Robert Dantzer

Summary

Affiliation: University of Illinois
Country: USA

Publications

  1. ncbi request reprint Innate immunity at the forefront of psychoneuroimmunology
    Robert Dantzer
    Integrative Neurobiology, Bordeaux, France
    Brain Behav Immun 18:1-6. 2004
  2. ncbi request reprint Chronic administration of tianeptine balances lipopolysaccharide-induced expression of cytokines in the spleen and hypothalamus of rats
    Nathalie Castanon
    INRA INSERM U394 Neurobiologie Intégrative, Institut Francois Magendie, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Psychoneuroendocrinology 29:778-90. 2004
  3. ncbi request reprint Immune alterations induced by social defeat do not alter the course of an on-going BCG infection in mice
    Elodie Merlot
    Neurobiologie Integrative, INRA INSERM, Institut Francois Magendie, Bordeaux, France
    Neuroimmunomodulation 11:414-8. 2004
  4. ncbi request reprint C-jun N-terminal kinase mediates tumor necrosis factor-alpha suppression of differentiation in myoblasts
    Klemen Strle
    Laboratories of Immunophysiology, Department of Animal Sciences, University of Illinois, Urbana, Illinois 61801, USA
    Endocrinology 147:4363-73. 2006
  5. pmc Cytokine, sickness behavior, and depression
    Robert Dantzer
    Laboratory of Integrative Neurobiology, CNRS, INRA, University of Bordeaux 2, 33077 Bordeaux Cedex, France
    Neurol Clin 24:441-60. 2006
  6. pmc Identification and treatment of symptoms associated with inflammation in medically ill patients
    Robert Dantzer
    Integrative Immunology and Behavior Program, 212 ERML, 1201 W Gregory Drive, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Psychoneuroendocrinology 33:18-29. 2008
  7. doi request reprint Autistic children: a neuroimmune perspective
    Robert Dantzer
    Integrative Immunology and Behavior Program, University of Illinois at Urbana Champaign, 212 ERML, 1201 W Gregory Drive, Urbana, IL 61801, USA
    Brain Behav Immun 22:804-5. 2008
  8. pmc Twenty years of research on cytokine-induced sickness behavior
    Robert Dantzer
    Integrative Immunology and Behavior Program, Laboratory of Integrative Immunophysiology, Department of Animal Sciences, University of Illinois at Urbana Champaign, IL 61801, USA
    Brain Behav Immun 21:153-60. 2007
  9. pmc From inflammation to sickness and depression: when the immune system subjugates the brain
    Robert Dantzer
    Integrative Immunology and Behavior, Department of Animal Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois, Urbana Champaign, Illinois 61801, USA
    Nat Rev Neurosci 9:46-56. 2008
  10. ncbi request reprint IL-1beta suppresses prolonged Akt activation and expression of E2F-1 and cyclin A in breast cancer cells
    Wen Hong Shen
    Laboratory of Immunophysiology, University of Illinois, Urbana, IL 61801, USA
    J Immunol 172:7272-81. 2004

Research Grants

  1. AIDS, Immune Activation and Mental Health
    Robert Dantzer; Fiscal Year: 2006

Collaborators

Detail Information

Publications82

  1. ncbi request reprint Innate immunity at the forefront of psychoneuroimmunology
    Robert Dantzer
    Integrative Neurobiology, Bordeaux, France
    Brain Behav Immun 18:1-6. 2004
    ..In this presidential address, I present the main methodological and conceptual developments that have allowed such progress...
  2. ncbi request reprint Chronic administration of tianeptine balances lipopolysaccharide-induced expression of cytokines in the spleen and hypothalamus of rats
    Nathalie Castanon
    INRA INSERM U394 Neurobiologie Intégrative, Institut Francois Magendie, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Psychoneuroendocrinology 29:778-90. 2004
    ..These results open new vistas in the pharmacological activity of tianeptine and provide further insights on the possible mechanisms of action involved in its neuroprotective properties...
  3. ncbi request reprint Immune alterations induced by social defeat do not alter the course of an on-going BCG infection in mice
    Elodie Merlot
    Neurobiologie Integrative, INRA INSERM, Institut Francois Magendie, Bordeaux, France
    Neuroimmunomodulation 11:414-8. 2004
    ..Accordingly, social defeat was unable to influence the mycobacterial growth in vivo. These results support the hypothesis postulating that stress does not affect antigen-specific response when it is applied after priming...
  4. ncbi request reprint C-jun N-terminal kinase mediates tumor necrosis factor-alpha suppression of differentiation in myoblasts
    Klemen Strle
    Laboratories of Immunophysiology, Department of Animal Sciences, University of Illinois, Urbana, Illinois 61801, USA
    Endocrinology 147:4363-73. 2006
    ..These results establish that the resistance of muscle progenitor cells to IGF-I, which is caused by inflammatory stimuli, is mediated by the JNK stress kinase pathway...
  5. pmc Cytokine, sickness behavior, and depression
    Robert Dantzer
    Laboratory of Integrative Neurobiology, CNRS, INRA, University of Bordeaux 2, 33077 Bordeaux Cedex, France
    Neurol Clin 24:441-60. 2006
    ..In addition, a dynamic view of the cellular interactions that occur at the brain sites of cytokine production and action is missing, together with a clarification of the mechanisms that favor the transition toward pathology...
  6. pmc Identification and treatment of symptoms associated with inflammation in medically ill patients
    Robert Dantzer
    Integrative Immunology and Behavior Program, 212 ERML, 1201 W Gregory Drive, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Psychoneuroendocrinology 33:18-29. 2008
    ..This resulted in a number of recommendations that should improve the recognition and management of inflammation-associated symptoms in medically ill patients...
  7. doi request reprint Autistic children: a neuroimmune perspective
    Robert Dantzer
    Integrative Immunology and Behavior Program, University of Illinois at Urbana Champaign, 212 ERML, 1201 W Gregory Drive, Urbana, IL 61801, USA
    Brain Behav Immun 22:804-5. 2008
  8. pmc Twenty years of research on cytokine-induced sickness behavior
    Robert Dantzer
    Integrative Immunology and Behavior Program, Laboratory of Integrative Immunophysiology, Department of Animal Sciences, University of Illinois at Urbana Champaign, IL 61801, USA
    Brain Behav Immun 21:153-60. 2007
    ..The time is ripe to begin to move these fundamental discoveries in mice to man and some of the pharmacological tools are already available to antagonize the detrimental actions of cytokines...
  9. pmc From inflammation to sickness and depression: when the immune system subjugates the brain
    Robert Dantzer
    Integrative Immunology and Behavior, Department of Animal Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois, Urbana Champaign, Illinois 61801, USA
    Nat Rev Neurosci 9:46-56. 2008
    ..Inflammation is therefore an important biological event that might increase the risk of major depressive episodes, much like the more traditional psychosocial factors...
  10. ncbi request reprint IL-1beta suppresses prolonged Akt activation and expression of E2F-1 and cyclin A in breast cancer cells
    Wen Hong Shen
    Laboratory of Immunophysiology, University of Illinois, Urbana, IL 61801, USA
    J Immunol 172:7272-81. 2004
    ..In this manner, Akt serves as a critical bridge that links proximal receptor signaling events to more distal cell cycle machinery...
  11. ncbi request reprint Proinflammatory cytokine impairment of insulin-like growth factor I-induced protein synthesis in skeletal muscle myoblasts requires ceramide
    Klemen Strle
    University of Illinois, Laboratory of Immunophysiology, 207 Edward R Madigan Laboratory, 1201 West Gregory Drive, Urbana, Illinois 61801, USA
    Endocrinology 145:4592-602. 2004
    ....
  12. pmc Aging leads to prolonged duration of inflammation-induced depression-like behavior caused by Bacillus Calmette-Guérin
    Keith W Kelley
    Integrative Immunology and Behavior Program, Department of Animal Sciences, College of ACES, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Brain Behav Immun 32:63-9. 2013
    ..These are the first data using a chronic infection model to establish that recovery from inflammation-induced depression-like behavior and tryptophan catabolism are prolonged in aged animals...
  13. pmc Induction of IDO by bacille Calmette-Guérin is responsible for development of murine depressive-like behavior
    Jason C O'Connor
    Integrative Immunology and Behavior Program, Department of Animal Sciences, College of Agriculture, Consumer, and Environmental Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Immunol 182:3202-12. 2009
    ....
  14. ncbi request reprint IL-1beta impairs insulin-like growth factor i-induced differentiation and downstream activation signals of the insulin-like growth factor i receptor in myoblasts
    Suzanne R Broussard
    Laboratories of Immunophysiology, 207 Edward R Madigan Laboratory, University of Illinois at Urbana Champaign, 1201 West Gregory Drive, Urbana, IL 61801, USA
    J Immunol 172:7713-20. 2004
    ..Collectively, the results are consistent with the notion that very low concentrations of IL-1beta significantly impair myogenesis, but they are unable to do so in the absence of the growth factor IGF-I...
  15. pmc Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin
    Jason C O'Connor
    Integrative Immunology and Behavior Program, Department of Animal Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois 61801 3873, USA
    J Neurosci 29:4200-9. 2009
    ..Together, these data demonstrate that IFNgamma, with TNFalpha, is necessary for induction of IDO and depressive-like behavior in mice after BCG infection...
  16. pmc Prototypical anti-inflammatory cytokine IL-10 prevents loss of IGF-I-induced myogenin protein expression caused by IL-1beta
    Klemen Strle
    Laboratory of Integrative Immunophysiology, Integrative Immunology and Behavior Program, Department of Animal Sciences, College of Agricultural, Consumer and Enviromental Sciences, University of Illinois, Urbana, IL 61801, USA
    Am J Physiol Endocrinol Metab 294:E709-18. 2008
    ..Collectively, these data demonstrate that IL-10 acts in a novel, nonclassical, protective manner in nonhematopoietic cells to inhibit the IL-1beta receptor-induced JNK kinase pathway, resulting in prevention of IGF-I resistance...
  17. ncbi request reprint Tumor necrosis factor alpha inhibits cyclin A expression and retinoblastoma hyperphosphorylation triggered by insulin-like growth factor-I induction of new E2F-1 synthesis
    Wen Hong Shen
    Laboratory of Immunophysiology, Department of Animal Sciences, University of Illinois, Urbana, Illinois 61801, USA
    J Biol Chem 279:7438-46. 2004
    ....
  18. pmc Novel activity of an anti-inflammatory cytokine: IL-10 prevents TNFalpha-induced resistance to IGF-I in myoblasts
    Klemen Strle
    Laboratories of Integrative Immunophysiology, College of Medicine, University of Illinois, Urbana, IL 61801, United States
    J Neuroimmunol 188:48-55. 2007
    ..Instead, IL-10 acts to prevent TNFalpha-induced phosphorylation of JNK. These findings demonstrate that IL-10 serves a previously unrecognized protective role in muscle progenitors by overcoming TNFalpha-induced resistance to IGF-I...
  19. ncbi request reprint Tumor necrosis factor alpha inhibits insulin-like growth factor I-induced hematopoietic cell survival and proliferation
    Wen Hong Shen
    University of Illinois, Laboratory of Immunophysiology, Department of Animal Sciences, 207 Edward R Madigan Laboratory, 1201 West Gregory Drive, Urbana, Illinois 61801, USA
    Endocrinology 145:3101-5. 2004
    ..These results support the general concept that proinflammatory cytokines impair the actions of hormones on hematopoietic cells, leading to IGF-I receptor resistance...
  20. pmc Central administration of lipopolysaccharide induces depressive-like behavior in vivo and activates brain indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice cultures
    Xin Fu
    Integrative Immunology and Behavior Program, Department of Animal Sciences, College of ACES, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Neuroinflammation 7:43. 2010
    ..It is unknown whether direct activation of the brain with LPS is sufficient to activate IDO and induce depressive-like behavior...
  21. pmc Effects of voluntary wheel running on LPS-induced sickness behavior in aged mice
    Stephen A Martin
    Departments of Kinesiology and Community Health, University of Illinois at Urbana Champaign, Urbana, IL, United States
    Brain Behav Immun 29:113-23. 2013
    ..33 mg/kg LPS or Saline) brain and peripheral proinflammatory cytokine gene expression. The necessity of the sickness response is critical for survival and may outweigh the subtle benefits of exercise training in aged animals...
  22. pmc Insulin-like growth factor-I peptides act centrally to decrease depression-like behavior of mice treated intraperitoneally with lipopolysaccharide
    Sook Eun Park
    Integrated Immunology and Behavior Program, University of Illinois at Urbana Champaign, Illinois 61801 3873, USA
    J Neuroinflammation 8:179. 2011
    ..Thus, both IGF-I and GPE elicit specific improvement in depression-like behavior independent of sickness, an action that could be due to their anti-inflammatory properties...
  23. pmc The type 1 TNF receptor and its associated adapter protein, FAN, are required for TNFalpha-induced sickness behavior
    Karine Palin
    Integrative Immunology and Behavior Program, Laboratory of Integrative Immunophysiology, Department of Animal Sciences, University of Illinois at Urbana Champaign, 227 Edward R Madigan Laboratory, 1201 West Gregory Drive, Urbana, IL 61801 3873, USA
    Psychopharmacology (Berl) 201:549-56. 2009
    ..TNFalpha activates neutral sphingomyelinase through the TNF-R1 adapter protein FAN (factor associated with neutral sphingomyelinase activation), but a behavioral role of FAN in the brain has never been reported...
  24. ncbi request reprint Cytokine-hormone interactions: tumor necrosis factor alpha impairs biologic activity and downstream activation signals of the insulin-like growth factor I receptor in myoblasts
    Suzanne R Broussard
    Laboratory of Immunophysiology, Department of Animal Sciences and Pathology, College of Medicine, University of Illinois at Urbana Champaign, 207 Edward R Madigan Laboratory, 1201 West Gregory Drive, Urbana, IL 61801, USA
    Endocrinology 144:2988-96. 2003
    ..These data are consistent with the notion that very low physiological concentrations of TNFalpha interfere with both protein synthesis and muscle cell development by inducing a state of IGF-I receptor resistance...
  25. pmc LPS-induced indoleamine 2,3-dioxygenase is regulated in an interferon-gamma-independent manner by a JNK signaling pathway in primary murine microglia
    Yunxia Wang
    Department of Animal Sciences, Integrative Immunology and Behavior Program, University of Illinois at Urbana Champaign, 227 Edward R Madigan Laboratory, 1201 W Gregory Drive, Urbana, IL 61801 3873, USA
    Brain Behav Immun 24:201-9. 2010
    ..Inhibition of the JNK pathway may provide a new therapy for inflammatory depression...
  26. pmc Inhibition of vagally mediated immune-to-brain signaling by vanadyl sulfate speeds recovery from sickness
    Daniel R Johnson
    Department of Animal Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 102:15184-9. 2005
    ..Taken together, these data indicate that VS improves recovery from LPS-induced sickness by blocking vagally mediated immune-to-brain signaling and by up-regulating brain expression of IL-1beta antagonists...
  27. pmc HIV-1 Tat activates indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice cultures in a p38 mitogen-activated protein kinase-dependent manner
    Xin Fu
    Integrative Immunology and Behavior Program, Department of Animal Sciences, College of ACES, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Neuroinflammation 8:88. 2011
    ..Because human immunodeficiency virus type 1 (HIV-1) Tat protein causes depressive-like behavior in mice, we investigated its ability to activate IDO in organotypic hippocampal slice cultures (OHSCs) derived from neonatal C57BL/6 mice...
  28. pmc Central administration of insulin-like growth factor-I decreases depressive-like behavior and brain cytokine expression in mice
    Sook Eun Park
    Integrated Immunology and Behavior Program, University of Illinois at Urbana Champaign, Urbana, Illinois 61801 3873, USA
    J Neuroinflammation 8:12. 2011
    ..These actions of IGF-I parallel its ability to diminish depressive-like behavior...
  29. ncbi request reprint Insulin-like growth factor-I and the cytokines IL-3 and IL-4 promote survival of progenitor myeloid cells by different mechanisms
    William Burgess
    Laboratory of Immunophysiology, Department of Animal Sciences, University of Illinois, 207 ERML, 1201 W Gregory Dr, Urbana, IL 61801, USA
    J Neuroimmunol 135:82-90. 2003
    ....
  30. pmc NMDA receptor blockade by ketamine abrogates lipopolysaccharide-induced depressive-like behavior in C57BL/6J mice
    Adam K Walker
    Integrative Immunology and Behavior Program, Department of Animal Sciences, University of Illinois at Urbana Champaign, Urbana, IL, USA
    Neuropsychopharmacology 38:1609-16. 2013
    ..These findings indicate that LPS-induced depressive-like behavior is mediated by NMDA receptor activation, probably as a consequence of formation of quinolinic acid...
  31. pmc TNFalpha-induced sickness behavior in mice with functional 55 kD TNF receptors is blocked by central IGF-I
    Karine Palin
    Department of Animal Sciences, Integrative Immunology and Behavior Program, Laboratory of Integrative Immunophysiology, University of Illinois at Urbana Champaign, IL, USA
    J Neuroimmunol 187:55-60. 2007
    ..c.v., 300 ng/mouse). These results establish that sickness behavior induced by central TNFalpha via the TNF-R1 (p55) is directly opposed by IGF-I in the brain...
  32. ncbi request reprint Proinflammatory cytokines block growth of breast cancer cells by impairing signals from a growth factor receptor
    Wen Hong Shen
    Laboratory of Immunophysiology, Department of Animal Sciences, University of Illinois, Urbana, Illinois 61801, USA
    Cancer Res 62:4746-56. 2002
    ..These data also highlight growth factor receptor adaptor molecules, such as insulin receptor substrate-1, rather than the receptors themselves as targets for antitumor therapeutic strategies...
  33. ncbi request reprint Cytokine-induced sickness behavior
    Keith W Kelley
    Department of Animal Sciences, Laboratory of Immunophysiology, University of Illinois, 207 Edward R Madigan Laboratory, 1201 West Gregory Drive, Urbana 61801, USA
    Brain Behav Immun 17:S112-8. 2003
    ..Advances that have been made during the past decade should now be extended to clinical studies in an attempt to alleviate sickness symptoms and improve quality of life for cancer patients...
  34. ncbi request reprint IL-1beta-mediated innate immunity is amplified in the db/db mouse model of type 2 diabetes
    Jason C O'Connor
    Department of Animal Sciences, University of Illinois at Urbana Champain, Urbana, IL 61801, USA
    J Immunol 174:4991-7. 2005
    ..Taken together, these results indicate that IL-1beta-mediated innate immunity is augmented in db/db mice both at the periphery and in the brain, and the mechanism is due to diabetes-associated loss of IL-1beta counterregulation...
  35. pmc Inflammation-associated depression: from serotonin to kynurenine
    Robert Dantzer
    Integrative Immunology and Behavior Program, Department of Animal Sciences, 227 Edward R Madigan Laboratory, 1201 West Gregory Drive, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Psychoneuroendocrinology 36:426-36. 2011
    ....
  36. pmc Primary murine microglia are resistant to nitric oxide inhibition of indoleamine 2,3-dioxygenase
    Yunxia Wang
    Integrative Immunology and Behavior Program, Department of Animal Sciences, 227 Edward R Madigan Laboratory, College of ACES, 1201 W Gregory Drive, University of Illinois at Urbana Champaign, Urbana, IL 61801 3873, USA
    Brain Behav Immun 24:1249-53. 2010
    ..These data establish that IDO regulation in murine microglia is not restrained by NO, thereby permitting the accumulation of kynurenine and its downstream metabolites in the central nervous system...
  37. pmc Regulation of IGF-I function by proinflammatory cytokines: at the interface of immunology and endocrinology
    Jason C O'Connor
    Integrative Immunology and Behavior Program, Department of Animal Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Cell Immunol 252:91-110. 2008
    ..We also highlight that IGF-I can induce resistance or reduce sensitivity to brain TNFalpha and discuss how TNFalpha, IL-1beta, and IGF-I interact to regulate several aspects of behavior and cognition...
  38. ncbi request reprint Insulin-like growth factor-I enhances the biological activity of brain-derived neurotrophic factor on cerebrocortical neurons
    Robert H McCusker
    250 Edward R Madigan Laboratory, Urbana, IL 61801 3873, USA
    J Neuroimmunol 179:186-90. 2006
    ..IGF-I enhanced expression of BDNF receptors (Trk-B) and increased the ability of BDNF to induce ERK1/2 phosphorylation. This IGF-I-induced increase in BDNF responsiveness describes a new interaction between these peptides in the brain...
  39. pmc Lipopolysaccharide induces delayed FosB/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behavior
    Francois Frenois
    Integrative Immunology and Behavior Program, University of Illinois at Urbana Champaign, 212 Edward R Madigan Laboratory, 1201 West Gregory Drive, Urbana, IL 61801, USA
    Psychoneuroendocrinology 32:516-31. 2007
    ....
  40. pmc Intracerebroventricular administration of HIV-1 Tat induces brain cytokine and indoleamine 2,3-dioxygenase expression: a possible mechanism for AIDS comorbid depression
    Marcus A Lawson
    Neuroscience Program University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Brain Behav Immun 25:1569-75. 2011
    ..The results reveal a potential role for Tat in the development of comorbid depression in HIV-infected individuals...
  41. pmc Voluntary wheel running reverses age-induced changes in hippocampal gene expression
    Rachel A Kohman
    Department of Psychology, Beckman Institute, University of Illinois, Urbana, Illinois, United States of America
    PLoS ONE 6:e22654. 2011
    ..Collectively, findings show that even late-onset exercise may attenuate age-related changes in gene expression and identifies possible pathways through which exercise may exert its beneficial effects...
  42. doi request reprint Voluntary wheel running does not affect lipopolysaccharide-induced depressive-like behavior in young adult and aged mice
    Stephen A Martin
    Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, Urbana, Ill, USA
    Neuroimmunomodulation 21:52-63. 2014
    ..The purpose of this study was to test the hypothesis that voluntary wheel running (VWR) would attenuate LPS-induced depressive-like behavior and brain IDO gene expression in 4- and 22-month-old C57BL/6J mice...
  43. pmc Acute hypoglycemia causes depressive-like behaviors in mice
    Min Jung Park
    Division of Nutritional Sciences, University of Illinois, Urbana, IL 61801, USA
    Metabolism 61:229-36. 2012
    ..These data indicate that, in mice, acute hypoglycemia through adrenergic pathways caused depressive-like behaviors that exist well beyond the resolution of hypoglycemia...
  44. ncbi request reprint Alcoholism and inflammation: neuroimmunology of behavioral and mood disorders
    Keith W Kelley
    Integrative Immunology and Behavior Program, Department of Animal Sciences, College of ACES, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Brain Behav Immun 25:S13-20. 2011
    ..These findings present new and challenging opportunities for scientists who are engaged in brain, behavior and immunity research...
  45. doi request reprint The associations of adiposity, physical activity and inflammation with fatigue in older adults
    Rudy J Valentine
    Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, USA
    Brain Behav Immun 25:1482-90. 2011
    ..In addition to depression and sleep quality, adiposity may represent a potential target for reducing fatigue in older adults...
  46. ncbi request reprint IL-10 promotes survival of microglia without activating Akt
    Klemen Strle
    Laboratory of Immunophysiology, Department of Animal Sciences, University of Illinois, 207 ERML, 1201 W Gregory Dr, Urbana, IL 61801, USA
    J Neuroimmunol 122:9-19. 2002
    ..These data establish that IL-10 activates Stat3 and inhibits the mitochondrial pathway of cell death without activating the Akt cell survival pathway...
  47. ncbi request reprint Age-associated loss of bone marrow hematopoietic cells is reversed by GH and accompanies thymic reconstitution
    Richard A French
    Laboratory of Immunophysiology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Endocrinology 143:690-9. 2002
    ....
  48. pmc Inoculation of Bacillus Calmette-Guerin to mice induces an acute episode of sickness behavior followed by chronic depressive-like behavior
    Maite Moreau
    INRA, UMR 1286 PsyNuGen, Bâtiment UFR Pharmacie, Case courrier 34, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, CNRS, UMR 5226, IFR8, F 33076 Bordeaux, France
    Brain Behav Immun 22:1087-95. 2008
    ....
  49. pmc In vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1 beta in the murine brain
    Rozenn Mingam
    PsyNuGen, INRA, UMR1286, CNRS, UMR5226, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33077 Bordeaux, France
    Brain Behav Immun 22:234-44. 2008
    ..These results show that P2X7R plays a key role in the brain cytokine response to immune stimuli, which certainly applies also to cytokine-dependent alterations in brain functions including sickness behavior...
  50. pmc A biological substrate for somatoform disorders: importance of pathophysiology
    Joel E Dimsdale
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
    Psychosom Med 69:850-4. 2007
    ..Studies on communication pathways from the immune system to the brain provide exciting new information on the pathophysiology of inflammation-associated symptoms...
  51. pmc Effects of insulin-like growth factor-I on cytokine-induced sickness behavior in mice
    Rose Marie Bluthé
    Integrative Neurobiology, CNRS INRA University Victor Segalen, Bordeaux, France
    Brain Behav Immun 20:57-63. 2006
    ..These findings indicate that IGF-I is more potent in attenuating sickness behavior induced by TNFalpha than that caused by IL-1beta, which is consistent with the relative specificity of the TNFalpha/IGF-I interactions in the brain...
  52. ncbi request reprint Cytokine-induced sickness behaviour: mechanisms and implications
    Jan Pieter Konsman
    Laboratory of Integrative Neurobiology, INRA INSERM U 394, rue Camille Saint Saens, Bordeaux, France
    Trends Neurosci 25:154-9. 2002
    ..The cellular and molecular components of this previously unsuspected system are being progressively identified. These advances are opening new avenues for understanding brain disorders, including depression...
  53. ncbi request reprint Long-term modulation of glucose utilization by IL-1 alpha and TNF-alpha in astrocytes: Na+ pump activity as a potential target via distinct signaling mechanisms
    Céline Véga
    Institut de Physiologie, Lausanne, Switzerland
    Glia 39:10-8. 2002
    ..These data suggest that Na(+) pump activity is a common target for both the long-term metabolic action of cytokines promoted by the activation of distinct signaling pathways and the enhanced metabolic response to glutamate...
  54. ncbi request reprint Are the symptoms of cancer and cancer treatment due to a shared biologic mechanism? A cytokine-immunologic model of cancer symptoms
    Charles S Cleeland
    Department of Symptom Research, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer 97:2919-25. 2003
    ..These symptoms include pain, wasting, fatigue, cognitive impairment, anxiety, and depression, many of which co-occur. There is growing recognition that at least some of these symptoms may share common biologic mechanisms...
  55. ncbi request reprint Chronic mild stress in mice decreases peripheral cytokine and increases central cytokine expression independently of IL-10 regulation of the cytokine network
    Cecile Mormede
    INRA INSERM U394, Neurobiologie Integrative, Institut Francois Magendie, Bordeaux, France
    Neuroimmunomodulation 10:359-66. 2002
    ..The production and action of pro-inflammatory cytokines are down-regulated by anti-inflammatory cytokines such as IL-10. This makes IL-10-deficient mice a potentially useful model to assess the effects of stress on cytokine production...
  56. ncbi request reprint Chronic psychosocial stress down-regulates central cytokines mRNA
    Alessandro Bartolomucci
    Dipartimento di Biologia Evolutiva e Funzionale, Universita di Parma, Parco Area delle Scienze 11 A, 43100, Parma, Italy
    Brain Res Bull 62:173-8. 2003
    ..These findings may open new perspectives for understanding the pathophysiological basis of chronic stress-induced disorders...
  57. ncbi request reprint Baseline mood and psychosocial characteristics of patients developing depressive symptoms during interleukin-2 and/or interferon-alpha cancer therapy
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Behav Immun 18:205-13. 2004
    ....
  58. ncbi request reprint The rank assessed in a food competition test influences subsequent reactivity to immune and social challenges in mice
    Elodie Merlot
    Neurobiologie Integrative, INRA, Institut Francois Magendie, rue Camille Saint Saens, 33077 Bordeaux, France
    Brain Behav Immun 18:468-75. 2004
    ..Therefore, social interactions emerging in a stable social group may be involved in the individual differences observed in endocrine activity and in immune system reactivity...
  59. ncbi request reprint Cytokine-induced sickness behaviour: a neuroimmune response to activation of innate immunity
    Robert Dantzer
    Neurobiologie Integrative, INRA, CNRS, Institut Francois Magendie, Universite Bordeaux 2, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Eur J Pharmacol 500:399-411. 2004
    ....
  60. ncbi request reprint Cytokines and depression: the need for a new paradigm
    Lucile Capuron
    Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Atlanta, GA 30322, USA
    Brain Behav Immun 17:S119-24. 2003
    ..This paper discusses ways in which these emerging data may lead to advances in the recognition and management of non-specific neurobehavioral symptoms associated with the development and progression of cancer...
  61. ncbi request reprint Affective components of the human-animal relationship in animal husbandry: development and validation of a questionnaire
    Jocelyne Porcher
    INRA SAD CNAM, Laboratoire de Psychologie du travail, Paris, France
    Psychol Rep 95:275-90. 2004
    ..These results validate a questionnaire with 21 items, allowing measurement of positive and negative affects of farmers towards their animals...
  62. ncbi request reprint [Neuro-immune interactions in psychopathology with the example of interferon-alpha-induced depression]
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30033, USA
    J Soc Biol 197:151-6. 2003
    ..In addition, some behavioral and biological markers of the vulnerability for IFN-alpha-induced depression were identified. These findings provide important information concerning the relationship between cytokines and depression...
  63. ncbi request reprint [Relationships between the brain and the immune system]
    Robert Dantzer
    INRA INSERM U394, rue Camille Saint Saens, 33077 Bordeaux, France
    J Soc Biol 197:81-8. 2003
    ..These locally produced cytokines diffuse throughout the brain parenchyma to act on target brain areas so as to organise the central components of the host response to infection (fever, neuroendocrine activation, and sickness behavior)...
  64. ncbi request reprint Anti-NR1 N-terminal-domain vaccination unmasks the crucial action of tPA on NMDA-receptor-mediated toxicity and spatial memory
    Karim Benchenane
    INSERM, INSERM Avenir tPA in the working brain, Universite de Caen Basse Normandie, Cyceron, 14074 Caen Cedex, France
    J Cell Sci 120:578-85. 2007
    ..Interesting therapeutic possibilities for several brain pathologies that involve excitotoxicity may now be envisaged...
  65. ncbi request reprint Cellular distribution of interleukin-1alpha-immunoreactivity after MPTP intoxication in mice
    Guillaume Hebert
    INSERM U394, Neurobiologie Integrative, Institut Francois Magendie, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Brain Res Mol Brain Res 138:156-63. 2005
    ..In the striatum, IL-1alpha-ir was also detected in a non-astrocytic perivascular component, with a distribution similar to GAP-43-ir. IL-1alpha could thus directly or indirectly influence striatal reorganization after MPTP...
  66. ncbi request reprint Conditioned place aversion with interleukin-1beta in mice is not associated with activation of the cytokine network
    Cecile Mormede
    INRA INSERM U394 Neurobiologie Intégrative, Institut Francois Magendie, rue Camille Saint Saens, 33077, Bordeaux Cedex, France
    Brain Behav Immun 17:110-20. 2003
    ..These data do not support the possibility of conditioned alterations in the cytokine network...
  67. ncbi request reprint Cytokines and depression: an update
    Robert Dantzer
    INRA INSERM U394, Institut Francois Magendie Integrative Neurobiology, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Brain Behav Immun 16:501-2. 2002
  68. ncbi request reprint Somatization: a psychoneuroimmune perspective
    Robert Dantzer
    Neurobiologie Integrative, CNRS INRA Université de Bordeaux 2, Institut Francois Magendie, 33077 Bordeaux Cedex, France
    Psychoneuroendocrinology 30:947-52. 2005
    ..All these new findings have the potential to contribute to a renewed biopsychological approach to somatization and somatoform disorders...
  69. ncbi request reprint Expression and regulation of interleukin-1 receptors in the brain. Role in cytokines-induced sickness behavior
    Patricia Parnet
    Laboratory of Integrative Neurobiology, INRA INSERM U394, Institut Francois Magendie, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    J Neuroimmunol 125:5-14. 2002
    ..Finally, modulation of IL-1 action on its receptor by various opposing factors including glucocorticoids and anti-inflammatory cytokines is discussed...
  70. ncbi request reprint Pentoxifylline and insulin-like growth factor-I (IGF-I) abrogate kainic acid-induced cognitive impairment in mice
    Rose Marie Bluthé
    Integrative Neurobiology, CNRS INRA University Victor Segalen, Bordeaux, France
    J Neuroimmunol 169:50-8. 2005
    ..These findings indicate that endogenous TNFalpha is probably involved in the detrimental effects of kainate on cognition and that exogenous IGF-I can oppose these effects, probably by antagonizing TNFalpha-induced neurotoxicity...
  71. ncbi request reprint Inactivation of the cerebral NFkappaB pathway inhibits interleukin-1beta-induced sickness behavior and c-Fos expression in various brain nuclei
    Agnes Nadjar
    UMR INRA I 244 CNRS Université Victor Segalen Bordeaux II, Institut Francois Magendie, rue Léo Saignat Bordeaux, Cedex, France
    Neuropsychopharmacology 30:1492-9. 2005
    ....
  72. ncbi request reprint Time-course of the expression of inflammatory cytokines and matrix metalloproteinases in the striatum and mesencephalon of mice injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, a dopaminergic neurotoxin
    Guillaume Hebert
    INSERM U 394 Neurobiologie Intégrative, Institut Francois Magendie, Bordeaux, France
    Neurosci Lett 349:191-5. 2003
    ....
  73. ncbi request reprint Nuclear factor kappaB nuclear translocation as a crucial marker of brain response to interleukin-1. A study in rat and interleukin-1 type I deficient mouse
    Agnes Nadjar
    INRA INSERM U 394, Institut F Magendie, Bordeaux, France
    J Neurochem 87:1024-36. 2003
    ..The study of the consequences of the impairment of NFkappaB pathway activation in in vivo experimentation should bring important clues about the precise role of this transcription factor...
  74. ncbi request reprint A cytokine-based neuroimmunologic mechanism of cancer-related symptoms
    Bang Ning Lee
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Neuroimmunomodulation 11:279-92. 2004
    ..These concepts open exciting new avenues for translational research in the pathophysiology and treatment of cancer-related symptoms...
  75. ncbi request reprint Cytokine production by spleen cells after social defeat in mice: activation of T cells and reduced inhibition by glucocorticoids
    Elodie Merlot
    Neurobiologie Integrative, INRA INSERM, Institut FrançMagendie, Bordeaux, France
    Stress 7:55-61. 2004
    ..Wounded and non-wounded mice presented similar responses to stress. This study shows that social disruption stress enhances the reactivity of cells from both the acquired and innate immune systems...
  76. ncbi request reprint Interleukin-1beta mediates the memory impairment associated with a delayed type hypersensitivity response to bacillus Calmette-Guérin in the rat hippocampus
    Karine Palin
    INRA UMR 1244 Université V Segalen Bordeaux 2, FRE CNRS Institut François Magendie, rue Camille Saint Saens, 33077 Bordeaux, France
    Brain Behav Immun 18:223-30. 2004
    ..These results show that overexpression of IL-1beta in the brain during the course of a chronic inflammation has deleterious consequences on cognitive processes, that are reversed by blockade of IL-1 receptors...
  77. ncbi request reprint Social factors and individual vulnerability to chronic stress exposure
    Alessandro Bartolomucci
    Dipartimento di Biologia Evolutiva e Funzionale, Universita di Parma, Parma, Italy
    Neurosci Biobehav Rev 29:67-81. 2005
    ....
  78. ncbi request reprint A role of IL-1 in MPTP-induced changes in striatal dopaminergic and serotoninergic transporter binding: clues from interleukin-1 type I receptor-deficient mice
    Guillaume Hebert
    INSERM U394, Neurobiologie Integrative, Institut Francois Magendie, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Brain Res Mol Brain Res 136:267-70. 2005
    ..These data point to a possible role of IL-1RI in the early MPTP-induced structural or functional remodeling of the nigrostriatal dopamine system...
  79. ncbi request reprint Conditioned taste aversion with lipopolysaccharide and peptidoglycan does not activate cytokine gene expression in the spleen and hypothalamus of mice
    Cecile Mormede
    INRA INSERM U394 Neurobiologie Intégrative, Institut Francois Magendie, rue Camille Saint Saens, 3307 Bordeaux Cedex, France
    Brain Behav Immun 18:186-200. 2004
    ..This modulation of the NFkappaB and MAPK signalling pathways is interpreted in terms of a possible conditioned sensitisation of the immune system...
  80. ncbi request reprint Dual effect of central injection of recombinant rat interleukin-4 on lipopolysaccharide-induced sickness behavior in rats
    Rose Marie Bluthé
    Integrative Neurobiology Laboratory, INRA INSERM U394, Institut Francois Magendie, rue Camille Saint Saens, 33077, Bordeaux Cedex, France
    Neuropsychopharmacology 26:86-93. 2002
    ..These results indicate that the regulation of cytokine-induced sickness behavior by IL-4 can be either inhibitory or stimulatory depending on the sequencing of IL-4 and LPS treatments...
  81. ncbi request reprint Importance of fighting in the immune effects of social defeat
    Elodie Merlot
    Neurobiologie Integrative, INRA INSERM, Institut Francois Magendie, rue Camille Saint Saens, 33077 Bordeaux, France
    Physiol Behav 80:351-7. 2003
    ..The increased immune reactivity observed in the fight-associated procedure could result from either a stronger psychological stress or a direct immune activation through the wounds...
  82. ncbi request reprint Influence of the course of brain inflammation on the endogenous IL-1beta/IL-1Ra balance in the model of brain delayed-type hypersensitivity response to bacillus Calmette-Guérin in Lewis rats
    Karine Palin
    INRA UMR 1244, Université V Segalen Bordeaux 2, FRE CNRS Institut François Magendie, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    J Neuroimmunol 149:22-30. 2004
    ..Besides showing that the course of inflammation alters the brain IL-1beta/IL-1Ra ratio, these findings point to the importance of monitoring plasma IL-1beta/IL-1Ra ratio to predict the course of brain inflammation...

Research Grants1

  1. AIDS, Immune Activation and Mental Health
    Robert Dantzer; Fiscal Year: 2006
    ....