J T Daugirdas

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. doi request reprint Effect of frequent hemodialysis on residual kidney function
    John T Daugirdas
    Department of Medicine, University of Illinois College of Medicine, Chicago, Illinois, USA
    Kidney Int 83:949-58. 2013
  2. doi request reprint Dialysis time, survival, and dose-targeting bias
    John T Daugirdas
    Division of Nephrology, Department of Medicine, University of Illinois College of Medicine, Chicago, IL 60612, USA
    Kidney Int 83:9-13. 2013
  3. doi request reprint Potential importance of low-sodium bread and breakfast cereal to a reduced sodium diet
    John T Daugirdas
    Department of Medicine, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    J Ren Nutr 23:1-3. 2013
  4. doi request reprint Hemodialysis effect on platelet count and function and hemodialysis-associated thrombocytopenia
    John T Daugirdas
    Department of Medicine, University of Illinois at Chicago School of Medicine, Chicago, IL 60612, USA
    Kidney Int 82:147-57. 2012
  5. pmc Effects of frequent hemodialysis on measures of CKD mineral and bone disorder
    John T Daugirdas
    University of Illinois at Chicago, Chicago, IL 60612, USA
    J Am Soc Nephrol 23:727-38. 2012
  6. doi request reprint Effects of reduced intradialytic urea generation rate and residual renal clearance on modeled urea distribution volume and Kt/V in conventional, daily, and nocturnal dialysis
    John T Daugirdas
    University of Illinois, Chicago, Illinois 60612, USA
    Semin Dial 23:19-24. 2010
  7. pmc Surface-area-normalized Kt/V: a method of rescaling dialysis dose to body surface area-implications for different-size patients by gender
    John T Daugirdas
    University of Illinois, Burr Ridge, Illinois 60527, USA
    Semin Dial 21:415-21. 2008
  8. pmc Dose of dialysis based on body surface area is markedly less in younger children than in older adolescents
    John T Daugirdas
    University of Illinois at Chicago, 820 S Wood Street, N C 793, Chicago, IL 60612, USA
    Clin J Am Soc Nephrol 5:821-7. 2010
  9. doi request reprint Effect of treatment spacing and frequency on three measures of equivalent clearance, including standard Kt/V
    John T Daugirdas
    University of Illinois at Chicago, Chicago, IL, USA
    Nephrol Dial Transplant 25:558-61. 2010
  10. pmc Scaling of measured glomerular filtration rate in kidney donor candidates by anthropometric estimates of body surface area, body water, metabolic rate, or liver size
    John T Daugirdas
    Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Clin J Am Soc Nephrol 4:1575-83. 2009

Detail Information

Publications32

  1. doi request reprint Effect of frequent hemodialysis on residual kidney function
    John T Daugirdas
    Department of Medicine, University of Illinois College of Medicine, Chicago, Illinois, USA
    Kidney Int 83:949-58. 2013
    ..Thus, frequent nocturnal hemodialysis appears to promote a more rapid loss of RKF, the mechanism of which remains to be determined. Whether RKF also declines with frequent daily treatment could not be determined...
  2. doi request reprint Dialysis time, survival, and dose-targeting bias
    John T Daugirdas
    Division of Nephrology, Department of Medicine, University of Illinois College of Medicine, Chicago, IL 60612, USA
    Kidney Int 83:9-13. 2013
    ....
  3. doi request reprint Potential importance of low-sodium bread and breakfast cereal to a reduced sodium diet
    John T Daugirdas
    Department of Medicine, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    J Ren Nutr 23:1-3. 2013
    ..Because bread and breakfast cereals are not commonly thought of as being salty foods, substituting these with low-sodium alternatives might help achieve additional substantial sodium intake reduction without much disruption of the diet...
  4. doi request reprint Hemodialysis effect on platelet count and function and hemodialysis-associated thrombocytopenia
    John T Daugirdas
    Department of Medicine, University of Illinois at Chicago School of Medicine, Chicago, IL 60612, USA
    Kidney Int 82:147-57. 2012
    ..Most recent cases of dialysis-associated thrombocytopenia have been with polysulfone membranes, especially polysulfone membranes sterilized by electron beam. The exact cause of these reactions remains unknown...
  5. pmc Effects of frequent hemodialysis on measures of CKD mineral and bone disorder
    John T Daugirdas
    University of Illinois at Chicago, Chicago, IL 60612, USA
    J Am Soc Nephrol 23:727-38. 2012
    ..In conclusion, frequent hemodialysis facilitates control of hyperphosphatemia and extended session lengths could allow more liberal diets and freedom from phosphorus binders...
  6. doi request reprint Effects of reduced intradialytic urea generation rate and residual renal clearance on modeled urea distribution volume and Kt/V in conventional, daily, and nocturnal dialysis
    John T Daugirdas
    University of Illinois, Chicago, Illinois 60612, USA
    Semin Dial 23:19-24. 2010
    ..The results suggest that, particularly for nocturnal dialysis, the standard "constant G" urea kinetic model may need to be modified...
  7. pmc Surface-area-normalized Kt/V: a method of rescaling dialysis dose to body surface area-implications for different-size patients by gender
    John T Daugirdas
    University of Illinois, Burr Ridge, Illinois 60527, USA
    Semin Dial 21:415-21. 2008
    ..Current dialysis practice would largely meet such an S-based adequacy standard if the dose were normalized to a V(wat):S(dub) ratio of 20...
  8. pmc Dose of dialysis based on body surface area is markedly less in younger children than in older adolescents
    John T Daugirdas
    University of Illinois at Chicago, 820 S Wood Street, N C 793, Chicago, IL 60612, USA
    Clin J Am Soc Nephrol 5:821-7. 2010
    ..Normalizing Kt/V to body surface area (S) has been proposed, but the implications of doing this in children have not been examined...
  9. doi request reprint Effect of treatment spacing and frequency on three measures of equivalent clearance, including standard Kt/V
    John T Daugirdas
    University of Illinois at Chicago, Chicago, IL, USA
    Nephrol Dial Transplant 25:558-61. 2010
    ..One would expect that a well-spaced schedule would be beneficial, and an optimal clearance measure should reflect this...
  10. pmc Scaling of measured glomerular filtration rate in kidney donor candidates by anthropometric estimates of body surface area, body water, metabolic rate, or liver size
    John T Daugirdas
    Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Clin J Am Soc Nephrol 4:1575-83. 2009
    ..GFR is scaled to body surface area (S), whereas hemodialysis dosage is scaled to total body water (V). Scaling to metabolic rate (M) or liver size (L) has also been proposed...
  11. doi request reprint Solute-solver: a web-based tool for modeling urea kinetics for a broad range of hemodialysis schedules in multiple patients
    John T Daugirdas
    University of Illinois at Chicago, Burr Ridge, IL 60527, USA
    Am J Kidney Dis 54:798-809. 2009
    ....
  12. pmc Can rescaling dose of dialysis to body surface area in the HEMO study explain the different responses to dose in women versus men?
    John T Daugirdas
    Division of Nephrology, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612 7323, USA
    Clin J Am Soc Nephrol 5:1628-36. 2010
    ....
  13. doi request reprint Automated monitoring of hemodialysis adequacy by dialysis machines: potential benefits to patients and cost savings
    John T Daugirdas
    Department of Medicine, University of Illinois College of Medicine, Chicago, Illinois 60612 7323, USA
    Kidney Int 78:833-5. 2010
    ..No disposables or reagents are required. Cost may be reduced by reducing the need for blood sampling and laboratory analysis...
  14. ncbi request reprint Dialysis dose as a determinant of adequacy
    John T Daugirdas
    University of Illinois at Chicago, Chicago, IL, USA
    Semin Nephrol 25:76-80. 2005
    ..Here, benefit may be related as much to better control of salt and water balance as to better removal of uremic toxins...
  15. doi request reprint The phosphate binder equivalent dose
    John T Daugirdas
    University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Semin Dial 24:41-9. 2011
    ....
  16. ncbi request reprint Factors that affect postdialysis rebound in serum urea concentration, including the rate of dialysis: results from the HEMO Study
    John T Daugirdas
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Am Soc Nephrol 15:194-203. 2004
    ..Slightly higher K/V slope coefficients (0.46 and 0.29, respectively) should be used if a shorter (e.g., 10 s) slow-flow period is used...
  17. pmc Modeled urea distribution volume and mortality in the HEMO Study
    John T Daugirdas
    University of Illinois at Chicago, Department of Medicine, 820 South Wood Street, Chicago, IL 60612, USA
    Clin J Am Soc Nephrol 6:1129-38. 2011
    ..Here we examine the association of mortality with modeled volume (V(m)), the denominator of equilibrated Kt/V(urea)...
  18. ncbi request reprint Anthropometrically estimated total body water volumes are larger than modeled urea volume in chronic hemodialysis patients: effects of age, race, and gender
    John T Daugirdas
    National Institutes of Health, NIDDK, Bethesda, Maryland, USA
    Kidney Int 64:1108-19. 2003
    ..The modeled volume of urea distribution (Vm) in intermittently hemodialyzed patients is often compared with total body water (TBW) volume predicted from population studies of patient anthropometrics (Vant)...
  19. ncbi request reprint Pathophysiology of dialysis hypotension: an update
    J T Daugirdas
    University of Illinois at Chicago, VA Chicago Hospital West Side, Chicago, IL 60612, USA
    Am J Kidney Dis 38:S11-7. 2001
    ..Use of adenosine antagonists remains experimental. Given the importance of sympathetic withdrawal, the use of pharmacologic sympathetic agonists is theoretically an attractive therapeutic strategy...
  20. ncbi request reprint Relationship between apparent (single-pool) and true (double-pool) urea distribution volume
    J T Daugirdas
    NIDDK, National Institutes of Health, Bethesda, MD, USA
    Kidney Int 56:1928-33. 1999
    ..The "true" volume derived from double-pool kinetics (Vdp) does not exhibit this effect. An equation has been derived to adjust Vsp to the expected Vdp...
  21. doi request reprint Standard Kt/Vurea: a method of calculation that includes effects of fluid removal and residual kidney clearance
    John T Daugirdas
    University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    Kidney Int 77:637-44. 2010
    ..Our new equation predicted modeled stdKt/V with a high level of accuracy, even when substantial fluid removal and residual urea clearance were present...
  22. ncbi request reprint Imprecision of the hemodialysis dose when measured directly from urea removal. Hemodialysis Study Group
    T A Depner
    Division of Nephrology, University of California, Davis, Sacramento, USA
    Kidney Int 55:635-47. 1999
    ..4 per dialysis, a 7% dialysate collection error causes a 20% error in eKt/V)...
  23. ncbi request reprint Seasonal variations in clinical and laboratory variables among chronic hemodialysis patients
    Alfred K Cheung
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Am Soc Nephrol 13:2345-52. 2002
    ..In addition, awareness of these variations might facilitate the interpretation of laboratory results and the clinical treatment of these patients...
  24. doi request reprint Solute clearances and fluid removal in the frequent hemodialysis network trials
    Tom Greene
    National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA
    Am J Kidney Dis 53:835-44. 2009
    ..The goal of this study was to project separation between the treatment and control arms of these studies for measures of dialysis dose by using simulations based on 2-compartment variable-volume models...
  25. ncbi request reprint Dialyzer performance in the HEMO Study: in vivo K0A and true blood flow determined from a model of cross-dialyzer urea extraction
    Thomas A Depner
    Hemodialysis HEMO Study Group, National Institutes of Health, Bethesda, MD, USA
    ASAIO J 50:85-93. 2004
    ....
  26. doi request reprint Prescribing and monitoring hemodialysis in a 3-4 x/week setting
    John T Daugirdas
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60527, USA
    Hemodial Int 12:215-20. 2008
    ..K/DOQI 2006 adequacy guidelines and practice recommendations are reviewed, and a practical method using a variety of nomograms is suggested to monitor and adjust the desired level of Kt/V...
  27. ncbi request reprint Prescribing an equilibrated intermittent hemodialysis dose in intensive care unit acute renal failure
    Nigel S Kanagasundaram
    Section of Dialysis and Extracorporeal Therapy, Department of Hypertension Nephrology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Kidney Int 64:2298-310. 2003
    ..Prospective, formal, blood-side, urea kinetic modeling (UKM) has yet to be applied in intermittent hemodialysis for acute renal failure (ARF). Methods for prescribing a target, equilibrated Kt/V (eKt/V) are described for this setting...
  28. ncbi request reprint Effect of dialysis dose and membrane flux in maintenance hemodialysis
    Garabed Eknoyan
    Baylor College of Medicine, Houston, USA
    N Engl J Med 347:2010-9. 2002
    ..The effects of the dose of dialysis and the level of flux of the dialyzer membrane on mortality and morbidity among patients undergoing maintenance hemodialysis are uncertain...
  29. ncbi request reprint Longitudinal and cross-sectional effects of C-reactive protein, equilibrated normalized protein catabolic rate, and serum bicarbonate on creatinine and albumin levels in dialysis patients
    George A Kaysen
    Veterans Affairs Northern California Health Care System, Mather, USA
    Am J Kidney Dis 42:1200-11. 2003
    ..Loss of muscle mass and hypoalbuminemia each may result in part from either malnutrition, inflammation, or a combination of both. Short-term acidosis increases muscle protein catabolism and inhibits albumin synthesis...
  30. ncbi request reprint Daily hemodialysis: a systematic review
    Rita S Suri
    Division of Nephrology, University of Western Ontario, London, Ontario, Canada
    Clin J Am Soc Nephrol 1:33-42. 2006
    ..Randomized trials with adequate statistical power are required to establish the efficacy and the safety of DHD...
  31. doi request reprint Dosing intermittent haemodialysis in the intensive care unit patient with acute renal failure--estimation of urea removal and evidence for the regional blood flow model
    Nigel S Kanagasundaram
    Section of Dialysis and Extracorporeal Therapy, Department of Hypertension Nephrology, OH, USA
    Nephrol Dial Transplant 23:2286-98. 2008
    ..The present study sought to quantify this mass balance error (MBE) and explore potential explanatory factors...
  32. ncbi request reprint Peritoneal dialysis in acute renal failure--why the bad outcome?
    John T Daugirdas
    N Engl J Med 347:933-5. 2002