Alan Daugherty

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. pmc Doxycycline does not influence established abdominal aortic aneurysms in angiotensin II-infused mice
    Xiaojie Xie
    Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS ONE 7:e46411. 2012
  2. pmc Regional variation in aortic AT1b receptor mRNA abundance is associated with contractility but unrelated to atherosclerosis and aortic aneurysms
    Aruna Poduri
    Saha Cardiovascular Research Center, University of Kentucky, Lexington, United States of America
    PLoS ONE 7:e48462. 2012
  3. pmc Depletion of endothelial or smooth muscle cell-specific angiotensin II type 1a receptors does not influence aortic aneurysms or atherosclerosis in LDL receptor deficient mice
    Debra L Rateri
    Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS ONE 7:e51483. 2012
  4. pmc PD123319 augments angiotensin II-induced abdominal aortic aneurysms through an AT2 receptor-independent mechanism
    Alan Daugherty
    Saha Cardiovascular Research Center, USA
    PLoS ONE 8:e61849. 2013
  5. ncbi request reprint Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis through the AT1A receptor
    Alan Daugherty
    Division of Cardiovascular Medicine, Wethington Building, Room 521, University of Kentucky, Lexington, KY 40536 0200, USA
    Circulation 110:3849-57. 2004
  6. ncbi request reprint Mouse models of abdominal aortic aneurysms
    Alan Daugherty
    Department of Medicine, Gill Heart Institute, University of Kentucky, Lexington, KY 40536 0230, USA
    Arterioscler Thromb Vasc Biol 24:429-34. 2004
  7. pmc Genetic variants of the Renin Angiotensin system: effects on atherosclerosis in experimental models and humans
    Alan Daugherty
    Saha Cardiovascular Research Center, University of Kentucky, BBSRB, room B 243, Lexington, KY 40536 0509, USA
    Curr Atheroscler Rep 12:167-73. 2010
  8. ncbi request reprint Angiotensin II-mediated development of vascular diseases
    Alan Daugherty
    Department of Medicine, and the Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA
    Trends Cardiovasc Med 14:117-20. 2004
  9. ncbi request reprint Atherosclerosis: cell biology and lipoproteins
    Alan Daugherty
    Division of Cardiovascular Medicine, University of Kentucky, Lexington, Kentucky 40536, USA
    Curr Opin Lipidol 15:93-5. 2004
  10. pmc Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE-/- mice
    Alan Daugherty
    Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536, U S A
    Clin Sci (Lond) 118:681-9. 2010

Collaborators

Detail Information

Publications105 found, 100 shown here

  1. pmc Doxycycline does not influence established abdominal aortic aneurysms in angiotensin II-infused mice
    Xiaojie Xie
    Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS ONE 7:e46411. 2012
    ..The purpose of the current study was to determine the effects of doxycycline on established AAAs when it was administered at a dose that produces therapeutic serum concentrations...
  2. pmc Regional variation in aortic AT1b receptor mRNA abundance is associated with contractility but unrelated to atherosclerosis and aortic aneurysms
    Aruna Poduri
    Saha Cardiovascular Research Center, University of Kentucky, Lexington, United States of America
    PLoS ONE 7:e48462. 2012
    ..This receptor is expressed as 2 structurally similar subtypes in rodents, termed AT1a and AT1b. Although AT1a receptors have been studied comprehensively, roles of AT1b receptors in the aorta have not been defined...
  3. pmc Depletion of endothelial or smooth muscle cell-specific angiotensin II type 1a receptors does not influence aortic aneurysms or atherosclerosis in LDL receptor deficient mice
    Debra L Rateri
    Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS ONE 7:e51483. 2012
    ..Therefore, the aim of this study was to determine whether deletion of AT1a receptors in either endothelial cells or smooth muscle cells influences the development of atherosclerosis and AAAs...
  4. pmc PD123319 augments angiotensin II-induced abdominal aortic aneurysms through an AT2 receptor-independent mechanism
    Alan Daugherty
    Saha Cardiovascular Research Center, USA
    PLoS ONE 8:e61849. 2013
    ..We also defined effects of AT2 receptors in AngII-induced atherosclerosis and thoracic aortic aneurysms...
  5. ncbi request reprint Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis through the AT1A receptor
    Alan Daugherty
    Division of Cardiovascular Medicine, Wethington Building, Room 521, University of Kentucky, Lexington, KY 40536 0200, USA
    Circulation 110:3849-57. 2004
    ..We hypothesized that hypercholesterolemia stimulates the production of angiotensin peptides to provide a rationale for the profound effect of AT1A receptor deficiency on atherogenesis...
  6. ncbi request reprint Mouse models of abdominal aortic aneurysms
    Alan Daugherty
    Department of Medicine, Gill Heart Institute, University of Kentucky, Lexington, KY 40536 0230, USA
    Arterioscler Thromb Vasc Biol 24:429-34. 2004
    ..The validation of mouse models of AAAs will provide insight into the mechanisms of progression of the human disease...
  7. pmc Genetic variants of the Renin Angiotensin system: effects on atherosclerosis in experimental models and humans
    Alan Daugherty
    Saha Cardiovascular Research Center, University of Kentucky, BBSRB, room B 243, Lexington, KY 40536 0509, USA
    Curr Atheroscler Rep 12:167-73. 2010
    ..Few studies have reported links of genetic variants of angiotensin II receptors to human atherosclerotic diseases. Further genetic studies are needed to define the role of RAS in atherosclerosis...
  8. ncbi request reprint Angiotensin II-mediated development of vascular diseases
    Alan Daugherty
    Department of Medicine, and the Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA
    Trends Cardiovasc Med 14:117-20. 2004
    ..The definition of the cellular mechanisms by which Ang II promotes these vascular pathologies may provide new therapeutic strategies...
  9. ncbi request reprint Atherosclerosis: cell biology and lipoproteins
    Alan Daugherty
    Division of Cardiovascular Medicine, University of Kentucky, Lexington, Kentucky 40536, USA
    Curr Opin Lipidol 15:93-5. 2004
  10. pmc Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE-/- mice
    Alan Daugherty
    Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536, U S A
    Clin Sci (Lond) 118:681-9. 2010
    ..This new model of ascending aortic aneurysms has pathology that differs markedly from AngII-induced atherosclerosis or AAAs, but all vascular pathologies were attenuated by CCR2 deficiency...
  11. ncbi request reprint Role of the renin-angiotensin system in the development of abdominal aortic aneurysms in animals and humans
    Alan Daugherty
    Cardiovascular Research Center, Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky 40536 0200, USA
    Ann N Y Acad Sci 1085:82-91. 2006
    ..However, there are a considerable number of drugs available to potentially test the efficacy of inhibiting the renin-angiotensin system on the progression of the human disease...
  12. ncbi request reprint Atherosclerosis: cell biology and lipoproteins
    Alan Daugherty
    Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky 40536 0200, USA
    Curr Opin Lipidol 17:705-7. 2006
  13. ncbi request reprint Thematic review series: The immune system and atherogenesis. Cytokine regulation of macrophage functions in atherogenesis
    Alan Daugherty
    Cardiovascular Research Center, Gill Heart Institute, University of Kentucky, Lexington, KY, USA
    J Lipid Res 46:1812-22. 2005
    ..There will be an emphasis on the role of cytokines in regulating lipid metabolism by macrophages. We will provide an overview of the major findings in cell culture and then put these in the context of in vivo studies...
  14. ncbi request reprint Development of experimental designs for atherosclerosis studies in mice
    Alan Daugherty
    Gill Heart Institute, Division of Cardiovascular Medicine, University of Kentucky, Lexington, KY 40536, USA
    Methods 36:129-38. 2005
    ..It is likely that other vascular regions will be increasingly used. In addition to size, there is an increased emphasis on identifying and quantifying the cellular and chemical composition of atherosclerotic lesions...
  15. ncbi request reprint Angiotensin II and abdominal aortic aneurysms
    Alan Daugherty
    Division of Cardiovascular Medicine, 2 Graduate Center for Nutritional Sciences, Wethington Building, Room 521, Gill Heart Institute, University of Kentucky, Lexington, KY 40536 0200, USA
    Curr Hypertens Rep 6:442-6. 2004
    ..Further definition of the role of the renin-angiotensin system in AAA formation and progression will identify potential therapeutic strategies for treatment of this disease...
  16. pmc IL-5 links adaptive and natural immunity in reducing atherosclerotic disease
    Alan Daugherty
    Gill Heart Institute, University of Kentucky, Lexington, Kentucky 40536 0200, USA
    J Clin Invest 114:317-9. 2004
    ..Atherosclerotic lesion size in LDL receptor-deficient mice is reduced as a consequence of the increase in natural antibody titers, and IL-5 is identified as the link between the adaptive and natural immune systems...
  17. pmc Complex pathologies of angiotensin II-induced abdominal aortic aneurysms
    Alan Daugherty
    Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536 0509, USA
    J Zhejiang Univ Sci B 12:624-8. 2011
    ....
  18. pmc ANG II infusion promotes abdominal aortic aneurysms independent of increased blood pressure in hypercholesterolemic mice
    Lisa A Cassis
    Rm 521b, Wethington Bldg, Graduate Center for Nutritional Sciences, Univ of Kentucky, Lexington, KY 40536 0200, USA
    Am J Physiol Heart Circ Physiol 296:H1660-5. 2009
    ..These results demonstrate that infusion of ANG II to hyperlipidemic mice induces AAAs and augments atherosclerosis independent of increased blood pressure...
  19. pmc Angiotensin-converting enzyme 2 deficiency in whole body or bone marrow-derived cells increases atherosclerosis in low-density lipoprotein receptor-/- mice
    Sean E Thatcher
    Graduate Center for Nutritional Sciences, Rm 521b, Wethington Bldg, 900 S Limestone, University of Kentucky, Lexington, KY 40536 0200, USA
    Arterioscler Thromb Vasc Biol 31:758-65. 2011
    ..Angiotensin-converting enzyme 2 (ACE2) catabolizes angiotensin II (Ang II) to angiotensin 1-7 (Ang-(1-7)) to limit effects of the renin-angiotensin system. The purpose of this study was to define the role of ACE2 in atherosclerosis...
  20. pmc Endothelial cell-specific deficiency of Ang II type 1a receptors attenuates Ang II-induced ascending aortic aneurysms in LDL receptor-/- mice
    Debra L Rateri
    Saha Cardiovascular Research Center, BBSRB, Room 243, University of Kentucky, Lexington, KY 40536 0509, USA
    Circ Res 108:574-81. 2011
    ..In agreement with this associative evidence, we have published recently that Ang II infusion induces aneurysmal pathology in the ascending aorta...
  21. ncbi request reprint Angiotensin II increases adipose angiotensinogen expression
    Hong Lu
    Cardiovascular Research Center, Gill Heart Institute, University of Kentucky, Lexington, Kentucky 4053 0200, USA
    Am J Physiol Endocrinol Metab 292:E1280-7. 2007
    ..Chronic infusion of ANG II robustly stimulated AT(1a)R and AGT mRNA abundance in adipose tissue, suggesting that adipose tissue serves as a primary contributor to the activated systemic renin-angiotensin system...
  22. pmc Angiotensin II induces a region-specific hyperplasia of the ascending aorta through regulation of inhibitor of differentiation 3
    A Phillip Owens
    Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536 0509, USA
    Circ Res 106:611-9. 2010
    ..Angiotensin II (Ang II) has diverse effects on smooth muscle cells (SMCs). The diversity of effects may relate to the regional location of this cell type...
  23. pmc Obesity promotes inflammation in periaortic adipose tissue and angiotensin II-induced abdominal aortic aneurysm formation
    Sara B Police
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40536 0200, USA
    Arterioscler Thromb Vasc Biol 29:1458-64. 2009
    ..We sought to determine whether obesity promotes macrophage infiltration and proinflammatory cytokines in periaortic adipose tissue surrounding abdominal aortas and increases AngII-induced AAAs...
  24. pmc Comparative effects of different modes of renin angiotensin system inhibition on hypercholesterolaemia-induced atherosclerosis
    Hong Lu
    Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536 0509, USA
    Br J Pharmacol 165:2000-8. 2012
    ..The purpose of this study was to determine the relative effects of these three modes of pharmacological RAS inhibition in reducing atherosclerosis by determining the dose-response relationships...
  25. pmc Androgen increases AT1a receptor expression in abdominal aortas to promote angiotensin II-induced AAAs in apolipoprotein E-deficient mice
    Tracy Henriques
    Graduate Center for Nutritional Sciences, Room 521b, Wethington Building, 900 S Limestone, University of Kentucky, Lexington, KY 40536 0200, USA
    Arterioscler Thromb Vasc Biol 28:1251-6. 2008
    ..The purpose of this study was to determine whether this reduction is attributable to androgen-mediated regulation of aortic Ang II type 1A receptors (AT1aR)...
  26. pmc Total lymphocyte deficiency attenuates AngII-induced atherosclerosis in males but not abdominal aortic aneurysms in apoE deficient mice
    Haruhito A Uchida
    Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536, USA
    Atherosclerosis 211:399-403. 2010
    ..In this study, we determined whether total lymphocyte deficiency reduced AngII-induced vascular diseases...
  27. pmc Adipocyte deficiency of angiotensinogen prevents obesity-induced hypertension in male mice
    Frederique Yiannikouris
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40536 0200, USA
    Hypertension 60:1524-30. 2012
    ..These results suggest that adipose tissue serves as a major source of angiotensin II in the development of obesity hypertension...
  28. pmc Telomerase deficiency in bone marrow-derived cells attenuates angiotensin II-induced abdominal aortic aneurysm formation
    Hannes M Findeisen
    Saha Cardiovascular Research Center, University of Kentucky, 900 S Limestone St, Lexington, KY 40536 0200, USA
    Arterioscler Thromb Vasc Biol 31:253-60. 2011
    ..In this study, we sought to determine whether the catalytic component of telomerase, telomerase reverse transcriptase (TERT), modulates angiotensin (Ang) II-induced AAA formation...
  29. ncbi request reprint Macrophage-expressed group IIA secretory phospholipase A2 increases atherosclerotic lesion formation in LDL receptor-deficient mice
    Nancy R Webb
    Department of Internal Medicine, University of Kentucky Medical Center MN520, 800 Rose St, Lexington, KY 40536 0084, USA
    Arterioscler Thromb Vasc Biol 23:263-8. 2003
    ..In the present study, we show for the first time that elicited peritoneal macrophages from transgenic mice express human group IIA sPLA(2). This study tested whether macrophage-expressed sPLA(2) contributes to atherogenesis...
  30. ncbi request reprint Bone marrow transplantation reveals that recipient AT1a receptors are required to initiate angiotensin II-induced atherosclerosis and aneurysms
    Lisa A Cassis
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY, USA
    Arterioscler Thromb Vasc Biol 27:380-6. 2007
    ..The purpose of this study was to define whether AngII interacts with receptors on infiltrating versus resident cells in promoting vascular pathologies...
  31. pmc Mineralocorticoid receptor agonists induce mouse aortic aneurysm formation and rupture in the presence of high salt
    Shu Liu
    Department of Internal Medicine, University of Kentucky, Lexington, KY 40536, USA
    Arterioscler Thromb Vasc Biol 33:1568-79. 2013
    ..Mineralocorticoid receptor antagonists provide additional benefits in patients with heart failure. However, whether aldosterone and the mineralocorticoid receptor are involved in aortic aneurysm is unknown...
  32. ncbi request reprint Rapid dilation of the abdominal aorta during infusion of angiotensin II detected by noninvasive high-frequency ultrasonography
    Chiara Barisione
    Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536, USA
    J Vasc Surg 44:372-6. 2006
    ..This system had 100% accuracy in detecting AngII-induced AAAs in vivo, with intrauser and interuser variation coefficients of less than 10% for quantification of the aortic lumen diameter...
  33. pmc Interleukin-4 does not influence development of hypercholesterolemia or angiotensin II-induced atherosclerotic lesions in mice
    Victoria L King
    Cardiovascular Research Center, Wethington Building, Room 562, University of Kentucky, Lexington, KY 40536 0200, USA
    Am J Pathol 171:2040-7. 2007
    ....
  34. pmc Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice
    Hong Lu
    Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky, USA
    J Clin Invest 118:984-93. 2008
    ..Therefore, although previous work suggests that angiotensin peptides have conflicting effects on atherogenesis, we found that renin inhibition profoundly decreased lesion development in mice...
  35. pmc G2A deficiency in mice promotes macrophage activation and atherosclerosis
    David T Bolick
    Cardiovascular Research Center, University of Charlottesville, Charlottesville, Virginia 22908, USA
    Circ Res 104:318-27. 2009
    ..In the absence of G2A, increased macrophage activation and decreased apoptosis is associated with accumulation of macrophages in the aorta and increased atherosclerosis...
  36. pmc Aldosterone does not mediate angiotensin II-induced atherosclerosis and abdominal aortic aneurysms
    Lisa A Cassis
    Graduate Center for Nutritional Sciences, Charles T Wethington Building, University of Kentucky, Lexington, KY 40536, U S A
    Br J Pharmacol 144:443-8. 2005
    ..These studies demonstrate that the AngII-induced vascular pathologies of atherosclerosis and AAA formation are not mediated through aldosterone...
  37. ncbi request reprint Angiotensin II infusion induces site-specific intra-laminar hemorrhage in macrophage colony-stimulating factor-deficient mice
    Fjoralba Babamusta
    Cardiovascular Research Center, Wethington Building, Room 521, University of Kentucky, Lexington, KY 40536 0200, USA
    Atherosclerosis 186:282-90. 2006
    ..In conclusion, deficiency of M-CSF attenuated AngII-induced atherosclerosis but led to an unanticipated pathology of intra-laminar hemorrhage in the upper aortic regions...
  38. ncbi request reprint Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway
    Binggang Xiang
    Division of Cardiovascular Medicine, Department of Internal Medicine, Saha Cardiovascular Center, University of Kentucky, Lexington, Kentucky 40536, USA
    Nat Commun 4:2657. 2013
    ..Thus, these findings demonstrate a previously unappreciated role for platelets in septic shock and suggest that platelet transfusion may be effective in treating severely septic patients...
  39. pmc Contributions of leukocyte angiotensin-converting enzyme to development of atherosclerosis
    Xiaofeng Chen
    Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536 0509, USA
    Arterioscler Thromb Vasc Biol 33:2075-80. 2013
    ..This study determined the role of angiotensin-converting enzyme (ACE) on the development of angiotensin I-induced atherosclerosis and the contribution of leukocyte-specific expression of this enzyme...
  40. pmc Regulation of peroxisome proliferator-activated receptor-γ by angiotensin II via transforming growth factor-β1-activated p38 mitogen-activated protein kinase in aortic smooth muscle cells
    Venkateswaran Subramanian
    Saha Cardiovascular Research Center, BBSRB, Rm B249, University of Kentucky, Lexington, KY 40536 0509, USA
    Arterioscler Thromb Vasc Biol 32:397-405. 2012
    ..Therefore, the purpose of this study was to determine the mechanism of Ang II-mediated intracellular regulation of PPARγ in VSMCs...
  41. pmc High density lipoprotein protects against polymicrobe-induced sepsis in mice
    Ling Guo
    Department of Pediatrics, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    J Biol Chem 288:17947-53. 2013
    ..Our study supports efforts to raise HDL levels as a therapeutic approach for sepsis. ..
  42. pmc Differential effects of dietary sodium intake on blood pressure and atherosclerosis in hypercholesterolemic mice
    Hong Lu
    Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536, USA
    J Nutr Biochem 24:49-53. 2013
    ..01% and Na 2% groups. In conclusion, while high dietary sodium intake led to higher systolic blood pressure, low dietary sodium intake augmented atherosclerosis in hypercholesterolemic mice...
  43. pmc Transient exposure of neonatal female mice to testosterone abrogates the sexual dimorphism of abdominal aortic aneurysms
    Xuan Zhang
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536 0200, USA
    Circ Res 110:e73-85. 2012
    ..However, mechanisms for sexual dimorphism of regional aortic angiotensin receptor expression and AAA formation are unknown...
  44. pmc Prolonged infusion of angiotensin II in apoE(-/-) mice promotes macrophage recruitment with continued expansion of abdominal aortic aneurysm
    Debra L Rateri
    Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky, USA
    Am J Pathol 179:1542-8. 2011
    ..Macrophages immunostained for CD206 more than for iNOS, consistent with an M2 phenotype. In conclusion, prolonged AngII infusion promotes AAA expansion, and is associated with enhanced rupture rates and increased macrophage infiltration...
  45. pmc Weight loss in obese C57BL/6 mice limits adventitial expansion of established angiotensin II-induced abdominal aortic aneurysms
    Sara B Police
    Graduate Center for Nutritional Sciences, Rm 521b, Wethington Bldg, 900 S Limestone, Univ of Kentucky, Lexington, KY 40536 0200, USA
    Am J Physiol Heart Circ Physiol 298:H1932-8. 2010
    ..These results demonstrate that weight loss limits adventitial expansion of ANG II-induced AAAs. Reduced neovascularization from weight loss may limit progression of AAAs...
  46. ncbi request reprint Zinc deficiency increases plasma lipids and atherosclerotic markers in LDL-receptor-deficient mice
    Gudrun Reiterer
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, 40546, USA
    J Nutr 135:2114-8. 2005
    ..These data also suggest that adequate zinc may be a critical component in protective PPAR signaling during atherosclerosis...
  47. ncbi request reprint Interleukin-4 deficiency promotes gallstone formation
    Victoria L King
    Gill Heart Institute, Division of Cardiovascular Medicine, Division of Hematology Oncology, University of Kentucky, Lexington, KY 40536, USA
    J Lipid Res 43:768-71. 2002
    ..IL-4(-/-) deficiency also increased serum concentrations of bilirubin following feeding a fat-enriched diet. Therefore, these studies revealed an unexpected finding that IL-4 deficiency predisposes to gallstone formation...
  48. pmc Pioglitazone-induced reductions in atherosclerosis occur via smooth muscle cell-specific interaction with PPAR{gamma}
    Venkateswaran Subramanian
    Saha Cardiovascular Research Center, BBSRB, Room B243, University of Kentucky, Lexington, KY 40536 0509, USA
    Circ Res 107:953-8. 2010
    ..Peroxisome proliferator-activated receptor (PPAR)γ agonists attenuate atherosclerosis and abdominal aortic aneurysms (AAAs). PPARγ, a nuclear receptor, is expressed on many cell types including smooth muscle cells (SMCs)...
  49. ncbi request reprint Differential effects of doxycycline, a broad-spectrum matrix metalloproteinase inhibitor, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysms
    Michael W Manning
    Department of Physiology, University of Kentucky, Lexington, KY 40536 0230, USA
    Arterioscler Thromb Vasc Biol 23:483-8. 2003
    ..To define the role of matrix metalloproteinases (MMPs) in the development of these vascular pathologies, we administered the broad-spectrum MMP inhibitor doxycycline to saline- and AngII-infused LDL receptor-/- mice...
  50. ncbi request reprint Interleukin-4 deficiency decreases atherosclerotic lesion formation in a site-specific manner in female LDL receptor-/- mice
    Victoria L King
    Gill Heart Institute, Division of Cardiovascular Medicine, University of Kentucky, Lexington 40536, USA
    Arterioscler Thromb Vasc Biol 22:456-61. 2002
    ..001) and the thoracic aorta (1.2 +/- 0.2% versus 0.4 +/- 0.1%, P<0.002). Therefore, IL-4 deficiency reduced atherosclerotic lesion formation in a site-specific manner in female LDL receptor-/- mice fed a high-fat diet...
  51. pmc Deficiency of angiotensin type 1a receptors in adipocytes reduces differentiation and promotes hypertrophy of adipocytes in lean mice
    Kelly Putnam
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky 40536 0200, USA
    Endocrinology 153:4677-86. 2012
    ..These results demonstrate that AngII regulates adipocyte differentiation and morphology through the adipocyte AT1aR in lean mice...
  52. pmc Urokinase-type plasminogen activator deficiency in bone marrow-derived cells augments rupture of angiotensin II-induced abdominal aortic aneurysms
    Haruhito A Uchida
    Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536 0509, USA
    Arterioscler Thromb Vasc Biol 31:2845-52. 2011
    ..Therefore, it is important to identify specific protease systems involved in extracellular matrix degradation during AAA formation. The present study determined the contribution of the urokinase system to AAA formation and rupture...
  53. ncbi request reprint Zinc deficiency alters lipid metabolism in LDL receptor deficient mice treated with rosiglitazone
    Huiyun Shen
    Molecular and Cell Nutrition Laboratory, College of Agriculture, University of Kentucky, Lexington, KY 40536, USA
    J Nutr 137:2339-45. 2007
    ..These data suggest that in this atherogenic mouse model treated with RSG, lipid metabolism can be compromised during zinc deficiency and that adequate dietary zinc may be considered during therapy with the antidiabetic medicine RSG...
  54. pmc Scavenger Receptor BI Protects against Septic Death through Its Role in Modulating Inflammatory Response
    Ling Guo
    Department of Pediatrics, University of Kentucky Medical School, Lexington, Kentucky 40536, USA
    J Biol Chem 284:19826-34. 2009
    ..SR-BI exerts its protective function through its role in modulating inflammatory response in macrophages and facilitating LPS recruitment and clearance...
  55. pmc MyD88 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation independent of signaling through Toll-like receptors 2 and 4
    A Phillip Owens
    Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536 0509, USA
    Arterioscler Thromb Vasc Biol 31:2813-9. 2011
    ....
  56. pmc Deficiency of the NR4A orphan nuclear receptor NOR1 decreases monocyte adhesion and atherosclerosis
    Yue Zhao
    Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536 0200, USA
    Circ Res 107:501-11. 2010
    ..Members of this subfamily have been characterized as early response genes regulating essential biological processes including inflammation and proliferation; however, the role of NOR1 in atherosclerosis remains unknown...
  57. ncbi request reprint Activation of the systemic and adipose renin-angiotensin system in rats with diet-induced obesity and hypertension
    Carine M Boustany
    Graduate Center for Nutritional Sciences, Rm 521b, Charles T Wethington Bldg, Univ of Kentucky, Lexington, KY 40536 0200, USA
    Am J Physiol Regul Integr Comp Physiol 287:R943-9. 2004
    ..05). These results demonstrate increased activity of the adipose and systemic RAS in obesity-related hypertension...
  58. pmc Group X secretory phospholipase A(2) augments angiotensin II-induced inflammatory responses and abdominal aortic aneurysm formation in apoE-deficient mice
    Melissa Zack
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40536 0200, USA
    Atherosclerosis 214:58-64. 2011
    ..Specific interventions that prevent AAA progression remain to be identified. In this study, we tested the hypothesis that Group X secretory phospholipase A(2) (GX sPLA(2)), an enzyme implicated in inflammatory processes, mediates AAA...
  59. ncbi request reprint Near-infrared spectrometry of abdominal aortic aneurysm in the ApoE-/- mouse
    Aaron Urbas
    Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506 0055, USA
    Anal Chem 75:3650-5. 2003
    ..99) and collagen/elastin (C/E) ratio (SEE = 0.38, SEP = 0.39, r2 = 0.85) in mouse aortas...
  60. pmc Amlodipine reduces AngII-induced aortic aneurysms and atherosclerosis in hypercholesterolemic mice
    Xiaofeng Chen
    Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS ONE 8:e81743. 2013
    ..The purpose of this study was to determine effects of amlodipine, a dihydropyridine calcium channel blocker, on development of angiotensin II (AngII)-induced vascular pathologies...
  61. pmc Novel mechanisms of abdominal aortic aneurysms
    Hong Lu
    Saha Cardiovascular Research Center, Biomedical Biological Sciences Research Building, B243, University of Kentucky, Lexington, KY 40536 0509, USA
    Curr Atheroscler Rep 14:402-12. 2012
    ..In addition, we advocate increased emphasis of collaborative studies using animal models and human tissues for determination of mechanisms that explore expansion and rupture of existing AAAs...
  62. pmc Interferon-gamma and the interferon-inducible chemokine CXCL10 protect against aneurysm formation and rupture
    Victoria L King
    Cardiovascular Research Center, University of Kentucky, Lexington, KY, USA
    Circulation 119:426-35. 2009
    ..T-helper type 1 cytokines, including interferon-gamma and CXCL10, have been strongly implicated in atherosclerotic plaque development...
  63. ncbi request reprint Interleukin-18 enhances atherosclerosis in apolipoprotein E(-/-) mice through release of interferon-gamma
    Stewart C Whitman
    Gill Heart Institute, Division of Cardiovascular Medicine, University of Kentucky, Lexington, KY 40536 0230, USA
    Circ Res 90:E34-8. 2002
    ..The full text of this article is available at http://www.circresaha.org...
  64. pmc Dietary fat interacts with PCBs to induce changes in lipid metabolism in mice deficient in low-density lipoprotein receptor
    Bernhard Hennig
    Molecular and Cell Nutrition Laboratory, College of Agriculture and Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky 40536 0200, USA
    Environ Health Perspect 113:83-7. 2005
    ..These findings have implications for understanding the interactions of nutrients with environmental contaminants on the pathology of inflammatory diseases such as atherosclerosis...
  65. ncbi request reprint Macrophage-specific expression of class A scavenger receptors in LDL receptor(-/-) mice decreases atherosclerosis and changes spleen morphology
    Stewart C Whitman
    Gill Heart Institute, Division of Hematology Oncology, University of Kentucky, Lexington, KY 40536, USA
    J Lipid Res 43:1201-8. 2002
    ..Therefore, macrophage-specific overexpression of SR-A resulted in reduced atherosclerosis in two vascular beds, reduced serum cholesterol concentrations, and changed the morphology of the spleen...
  66. ncbi request reprint Role of metabolism and receptor responsiveness in the attenuated responses to Angiotensin II in mice compared to rats
    Lisa A Cassis
    Room 434, Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Regul Pept 117:107-16. 2004
    ..Results from this study suggest that considerably higher doses of AngII may be required to elicit physiologic effects of AngII in mice...
  67. pmc Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice
    Frederique Yiannikouris
    Graduate Center for Nutritional Sciences, Univ of Kentucky, Lexington, KY 40536 0200, USA
    Am J Physiol Regul Integr Comp Physiol 302:R244-51. 2012
    ..05). These results demonstrate that adipocyte-derived AGT contributes to the systemic RAS and blood pressure control...
  68. doi request reprint Relevance of angiotensin II-induced aortic pathologies in mice to human aortic aneurysms
    Dennis Bruemmer
    Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky, USA
    Ann N Y Acad Sci 1245:7-10. 2011
    ..Angiotensin II infusion in mice promotes abdominal and thoracic aortic aneurysms, which provides a feasible approach to study the mechanisms of these two distinct diseases...
  69. doi request reprint Dietary coenzyme Q10 does not protect against cigarette smoke-augmented atherosclerosis in apoE-deficient mice
    C Gary Gairola
    Graduate Center for Toxicology, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Free Radic Biol Med 48:1535-9. 2010
    ..The results suggest a role of oxidative processes in smoke-augmented atherosclerosis that are different than those mitigated by CoQ10...
  70. ncbi request reprint Quantification of atherosclerosis in mice
    Alan Daugherty
    Gill Heart Institute, Division of Cardiovascular Medicine, University of Kentucky, Lexington, KY, USA
    Methods Mol Biol 209:293-309. 2003
  71. pmc The role of the renin-angiotensin system in aortic aneurysmal diseases
    Hong Lu
    Graduate Center for Nutritional Sciences, Wethington Building, Room 521b, 900 South Limestone Street, University of Kentucky, Lexington, KY 40536 0200, USA
    Curr Hypertens Rep 10:99-106. 2008
    ..A clinical study is currently ongoing to demonstrate the efficacy of AT1 receptor antagonism in humans...
  72. ncbi request reprint Orchidectomy, but not ovariectomy, regulates angiotensin II-induced vascular diseases in apolipoprotein E-deficient mice
    Tracy A Henriques
    Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536 0082, USA
    Endocrinology 145:3866-72. 2004
    ..In contrast, androgens mediate a higher incidence of AngII- induced AAA, through mechanisms that do not appear to involve circulating renin or angiotensin receptor density...
  73. doi request reprint Atherogenic and pulmonary responses of ApoE- and LDL receptor-deficient mice to sidestream cigarette smoke
    Sung Gu Han
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY, USA
    Toxicology 299:133-8. 2012
    ..SSCS-1577±142mg/dl, p=0.008). These results showing different effects of identical SSCS exposure on plasma cholesterol concentrations in these two mouse models suggest a role of multiple mechanisms in SSCS-induced atherosclerosis...
  74. pmc Deficiency of receptor-associated protein attenuates angiotensin II-induced atherosclerosis in hypercholesterolemic mice without influencing abdominal aortic aneurysms
    Shaoping Wang
    28th Division, Beijing An Zhen Hospital, Capital Medical University, Beijing 100029, China
    Atherosclerosis 220:375-80. 2012
    ....
  75. pmc Membrane cholesterol modulates the fluid shear stress response of polymorphonuclear leukocytes via its effects on membrane fluidity
    Xiaoyan Zhang
    Center for Biomedical Engineering, University of Kentucky, Lexington, KY 40506 0070, USA
    Am J Physiol Cell Physiol 301:C451-60. 2011
    ..This cholesterol-linked perturbation may contribute to dysregulated PMNL activity (e.g., chronic inflammation) related to hypercholesterolemia and causal for cardiovascular pathologies (e.g., atherosclerosis)...
  76. ncbi request reprint Aortic dissection precedes formation of aneurysms and atherosclerosis in angiotensin II-infused, apolipoprotein E-deficient mice
    Kiran Saraff
    Division of Cardiovascular Medicine, Gill Heart Institute, Lexington, KY, USA
    Arterioscler Thromb Vasc Biol 23:1621-6. 2003
    ....
  77. pmc Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin
    A Phillip Owens
    Department of Medicine, Division of Hematology and Oncology, McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Clin Invest 122:558-68. 2012
    ..Our results suggest that the prothrombotic state associated with hypercholesterolemia is caused by oxLDL-mediated induction of TF expression in monocytes via engagement of a TLR4/TLR6 complex...
  78. ncbi request reprint Overexpression of SR-BI by adenoviral vector promotes clearance of apoA-I, but not apoB, in human apoB transgenic mice
    Nancy R Webb
    Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY 40536
    J Lipid Res 43:1421-8. 2002
    ..However, such uptake was not significantly increased in mice over-expressing SR-BI. We conclude that SR-BI-mediated selective uptake from LDL plays a minor role in LDL metabolism in vivo...
  79. ncbi request reprint COX-2 up-regulation and vascular smooth muscle contractile hyperreactivity in spontaneous diabetic db/db mice
    Zhenheng Guo
    Department of Physiology, University of Kentucky, 509 Wethington Building, 900 South Limestone, Lexington, KY 40536, USA
    Cardiovasc Res 67:723-35. 2005
    ..However, mechanisms underlying such vascular dysfunction remain to be fully elucidated. The current study tests the role of cyclooxygenase-2 (COX-2) in diabetic vascular smooth muscle dysfunction...
  80. ncbi request reprint Mouse models of atherosclerosis
    Alan Daugherty
    Gill Heart Institute, Division of Cardiovascular Medicine, University of Kentucky, Lexington 40536, USA
    Am J Med Sci 323:3-10. 2002
    ..This review selectively highlights some of the most commonly used mouse models of atherosclerosis and compare their lesions to those formed in the human disease...
  81. doi request reprint Modes of defining atherosclerosis in mouse models: relative merits and evolving standards
    Alan Daugherty
    Cardiovascular Research Center, University of Kentucky, Lexington, KY, USA
    Methods Mol Biol 573:1-15. 2009
    ..This chapter will discuss the imaging, biochemical, and compositional modes of evaluating atherosclerosis with suggestions for standard execution of these techniques...
  82. ncbi request reprint Atherosclerosis and arterial blood pressure in mice
    Hong Lu
    Cardiovascular Research Center, Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky 40536 0200, USA
    Curr Drug Targets 8:1181-9. 2007
    ..A consistent theme in the literature has been that perturbations of the renin angiotensin system display the strongest correlations between blood pressure and atherosclerosis...
  83. pmc Acid Sphingomyelinase Deficiency Prevents Diet-induced Hepatic Triacylglycerol Accumulation and Hyperglycemia in Mice
    Gergana M Deevska
    Departments of Physiology, Pediatrics, and Internal Medicine, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    J Biol Chem 284:8359-68. 2009
    ....
  84. ncbi request reprint Proinflammatory properties of coplanar PCBs: in vitro and in vivo evidence
    Bernhard Hennig
    Cell Nutrition Group, Department of Animal Sciences, University of Kentucky, Lexington 40506 0054, USA
    Toxicol Appl Pharmacol 181:174-83. 2002
    ..An intact AhR may be necessary for the observed PCB-induced responses. These findings suggest that activation of the AhR can be an underlying mechanism of atherosclerosis mediated by certain environmental contaminants...
  85. ncbi request reprint Mechanisms of abdominal aortic aneurysm formation
    Alan Daugherty
    Division of Cardiovascular Medicine and Division of Pharmaceutical Science, Gill Heart Institute, University of Kentucky, Sanders Brown Building, Room 424, Lexington 40536 0230, USA
    Curr Atheroscler Rep 4:222-7. 2002
    ..Definition of specific mechanisms would identify target sites for potential pharmacologic intervention and markedly improve the medical treatment and prognosis of AAA...
  86. ncbi request reprint Class A scavenger receptor-mediated adhesion and internalization require distinct cytoplasmic domains
    Ninetta Kosswig
    Department of Internal Medicine, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    J Biol Chem 278:34219-25. 2003
    ..Together, our results indicate a critical role for the membrane-proximal amino acids in SR-A trafficking and demonstrate that SR-A-mediated adhesion and internalization require distinct cytoplasmic domains...
  87. ncbi request reprint Abdominal aortic aneurysms: fresh insights from a novel animal model of the disease
    Michael W Manning
    Department of Physiology, College of Pharmacy, University of Kentucky, Lexington 40536, USA
    Vasc Med 7:45-54. 2002
    ..The AngII-induced model of AAA has the potential to provide novel insights into the underlying mechanisms of this disease and assist with the development of pharmacological therapies...
  88. ncbi request reprint Atherosclerosis: cell biology and lipoproteins
    Alan Daugherty
    Curr Opin Lipidol 13:453-5. 2002
  89. ncbi request reprint Reduction in ABCG1 in Type 2 diabetic mice increases macrophage foam cell formation
    Jeremy P Mauldin
    Department of Pharmacology, Division of Endocrinology and Metabolism, University of Virginia, Charlottesville, 22908, USA
    J Biol Chem 281:21216-24. 2006
    ..These observations demonstrate that ABCG1 plays a major role in macrophage cholesterol efflux and that decreased ABCG1 function can facilitate foam cell formation in Type 2 diabetic mice...
  90. ncbi request reprint T lymphocytes in atherosclerosis: the yin-yang of Th1 and Th2 influence on lesion formation
    Alan Daugherty
    Circ Res 90:1039-40. 2002
  91. ncbi request reprint Depletion of natural killer cell function decreases atherosclerosis in low-density lipoprotein receptor null mice
    Stewart C Whitman
    Departments of Pathology and Laboratory Medicine, University of Ottawa Heart Institute, 40 Ruskin St, Room H259A, Ottawa, Ontario, Canada, K1Y 4W7
    Arterioscler Thromb Vasc Biol 24:1049-54. 2004
    ..To determine this role, we created chimeric atherosclerosis-susceptible low-density lipoprotein (LDL) receptor null (ldl-r-/-) mice that were deficient in functional NK cells through expression of a transgene encoding for Ly49A...
  92. ncbi request reprint Atherosclerosis: cell biology and lipoproteins
    Alan Daugherty
    Curr Opin Lipidol 17:95-7. 2006
  93. pmc Deletion of p47phox attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice
    Manesh Thomas
    Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Circulation 114:404-13. 2006
    ..Here, we tested the hypothesis that deletion of p47phox will attenuate oxidative stress and AAA formation in Ang II-infused apoE-/- mice...
  94. ncbi request reprint IFN-gamma deficiency exerts gender-specific effects on atherogenesis in apolipoprotein E-/- mice
    Stewart C Whitman
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada, K1Y 4W7
    J Interferon Cytokine Res 22:661-70. 2002
    ..However, this effect is strikingly restricted to male mice...
  95. pmc Vitamin E inhibits abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice
    Dan Gavrila
    Department of Internal Medicine, University of Iowa, Iowa City, IA, USA
    Arterioscler Thromb Vasc Biol 25:1671-7. 2005
    ..We investigated the hypothesis that vitamin E, an antioxidant with documented efficacy in mice, can attenuate AAA formation during angiotensin II (Ang II) infusion in apolipoprotein E-deficient mice...
  96. ncbi request reprint Translating molecular discoveries into new therapies for atherosclerosis
    Daniel J Rader
    Cardiovascular Institute and Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, 654 BRBII III, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Nature 451:904-13. 2008
    ....
  97. ncbi request reprint Alpha(1,3)fucosyltransferases FucT-IV and FucT-VII control susceptibility to atherosclerosis in apolipoprotein E-/- mice
    Jonathon W Homeister
    Department of Pathology and The Howard Hughes Medical Institute, University of Michigan, M5240 Medical Science I, 1301 Catherine Street, Ann Arbor, MI 48109 0602, USA
    Arterioscler Thromb Vasc Biol 24:1897-903. 2004
    ..They also determine the functional contribution of FucT-IV and FucT-VII to shear-dependent tethering of monocytes to P-selectin, a process believed to be required for atherogenesis...
  98. pmc As macrophages indulge, atherosclerotic lesions bulge
    Alan Daugherty
    Circ Res 102:1445-7. 2008
  99. ncbi request reprint Nobiletin, a citrus flavonoid isolated from tangerines, selectively inhibits class A scavenger receptor-mediated metabolism of acetylated LDL by mouse macrophages
    Stewart C Whitman
    Laboratory Medicine and Cellular and Molecular Medicine, Department of Pathology, University of Ottawa Heart Institute, 40 Ruskin St, Room H259A, Ottawa, Ont, Canada K1Y 4W7
    Atherosclerosis 178:25-32. 2005
    ..In conclusion, our findings suggest that in addition to reducing plasma cholesterol concentrations, nobiletin may prevent atherosclerosis at the level of the vascular wall by inhibiting macrophage foam-cell formation...
  100. ncbi request reprint Atherosclerosis: cell biology and lipoproteins
    Alan Daugherty
    Curr Opin Lipidol 16:257-9. 2005

Research Grants13

  1. ANGII PROINFLAMMATORY PROCESSES IN ATHEROGENESIS
    Alan Daugherty; Fiscal Year: 2000
    ..These studies will define mechanisms for AngII augmentation of atherogenesis. Moreover, the development of this animal model for aortic aneurysm formation will allow for definition of mechanisms contributing to this vascular pathology. ..
  2. Sources and effects of angiotensin peptides in atherosclerosis
    Alan Daugherty; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Atherosclerotic diseases are the major cause of morbidity and mortality in the US population. Therefore, investigations to prevent these diseases have vast public health implications. ..
  3. Sources and effects of angiotensin peptides in atherosclerosis
    Alan Daugherty; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: Atherosclerotic diseases are the major cause of morbidity and mortality in the US population. Therefore, investigations to prevent these diseases have vast public health implications. ..
  4. Role of MMPs in AngII induced abdominal aortic aneurysms
    Alan Daugherty; Fiscal Year: 2005
    ..The significance of this research relates to delineation of mechanism for AA formation and maturation, with emphasis on potential development of pharmacological treatments of the disease. ..
  5. Role of MMPs in AngII induced abdominal aortic aneurysms
    Alan Daugherty; Fiscal Year: 2003
    ..The significance of this research relates to delineation of mechanism for AA formation and maturation, with emphasis on potential development of pharmacological treatments of the disease. ..
  6. Role of MMPs in AngII induced abdominal aortic aneurysms
    Alan Daugherty; Fiscal Year: 2004
    ..The significance of this research relates to delineation of mechanism for AA formation and maturation, with emphasis on potential development of pharmacological treatments of the disease. ..
  7. Role of MMPs in AngII induced abdominal aortic aneurysms
    Alan Daugherty; Fiscal Year: 2003
    ..The significance of this research relates to delineation of mechanism for AA formation and maturation, with emphasis on potential development of pharmacological treatments of the disease. ..
  8. ANGII PROINFLAMMATORY PROCESSES IN ATHEROGENESIS
    Alan Daugherty; Fiscal Year: 2003
    ..These studies will define mechanisms for AngII augmentation of atherogenesis. Moreover, the development of this animal model for aortic aneurysm formation will allow for definition of mechanisms contributing to this vascular pathology. ..
  9. ANGII PROINFLAMMATORY PROCESSES IN ATHEROGENESIS
    Alan Daugherty; Fiscal Year: 2002
    ..These studies will define mechanisms for AngII augmentation of atherogenesis. Moreover, the development of this animal model for aortic aneurysm formation will allow for definition of mechanisms contributing to this vascular pathology. ..
  10. Role of MMPs in AngII induced abdominal aortic aneurysms
    Alan Daugherty; Fiscal Year: 2002
    ..The significance of this research relates to delineation of mechanism for AA formation and maturation, with emphasis on potential development of pharmacological treatments of the disease. ..
  11. ANGII PROINFLAMMATORY PROCESSES IN ATHEROGENESIS
    Alan Daugherty; Fiscal Year: 2001
    ..These studies will define mechanisms for AngII augmentation of atherogenesis. Moreover, the development of this animal model for aortic aneurysm formation will allow for definition of mechanisms contributing to this vascular pathology. ..
  12. Sources and effects of angiotensin peptides in atherosclerosis
    Alan Daugherty; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: Atherosclerotic diseases are the major cause of morbidity and mortality in the US population. Therefore, investigations to prevent these diseases have vast public health implications. ..