Mohan R Dasu

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Increased toll-like receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects
    Mohan R Dasu
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, California, USA
    Diabetes Care 33:861-8. 2010
  2. doi request reprint Toll-like receptors and diabetes: a therapeutic perspective
    Mohan R Dasu
    Department of Dermatology, University of California Davis, Sacramento, CA 95816, USA
    Clin Sci (Lond) 122:203-14. 2012
  3. pmc Amelioration in wound healing in diabetic toll-like receptor-4 knockout mice
    Mohan R Dasu
    Department of Dermatology, University of California at Davis, Sacramento, CA 95816, USA Electronic address
    J Diabetes Complications 27:417-21. 2013
  4. ncbi request reprint Toll-like receptors and diabetes complications: recent advances
    Sandra Rosa Ramirez
    Department of Dermatology, U C Davis 3301 C Street, Sacramento CA 95816, USA
    Curr Diabetes Rev 8:480-8. 2012
  5. pmc Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors
    Mohan R Dasu
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, CA 95817, USA
    Am J Physiol Endocrinol Metab 300:E145-54. 2011
  6. pmc Pioglitazone inhibits Toll-like receptor expression and activity in human monocytes and db/db mice
    Mohan R Dasu
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis, Medical Center, Sacramento, California 95817, USA
    Endocrinology 150:3457-64. 2009
  7. pmc High glucose induces toll-like receptor expression in human monocytes: mechanism of activation
    Mohan R Dasu
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, California, USA
    Diabetes 57:3090-8. 2008
  8. pmc Candesartan inhibits Toll-like receptor expression and activity both in vitro and in vivo
    Mohan R Dasu
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, CA 95817, United States
    Atherosclerosis 202:76-83. 2009
  9. pmc Increased toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: further evidence of a proinflammatory state
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, California 95817, USA
    J Clin Endocrinol Metab 93:578-83. 2008
  10. ncbi request reprint The biological effects of CRP are not attributable to endotoxin contamination: evidence from TLR4 knockdown human aortic endothelial cells
    Mohan R Dasu
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, CA, USA
    J Lipid Res 48:509-12. 2007

Collaborators

Detail Information

Publications18

  1. pmc Increased toll-like receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects
    Mohan R Dasu
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, California, USA
    Diabetes Care 33:861-8. 2010
    ..Thus, in the present study, we examined TLR2 and TLR4 mRNA and protein expression, their ligands, and signaling in monocytes of recently diagnosed type 2 diabetic patients...
  2. doi request reprint Toll-like receptors and diabetes: a therapeutic perspective
    Mohan R Dasu
    Department of Dermatology, University of California Davis, Sacramento, CA 95816, USA
    Clin Sci (Lond) 122:203-14. 2012
    ..Furthermore, we will highlight some of the therapeutic strategies targeted at decreasing TLRs to abrogate inflammation in diabetes that may eventually result in decreased complications...
  3. pmc Amelioration in wound healing in diabetic toll-like receptor-4 knockout mice
    Mohan R Dasu
    Department of Dermatology, University of California at Davis, Sacramento, CA 95816, USA Electronic address
    J Diabetes Complications 27:417-21. 2013
    ....
  4. ncbi request reprint Toll-like receptors and diabetes complications: recent advances
    Sandra Rosa Ramirez
    Department of Dermatology, U C Davis 3301 C Street, Sacramento CA 95816, USA
    Curr Diabetes Rev 8:480-8. 2012
    ..Thus, in this review, we will provide summaries of the TLR expression and activation and elucidate their role in propagating inflammation seen in DM complications...
  5. pmc Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors
    Mohan R Dasu
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, CA 95817, USA
    Am J Physiol Endocrinol Metab 300:E145-54. 2011
    ..We conclude that FFA exacerbates HG-induced TLR expression and activity in monocytic cells with excess superoxide release, enhanced NF-κB activity, and induced proinflammatory factor release...
  6. pmc Pioglitazone inhibits Toll-like receptor expression and activity in human monocytes and db/db mice
    Mohan R Dasu
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis, Medical Center, Sacramento, California 95817, USA
    Endocrinology 150:3457-64. 2009
    ..Data suggest that Pam- and LPS-induced TLR2 and TLR4 expression are inhibited by PIO in human monocytes and db/db mice. Thus, we define a novel pathway by which PIO could induce antiinflammatory effects...
  7. pmc High glucose induces toll-like receptor expression in human monocytes: mechanism of activation
    Mohan R Dasu
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, California, USA
    Diabetes 57:3090-8. 2008
    ..Thus, in the present study, we examined TLR2 and TLR4 mRNA and protein expression and mechanism of their induction in monocytic cells under high-glucose conditions...
  8. pmc Candesartan inhibits Toll-like receptor expression and activity both in vitro and in vivo
    Mohan R Dasu
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, CA 95817, United States
    Atherosclerosis 202:76-83. 2009
    ..Thus, we investigated whether an ARB exerts anti-inflammatory effects via inhibiting TLR2 and TLR4 expression...
  9. pmc Increased toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: further evidence of a proinflammatory state
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, California 95817, USA
    J Clin Endocrinol Metab 93:578-83. 2008
    ..TLR2 and TLR4 are important in atherosclerosis. However, there is a paucity of data examining TLR2 and TLR4 expression in T1DM and examining its contribution to the proinflammatory state...
  10. ncbi request reprint The biological effects of CRP are not attributable to endotoxin contamination: evidence from TLR4 knockdown human aortic endothelial cells
    Mohan R Dasu
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, CA, USA
    J Lipid Res 48:509-12. 2007
    ..This is the first study to positively authenticate the significance of earlier in vitro reports on CRP biological effects...
  11. pmc C-reactive protein stimulates superoxide anion release and tissue factor activity in vivo
    Sridevi Devaraj
    The Laboratory for Atherosclerosis and Metabolic Research, Department of Medical Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, CA 95817, United States
    Atherosclerosis 203:67-74. 2009
    ..CRP-induced ROS appears to precede tissue factor release. These effects are abrogated by blocking Fc gamma receptors, CD32 and CD64. This in vivo demonstration provides further evidence for a role for CRP in atherothrombosis...
  12. doi request reprint TLR2 expression and signaling-dependent inflammation impair wound healing in diabetic mice
    Mohan R Dasu
    Department of Pathology, University of California Davis, Sacramento, CA, USA
    Lab Invest 90:1628-36. 2010
    ....
  13. pmc High glucose induces IL-1beta expression in human monocytes: mechanistic insights
    Mohan R Dasu
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, 4635 2nd Ave, Research Bldg 1, Sacramento, CA 95817, USA
    Am J Physiol Endocrinol Metab 293:E337-46. 2007
    ..Targeting signaling pathways mediating IL-1beta release could result in the amelioration of inflammation and possibly diabetic vasculopathies...
  14. pmc Adiponectin decreases C-reactive protein synthesis and secretion from endothelial cells: evidence for an adipose tissue-vascular loop
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, 4635 Second Avenue, Sacramento, CA 95817, USA
    Arterioscler Thromb Vasc Biol 28:1368-74. 2008
    ..We tested the hypothesis that adiponectin reduces CRP synthesis and secretion in HAECs under normoglycemic (5.5 mmol/L glucose) and hyperglycemic conditions (15 mmol/L glucose)...
  15. ncbi request reprint C-reactive protein adversely alters the protein-protein interaction of the endothelial isoform of nitric oxide synthase
    Simona Valleggi
    Laboratory for Atherosclerosis and Metabolic Research, Department of Medical Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, CA 95817, USA
    Clin Chem 56:1345-8. 2010
    ..In this study, we examined the effect of CRP treatment of human aortic endothelial cells (HAECs) on eNOS interaction with caveolin-1, Hsp90, and porin...
  16. ncbi request reprint C-reactive protein decreases interleukin-10 secretion in activated human monocyte-derived macrophages via inhibition of cyclic AMP production
    Uma Singh
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    Arterioscler Thromb Vasc Biol 26:2469-75. 2006
    ..IL-10 deficiency results in increased lesion formation, whereas IL-10 delivery attenuates lesions. We tested the effect of CRP on lipopolysaccharide (LPS)-induced IL-10 secretion in human monocyte-derived macrophages (HMDMs)...
  17. doi request reprint Plant-based modulation of Toll-like receptors: an emerging therapeutic model
    Dev S Chahal
    Department of Dermatology, University of California Davis, Sacramento, CA, USA
    Phytother Res 27:1423-38. 2013
    ..Further research is needed to identify bioactive components of the extracts, mechanisms of their action, and in vivo pharmacological effects using appropriate disease models to ultimately adapt the findings for clinical use...
  18. doi request reprint Toll-like receptors in wound healing: location, accessibility, and timing
    Mohan R Dasu
    Department of Dermatology, VA Northern California Health Care Systems, and the University of California, Davis, California 95616, USA
    J Invest Dermatol 132:1955-8. 2012
    ..Understanding these attributes could improve therapeutic strategies for treating chronic wounds...