DARYL DAVIES

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. pmc Recent advances in the discovery and preclinical testing of novel compounds for the prevention and/or treatment of alcohol use disorders
    Daryl L Davies
    School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA
    Alcohol Clin Exp Res 37:8-15. 2013
  2. pmc Charge and geometry of residues in the loop 2 β hairpin differentially affect agonist and ethanol sensitivity in glycine receptors
    Daya I Perkins
    Alcohol and Brain Research Laboratories, Departments of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA, USA
    J Pharmacol Exp Ther 341:543-51. 2012
  3. ncbi request reprint Benzodiazepine agonist and inverse agonist coupling in GABAA receptors antagonized by increased atmospheric pressure
    Daryl L Davies
    Alcohol and Brain Research Laboratory, Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, USA
    Eur J Pharmacol 469:37-45. 2003
  4. ncbi request reprint Multiple sites of ethanol action in alpha1 and alpha2 glycine receptors suggested by sensitivity to pressure antagonism
    Daryl L Davies
    Alcohol and Brain Research Laboratory, Department of Molecular Pharmacology and Toxicology, University of Southern California School of Pharmacy, 1985 Zonal Avenue, Los Angeles, CA 90013, USA
    J Neurochem 89:1175-85. 2004
  5. ncbi request reprint Ethanol potentiation of glycine receptors expressed in Xenopus oocytes antagonized by increased atmospheric pressure
    Daryl L Davies
    Alcohol and Brain Research Laboratory, Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA
    Alcohol Clin Exp Res 27:743-55. 2003
  6. ncbi request reprint Ethanol differentially affects ATP-gated P2X(3) and P2X(4) receptor subtypes expressed in Xenopus oocytes
    Daryl L Davies
    Department of Molecular Pharmacology Toxicology, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, USA
    Neuropharmacology 49:243-53. 2005
  7. ncbi request reprint Biophysical evidence for His57 as a proton-binding site in the mammalian intestinal transporter hPepT1
    Tomomi Uchiyama
    Department of Pharmaceutical Sciences, University of Southern California, 1985 Zonal Ave, Los Angeles, CA 90089 9121, USA
    Pharm Res 20:1911-6. 2003
  8. pmc Roles for loop 2 residues of alpha1 glycine receptors in agonist activation
    Daniel K Crawford
    Alcohol and Brain Research Laboratory, Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 283:27698-706. 2008
  9. pmc Mutagenesis and cysteine scanning of transmembrane domain 10 of the human dipeptide transporter
    Liya Xu
    Alcohol and Brain Research Laboratory, Titus Family Department of Clinical Pharmacy and Pharmaceutical Economics and Policy, School of Pharmacy, University of Southern California, Los Angeles, California 90033, USA
    Pharm Res 26:2358-66. 2009
  10. ncbi request reprint Evidence that ethanol acts on a target in Loop 2 of the extracellular domain of alpha1 glycine receptors
    Daniel K Crawford
    Alcohol and Brain Research Laboratory, Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90089, USA
    J Neurochem 102:2097-109. 2007

Research Grants

Collaborators

Detail Information

Publications24

  1. pmc Recent advances in the discovery and preclinical testing of novel compounds for the prevention and/or treatment of alcohol use disorders
    Daryl L Davies
    School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA
    Alcohol Clin Exp Res 37:8-15. 2013
    ..This mini-review highlights recent findings from 4 laboratories with a focus on compounds that have the potential to be novel therapeutic agents that can be developed for the prevention and/or treatment of AUDs...
  2. pmc Charge and geometry of residues in the loop 2 β hairpin differentially affect agonist and ethanol sensitivity in glycine receptors
    Daya I Perkins
    Alcohol and Brain Research Laboratories, Departments of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA, USA
    J Pharmacol Exp Ther 341:543-51. 2012
    ..This knowledge will help to define the key physical-chemical parameters that cause the actions of ethanol in GlyRs...
  3. ncbi request reprint Benzodiazepine agonist and inverse agonist coupling in GABAA receptors antagonized by increased atmospheric pressure
    Daryl L Davies
    Alcohol and Brain Research Laboratory, Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, USA
    Eur J Pharmacol 469:37-45. 2003
    ....
  4. ncbi request reprint Multiple sites of ethanol action in alpha1 and alpha2 glycine receptors suggested by sensitivity to pressure antagonism
    Daryl L Davies
    Alcohol and Brain Research Laboratory, Department of Molecular Pharmacology and Toxicology, University of Southern California School of Pharmacy, 1985 Zonal Avenue, Los Angeles, CA 90013, USA
    J Neurochem 89:1175-85. 2004
    ..Parallel studies with butanol support this conclusion. The mutant alpha1(A52S) GlyR findings suggest that increased attention should be focused on the amino terminus as a potential target for ethanol action...
  5. ncbi request reprint Ethanol potentiation of glycine receptors expressed in Xenopus oocytes antagonized by increased atmospheric pressure
    Daryl L Davies
    Alcohol and Brain Research Laboratory, Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA
    Alcohol Clin Exp Res 27:743-55. 2003
    ....
  6. ncbi request reprint Ethanol differentially affects ATP-gated P2X(3) and P2X(4) receptor subtypes expressed in Xenopus oocytes
    Daryl L Davies
    Department of Molecular Pharmacology Toxicology, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, USA
    Neuropharmacology 49:243-53. 2005
    ....
  7. ncbi request reprint Biophysical evidence for His57 as a proton-binding site in the mammalian intestinal transporter hPepT1
    Tomomi Uchiyama
    Department of Pharmaceutical Sciences, University of Southern California, 1985 Zonal Ave, Los Angeles, CA 90089 9121, USA
    Pharm Res 20:1911-6. 2003
    ....
  8. pmc Roles for loop 2 residues of alpha1 glycine receptors in agonist activation
    Daniel K Crawford
    Alcohol and Brain Research Laboratory, Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 283:27698-706. 2008
    ....
  9. pmc Mutagenesis and cysteine scanning of transmembrane domain 10 of the human dipeptide transporter
    Liya Xu
    Alcohol and Brain Research Laboratory, Titus Family Department of Clinical Pharmacy and Pharmaceutical Economics and Policy, School of Pharmacy, University of Southern California, Los Angeles, California 90033, USA
    Pharm Res 26:2358-66. 2009
    ..The role of transmembrane domain 10 (TMD10) of hPEPT1 in substrate translocation was investigated using cysteine-scanning mutagenesis with 2-Trimethylammonioethyl methanethiosulfonate (MTSET)...
  10. ncbi request reprint Evidence that ethanol acts on a target in Loop 2 of the extracellular domain of alpha1 glycine receptors
    Daniel K Crawford
    Alcohol and Brain Research Laboratory, Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90089, USA
    J Neurochem 102:2097-109. 2007
    ....
  11. ncbi request reprint A charge pair interaction between Arg282 in transmembrane segment 7 and Asp341 in transmembrane segment 8 of hPepT1
    Ashutosh A Kulkarni
    Department of Pharmaceutical Sciences, University of Southern California, 1985 Zonal Avenue, Los Angeles, California 90089 9121, USA
    Pharm Res 24:66-72. 2007
    ..To determine whether R282 in transmembrane segment 7 (TMS7) of hPepT1 forms a salt bridge with D341 in TMS8...
  12. pmc A point mutation in the ectodomain-transmembrane 2 interface eliminates the inhibitory effects of ethanol in P2X4 receptors
    MAYA POPOVA
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, USA
    J Neurochem 112:307-17. 2010
    ..The results support the proposed hypothesis and represent an important step toward developing ethanol-insensitive receptors for investigating the role of P2X4Rs in mediating behavioral effects of ethanol...
  13. pmc Ivermectin antagonizes ethanol inhibition in purinergic P2X4 receptors
    Liana Asatryan
    Titus Family Department of Clinical Pharmacy and Pharmaceutical Economics and Policy, School of Pharmacy, University of Southern California, Los Angeles, California 90033, USA
    J Pharmacol Exp Ther 334:720-8. 2010
    ..Taken with the building evidence supporting a role for P2X4Rs in ethanol intake, the present findings suggest that the newly identified alcohol pocket is a potential site for development of medication for alcohol use disorders...
  14. pmc Roles of ectodomain and transmembrane regions in ethanol and agonist action in purinergic P2X2 and P2X3 receptors
    Liana Asatryan
    Titus Family Department of Clinical Pharmacy and Pharmaceutical Economics and Policy, University of Southern California, Los Angeles, CA 90033, USA
    Neuropharmacology 55:835-43. 2008
    ..Overall, these findings are the first to identify potential targets for ethanol in P2X2 and P2X3Rs and should provide insight into the sites of ethanol action in other P2XRs...
  15. ncbi request reprint Ethanol sensitivity in ATP-gated P2X receptors is subunit dependent
    Daryl L Davies
    Alcohol and Brain Research Laboratory, Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles 90033, USA
    Alcohol Clin Exp Res 26:773-8. 2002
    ..The two recombinant studies were conducted in different expression systems by using different techniques; therefore, questions remain. The present study tests the hypothesis that ethanol sensitivity in P2X receptors is subunit dependent...
  16. doi request reprint Targets for ethanol action and antagonism in loop 2 of the extracellular domain of glycine receptors
    Daya I Perkins
    Alcohol and Brain Research Laboratory, Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, USA
    J Neurochem 106:1337-49. 2008
    ..These findings should help in the development of pharmacological agents that antagonize ethanol...
  17. pmc Ethanol inhibits functional activity of the human intestinal dipeptide transporter hPepT1 expressed in Xenopus oocytes
    Kaixun Li
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90033, USA
    Alcohol Clin Exp Res 32:777-84. 2008
    ..g., penicillin), angiotensin-converting enzyme inhibitors, the anti-neoplastic agent bestatin, and prodrugs of acyclovir...
  18. ncbi request reprint Cysteine scanning of transmembrane domain three of the human dipeptide transporter: implications for substrate transport
    Jennifer L S Links
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089 9121, USA
    J Drug Target 15:218-25. 2007
    ..We interpret these data in terms of the spatial properties of the hPepT1 substrate translocation channel and possible interactions of TMD3 with other transmembrane domains...
  19. pmc Loop 2 structure in glycine and GABA(A) receptors plays a key role in determining ethanol sensitivity
    Daya I Perkins
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 284:27304-14. 2009
    ..In addition to being the first GlyR model threaded on GLIC, the juxtaposition of the two structures led to a possible mechanistic explanation for the effects of ethanol on GlyR-based on changes in Loop 2 structure...
  20. pmc Effects of ethanol on adenosine 5'-triphosphate-gated purinergic and 5-hydroxytryptamine receptors
    Daryl L Davies
    University of Southern California, Los Angeles, California, USA
    Alcohol Clin Exp Res 30:349-58. 2006
    ..Collectively, the presentations provided strong evidence that P2X and 5-HT3 receptors are important targets for ethanol action...
  21. pmc Molecular targets and mechanisms for ethanol action in glycine receptors
    Daya I Perkins
    Alcohol and Brain Research Laboratories, Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Pharmacol Ther 127:53-65. 2010
    ..Recent molecular models of the sites of ethanol action in GlyRs and their implications to our understanding of possible mechanism of ethanol action and novel targets for drug development in GlyRs are discussed...
  22. pmc Ethanol is a fast channel inhibitor of P2X4 receptors
    Olga Ostrovskaya
    Titus Family Department of Clinical Pharmacy and Pharmaceutical Economics and Policy, University of Southern California, Los Angeles, CA 90033, USA
    J Pharmacol Exp Ther 337:171-9. 2011
    ..Overall, these findings provide key information regarding the mechanism of ethanol action on ATP-gated currents in P2X4Rs and provide new insights into the biophysical properties of P2X4Rs...
  23. ncbi request reprint Effects of the abused solvent toluene on recombinant P2X receptors expressed in HEK293 cells
    John J Woodward
    Department of Psychiatry and Neuroscience, Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston 29425, USA
    Brain Res Mol Brain Res 125:86-95. 2004
    ..The results of this study suggest that the abused solvent toluene affects the function of P2X receptors in a subunit-dependent and agonist-dependent fashion...
  24. pmc Purinergic type 2 receptors at GABAergic synapses on ventral tegmental area dopamine neurons are targets for ethanol action
    Cheng Xiao
    Department of Anesthesiology, Pharmacology and Physiology, New Jersey Medical School UMDNJ, 185 South Orange Avenue, Newark, NJ 07103 2714, USA
    J Pharmacol Exp Ther 327:196-205. 2008
    ..These findings are also consistent with the notion that P2Rs at GABA-releasing terminals on VTA dopaminergic neurons are important targets for ethanol action...

Research Grants7

  1. Pressure-Based Pharmacological Alcoholism Treatments
    DARYL DAVIES; Fiscal Year: 2005
    ..These agents can form the bases of novel prevention and treatment strategies for alcoholism and alcohol abuse. ..
  2. Sites and Mechanisms of Ethanol Action in P2X receptors
    DARYL DAVIES; Fiscal Year: 2007
    ....
  3. Sites and Mechanisms of Ethanol Action in P2X receptors
    DARYL DAVIES; Fiscal Year: 2009
    ....