Research Topics
| J T DaugirdasSummaryAffiliation: University of Illinois at Chicago Country: USA Publications
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Detail Information
Publications
Dialysis time, survival, and dose-targeting biasJohn T Daugirdas
Division of Nephrology, Department of Medicine, University of Illinois College of Medicine, Chicago, IL 60612, USA
Kidney Int 83:9-13. 2013....- Potential importance of low-sodium bread and breakfast cereal to a reduced sodium dietJohn T Daugirdas
Department of Medicine, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
J Ren Nutr 23:1-3. 2013..Because bread and breakfast cereals are not commonly thought of as being salty foods, substituting these with low-sodium alternatives might help achieve additional substantial sodium intake reduction without much disruption of the diet... - Hemodialysis effect on platelet count and function and hemodialysis-associated thrombocytopeniaJohn T Daugirdas
Department of Medicine, University of Illinois at Chicago School of Medicine, Chicago, IL 60612, USA
Kidney Int 82:147-57. 2012..Most recent cases of dialysis-associated thrombocytopenia have been with polysulfone membranes, especially polysulfone membranes sterilized by electron beam. The exact cause of these reactions remains unknown... 
Effects of frequent hemodialysis on measures of CKD mineral and bone disorderJohn T Daugirdas
University of Illinois at Chicago, Chicago, IL 60612, USA
J Am Soc Nephrol 23:727-38. 2012..In conclusion, frequent hemodialysis facilitates control of hyperphosphatemia and extended session lengths could allow more liberal diets and freedom from phosphorus binders...- Effect of treatment spacing and frequency on three measures of equivalent clearance, including standard Kt/VJohn T Daugirdas
University of Illinois at Chicago, Chicago, IL, USA
Nephrol Dial Transplant 25:558-61. 2010..One would expect that a well-spaced schedule would be beneficial, and an optimal clearance measure should reflect this... - Scaling of measured glomerular filtration rate in kidney donor candidates by anthropometric estimates of body surface area, body water, metabolic rate, or liver sizeJohn T Daugirdas
Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
Clin J Am Soc Nephrol 4:1575-83. 2009..GFR is scaled to body surface area (S), whereas hemodialysis dosage is scaled to total body water (V). Scaling to metabolic rate (M) or liver size (L) has also been proposed... - Solute-solver: a web-based tool for modeling urea kinetics for a broad range of hemodialysis schedules in multiple patientsJohn T Daugirdas
University of Illinois at Chicago, Burr Ridge, IL 60527, USA
Am J Kidney Dis 54:798-809. 2009.... - Standard Kt/Vurea: a method of calculation that includes effects of fluid removal and residual kidney clearanceJohn T Daugirdas
University of Illinois College of Medicine, Chicago, Illinois 60612, USA
Kidney Int 77:637-44. 2010..Our new equation predicted modeled stdKt/V with a high level of accuracy, even when substantial fluid removal and residual urea clearance were present... - Dose of dialysis based on body surface area is markedly less in younger children than in older adolescentsJohn T Daugirdas
University of Illinois at Chicago, 820 S Wood Street, N C 793, Chicago, IL 60612, USA
Clin J Am Soc Nephrol 5:821-7. 2010..Normalizing Kt/V to body surface area (S) has been proposed, but the implications of doing this in children have not been examined... - Effects of reduced intradialytic urea generation rate and residual renal clearance on modeled urea distribution volume and Kt/V in conventional, daily, and nocturnal dialysisJohn T Daugirdas
University of Illinois, Chicago, Illinois 60612, USA
Semin Dial 23:19-24. 2010..The results suggest that, particularly for nocturnal dialysis, the standard "constant G" urea kinetic model may need to be modified... - Can rescaling dose of dialysis to body surface area in the HEMO study explain the different responses to dose in women versus men?John T Daugirdas
Division of Nephrology, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612 7323, USA
Clin J Am Soc Nephrol 5:1628-36. 2010.... - Automated monitoring of hemodialysis adequacy by dialysis machines: potential benefits to patients and cost savingsJohn T Daugirdas
Department of Medicine, University of Illinois College of Medicine, Chicago, Illinois 60612 7323, USA
Kidney Int 78:833-5. 2010..No disposables or reagents are required. Cost may be reduced by reducing the need for blood sampling and laboratory analysis... - The phosphate binder equivalent doseJohn T Daugirdas
University of Illinois at Chicago, Chicago, Illinois 60612, USA
Semin Dial 24:41-9. 2011.... - Modeled urea distribution volume and mortality in the HEMO StudyJohn T Daugirdas
University of Illinois at Chicago, Department of Medicine, 820 South Wood Street, Chicago, IL 60612, USA
Clin J Am Soc Nephrol 6:1129-38. 2011..Here we examine the association of mortality with modeled volume (V(m)), the denominator of equilibrated Kt/V(urea)... - Surface-area-normalized Kt/V: a method of rescaling dialysis dose to body surface area-implications for different-size patients by genderJohn T Daugirdas
University of Illinois, Burr Ridge, Illinois 60527, USA
Semin Dial 21:415-21. 2008..Current dialysis practice would largely meet such an S-based adequacy standard if the dose were normalized to a V(wat):S(dub) ratio of 20... 
Relationship between apparent (single-pool) and true (double-pool) urea distribution volumeJ T Daugirdas
NIDDK, National Institutes of Health, Bethesda, MD, USA
Kidney Int 56:1928-33. 1999..The "true" volume derived from double-pool kinetics (Vdp) does not exhibit this effect. An equation has been derived to adjust Vsp to the expected Vdp...- Pathophysiology of dialysis hypotension: an updateJ T Daugirdas
University of Illinois at Chicago, VA Chicago Hospital West Side, Chicago, IL 60612, USA
Am J Kidney Dis 38:S11-7. 2001..Use of adenosine antagonists remains experimental. Given the importance of sympathetic withdrawal, the use of pharmacologic sympathetic agonists is theoretically an attractive therapeutic strategy... - Dialysis dose as a determinant of adequacyJohn T Daugirdas
University of Illinois at Chicago, Chicago, IL, USA
Semin Nephrol 25:76-80. 2005..Here, benefit may be related as much to better control of salt and water balance as to better removal of uremic toxins... - Anthropometrically estimated total body water volumes are larger than modeled urea volume in chronic hemodialysis patients: effects of age, race, and genderJohn T Daugirdas
National Institutes of Health, NIDDK, Bethesda, Maryland, USA
Kidney Int 64:1108-19. 2003..The modeled volume of urea distribution (Vm) in intermittently hemodialyzed patients is often compared with total body water (TBW) volume predicted from population studies of patient anthropometrics (Vant)... - Factors that affect postdialysis rebound in serum urea concentration, including the rate of dialysis: results from the HEMO StudyJohn T Daugirdas
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Am Soc Nephrol 15:194-203. 2004..Slightly higher K/V slope coefficients (0.46 and 0.29, respectively) should be used if a shorter (e.g., 10 s) slow-flow period is used... - Imprecision of the hemodialysis dose when measured directly from urea removal. Hemodialysis Study GroupT A Depner
Division of Nephrology, University of California, Davis, Sacramento, USA
Kidney Int 55:635-47. 1999..4 per dialysis, a 7% dialysate collection error causes a 20% error in eKt/V)... - Seasonal variations in clinical and laboratory variables among chronic hemodialysis patientsAlfred K Cheung
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Am Soc Nephrol 13:2345-52. 2002..In addition, awareness of these variations might facilitate the interpretation of laboratory results and the clinical treatment of these patients... - Prescribing and monitoring hemodialysis in a 3-4 x/week settingJohn T Daugirdas
Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60527, USA
Hemodial Int 12:215-20. 2008..K/DOQI 2006 adequacy guidelines and practice recommendations are reviewed, and a practical method using a variety of nomograms is suggested to monitor and adjust the desired level of Kt/V... - Dialyzer performance in the HEMO Study: in vivo K0A and true blood flow determined from a model of cross-dialyzer urea extractionThomas A Depner
Hemodialysis HEMO Study Group, National Institutes of Health, Bethesda, MD, USA
ASAIO J 50:85-93. 2004.... - Solute clearances and fluid removal in the frequent hemodialysis network trialsTom Greene
National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA
Am J Kidney Dis 53:835-44. 2009..The goal of this study was to project separation between the treatment and control arms of these studies for measures of dialysis dose by using simulations based on 2-compartment variable-volume models... - Longitudinal and cross-sectional effects of C-reactive protein, equilibrated normalized protein catabolic rate, and serum bicarbonate on creatinine and albumin levels in dialysis patientsGeorge A Kaysen
Veterans Affairs Northern California Health Care System, Mather, USA
Am J Kidney Dis 42:1200-11. 2003..Loss of muscle mass and hypoalbuminemia each may result in part from either malnutrition, inflammation, or a combination of both. Short-term acidosis increases muscle protein catabolism and inhibits albumin synthesis... - Effect of dialysis dose and membrane flux in maintenance hemodialysisGarabed Eknoyan
Baylor College of Medicine, Houston, USA
N Engl J Med 347:2010-9. 2002..CONCLUSIONS: Patients undergoing hemodialysis thrice weekly appear to have no major benefit from a higher dialysis dose than that recommended by current U.S. guidelines or from the use of a high-flux membrane... - Prescribing an equilibrated intermittent hemodialysis dose in intensive care unit acute renal failureNigel S Kanagasundaram
Section of Dialysis and Extracorporeal Therapy, Department of Hypertension Nephrology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Kidney Int 64:2298-310. 2003..Prospective, formal, blood-side, urea kinetic modeling (UKM) has yet to be applied in intermittent hemodialysis for acute renal failure (ARF). Methods for prescribing a target, equilibrated Kt/V (eKt/V) are described for this setting... - Peritoneal dialysis in acute renal failure--why the bad outcome?John T Daugirdas
N Engl J Med 347:933-5. 2002 - Daily hemodialysis: a systematic reviewRita S Suri
Division of Nephrology, University of Western Ontario, London, Ontario, Canada
Clin J Am Soc Nephrol 1:33-42. 2006..Randomized trials with adequate statistical power are required to establish the efficacy and the safety of DHD... - Dosing intermittent haemodialysis in the intensive care unit patient with acute renal failure--estimation of urea removal and evidence for the regional blood flow modelNigel S Kanagasundaram
Section of Dialysis and Extracorporeal Therapy, Department of Hypertension Nephrology, OH, USA
Nephrol Dial Transplant 23:2286-98. 2008..The present study sought to quantify this mass balance error (MBE) and explore potential explanatory factors...