HRIDAY DAS

Summary

Affiliation: University of North Texas
Country: USA

Publications

  1. ncbi request reprint Genes implicated in the pathogenesis of Alzheimer's disease
    H K Das
    Department of Pharmacology, University of North Texas Health Science Center at Fort Worth, Texas 76107, USA
    Front Biosci 2:d253-9. 1997
  2. ncbi request reprint Transcriptional regulation of the presenilin-1 gene: implication in Alzheimer's disease
    Hriday K Das
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas 76107, USA
    Front Biosci 13:822-32. 2008
  3. ncbi request reprint ADR1 interacts with a down-stream positive element to activate PS1 transcription
    Hriday K Das
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
    Front Biosci 13:3439-47. 2008
  4. ncbi request reprint Regulation of transcription of the human presenilin-1 gene by ets transcription factors and the p53 protooncogene
    M Pastorcic
    Department of Pharmacology and Neuroscience and Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    J Biol Chem 275:34938-45. 2000
  5. ncbi request reprint An upstream element containing an ETS binding site is crucial for transcription of the human presenilin-1 gene
    M Pastorcic
    Department of Pharmacology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    J Biol Chem 274:24297-307. 1999
  6. ncbi request reprint Ets transcription factors ER81 and Elk1 regulate the transcription of the human presenilin 1 gene promoter
    Martine Pastorcic
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, 76107, USA
    Brain Res Mol Brain Res 113:57-66. 2003
  7. ncbi request reprint An abbreviated procedure for the cloning and identification of Ets transcription factors regulating the expression of the human presenilin 1 gene
    Martine Pastorcic
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Brain Res Brain Res Protoc 12:35-40. 2003
  8. ncbi request reprint Regulatory roles of presenilin-1 and nicastrin in neuronal differentiation during in vitro neurogenesis
    Saumyendra N Sarkar
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 76107, USA
    J Neurochem 87:333-43. 2003
  9. pmc Analysis of transcriptional modulation of the presenilin 1 gene promoter by ZNF237, a candidate binding partner of the Ets transcription factor ERM
    Martine Pastorcic
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Brain Res 1128:21-32. 2007
  10. ncbi request reprint The C-terminal region of CHD3/ZFH interacts with the CIDD region of the Ets transcription factor ERM and represses transcription of the human presenilin 1 gene
    Martine Pastorcic
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    FEBS J 274:1434-48. 2007

Research Grants

  1. HEPATIC REGULATION OF THE HUMAN APOB GENE
    HRIDAY DAS; Fiscal Year: 2002
  2. Regulation of Human Presenilin-1
    HRIDAY DAS; Fiscal Year: 2004

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Genes implicated in the pathogenesis of Alzheimer's disease
    H K Das
    Department of Pharmacology, University of North Texas Health Science Center at Fort Worth, Texas 76107, USA
    Front Biosci 2:d253-9. 1997
    ..Identification of lesions in the molecules that are important in the Alzheimer's disease should allow developing therapeutic approaches for its treatment...
  2. ncbi request reprint Transcriptional regulation of the presenilin-1 gene: implication in Alzheimer's disease
    Hriday K Das
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas 76107, USA
    Front Biosci 13:822-32. 2008
    ..An in depth understanding of the regulatory mechanism of PS1 transcription can identify the targets that can potentially be used in therapeutic intervention of AD...
  3. ncbi request reprint ADR1 interacts with a down-stream positive element to activate PS1 transcription
    Hriday K Das
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
    Front Biosci 13:3439-47. 2008
    ..These data suggest that a novel mammalian trans-activator protein ADR1 binds to the downstream element (+140 to +165) to activate PS1 transcription...
  4. ncbi request reprint Regulation of transcription of the human presenilin-1 gene by ets transcription factors and the p53 protooncogene
    M Pastorcic
    Department of Pharmacology and Neuroscience and Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    J Biol Chem 275:34938-45. 2000
    ..We show that p53 does not bind directly to the PS1 promoter. Hence the repression of PS1 transcription by p53 is likely to be mediated through protein-protein interactions...
  5. ncbi request reprint An upstream element containing an ETS binding site is crucial for transcription of the human presenilin-1 gene
    M Pastorcic
    Department of Pharmacology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    J Biol Chem 274:24297-307. 1999
    ..Hence, this suggests that protein-protein interactions between factors recognizing downstream and upstream sequences are involved...
  6. ncbi request reprint Ets transcription factors ER81 and Elk1 regulate the transcription of the human presenilin 1 gene promoter
    Martine Pastorcic
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, 76107, USA
    Brain Res Mol Brain Res 113:57-66. 2003
    ..However, GABPbeta alone activated PS1 transcription by two- to threefold. In contrast, the more distantly related Ets factor Elk1 repressed PS1 transcription very effectively...
  7. ncbi request reprint An abbreviated procedure for the cloning and identification of Ets transcription factors regulating the expression of the human presenilin 1 gene
    Martine Pastorcic
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Brain Res Brain Res Protoc 12:35-40. 2003
    ....
  8. ncbi request reprint Regulatory roles of presenilin-1 and nicastrin in neuronal differentiation during in vitro neurogenesis
    Saumyendra N Sarkar
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 76107, USA
    J Neurochem 87:333-43. 2003
    ..These results taken together provide direct evidence that PS1 and NICA may participate in neuronal differentiation during neurogenesis in vitro...
  9. pmc Analysis of transcriptional modulation of the presenilin 1 gene promoter by ZNF237, a candidate binding partner of the Ets transcription factor ERM
    Martine Pastorcic
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Brain Res 1128:21-32. 2007
    ..Data from electrophoretic mobility shift assays indicate that ERM and possibly ZNF237 interact with a fragment of the PS1 promoter...
  10. ncbi request reprint The C-terminal region of CHD3/ZFH interacts with the CIDD region of the Ets transcription factor ERM and represses transcription of the human presenilin 1 gene
    Martine Pastorcic
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    FEBS J 274:1434-48. 2007
    ..Furthermore, data from chromatin immunoprecipitation (ChIP) indicate that CHD3/ZFH interacts with the PS1 promoter in vivo...
  11. doi request reprint Inhibition of basal activity of c-jun-NH2-terminal kinase (JNK) represses the expression of presenilin-1 by a p53-dependent mechanism
    Sebum Lee
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, Texas 76107, USA
    Brain Res 1207:19-31. 2008
    ....
  12. ncbi request reprint Alternative initiation of transcription of the human presenilin 1 gene in SH-SY5Y and SK-N-SH cells. The role of Ets factors in the regulation of presenilin 1
    Martine Pastorcic
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, TX 76107, USA
    Eur J Biochem 271:4485-94. 2004
    ..We show here that ERM specifically recognizes Ets motifs on the PS1 promoter located at -10 as well as downstream at +90, +129 and +165 and activates PS1 transcription with promoter fragments containing or not the -10 Ets site...

Research Grants11

  1. HEPATIC REGULATION OF THE HUMAN APOB GENE
    HRIDAY DAS; Fiscal Year: 2002
    ..Understanding the mechanism of apoB transcription may someday lead to the control of apoB expression and consequently to the control of LDL cholesterol levels. ..
  2. Regulation of Human Presenilin-1
    HRIDAY DAS; Fiscal Year: 2004
    ..These experiments will provide detailed analysis of trans-acting factors that are likely to be involved in mammalian development and also in the pathogenesis of both early-onset and late-onset Alzheimer's disease. ..