DARYL DAVIES

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. Huynh N, Arabian N, Lieu D, Asatryan L, Davies D. Utilizing an Orally Dissolving Strip for Pharmacological and Toxicological Studies: A Simple and Humane Alternative to Oral Gavage for Animals. J Vis Exp. 2016;:e53770 pubmed publisher
    ..Herein, we demonstrate that preclinical, oral drug delivery using the ODS method represents a safe, convenient, and humane alternative to oral gavage. ..
  2. Huynh N, Arabian N, Naito A, Louie S, Jakowec M, Asatryan L, et al. Preclinical development of moxidectin as a novel therapeutic for alcohol use disorder. Neuropharmacology. 2017;113:60-70 pubmed publisher
    ..Overall, the results illustrate the potential for development of MOX as a novel pharmacotherapy for the treatment of AUD. ..
  3. Khoja S, Huynh N, Asatryan L, Jakowec M, Davies D. Reduced expression of purinergic P2X4 receptors increases voluntary ethanol intake in C57BL/6J mice. Alcohol. 2017;68:63-70 pubmed publisher
    ..Collectively, the findings support the hypothesis that P2X4Rs play a role in regulation of ethanol intake and that P2X4Rs represent a novel drug target for treatment of alcohol use disorder. ..
  4. request reprint
    Davies D, Trudell J, Mihic S, Crawford D, Alkana R. Ethanol potentiation of glycine receptors expressed in Xenopus oocytes antagonized by increased atmospheric pressure. Alcohol Clin Exp Res. 2003;27:743-55 pubmed
    ..The findings also support the hypothesis that ethanol potentiation of GlyR function plays a role in mediating the sedative-hypnotic effects of ethanol. ..
  5. request reprint
    Davies D, Crawford D, Trudell J, Mihic S, Alkana R. Multiple sites of ethanol action in alpha1 and alpha2 glycine receptors suggested by sensitivity to pressure antagonism. J Neurochem. 2004;89:1175-85 pubmed
    ..Parallel studies with butanol support this conclusion. The mutant alpha1(A52S) GlyR findings suggest that increased attention should be focused on the amino terminus as a potential target for ethanol action. ..
  6. Khoja S, Shah V, Garcia D, Asatryan L, Jakowec M, Davies D. Role of purinergic P2X4 receptors in regulating striatal dopamine homeostasis and dependent behaviors. J Neurochem. 2016;139:134-48 pubmed publisher
    ..Ivermectin (IVM), a positive modulator of P2X4Rs, enhanced levodopa (L-DOPA)-induced motor behavior. These studies highlight potential interactions between P2X4Rs and DA system. ..

Detail Information

Publications6

  1. Huynh N, Arabian N, Lieu D, Asatryan L, Davies D. Utilizing an Orally Dissolving Strip for Pharmacological and Toxicological Studies: A Simple and Humane Alternative to Oral Gavage for Animals. J Vis Exp. 2016;:e53770 pubmed publisher
    ..Herein, we demonstrate that preclinical, oral drug delivery using the ODS method represents a safe, convenient, and humane alternative to oral gavage. ..
  2. Huynh N, Arabian N, Naito A, Louie S, Jakowec M, Asatryan L, et al. Preclinical development of moxidectin as a novel therapeutic for alcohol use disorder. Neuropharmacology. 2017;113:60-70 pubmed publisher
    ..Overall, the results illustrate the potential for development of MOX as a novel pharmacotherapy for the treatment of AUD. ..
  3. Khoja S, Huynh N, Asatryan L, Jakowec M, Davies D. Reduced expression of purinergic P2X4 receptors increases voluntary ethanol intake in C57BL/6J mice. Alcohol. 2017;68:63-70 pubmed publisher
    ..Collectively, the findings support the hypothesis that P2X4Rs play a role in regulation of ethanol intake and that P2X4Rs represent a novel drug target for treatment of alcohol use disorder. ..
  4. request reprint
    Davies D, Trudell J, Mihic S, Crawford D, Alkana R. Ethanol potentiation of glycine receptors expressed in Xenopus oocytes antagonized by increased atmospheric pressure. Alcohol Clin Exp Res. 2003;27:743-55 pubmed
    ..The findings also support the hypothesis that ethanol potentiation of GlyR function plays a role in mediating the sedative-hypnotic effects of ethanol. ..
  5. request reprint
    Davies D, Crawford D, Trudell J, Mihic S, Alkana R. Multiple sites of ethanol action in alpha1 and alpha2 glycine receptors suggested by sensitivity to pressure antagonism. J Neurochem. 2004;89:1175-85 pubmed
    ..Parallel studies with butanol support this conclusion. The mutant alpha1(A52S) GlyR findings suggest that increased attention should be focused on the amino terminus as a potential target for ethanol action. ..
  6. Khoja S, Shah V, Garcia D, Asatryan L, Jakowec M, Davies D. Role of purinergic P2X4 receptors in regulating striatal dopamine homeostasis and dependent behaviors. J Neurochem. 2016;139:134-48 pubmed publisher
    ..Ivermectin (IVM), a positive modulator of P2X4Rs, enhanced levodopa (L-DOPA)-induced motor behavior. These studies highlight potential interactions between P2X4Rs and DA system. ..