Research Topics
Genomes and Genes
| Robert DantzerSummaryAffiliation: University of Illinois Country: USA Publications
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Detail Information
Publications
Innate immunity at the forefront of psychoneuroimmunologyRobert Dantzer
Integrative Neurobiology, Bordeaux, France
Brain Behav Immun 18:1-6. 2004..In this presidential address, I present the main methodological and conceptual developments that have allowed such progress...- Chronic administration of tianeptine balances lipopolysaccharide-induced expression of cytokines in the spleen and hypothalamus of ratsNathalie Castanon
, , , 33077 Bordeaux Cedex, France
Psychoneuroendocrinology 29:778-90. 2004..These results open new vistas in the pharmacological activity of tianeptine and provide further insights on the possible mechanisms of action involved in its neuroprotective properties... - Immune alterations induced by social defeat do not alter the course of an on-going BCG infection in miceElodie Merlot
Neurobiologie Integrative, INRA INSERM, Institut Francois Magendie, Bordeaux, France
Neuroimmunomodulation 11:414-8. 2004..Accordingly, social defeat was unable to influence the mycobacterial growth in vivo. These results support the hypothesis postulating that stress does not affect antigen-specific response when it is applied after priming... - C-jun N-terminal kinase mediates tumor necrosis factor-alpha suppression of differentiation in myoblastsKlemen Strle
Laboratories of Immunophysiology, Department of Animal Sciences, University of Illinois, Urbana, Illinois 61801, USA
Endocrinology 147:4363-73. 2006..These results establish that the resistance of muscle progenitor cells to IGF-I, which is caused by inflammatory stimuli, is mediated by the JNK stress kinase pathway... 
Cytokine, sickness behavior, and depressionRobert Dantzer
Laboratory of Integrative Neurobiology, CNRS, INRA, University of Bordeaux 2, 33077 Bordeaux Cedex, France
Neurol Clin 24:441-60. 2006..In addition, a dynamic view of the cellular interactions that occur at the brain sites of cytokine production and action is missing, together with a clarification of the mechanisms that favor the transition toward pathology...- Twenty years of research on cytokine-induced sickness behaviorRobert Dantzer
Integrative Immunology and Behavior Program, Laboratory of Integrative Immunophysiology, Department of Animal Sciences, University of Illinois at Urbana Champaign, IL 61801, USA
Brain Behav Immun 21:153-60. 2007..The time is ripe to begin to move these fundamental discoveries in mice to man and some of the pharmacological tools are already available to antagonize the detrimental actions of cytokines... - Identification and treatment of symptoms associated with inflammation in medically ill patientsRobert Dantzer
Integrative Immunology and Behavior Program, 212 ERML, 1201 W Gregory Drive, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Psychoneuroendocrinology 33:18-29. 2008..This resulted in a number of recommendations that should improve the recognition and management of inflammation-associated symptoms in medically ill patients... - From inflammation to sickness and depression: when the immune system subjugates the brainRobert Dantzer
Integrative Immunology and Behavior, Department of Animal Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois, Urbana Champaign, Illinois 61801, USA
Nat Rev Neurosci 9:46-56. 2008..Inflammation is therefore an important biological event that might increase the risk of major depressive episodes, much like the more traditional psychosocial factors... - Autistic children: a neuroimmune perspectiveRobert Dantzer
Integrative Immunology and Behavior Program, University of Illinois at Urbana-Champaign, 212 ERML, 1201 W Gregory Drive, Urbana, IL 61801, USA
Brain Behav Immun 22:804-5. 2008 - IL-1beta suppresses prolonged Akt activation and expression of E2F-1 and cyclin A in breast cancer cellsWen Hong Shen
Laboratory of Immunophysiology, University of Illinois, Urbana, IL 61801, USA
J Immunol 172:7272-81. 2004..In this manner, Akt serves as a critical bridge that links proximal receptor signaling events to more distal cell cycle machinery... - Proinflammatory cytokine impairment of insulin-like growth factor I-induced protein synthesis in skeletal muscle myoblasts requires ceramideKlemen Strle
University of Illinois, Laboratory of Immunophysiology, 207 Edward R Madigan Laboratory, 1201 West Gregory Drive, Urbana, Illinois 61801, USA
Endocrinology 145:4592-602. 2004.... - Induction of IDO by bacille Calmette-Guérin is responsible for development of murine depressive-like behaviorJason C O'Connor
Integrative Immunology and Behavior Program, Department of Animal Sciences, College of Agriculture, Consumer, and Environmental Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
J Immunol 182:3202-12. 2009.... - Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-GuerinJason C O'Connor
Integrative Immunology and Behavior Program, Department of Animal Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois 61801 3873, USA
J Neurosci 29:4200-9. 2009..Together, these data demonstrate that IFNgamma, with TNFalpha, is necessary for induction of IDO and depressive-like behavior in mice after BCG infection... - Prototypical anti-inflammatory cytokine IL-10 prevents loss of IGF-I-induced myogenin protein expression caused by IL-1betaKlemen Strle
Laboratory of Integrative Immunophysiology, Integrative Immunology and Behavior Program, Department of Animal Sciences, College of Agricultural, Consumer and Enviromental Sciences, University of Illinois, Urbana, IL 61801, USA
Am J Physiol Endocrinol Metab 294:E709-18. 2008..Collectively, these data demonstrate that IL-10 acts in a novel, nonclassical, protective manner in nonhematopoietic cells to inhibit the IL-1beta receptor-induced JNK kinase pathway, resulting in prevention of IGF-I resistance... - IL-1beta impairs insulin-like growth factor i-induced differentiation and downstream activation signals of the insulin-like growth factor i receptor in myoblastsSuzanne R Broussard
Laboratories of Immunophysiology, 207 Edward R Madigan Laboratory, University of Illinois at Urbana Champaign, 1201 West Gregory Drive, Urbana, IL 61801, USA
J Immunol 172:7713-20. 2004..Collectively, the results are consistent with the notion that very low concentrations of IL-1beta significantly impair myogenesis, but they are unable to do so in the absence of the growth factor IGF-I... - Tumor necrosis factor alpha inhibits cyclin A expression and retinoblastoma hyperphosphorylation triggered by insulin-like growth factor-I induction of new E2F-1 synthesisWen Hong Shen
Laboratory of Immunophysiology, Department of Animal Sciences, University of Illinois, Urbana, Illinois 61801, USA
J Biol Chem 279:7438-46. 2004.... - Novel activity of an anti-inflammatory cytokine: IL-10 prevents TNFalpha-induced resistance to IGF-I in myoblastsKlemen Strle
Laboratories of Integrative Immunophysiology, College of Medicine, University of Illinois, Urbana, IL 61801, United States
J Neuroimmunol 188:48-55. 2007..Instead, IL-10 acts to prevent TNFalpha-induced phosphorylation of JNK. These findings demonstrate that IL-10 serves a previously unrecognized protective role in muscle progenitors by overcoming TNFalpha-induced resistance to IGF-I... - Central administration of lipopolysaccharide induces depressive-like behavior in vivo and activates brain indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice culturesXin Fu
Integrative Immunology and Behavior Program, Department of Animal Sciences, College of ACES, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
J Neuroinflammation 7:43. 2010..It is unknown whether direct activation of the brain with LPS is sufficient to activate IDO and induce depressive-like behavior... - Tumor necrosis factor alpha inhibits insulin-like growth factor I-induced hematopoietic cell survival and proliferationWen Hong Shen
University of Illinois, Laboratory of Immunophysiology, Department of Animal Sciences, 207 Edward R. Madigan Laboratory, 1201 West Gregory Drive, Urbana, Illinois 61801, USA
Endocrinology 145:3101-5. 2004..These results support the general concept that proinflammatory cytokines impair the actions of hormones on hematopoietic cells, leading to IGF-I receptor resistance... - Insulin-like growth factor-I peptides act centrally to decrease depression-like behavior of mice treated intraperitoneally with lipopolysaccharideSook Eun Park
Integrated Immunology and Behavior Program, University of Illinois at Urbana Champaign, Illinois 61801 3873, USA
J Neuroinflammation 8:179. 2011..Thus, both IGF-I and GPE elicit specific improvement in depression-like behavior independent of sickness, an action that could be due to their anti-inflammatory properties... - Cytokine-hormone interactions: tumor necrosis factor alpha impairs biologic activity and downstream activation signals of the insulin-like growth factor I receptor in myoblastsSuzanne R Broussard
Laboratory of Immunophysiology, Department of Animal Sciences and Pathology, College of Medicine, University of Illinois at Urbana Champaign, 207 Edward R Madigan Laboratory, 1201 West Gregory Drive, Urbana, IL 61801, USA
Endocrinology 144:2988-96. 2003..These data are consistent with the notion that very low physiological concentrations of TNFalpha interfere with both protein synthesis and muscle cell development by inducing a state of IGF-I receptor resistance... - The type 1 TNF receptor and its associated adapter protein, FAN, are required for TNFalpha-induced sickness behaviorKarine Palin
Integrative Immunology and Behavior Program, Laboratory of Integrative Immunophysiology, Department of Animal Sciences, University of Illinois at Urbana Champaign, 227 Edward R Madigan Laboratory, 1201 West Gregory Drive, Urbana, IL 61801 3873, USA
Psychopharmacology (Berl) 201:549-56. 2009..TNFalpha activates neutral sphingomyelinase through the TNF-R1 adapter protein FAN (factor associated with neutral sphingomyelinase activation), but a behavioral role of FAN in the brain has never been reported... - LPS-induced indoleamine 2,3-dioxygenase is regulated in an interferon-gamma-independent manner by a JNK signaling pathway in primary murine microgliaYunxia Wang
Department of Animal Sciences, Integrative Immunology and Behavior Program, University of Illinois at Urbana Champaign, 227 Edward R Madigan Laboratory, 1201 W Gregory Drive, Urbana, IL 61801 3873, USA
Brain Behav Immun 24:201-9. 2010..Inhibition of the JNK pathway may provide a new therapy for inflammatory depression... - HIV-1 Tat activates indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice cultures in a p38 mitogen-activated protein kinase-dependent mannerXin Fu
Integrative Immunology and Behavior Program, Department of Animal Sciences, College of ACES, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
J Neuroinflammation 8:88. 2011..Because human immunodeficiency virus type 1 (HIV-1) Tat protein causes depressive-like behavior in mice, we investigated its ability to activate IDO in organotypic hippocampal slice cultures (OHSCs) derived from neonatal C57BL/6 mice... - TNFalpha-induced sickness behavior in mice with functional 55 kD TNF receptors is blocked by central IGF-IKarine Palin
Department of Animal Sciences, Integrative Immunology and Behavior Program, Laboratory of Integrative Immunophysiology, University of Illinois at Urbana Champaign, IL, USA
J Neuroimmunol 187:55-60. 2007..c.v., 300 ng/mouse). These results establish that sickness behavior induced by central TNFalpha via the TNF-R1 (p55) is directly opposed by IGF-I in the brain... - Cytokine-induced sickness behaviorKeith W Kelley
Department of Animal Sciences, Laboratory of Immunophysiology, University of Illinois, 207 Edward R Madigan Laboratory, 1201 West Gregory Drive, Urbana 61801, USA
Brain Behav Immun 17:S112-8. 2003..Advances that have been made during the past decade should now be extended to clinical studies in an attempt to alleviate sickness symptoms and improve quality of life for cancer patients... - Insulin-like growth factor-I and the cytokines IL-3 and IL-4 promote survival of progenitor myeloid cells by different mechanismsWilliam Burgess
Laboratory of Immunophysiology, Department of Animal Sciences, University of Illinois, 207 ERML, 1201 W. Gregory Dr, Urbana, IL 61801, USA
J Neuroimmunol 135:82-90. 2003.... - Central administration of insulin-like growth factor-I decreases depressive-like behavior and brain cytokine expression in miceSook Eun Park
Integrated Immunology and Behavior Program, University of Illinois at Urbana Champaign, Urbana, Illinois 61801 3873, USA
J Neuroinflammation 8:12. 2011..These actions of IGF-I parallel its ability to diminish depressive-like behavior... - Inhibition of vagally mediated immune-to-brain signaling by vanadyl sulfate speeds recovery from sicknessDaniel R Johnson
Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
Proc Natl Acad Sci U S A 102:15184-9. 2005..Taken together, these data indicate that VS improves recovery from LPS-induced sickness by blocking vagally mediated immune-to-brain signaling and by up-regulating brain expression of IL-1beta antagonists... - IL-1beta-mediated innate immunity is amplified in the db/db mouse model of type 2 diabetesJason C O'Connor
Department of Animal Sciences, University of Illinois at Urbana Champain, Urbana, IL 61801, USA
J Immunol 174:4991-7. 2005..Taken together, these results indicate that IL-1beta-mediated innate immunity is augmented in db/db mice both at the periphery and in the brain, and the mechanism is due to diabetes-associated loss of IL-1beta counterregulation... - Proinflammatory cytokines block growth of breast cancer cells by impairing signals from a growth factor receptorWen-Hong Shen
Laboratory of Immunophysiology, Department of Animal Sciences, University of Illinois, Urbana, Illinois 61801, USA
Cancer Res 62:4746-56. 2002..These data also highlight growth factor receptor adaptor molecules, such as insulin receptor substrate-1, rather than the receptors themselves as targets for antitumor therapeutic strategies... - Inflammation-associated depression: from serotonin to kynurenineRobert Dantzer
Integrative Immunology and Behavior Program, Department of Animal Sciences, 227 Edward R Madigan Laboratory, 1201 West Gregory Drive, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Psychoneuroendocrinology 36:426-36. 2011.... - Regulation of IGF-I function by proinflammatory cytokines: at the interface of immunology and endocrinologyJason C O'Connor
Integrative Immunology and Behavior Program, Department of Animal Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Cell Immunol 252:91-110. 2008..We also highlight that IGF-I can induce resistance or reduce sensitivity to brain TNFalpha and discuss how TNFalpha, IL-1beta, and IGF-I interact to regulate several aspects of behavior and cognition... - Primary murine microglia are resistant to nitric oxide inhibition of indoleamine 2,3-dioxygenaseYunxia Wang
Integrative Immunology and Behavior Program, Department of Animal Sciences, 227 Edward R Madigan Laboratory, College of ACES, 1201 W Gregory Drive, University of Illinois at Urbana Champaign, Urbana, IL 61801 3873, USA
Brain Behav Immun 24:1249-53. 2010..These data establish that IDO regulation in murine microglia is not restrained by NO, thereby permitting the accumulation of kynurenine and its downstream metabolites in the central nervous system... - Insulin-like growth factor-I enhances the biological activity of brain-derived neurotrophic factor on cerebrocortical neuronsRobert H McCusker
250 Edward R Madigan Laboratory, Urbana, IL 61801 3873, USA
J Neuroimmunol 179:186-90. 2006..IGF-I enhanced expression of BDNF receptors (Trk-B) and increased the ability of BDNF to induce ERK1/2 phosphorylation. This IGF-I-induced increase in BDNF responsiveness describes a new interaction between these peptides in the brain... - Lipopolysaccharide induces delayed FosB/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behaviorFrancois Frenois
Integrative Immunology and Behavior Program, University of Illinois at Urbana Champaign, 212 Edward R Madigan Laboratory, 1201 West Gregory Drive, Urbana, IL 61801, USA
Psychoneuroendocrinology 32:516-31. 2007.... - Intracerebroventricular administration of HIV-1 Tat induces brain cytokine and indoleamine 2,3-dioxygenase expression: a possible mechanism for AIDS comorbid depressionMarcus A Lawson
Neuroscience Program University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Brain Behav Immun 25:1569-75. 2011..The results reveal a potential role for Tat in the development of comorbid depression in HIV-infected individuals... - Voluntary wheel running reverses age-induced changes in hippocampal gene expressionRachel A Kohman
Department of Psychology, Beckman Institute, University of Illinois, Urbana, Illinois, United States of America
PLoS ONE 6:e22654. 2011..Collectively, findings show that even late-onset exercise may attenuate age-related changes in gene expression and identifies possible pathways through which exercise may exert its beneficial effects... - Acute hypoglycemia causes depressive-like behaviors in miceMin Jung Park
Division of Nutritional Sciences, University of Illinois, Urbana, IL 61801, USA
Metabolism 61:229-36. 2012..These data indicate that, in mice, acute hypoglycemia through adrenergic pathways caused depressive-like behaviors that exist well beyond the resolution of hypoglycemia... 
Alcoholism and inflammation: neuroimmunology of behavioral and mood disordersKeith W Kelley
Integrative Immunology and Behavior Program, Department of Animal Sciences, College of ACES, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Brain Behav Immun 25:S13-20. 2011..These findings present new and challenging opportunities for scientists who are engaged in brain, behavior and immunity research...- Effects of voluntary wheel running on LPS-induced sickness behavior in aged miceStephen A Martin
Departments of Kinesiology and Community Health, University of Illinois at Urbana Champaign, Urbana, IL, United States
Brain Behav Immun 29:113-23. 2013..33 mg/kg LPS or Saline) brain and peripheral proinflammatory cytokine gene expression. The necessity of the sickness response is critical for survival and may outweigh the subtle benefits of exercise training in aged animals... - IL-10 promotes survival of microglia without activating AktKlemen Strle
Laboratory of Immunophysiology, Department of Animal Sciences, University of Illinois, 207 ERML, 1201 W. Gregory Dr, Urbana, IL 61801, USA
J Neuroimmunol 122:9-19. 2002..These data establish that IL-10 activates Stat3 and inhibits the mitochondrial pathway of cell death without activating the Akt cell survival pathway... - Age-associated loss of bone marrow hematopoietic cells is reversed by GH and accompanies thymic reconstitutionRichard A French
Laboratory of Immunophysiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
Endocrinology 143:690-9. 2002.... - The associations of adiposity, physical activity and inflammation with fatigue in older adultsRudy J Valentine
Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, USA
Brain Behav Immun 25:1482-90. 2011..In addition to depression and sleep quality, adiposity may represent a potential target for reducing fatigue in older adults... - Chronic psychosocial stress down-regulates central cytokines mRNAAlessandro Bartolomucci
Dipartimento di Biologia Evolutiva e Funzionale, Universita di Parma, Parco Area delle Scienze 11 A, 43100, Parma, Italy
Brain Res Bull 62:173-8. 2003..These findings may open new perspectives for understanding the pathophysiological basis of chronic stress-induced disorders... - Cytokines and depression: the need for a new paradigmLucile Capuron
Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Atlanta, GA 30322, USA
Brain Behav Immun 17:S119-24. 2003..This paper discusses ways in which these emerging data may lead to advances in the recognition and management of non-specific neurobehavioral symptoms associated with the development and progression of cancer... - In vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1 beta in the murine brainRozenn Mingam
PsyNuGen, INRA, UMR1286, CNRS, UMR5226, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33077 Bordeaux, France
Brain Behav Immun 22:234-44. 2008..These results show that P2X7R plays a key role in the brain cytokine response to immune stimuli, which certainly applies also to cytokine-dependent alterations in brain functions including sickness behavior... - A biological substrate for somatoform disorders: importance of pathophysiologyJoel E Dimsdale
Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
Psychosom Med 69:850-4. 2007..Studies on communication pathways from the immune system to the brain provide exciting new information on the pathophysiology of inflammation-associated symptoms... - Are the symptoms of cancer and cancer treatment due to a shared biologic mechanism? A cytokine-immunologic model of cancer symptomsCharles S Cleeland
Department of Symptom Research, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
Cancer 97:2919-25. 2003..These symptoms include pain, wasting, fatigue, cognitive impairment, anxiety, and depression, many of which co-occur. There is growing recognition that at least some of these symptoms may share common biologic mechanisms... - Inoculation of Bacillus Calmette-Guerin to mice induces an acute episode of sickness behavior followed by chronic depressive-like behaviorMaite Moreau
INRA, UMR 1286 PsyNuGen, Bâtiment UFR Pharmacie, Case courrier 34, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, CNRS, UMR 5226, IFR8, F 33076 Bordeaux, France
Brain Behav Immun 22:1087-95. 2008.... - Cytokine-induced sickness behaviour: a neuroimmune response to activation of innate immunityRobert Dantzer
Neurobiologie Integrative, INRA, CNRS, Institut Francois Magendie, Universite Bordeaux 2, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
Eur J Pharmacol 500:399-411. 2004.... - Long-term modulation of glucose utilization by IL-1 alpha and TNF-alpha in astrocytes: Na+ pump activity as a potential target via distinct signaling mechanismsCéline Véga
Institut de Physiologie, Lausanne, Switzerland
Glia 39:10-8. 2002..These data suggest that Na(+) pump activity is a common target for both the long-term metabolic action of cytokines promoted by the activation of distinct signaling pathways and the enhanced metabolic response to glutamate... - The rank assessed in a food competition test influences subsequent reactivity to immune and social challenges in miceElodie Merlot
Neurobiologie Integrative, INRA, Institut Francois Magendie, rue Camille Saint Saens, 33077 Bordeaux, France
Brain Behav Immun 18:468-75. 2004..Therefore, social interactions emerging in a stable social group may be involved in the individual differences observed in endocrine activity and in immune system reactivity... - Baseline mood and psychosocial characteristics of patients developing depressive symptoms during interleukin-2 and/or interferon-alpha cancer therapyLucile Capuron
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
Brain Behav Immun 18:205-13. 2004.... - Cytokine-induced sickness behaviour: mechanisms and implicationsJan Pieter Konsman
Laboratory of Integrative Neurobiology, INRA-INSERM U 394, Rue Camille Saint-Saens, Bordeaux, France
Trends Neurosci 25:154-9. 2002..The cellular and molecular components of this previously unsuspected system are being progressively identified. These advances are opening new avenues for understanding brain disorders, including depression... - Chronic mild stress in mice decreases peripheral cytokine and increases central cytokine expression independently of IL-10 regulation of the cytokine networkCecile Mormede
INRA INSERM U394, Neurobiologie Integrative, Institut Francois Magendie, Bordeaux, France
Neuroimmunomodulation 10:359-66. 2002..The production and action of pro-inflammatory cytokines are down-regulated by anti-inflammatory cytokines such as IL-10. This makes IL-10-deficient mice a potentially useful model to assess the effects of stress on cytokine production... - Effects of insulin-like growth factor-I on cytokine-induced sickness behavior in miceRose Marie Bluthé
Integrative Neurobiology, CNRS INRA University Victor Segalen, Bordeaux, France
Brain Behav Immun 20:57-63. 2006..These findings indicate that IGF-I is more potent in attenuating sickness behavior induced by TNFalpha than that caused by IL-1beta, which is consistent with the relative specificity of the TNFalpha/IGF-I interactions in the brain... - Dual effect of central injection of recombinant rat interleukin-4 on lipopolysaccharide-induced sickness behavior in ratsRose Marie Bluthé
Integrative Neurobiology Laboratory, INRA INSERM U394, Institut Francois Magendie, rue Camille Saint Saens, 33077, Bordeaux Cedex, France
Neuropsychopharmacology 26:86-93. 2002..These results indicate that the regulation of cytokine-induced sickness behavior by IL-4 can be either inhibitory or stimulatory depending on the sequencing of IL-4 and LPS treatments... - Conditioned place aversion with interleukin-1beta in mice is not associated with activation of the cytokine networkCecile Mormede
INRA INSERM U394 Neurobiologie Intégrative, Institut Francois Magendie, rue Camille Saint Saens, 33077, Bordeaux Cedex, France
Brain Behav Immun 17:110-20. 2003..These data do not support the possibility of conditioned alterations in the cytokine network... - Cytokines and depression: an updateRobert Dantzer
INRA-INSERM U394, Institut Francois Magendie Integrative Neurobiology, Rue Camille Saint-Saens, 33077 Bordeaux Cedex, France
Brain Behav Immun 16:501-2. 2002 - Expression and regulation of interleukin-1 receptors in the brain. Role in cytokines-induced sickness behaviorPatricia Parnet
Laboratory of Integrative Neurobiology, INRA INSERM U394, Institut Francois Magendie, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
J Neuroimmunol 125:5-14. 2002..Finally, modulation of IL-1 action on its receptor by various opposing factors including glucocorticoids and anti-inflammatory cytokines is discussed... - [Relationships between the brain and the immune system]Robert Dantzer
INRA INSERM U394, rue Camille Saint Saens, 33077 Bordeaux, France
J Soc Biol 197:81-8. 2003..These locally produced cytokines diffuse throughout the brain parenchyma to act on target brain areas so as to organise the central components of the host response to infection (fever, neuroendocrine activation, and sickness behavior)... - Interleukin-1beta mediates the memory impairment associated with a delayed type hypersensitivity response to bacillus Calmette-Guérin in the rat hippocampusKarine Palin
INRA UMR 1244 Université V Segalen Bordeaux 2, FRE CNRS Institut François Magendie, rue Camille Saint Saens, 33077 Bordeaux, France
Brain Behav Immun 18:223-30. 2004..These results show that overexpression of IL-1beta in the brain during the course of a chronic inflammation has deleterious consequences on cognitive processes, that are reversed by blockade of IL-1 receptors... - A cytokine-based neuroimmunologic mechanism of cancer-related symptomsBang-Ning Lee
Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
Neuroimmunomodulation 11:279-92. 2004..These concepts open exciting new avenues for translational research in the pathophysiology and treatment of cancer-related symptoms... - Affective components of the human-animal relationship in animal husbandry: development and validation of a questionnaireJocelyne Porcher
INRA SAD CNAM, Laboratoire de Psychologie du travail, Paris, France
Psychol Rep 95:275-90. 2004..These results validate a questionnaire with 21 items, allowing measurement of positive and negative affects of farmers towards their animals... - Social factors and individual vulnerability to chronic stress exposureAlessandro Bartolomucci
Dipartimento di Biologia Evolutiva e Funzionale, Universita di Parma, Parma, Italy
Neurosci Biobehav Rev 29:67-81. 2005.... - A role of IL-1 in MPTP-induced changes in striatal dopaminergic and serotoninergic transporter binding: clues from interleukin-1 type I receptor-deficient miceGuillaume Hebert
INSERM U394, Neurobiologie Integrative, Institut Francois Magendie, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
Brain Res Mol Brain Res 136:267-70. 2005..These data point to a possible role of IL-1RI in the early MPTP-induced structural or functional remodeling of the nigrostriatal dopamine system... - Inactivation of the cerebral NFkappaB pathway inhibits interleukin-1beta-induced sickness behavior and c-Fos expression in various brain nucleiAgnes Nadjar
UMR INRA I 244 CNRS Université Victor Segalen Bordeaux II, Institut Francois Magendie, rue Léo Saignat Bordeaux, Cedex, France
Neuropsychopharmacology 30:1492-9. 2005.... - Cellular distribution of interleukin-1alpha-immunoreactivity after MPTP intoxication in miceGuillaume Hebert
INSERM U394, Neurobiologie Integrative, Institut Francois Magendie, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
Brain Res Mol Brain Res 138:156-63. 2005..In the striatum, IL-1alpha-ir was also detected in a non-astrocytic perivascular component, with a distribution similar to GAP-43-ir. IL-1alpha could thus directly or indirectly influence striatal reorganization after MPTP... - Somatization: a psychoneuroimmune perspectiveRobert Dantzer
Neurobiologie Integrative, CNRS INRA Université de Bordeaux 2, Institut Francois Magendie, 33077 Bordeaux Cedex, France
Psychoneuroendocrinology 30:947-52. 2005..All these new findings have the potential to contribute to a renewed biopsychological approach to somatization and somatoform disorders... - Pentoxifylline and insulin-like growth factor-I (IGF-I) abrogate kainic acid-induced cognitive impairment in miceRose Marie Bluthé
Integrative Neurobiology, CNRS INRA University Victor Segalen, Bordeaux, France
J Neuroimmunol 169:50-8. 2005..These findings indicate that endogenous TNFalpha is probably involved in the detrimental effects of kainate on cognition and that exogenous IGF-I can oppose these effects, probably by antagonizing TNFalpha-induced neurotoxicity... - Influence of the course of brain inflammation on the endogenous IL-1beta/IL-1Ra balance in the model of brain delayed-type hypersensitivity response to bacillus Calmette-Guérin in Lewis ratsKarine Palin
INRA UMR 1244, Université V Segalen Bordeaux 2, FRE CNRS Institut François Magendie, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
J Neuroimmunol 149:22-30. 2004..Besides showing that the course of inflammation alters the brain IL-1beta/IL-1Ra ratio, these findings point to the importance of monitoring plasma IL-1beta/IL-1Ra ratio to predict the course of brain inflammation... - Conditioned taste aversion with lipopolysaccharide and peptidoglycan does not activate cytokine gene expression in the spleen and hypothalamus of miceCecile Mormede
INRA INSERM U394 Neurobiologie Intégrative, Institut Francois Magendie, rue Camille Saint Saens, 3307 Bordeaux Cedex, France
Brain Behav Immun 18:186-200. 2004..This modulation of the NFkappaB and MAPK signalling pathways is interpreted in terms of a possible conditioned sensitisation of the immune system... - Anti-NR1 N-terminal-domain vaccination unmasks the crucial action of tPA on NMDA-receptor-mediated toxicity and spatial memoryKarim Benchenane
INSERM, INSERM Avenir tPA in the working brain, Universite de Caen Basse Normandie, Cyceron, 14074 Caen Cedex, France
J Cell Sci 120:578-85. 2007..Interesting therapeutic possibilities for several brain pathologies that involve excitotoxicity may now be envisaged... - Importance of fighting in the immune effects of social defeatElodie Merlot
Neurobiologie Integrative, INRA INSERM, Institut Francois Magendie, rue Camille Saint Saens, 33077 Bordeaux, France
Physiol Behav 80:351-7. 2003..The increased immune reactivity observed in the fight-associated procedure could result from either a stronger psychological stress or a direct immune activation through the wounds... - Nuclear factor kappaB nuclear translocation as a crucial marker of brain response to interleukin-1. A study in rat and interleukin-1 type I deficient mouseAgnes Nadjar
INRA INSERM U 394, Institut F Magendie, Bordeaux, France
J Neurochem 87:1024-36. 2003..The study of the consequences of the impairment of NFkappaB pathway activation in in vivo experimentation should bring important clues about the precise role of this transcription factor... - Time-course of the expression of inflammatory cytokines and matrix metalloproteinases in the striatum and mesencephalon of mice injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, a dopaminergic neurotoxinGuillaume Hebert
INSERM U 394 Neurobiologie Intégrative, Institut Francois Magendie, Bordeaux, France
Neurosci Lett 349:191-5. 2003.... - [Neuro-immune interactions in psychopathology with the example of interferon-alpha-induced depression]Lucile Capuron
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30033, USA
J Soc Biol 197:151-6. 2003..In addition, some behavioral and biological markers of the vulnerability for IFN-alpha-induced depression were identified. These findings provide important information concerning the relationship between cytokines and depression... - Cytokine production by spleen cells after social defeat in mice: activation of T cells and reduced inhibition by glucocorticoidsElodie Merlot
Neurobiologie Integrative, INRA INSERM, Institut FrançMagendie, Bordeaux, France
Stress 7:55-61. 2004..Wounded and non-wounded mice presented similar responses to stress. This study shows that social disruption stress enhances the reactivity of cells from both the acquired and innate immune systems...