEN RADICAL TOXICITY AND PROTEIN DEGRADATION
    Kelvin J A Davies; Fiscal Year: 2010
    ..Our studies will contribute to public health through improved understanding of mechanisms of toxicity, especially acute exposure versus chronic or repeated insults. ..
  5. OXYGEN RADICAL TOXICITY AND PROTEIN DEGRADATION
    Kelvin Davies; Fiscal Year: 1999
    ..Since degraded proteins must be replaced following oxidative stress we will perform Western, Northern, and nuclear run-on studies of transcription and translation during recovery from H2O2 exposure. ..
  6. OXYGEN RADICAL TOXICITY AND RED CELL PROTEIN DEGRADATION
    Kelvin Davies; Fiscal Year: 1990
    ....
  7. OXYGEN RADICAL TOXICITY AND PROTEIN DEGRADATION
    Kelvin Davies; Fiscal Year: 2009
    ..Our studies will contribute to public health through improved understanding of mechanisms of toxicity, especially acute exposure versus chronic or repeated insults. ..