Affiliation: University of Colorado Health Sciences Center
- Hypoxia-induced proliferative response of vascular adventitial fibroblasts is dependent on g protein-mediated activation of mitogen-activated protein kinasesM Das
Cardiovascular Pulmonary and Developmental Lung Biology Research Labs and the Department of Renal Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Biol Chem 276:15631-40. 2001....
- Selective expansion of fibroblast subpopulations from pulmonary artery adventitia in response to hypoxiaM Das
Cardiovascular Pulmonary and Developmental Lung Biology Research Laboratories, University of Colorado Health Sciences Center, Denver 80262, USA
Am J Physiol Lung Cell Mol Physiol 282:L976-86. 2002..We conclude that the bovine PA adventitia comprises numerous phenotypically and biochemically distinct fibroblast subpopulations and that select subpopulations expand in response to chronic hypoxia...
- Hypoxia exposure induces the emergence of fibroblasts lacking replication repressor signals of PKCzeta in the pulmonary artery adventitiaMita Das
Department of Pediatrics, B131, University of Colorado Denver, School of Medicine, 4200 E 9th Avenue, Denver, CO 80262, USA
Cardiovasc Res 78:440-8. 2008....
- Protein kinase Czeta attenuates hypoxia-induced proliferation of fibroblasts by regulating MAP kinase phosphatase-1 expressionMegan D Short
Developmental Lung Biology Research Laboratory, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Mol Biol Cell 17:1995-2008. 2006....
- Hypoxia induces differentiation of pulmonary artery adventitial fibroblasts into myofibroblastsMegan Short
Department of Pediatrics, Developmental Lung Biology Research Laboratories, University of Colorado Health Sciences Center, 4200 E. 9th Ave, Denver, CO 80262, USA
Am J Physiol Cell Physiol 286:C416-25. 2004....
- Hypoxia-induced alterations in protein kinase C zeta signaling result in augmented fibroblast proliferationMegan Short
Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Chest 128:582S. 2005
- Role of the adventitia in pulmonary vascular remodelingKurt R Stenmark
Division of Pediatric Critical Care, University of Colorado at Denver and Health Sciences Center, Denver, Colorado, USA
Physiology (Bethesda) 21:134-45. 2006..The purpose of this review is to present the current evidence demonstrating that the adventitial fibroblast acts as a key regulator of pulmonary vascular function and structure from the "outside-in."..
- Hypoxic activation of adventitial fibroblasts: role in vascular remodelingKurt R Stenmark
Developmental Lung Biology Research Laboratory, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Chest 122:326S-334S. 2002....
- Mitogen-activated protein kinase phosphatase-1 is a key regulator of hypoxia-induced vascular endothelial growth factor expression and vessel density in lungKristin M Shields
Department of Pediatrics, University of Colorado Denver, Aurora, Colorado, USA
Am J Pathol 178:98-109. 2011..Therefore, our data strongly suggest that MKP-1 might be the key regulator of vascular densities through the regulation of VEGF levels in hypoxic lung...
- Neurotransplantation of stem cells genetically modified to express human dopamine transporter reduces alcohol consumptionTom N Grammatopoulos
Department of Medicine, University of Colorado Denver, 12800 East 19th Avenue, Aurora, CO 80045, USA
Stem Cell Res Ther 1:36. 2010..We reasoned that reducing extracellular DA levels, by engrafting into NAC DA-sequestering stem cells expressing hDAT, would alter alcohol intake...
- Dopamine selectively sensitizes dopaminergic neurons to rotenone-induced apoptosisFerogh A Ahmadi
Division of Clinical Pharmacology and Toxicology, Department of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
Neurochem Res 33:886-901. 2008..Our results demonstrate that an inhibitor of mitochondrial complex I and increased cytosolic DA may cooperatively lead to conditions of elevated oxidative stress and thereby promote selective demise of dopaminergic neurons...