Arup Das

Summary

Affiliation: University of New Mexico
Country: USA

Publications

  1. doi request reprint Diabetic Macular Edema: Pathophysiology and Novel Therapeutic Targets
    Arup Das
    Department of Surgery Ophthalmology, University of New Mexico School of Medicine, Albuquerque, New Mexico New Mexico VA Health Care System, Albuquerque, New Mexico Electronic address
    Ophthalmology 122:1375-94. 2015
  2. pmc Diabetic retinopathy and inflammation: novel therapeutic targets
    Sampathkumar Rangasamy
    Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, NM 87131
    Middle East Afr J Ophthalmol 19:52-9. 2012
  3. ncbi request reprint Retinal neovascularization is suppressed with a matrix metalloproteinase inhibitor
    A Das
    Division of Ophthalmology, University of New Mexico School of Medicine, and Veterans Affairs Administration Medical Center, Albuquerque 87131, USA
    Arch Ophthalmol 117:498-503. 1999
  4. ncbi request reprint Role of urokinase inhibitors in choroidal neovascularization
    Arup Das
    Division of Ophthalmology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Semin Ophthalmol 21:23-7. 2006
  5. ncbi request reprint Inhibition of choroidal neovascularization by a peptide inhibitor of the urokinase plasminogen activator and receptor system in a mouse model
    Arup Das
    Department of Surgery, University of New Mexico School of Medicine, Albuquerque 87131, USA
    Arch Ophthalmol 122:1844-9. 2004
  6. ncbi request reprint Angiopoietin/Tek interactions regulate mmp-9 expression and retinal neovascularization
    Arup Das
    Department of Surgery, University of New Mexico School of Medicine, Albuquerque, New Mexico
    Lab Invest 83:1637-45. 2003
  7. ncbi request reprint Retinal and choroidal angiogenesis: pathophysiology and strategies for inhibition
    Arup Das
    School of Medicine, University of New Mexico, Albuquerque, USA
    Prog Retin Eye Res 22:721-48. 2003
  8. ncbi request reprint The urokinase/urokinase receptor system in retinal neovascularization: inhibition by A6 suggests a new therapeutic target
    Paul G McGuire
    Departments of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    Invest Ophthalmol Vis Sci 44:2736-42. 2003
  9. pmc Plasminogen activator inhibitor-1 (PAI-1) facilitates retinal angiogenesis in a model of oxygen-induced retinopathy
    Anupam Basu
    Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    Invest Ophthalmol Vis Sci 50:4974-81. 2009
  10. ncbi request reprint Hepatocyte growth factor/scatter factor promotes retinal angiogenesis through increased urokinase expression
    Elizabeth S Colombo
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Invest Ophthalmol Vis Sci 48:1793-800. 2007

Research Grants

Collaborators

  • Paul G McGuire
  • Jun Xu
  • V Vinod Mootha
  • Xiao Yang
  • Sampathkumar Rangasamy
  • Deepti Navaratna
  • Gina Menicucci
  • Joann Maestas
  • Finny Monickaraj
  • Carolina Franco Nitta
  • Ramprasad Srinivasan
  • Anupam Basu
  • Elizabeth S Colombo
  • Stephen J Giebel
  • Kaustabh Ghosh
  • Sreenivasa R Oruganti
  • Susan Majka

Detail Information

Publications22

  1. doi request reprint Diabetic Macular Edema: Pathophysiology and Novel Therapeutic Targets
    Arup Das
    Department of Surgery Ophthalmology, University of New Mexico School of Medicine, Albuquerque, New Mexico New Mexico VA Health Care System, Albuquerque, New Mexico Electronic address
    Ophthalmology 122:1375-94. 2015
    ..Potential novel therapies targeting molecules other than VEGF and using new drug-delivery systems currently are being developed and evaluated in clinical trials...
  2. pmc Diabetic retinopathy and inflammation: novel therapeutic targets
    Sampathkumar Rangasamy
    Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, NM 87131
    Middle East Afr J Ophthalmol 19:52-9. 2012
    ....
  3. ncbi request reprint Retinal neovascularization is suppressed with a matrix metalloproteinase inhibitor
    A Das
    Division of Ophthalmology, University of New Mexico School of Medicine, and Veterans Affairs Administration Medical Center, Albuquerque 87131, USA
    Arch Ophthalmol 117:498-503. 1999
    ..To determine the role of extracellular proteinases in ischemia-induced retinal neovascularization in an animal model and to examine the effect of proteinase inhibitors on retinal neovascularization...
  4. ncbi request reprint Role of urokinase inhibitors in choroidal neovascularization
    Arup Das
    Division of Ophthalmology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Semin Ophthalmol 21:23-7. 2006
    ..As the current treatments of CNV are not optimal, the urokinase-uPAR system appears to be an attractive target for alternative pharamacological therapy for CNV...
  5. ncbi request reprint Inhibition of choroidal neovascularization by a peptide inhibitor of the urokinase plasminogen activator and receptor system in a mouse model
    Arup Das
    Department of Surgery, University of New Mexico School of Medicine, Albuquerque 87131, USA
    Arch Ophthalmol 122:1844-9. 2004
    ....
  6. ncbi request reprint Angiopoietin/Tek interactions regulate mmp-9 expression and retinal neovascularization
    Arup Das
    Department of Surgery, University of New Mexico School of Medicine, Albuquerque, New Mexico
    Lab Invest 83:1637-45. 2003
    ..Inhibition of the binding activity of the angiopoietins in vivo suppressed retinal neovascularization concomitant with a reduction in the expression of MMP-9...
  7. ncbi request reprint Retinal and choroidal angiogenesis: pathophysiology and strategies for inhibition
    Arup Das
    School of Medicine, University of New Mexico, Albuquerque, USA
    Prog Retin Eye Res 22:721-48. 2003
    ..This review discusses the pathogenesis of retinal and choroidal angiogenesis, and alternative pharmacological approaches to inhibit angiogenesis in ocular diseases...
  8. ncbi request reprint The urokinase/urokinase receptor system in retinal neovascularization: inhibition by A6 suggests a new therapeutic target
    Paul G McGuire
    Departments of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    Invest Ophthalmol Vis Sci 44:2736-42. 2003
    ....
  9. pmc Plasminogen activator inhibitor-1 (PAI-1) facilitates retinal angiogenesis in a model of oxygen-induced retinopathy
    Anupam Basu
    Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    Invest Ophthalmol Vis Sci 50:4974-81. 2009
    ..The aim of the present study was to investigate the role of the serine proteinase inhibitor plasminogen activator inhibitor -1 (PAI-1) in facilitating retinal angiogenesis...
  10. ncbi request reprint Hepatocyte growth factor/scatter factor promotes retinal angiogenesis through increased urokinase expression
    Elizabeth S Colombo
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Invest Ophthalmol Vis Sci 48:1793-800. 2007
    ....
  11. pmc Suppression of retinal neovascularization with an antagonist to vascular endothelial cadherin
    Deepti Navaratna
    Department of Cell Biology and Physiology, University of New Mexico, Albuquerque, NM 87131 0001, USA
    Arch Ophthalmol 126:1082-8. 2008
    ..To examine the role of vascular endothelial cadherin (VE-cadherin) in cellular processes underlying angiogenesis and the effects of VE-cadherin inhibition on retinal angiogenesis...
  12. pmc A peptide inhibitor of the urokinase/urokinase receptor system inhibits alteration of the blood-retinal barrier in diabetes
    Deepti Navaratna
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    FASEB J 22:3310-7. 2008
    ..The ability of A6 to block retinal vascular permeability in diabetes suggests a potential therapeutic approach for the treatment of diabetic macular edema...
  13. pmc A potential role for angiopoietin 2 in the regulation of the blood-retinal barrier in diabetic retinopathy
    Sampathkumar Rangasamy
    Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    Invest Ophthalmol Vis Sci 52:3784-91. 2011
    ..The expression of angiopoietins was analyzed in an animal model of diabetic retinopathy, and the role of Ang-2 in the regulation of diabetes-induced alterations of vascular permeability was characterized...
  14. ncbi request reprint Proteolytic degradation of VE-cadherin alters the blood-retinal barrier in diabetes
    Deepti Navaratna
    Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    Diabetes 56:2380-7. 2007
    ....
  15. pmc Pericyte-derived sphingosine 1-phosphate induces the expression of adhesion proteins and modulates the retinal endothelial cell barrier
    Paul G McGuire
    Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA
    Arterioscler Thromb Vasc Biol 31:e107-15. 2011
    ..We determined the extent to which vascular pericytes could regulate pericyte-endothelial adhesion and the consequences that this disruption might have on the function of the endothelial barrier...
  16. ncbi request reprint Matrix metalloproteinases in early diabetic retinopathy and their role in alteration of the blood-retinal barrier
    Stephen J Giebel
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
    Lab Invest 85:597-607. 2005
    ....
  17. ncbi request reprint Regulation of matrix metalloproteinase expression by tumor necrosis factor in a murine model of retinal neovascularization
    Susan Majka
    Division of Ophthalmology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    Invest Ophthalmol Vis Sci 43:260-6. 2002
    ..The present study examines the potential role of tumor necrosis factor (TNF)-alpha as a regulator of MMPs in the retinal neovascularization process...
  18. ncbi request reprint Intraocular hemorrhages due to warfarin fluconazole drug interaction in a patient with presumed Candida endophthalmitis
    V Vinod Mootha
    University of New Mexico Health Sciences Center, 2211 Lomas Blvd NE, Albuquerque, NM 87131 5341, USA
    Arch Ophthalmol 120:94-5. 2002
  19. pmc Cathepsin D: an Mϕ-derived factor mediating increased endothelial cell permeability with implications for alteration of the blood-retinal barrier in diabetic retinopathy
    Finny Monickaraj
    Department of Surgery and Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA New Mexico Veterans Affairs Health Care System, Albuquerque, New Mexico, USA and Department of Bioengineering, University of California, Riverside, Riverside, California, USA
    FASEB J 30:1670-82. 2016
    ..Monickaraj, F., McGuire, P. G., Nitta, C. F., Ghosh, K., Das, A. Cathepsin D: an Mϕ-derived factor mediating increased endothelial cell permeability with implications for alteration of the blood-retinal barrier in diabetic retinopathy. ..
  20. doi request reprint Basement membrane stiffening promotes retinal endothelial activation associated with diabetes
    Xiao Yang
    Department of Bioengineering and Department of Physics and Astronomy, University of California, Riverside, Riverside, California, USA Department of Surgery and Department of Cell Biology and Physiology, University of New Mexico, Albuquerque, New Mexico, USA and New Mexico Veterans Affairs Health Care System, Albuquerque, New Mexico, USA
    FASEB J 30:601-11. 2016
    ....
  21. pmc Novel pharmacotherapies in diabetic retinopathy: Current status and what's in the horizon?
    Arup Das
    Department of Surgery, Division of Ophthalmology, University of New Mexico School of Medicine Department of Surgery, New Mexico VA Health Care System Department of Cell Biology and Physiology, University of New Mexico, Albuquerque, New Mexico, USA
    Indian J Ophthalmol 64:4-13. 2016
    ..The effect seems transient in this latter group, and many patients do not show complete resolution of fluid. Potential novel therapies targeting molecules beyond VEGF are being developed and examined in clinical trials. ..
  22. pmc Chemokine mediated monocyte trafficking into the retina: role of inflammation in alteration of the blood-retinal barrier in diabetic retinopathy
    Sampathkumar Rangasamy
    Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America
    PLoS ONE 9:e108508. 2014
    ..Thus, CCL2 may be an important therapeutic target for the treatment of diabetic macular edema. ..

Research Grants1

  1. Extracellular Proteinases in Ocular Neovascularization
    Arup Das; Fiscal Year: 2010
    ..Such an approach will provide a rational basis for the development of potentially powerful and effective therapeutics for ocular neovascularization. ..