T Darville

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. ncbi Chlamydia trachomatis infections in neonates and young children
    Toni Darville
    Division of Pediatric Infectious Diseases, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Semin Pediatr Infect Dis 16:235-44. 2005
  2. ncbi Protection against Chlamydia trachomatis infection in vitro and modulation of inflammatory response in vivo by membrane-bound glycosaminoglycans
    Toni Darville
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, 4301 W Markham, Little Rock, AR 72205, USA
    Microbes Infect 6:369-76. 2004
  3. ncbi Toll-like receptor-2, but not Toll-like receptor-4, is essential for development of oviduct pathology in chlamydial genital tract infection
    Toni Darville
    Division of Pediatric Infectious Diseases, Arkansas Children s Hospital and University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Immunol 171:6187-97. 2003
  4. pmc Mouse strain-dependent chemokine regulation of the genital tract T helper cell type 1 immune response
    T Darville
    Department of Pediatric Infectious Diseases, Arkansas Children s Hospital, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    Infect Immun 69:7419-24. 2001
  5. pmc Early local cytokine profiles in strains of mice with different outcomes from chlamydial genital tract infection
    T Darville
    Department of Pediatric Infectious Diseases, Arkansas Children s Hospital, Little Rock 72202, USA
    Infect Immun 69:3556-61. 2001
  6. pmc Mouse strain-dependent variation in the course and outcome of chlamydial genital tract infection is associated with differences in host response
    T Darville
    Department of Pediatric Infectious Diseases, Arkansas Children s Hospital, University of Arkansas for Medical Sciences, Little Rock 72202, USA
    Infect Immun 65:3065-73. 1997
  7. pmc Stimulator of IFN gene is critical for induction of IFN-beta during Chlamydia muridarum infection
    Daniel Prantner
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Immunol 184:2551-60. 2010
  8. pmc Critical role for interleukin-1beta (IL-1beta) during Chlamydia muridarum genital infection and bacterial replication-independent secretion of IL-1beta in mouse macrophages
    Daniel Prantner
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Infect Immun 77:5334-46. 2009
  9. pmc Does inhibition of tumor necrosis factor alpha affect chlamydial genital tract infection in mice and guinea pigs?
    T Darville
    Department of Pediatric Infectious Diseases, Arkansas Children s Hospital, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    Infect Immun 68:5299-305. 2000
  10. ncbi Effect of the purinergic receptor P2X7 on Chlamydia infection in cervical epithelial cells and vaginally infected mice
    Toni Darville
    Division of Pediatric Infectious Diseases, Arkansas Children s Hospital and University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Immunol 179:3707-14. 2007

Collaborators

  • R G Rank
  • Jay K Kolls
  • ROBIN INGALLS
  • Kathleen A Kelly
  • W Liu
  • G Burnstock
  • Alice Dautry-Varsat
  • UMA NAGARAJAN
  • Shanmugam Nagarajan
  • David M Ojcius
  • Charles W Andrews
  • Daniel Prantner
  • Philippe Verbeke
  • Amy M Scurlock
  • CATHERINE M O'CONNELL
  • Jean Luc Perfettini
  • Lynn Welter-Stahl
  • Rachel A Vonck
  • Thomas Jungas
  • Dawn M Reeves
  • Adel M Mansour
  • Keith Coward
  • Robson Coutinho-Silva
  • Isaac P Foote
  • Sarabeth L Bailey
  • C M O'Connell
  • Kumar Chandra-Kuntal
  • Lauren C Frazer
  • Ann E Jerse
  • James D Sikes
  • Helmut Brade
  • Catherine O'Connell
  • Stéphane Girardin
  • Christiane Delarbre
  • Georg Hacker
  • Jérôme Viala
  • Songmin Ying
  • Dana Philpott
  • Jon Hansen
  • Patrik M Bavoil
  • Thomas F Wierzba
  • Isabelle A Nakhla
  • Magdy I Bassiouny
  • Richard F Jacobs
  • Robert W Frenck
  • Kathryn McCarthy
  • Yehia Sultan
  • Lynn Stahl
  • Marie Noëlle Raymond
  • Stanley J Korsmeyer
  • Nancy Tucker

Detail Information

Publications29

  1. ncbi Chlamydia trachomatis infections in neonates and young children
    Toni Darville
    Division of Pediatric Infectious Diseases, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Semin Pediatr Infect Dis 16:235-44. 2005
    ..Appropriate testing for chlamydial infection in a pediatric victim of sexual assault and the implications of identifying C. trachomatis in suspected cases of childhood sexual abuse also are reviewed...
  2. ncbi Protection against Chlamydia trachomatis infection in vitro and modulation of inflammatory response in vivo by membrane-bound glycosaminoglycans
    Toni Darville
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, 4301 W Markham, Little Rock, AR 72205, USA
    Microbes Infect 6:369-76. 2004
    ..The inconclusive in vivo results might be due to the physical properties of the tested MAG or an insufficient application protocol, and their improvement might provide the desired inhibitory effects...
  3. ncbi Toll-like receptor-2, but not Toll-like receptor-4, is essential for development of oviduct pathology in chlamydial genital tract infection
    Toni Darville
    Division of Pediatric Infectious Diseases, Arkansas Children s Hospital and University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Immunol 171:6187-97. 2003
    ..TLR2 is an important mediator in the innate immune response to C. trachomatis infection and appears to play a role in both early production of inflammatory mediators and development of chronic inflammatory pathology...
  4. pmc Mouse strain-dependent chemokine regulation of the genital tract T helper cell type 1 immune response
    T Darville
    Department of Pediatric Infectious Diseases, Arkansas Children s Hospital, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    Infect Immun 69:7419-24. 2001
    ..Inhibition of MCP-1 is not beneficial in chlamydial infection because of its pleiotropic effects...
  5. pmc Early local cytokine profiles in strains of mice with different outcomes from chlamydial genital tract infection
    T Darville
    Department of Pediatric Infectious Diseases, Arkansas Children s Hospital, Little Rock 72202, USA
    Infect Immun 69:3556-61. 2001
    ..Increased levels of MIP-2 and neutrophils in BALB/c and C3H/HeN mice relative to C57BL/6 mice suggest that these responses may contribute to pathology...
  6. pmc Mouse strain-dependent variation in the course and outcome of chlamydial genital tract infection is associated with differences in host response
    T Darville
    Department of Pediatric Infectious Diseases, Arkansas Children s Hospital, University of Arkansas for Medical Sciences, Little Rock 72202, USA
    Infect Immun 65:3065-73. 1997
    ..Increased TNF-alpha may be beneficial to the host by leading to earlier eradication of infection, thereby preventing infection of the oviduct and thus the major disease sequelae associated with chlamydial infection of the genital tract...
  7. pmc Stimulator of IFN gene is critical for induction of IFN-beta during Chlamydia muridarum infection
    Daniel Prantner
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Immunol 184:2551-60. 2010
    ....
  8. pmc Critical role for interleukin-1beta (IL-1beta) during Chlamydia muridarum genital infection and bacterial replication-independent secretion of IL-1beta in mouse macrophages
    Daniel Prantner
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Infect Immun 77:5334-46. 2009
    ..Additionally, prestimulation of macrophages by chlamydial TLR ligands may account for the elevated levels of pro-IL-1beta mRNA observed in vivo in this cell type...
  9. pmc Does inhibition of tumor necrosis factor alpha affect chlamydial genital tract infection in mice and guinea pigs?
    T Darville
    Department of Pediatric Infectious Diseases, Arkansas Children s Hospital, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    Infect Immun 68:5299-305. 2000
    ..Blockade of TNF-alpha does not affect the level of infection in mice or guinea pigs, but it may decrease TNF-alpha-induced apoptosis of infiltrating inflammatory cells...
  10. ncbi Effect of the purinergic receptor P2X7 on Chlamydia infection in cervical epithelial cells and vaginally infected mice
    Toni Darville
    Division of Pediatric Infectious Diseases, Arkansas Children s Hospital and University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Immunol 179:3707-14. 2007
    ..Taken together, these results suggest that P2X7R affects Chlamydia infection by directly inhibiting infection in epithelial cells, rather than through the ability of P2X7R to modulate IL-1beta secretion...
  11. ncbi Plasmid-deficient Chlamydia muridarum fail to induce immune pathology and protect against oviduct disease
    CATHERINE M O'CONNELL
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Immunol 179:4027-34. 2007
    ..muridarum. If plasmid-cured derivatives of human C. trachomatis biovars exhibit similar phenotypic characteristics, they have the potential to serve as vaccines to prevent human disease...
  12. pmc Type I interferon signaling exacerbates Chlamydia muridarum genital infection in a murine model
    Uma M Nagarajan
    Division of Pediatric Infectious Diseases, Arkansas Children s Hospital Research Institute, Little Rock, Arkansas 72202, USA
    Infect Immun 76:4642-8. 2008
    ..These data suggest that type I IFNs exacerbate C. muridarum genital infection through an inhibition of the chlamydial-specific CD4 T-cell response...
  13. pmc Characterization of chlamydial genital infection resulting from sexual transmission from male to female guinea pigs and determination of infectious dose
    Roger G Rank
    Departments of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Infect Immun 71:6148-54. 2003
    ..There is currently no other animal model available for any sexually transmitted disease in which the disease or the ability to prevent the disease may be studied in animals infected by the natural means...
  14. pmc Interleukin-17 contributes to generation of Th1 immunity and neutrophil recruitment during Chlamydia muridarum genital tract infection but is not required for macrophage influx or normal resolution of infection
    Amy M Scurlock
    Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children s Hospital Research Institute, 13 Children s Way, Slot 512 13, Little Rock, AR 72202, USA
    Infect Immun 79:1349-62. 2011
    ..muridarum genital infection. These data highlight the redundant immune mechanisms operative at this mucosal site and the importance of examining site-specific responses to mucosal pathogens...
  15. ncbi Chlamydia trachomatis induces expression of IFN-gamma-inducible protein 10 and IFN-beta independent of TLR2 and TLR4, but largely dependent on MyD88
    Uma M Nagarajan
    Division of Pediatric Infectious Diseases, Arkansas Children s Hospital, Little Rock, AR 72202, USA
    J Immunol 175:450-60. 2005
    ..Furthermore, the intracellular pathways that lead to chlamydial-induced IFN-beta function through TANK-binding kinase mediated phosphorylation and nuclear translocation of IFN regulatory factor-3...
  16. pmc Intravenous immunoglobulin inhibits staphylococcal toxin-induced human mononuclear phagocyte tumor necrosis factor alpha production
    T Darville
    Department of Pediatric Infectious Diseases, University of Arkansas for Medical Sciences, Little Rock, USA
    Infect Immun 65:366-72. 1997
    ..These data indicate that IVIG can act in a toxin-specific manner to decrease the MO TNF-alpha response to superantigens. Such inhibition may be one mechanism by which IVIG exerts an immunoregulatory role in superantigen-mediated disease...
  17. pmc Lack of an effect of antibiotic treatment on prolonged detection of chlamydial DNA in murine genital tract infection
    Dawn M Reeves
    Department of Pediatric Infectious Diseases and Microbiology and Immunology, Arkansas Children s Hospital and University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    Antimicrob Agents Chemother 51:2646-8. 2007
    ..The early eradication of infection limited oviduct pathology, despite the continued detection of chlamydial DNA by nested PCR. Late antibiotic treatment had no effect on the ability to detect DNA or oviduct pathology...
  18. ncbi Chlamydia trachomatis genital infection in adolescents and young adults
    Toni Darville
    Department of Pediatrics and Microbiology Immunology, University of Arkansas for Medical Sciences, Little Rock, USA
    Adv Exp Med Biol 582:85-100. 2006
  19. pmc Chlamydial infection increases gonococcal colonization in a novel murine coinfection model
    Rachel A Vonck
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Infect Immun 79:1566-77. 2011
    ..We conclude that female mice can be successfully infected with both C. muridarum and N. gonorrhoeae and that chlamydia-induced alterations in host innate responses may enhance gonococcal infection...
  20. pmc Relationship between intracranial granulomas and cerebrospinal fluid levels of gamma interferon and interleukin-10 in patients with tuberculous meningitis
    Adel M Mansour
    University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Clin Diagn Lab Immunol 12:363-5. 2005
    ..Cytokine levels did not predict intracranial granuloma (IG) development, but IFN-gamma levels in the top quartile after 1 month of therapy were highly associated (odds ratio = 18) with detection of an IG by computed tomography scanning...
  21. ncbi Infective endocarditis in Arkansan children from 1990 through 2002
    Keith Coward
    Department of Pediatrics, Arkansas Children s Hospital and University of Arkansas for Medical Sciences, Little Rock, USA
    Pediatr Infect Dis J 22:1048-52. 2003
    ..Recent medical and surgical advances have increased the potential risk of endocarditis. Epidemiology, pathogens, morbidity and/or mortality may have evolved in the past decade in pediatric patients diagnosed with endocarditis...
  22. ncbi Management of acute hematogenous osteomyelitis in children
    Toni Darville
    University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Pediatr Infect Dis J 23:255-7. 2004
  23. ncbi Cell death, BAX activation, and HMGB1 release during infection with Chlamydia
    Thomas Jungas
    Institut Jacques Monod, Universite Paris 7, 75251 Paris cedex 5, France
    Microbes Infect 6:1145-55. 2004
    ..trachomatis, compared to uninfected controls. These results suggest that cells infected with Chlamydia release intracellular factors that may contribute to the inflammatory response observed in vivo...
  24. ncbi Can chlamydia be stopped?
    David M Ojcius
    University of California, USA
    Sci Am 292:72-9. 2005
    ..Chlamydia is a rampant sexually transmitted disease, the world's leading cause of preventable blindness and a possible contributor to heart disease. Recent discoveries are suggesting new ways to curtail its spread..
  25. ncbi Inhibition of chlamydial infectious activity due to P2X7R-dependent phospholipase D activation
    Robson Coutinho-Silva
    Universite Paris 7, Institut Jacques Monod, CNRS UMR 7592, 2 place Jussieu, 75251 Paris cedex 5, France
    Immunity 19:403-12. 2003
    ..These results suggest that P2X(7)R ligation leads to PLD activation, which is directly responsible for inhibition of infection...
  26. ncbi Role of proapoptotic BAX in propagation of Chlamydia muridarum (the mouse pneumonitis strain of Chlamydia trachomatis) and the host inflammatory response
    Jean Luc Perfettini
    Universite Paris 7, Institut Pasteur, Unité de Biologie Moléculaire du Gène, INSERM U277, Paris, France
    J Biol Chem 278:9496-502. 2003
    ..Bax deficiency results in lower infection and an increased inflammatory cytokine response associated with more severe pathology...
  27. pmc Inhibition of apoptosis by gamma interferon in cells and mice infected with Chlamydia muridarum (the mouse pneumonitis strain of Chlamydia trachomatis)
    Jean Luc Perfettini
    Unité de Biologie Moléculaire du Gène, INSERM U277, Universite Paris 7, 75724 Paris Cedex 15, France
    Infect Immun 70:2559-65. 2002
    ..These results suggest that IFN-gamma may contribute to pathogenesis of persistent Chlamydia infections in vivo by preventing apoptosis of infected cells...
  28. ncbi Stimulation of the cytosolic receptor for peptidoglycan, Nod1, by infection with Chlamydia trachomatis or Chlamydia muridarum
    Lynn Welter-Stahl
    Université Paris Denis Diderot, Institut Jacques Monod, 75251 Paris, France
    Cell Microbiol 8:1047-57. 2006
    ....
  29. pmc Recruitment of BAD by the Chlamydia trachomatis vacuole correlates with host-cell survival
    Philippe Verbeke
    Institut Jacques Monod, Université Paris Denis Diderot, Paris, France
    PLoS Pathog 2:e45. 2006
    ..trachomatis with a mechanism to protect the host cell from apoptosis via the interaction of a C. trachomatis-encoded inclusion protein with a host-cell phosphoserine-binding protein...