Sandip K Datta

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint The therapeutic potential of antigen-oligonucleotide conjugates
    Sandip K Datta
    The Sam and Rose Stein Institute for Research on Aging, Department of Medicine, University of California San Diego, La Jolla, California 92093 0663, USA
    Ann N Y Acad Sci 1002:105-11. 2003
  2. ncbi request reprint Induction of antigen cross-presentation by Toll-like receptors
    Sandip K Datta
    University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0663, USA
    Springer Semin Immunopathol 26:247-55. 2005
  3. ncbi request reprint Vaccination with irradiated Listeria induces protective T cell immunity
    Sandip K Datta
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093, USA
    Immunity 25:143-52. 2006
  4. ncbi request reprint A subset of Toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells
    Sandip K Datta
    Department of Medicine and The Sam and Rose Stein Institute for Research on Aging, University of California, La Jolla, CA 92093, USA
    J Immunol 170:4102-10. 2003
  5. pmc TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice
    Jose M Gonzalez-Navajas
    Department of Medicine, UCSD, La Jolla, California, USA
    J Clin Invest 120:570-81. 2010
  6. ncbi request reprint Cutting edge: activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma
    Vanessa Redecke
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Immunol 172:2739-43. 2004
  7. ncbi request reprint Antigen-immunostimulatory oligonucleotide conjugates: mechanisms and applications
    Sandip K Datta
    The Sam and Rose Stein Institute for Research on Aging, Department of Medicine, University of California, San Diego, CA 92093 0663, USA
    Immunol Rev 199:217-26. 2004
  8. ncbi request reprint CpG oligonucleotides partially inhibit growth of Mycobacterium tuberculosis, but not Salmonella or Listeria, in human monocyte-derived macrophages
    Jennifer P Wang
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    FEMS Immunol Med Microbiol 45:303-10. 2005
  9. ncbi request reprint Evidence for interleukin-1-independent stimulation of interleukin-12 and down-regulation by interleukin-10 in Helicobacter pylori-infected murine dendritic cells deficient in the interleukin-1 receptor
    Marygorret Obonyo
    Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0640, USA
    FEMS Immunol Med Microbiol 47:414-9. 2006
  10. ncbi request reprint Molecular and cellular mechanisms of protective immunity to coccidioidomycosis
    Theo N Kirkland
    the Department of Pathology and Medicine, University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Vaccine 24:495-500. 2006

Research Grants

Collaborators

Detail Information

Publications12

  1. ncbi request reprint The therapeutic potential of antigen-oligonucleotide conjugates
    Sandip K Datta
    The Sam and Rose Stein Institute for Research on Aging, Department of Medicine, University of California San Diego, La Jolla, California 92093 0663, USA
    Ann N Y Acad Sci 1002:105-11. 2003
    ..This review summarizes the available data on the use of antigen-oligonucleotide conjugates and discusses their potential use for the treatment of infectious, oncologic, and allergic diseases in humans...
  2. ncbi request reprint Induction of antigen cross-presentation by Toll-like receptors
    Sandip K Datta
    University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0663, USA
    Springer Semin Immunopathol 26:247-55. 2005
    ..The implications of these studies for understanding CD8(+) T cell activation and implementing novel vaccine strategies is considered...
  3. ncbi request reprint Vaccination with irradiated Listeria induces protective T cell immunity
    Sandip K Datta
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093, USA
    Immunity 25:143-52. 2006
    ..gamma-irradiation may be potentially applied to numerous bacterial vaccine candidates, and irradiated bacteria could serve as a vaccine platform for recombinant antigens derived from other pathogens, allergens, or tumors...
  4. ncbi request reprint A subset of Toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells
    Sandip K Datta
    Department of Medicine and The Sam and Rose Stein Institute for Research on Aging, University of California, La Jolla, CA 92093, USA
    J Immunol 170:4102-10. 2003
    ..In contrast to presentation of Ag to CD4(+) T cells by immature DCs, TLR-induced cross-presentation is mediated by mature DCs, is independent of endosomal acidification, and relies on cytosolic Ag processing machinery...
  5. pmc TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice
    Jose M Gonzalez-Navajas
    Department of Medicine, UCSD, La Jolla, California, USA
    J Clin Invest 120:570-81. 2010
    ..Our data therefore reveal a tonic inhibitory role for TLR4 signaling on subsequent TCR-dependent CD4+ T cell responses...
  6. ncbi request reprint Cutting edge: activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma
    Vanessa Redecke
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Immunol 172:2739-43. 2004
    ....
  7. ncbi request reprint Antigen-immunostimulatory oligonucleotide conjugates: mechanisms and applications
    Sandip K Datta
    The Sam and Rose Stein Institute for Research on Aging, Department of Medicine, University of California, San Diego, CA 92093 0663, USA
    Immunol Rev 199:217-26. 2004
    ..This review considers the mechanisms of action of antigen-oligonucleotide conjugates and discusses available data regarding their use for the prevention and treatment of infectious, oncologic, and allergic diseases...
  8. ncbi request reprint CpG oligonucleotides partially inhibit growth of Mycobacterium tuberculosis, but not Salmonella or Listeria, in human monocyte-derived macrophages
    Jennifer P Wang
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    FEMS Immunol Med Microbiol 45:303-10. 2005
    ..These data indicate that CpG-ODN can improve the ability of hMDM to contain growth of virulent M. tuberculosis...
  9. ncbi request reprint Evidence for interleukin-1-independent stimulation of interleukin-12 and down-regulation by interleukin-10 in Helicobacter pylori-infected murine dendritic cells deficient in the interleukin-1 receptor
    Marygorret Obonyo
    Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0640, USA
    FEMS Immunol Med Microbiol 47:414-9. 2006
    ..pylori when the bacterial load is high, allowing for persistent colonization of the gastric mucosa...
  10. ncbi request reprint Molecular and cellular mechanisms of protective immunity to coccidioidomycosis
    Theo N Kirkland
    the Department of Pathology and Medicine, University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Vaccine 24:495-500. 2006
    ..This study elucidates the mechanisms needed to elicit successful immunity against coccidioidomycosis, and holds promise for development of an effective coccidioidal vaccine against coccidioidomycosis...
  11. pmc Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7
    Tomoko Hayashi
    Moores Cancer Center, and Department Medicine, University California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 106:2764-9. 2009
    ..These findings suggest that induction of TLR7 tolerance might be a new therapeutic approach to subdue inflammation in autoimmune diseases...
  12. ncbi request reprint IFN-alpha beta promote priming of antigen-specific CD8+ and CD4+ T lymphocytes by immunostimulatory DNA-based vaccines
    Hearn Jay Cho
    Division of Hematology Medical Oncology, Department of Medicine, New York Presbyterian Hospital and Cornell Medical Center, 525 East 68th Street, New York, NY 10021
    J Immunol 168:4907-13. 2002
    ..Coordinated regulation of B7 costimulation and TAP-dependent cross-presentation results in priming of Ag-specific CD8(+) CTL, whereas CD40, B7, and IL-12 costimulation is required for priming of CD4(+) Th cells by ISS-based vaccines...

Research Grants1