PHILIP DAVIDSON

..For some endpoints we found performance improved with increasing prenatal exposure to MeHg. Follow up studies indicate this association is related to the beneficial nutrients present in fish...

..These findings suggest a possible confounding role of maternal nutrition in studies examining associations between prenatal MeHg exposures and developmental outcomes in children...

..04), but not when the single outlier was removed (p=0.07). In a population whose exposure to MeHg is from fish consumption, we continue to find no consistent adverse association between MeHg and visual motor coordination...

..We performed secondary analyses to determine if effect modification (EM) from social and environmental factors was affecting associations between MeHg and outcomes...

..These findings suggest that the associations observed between MeHg and developmental outcomes may vary with developmental stage...

..Further studies are needed to confirm the capability of the RTB to detect subtle changes associated with neurotoxic exposures...

..This suggests that the association between prenatal exposure and child development may be more complex than originally believed. This paper reviews the SCDS main cohort study results and presents our current interpretations...

..Our findings suggest a number of tests and procedures with the potential for inclusion in test batteries aimed at the exploration of adverse neurodevelopmental effects...

..We performed a similar analysis of the 66-month evaluations to determine if the modifying influences of social and environmental factors were consistent with those previously observed...

..Our intent is to focus the debate about mercury on 1) additional research that should be sought and 2) defining the principal issues that public policy makers face...

..Moreover, behavioral disorders may be sentinels for occult medical morbidity, which in turn may be responsive to intervention...

..The adverse association of educational measures with postnatal exposure in males is intriguing, but will need to be confirmed by further studies examining factors that influence scholastic achievement...

..The results encourage more emphasis on a holistic view of the risks and benefits of fish consumption as it relates to infant development...

....

..Simulation studies examine the model performance under alternative scenarios. Our results demonstrate that a sizeable increase in power is possible...

..These studies evaluate a large number of developmental tests. We propose an alternative analysis strategy that reduces the number of comparisons tested in these studies...

..We conclude that this reanalysis supports the primary linear analysis, showing little evidence for a prenatal adverse effect...

..The most common form of prenatal exposure is maternal fish consumption, but whether such exposure harms the fetus is unknown. We aimed to identify adverse neurodevelopmental effects in a fish-consuming population...

..Preliminary findings from this study suggest that the beneficial influence of nutrients from fish may counter any adverse effects of MeHg on the developing nervous system...

..The regression tree results support previous analyses of outcomes in this cohort. However, this analysis raises the intriguing possibility that an effect may be non-homogeneous among children with different backgrounds and IQ levels...

..We examined this relationship in the Seychelles Islands to determine if it was present in a society exposed primarily to MeHg from consuming ocean fish...

..Our reanalysis indicated that adjustment for measurement errors in explanatory variables had no appreciable effect on the original results...

..These estimates are somewhat lower than those obtained after 66 months of follow-up. The Seychelles Child Development Study continues to provide a firm scientific basis for the derivation of safe levels of MeHg consumption...

..This area will lead to a report of recommendations for the establishment of practice guidelines for medical care jointly issued by the AAMR and the AMA. ..

....

..abstract_text> ..

..The results should have immediate and important public health implications not only for agencies that advise the public about fish consumption, but also for public health policies regarding nutrient intake during pregnancy. ..

..abstract_text> ..

..This study will inform public health policy concerning the balance of risks and benefits of consuming fish during pregnancy with respect to cardiovascular health and cognitive information processing. ..

..The results should have immediate and important public health implications not only for agencies that advise the public about fish consumption, but also for public health policies regarding nutrient intake during pregnancy. ..