Stephen G Dann

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi request reprint The amino acid sensitive TOR pathway from yeast to mammals
    Stephen G Dann
    University of Cincinnati Genome Research Institute, 2180 East Galbraith Road, Cincinnati, OH 45237, USA
    FEBS Lett 580:2821-9. 2006
  2. ncbi request reprint mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer
    Stephen G Dann
    Genome Research Institute, University of Cincinnati, 2180 E Galbraith Road, Cincinnati, OH 45237, USA
    Trends Mol Med 13:252-9. 2007
  3. pmc Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34
    Pawan Gulati
    Department of Molecular Oncogenesis, Genome Research Institute, University of Cincinnati, Cincinnati, OH 45237, USA
    Cell Metab 7:456-65. 2008
  4. pmc Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development
    Yann Gaël Gangloff
    Genome Research Institute, University of Cincinnati, 2180 E Galbraith Rd, Cincinnati, OH 45237, USA
    Mol Cell Biol 24:9508-16. 2004
  5. pmc Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
    Takahiro Nobukuni
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
    Proc Natl Acad Sci U S A 102:14238-43. 2005

Collaborators

  • George Thomas
  • Manel Joaquin
  • Lawrence D Gaspers
  • Eric J Brown
  • Pawan Gulati
  • Takahiro Nobukuni
  • Francois Natt
  • Sara C Kozma
  • Yann Gaël Gangloff
  • Andrew P Thomas
  • Maya P Byfield
  • Marta Roccio
  • Fried J T Zwartkruis
  • Jonathan M Backer
  • Johannes L Bos
  • So Young Kim
  • Sung Hee Um
  • Melanie Sticker
  • Silvia Cereghini
  • Jean Francois Spetz
  • Petr Svoboda
  • Matthias Mueller

Detail Information

Publications5

  1. ncbi request reprint The amino acid sensitive TOR pathway from yeast to mammals
    Stephen G Dann
    University of Cincinnati Genome Research Institute, 2180 East Galbraith Road, Cincinnati, OH 45237, USA
    FEBS Lett 580:2821-9. 2006
    ..This review describes recent advances in nutrient signaling that impinge on mTOR and its targets including hVps34, class III PI3K, a transducer of nutrient availability to mTOR...
  2. ncbi request reprint mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer
    Stephen G Dann
    Genome Research Institute, University of Cincinnati, 2180 E Galbraith Road, Cincinnati, OH 45237, USA
    Trends Mol Med 13:252-9. 2007
    ..Thus, to orchestrate the control of homeostatic responses, mTOR Complex1 must integrate signals from distinct cues. Here, we review recent findings concerning the regulation and pathophysiology associated with mTOR Complex1 and S6K1...
  3. pmc Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34
    Pawan Gulati
    Department of Molecular Oncogenesis, Genome Research Institute, University of Cincinnati, Cincinnati, OH 45237, USA
    Cell Metab 7:456-65. 2008
    ..These findings have important implications regarding the basic signaling mechanisms linking metabolic disorders with cancer progression...
  4. pmc Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development
    Yann Gaël Gangloff
    Genome Research Institute, University of Cincinnati, 2180 E Galbraith Rd, Cincinnati, OH 45237, USA
    Mol Cell Biol 24:9508-16. 2004
    ..Moreover, mTOR(-/-) embryos display a lesion in inner cell mass proliferation, consistent with the inability to establish embryonic stem cells from mTOR(-/-) embryos...
  5. pmc Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
    Takahiro Nobukuni
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
    Proc Natl Acad Sci U S A 102:14238-43. 2005
    ....