ISTVAN DANKO

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Nonviral gene transfer into liver and muscle for treatment of hyperbilirubinemia in the gunn rat
    ISTVAN DANKO
    Department of Pediatrics, Waisman Center, University of Wisconsin Madison, Madison, WI 53792, USA
    Hum Gene Ther 15:1279-86. 2004
  2. ncbi request reprint Long-term correction of hyperbilirubinemia in the Gunn rat by repeated intravenous delivery of naked plasmid DNA into muscle
    Zhen Jia
    Department of Pediatrics, Waisman Center, University of Wisconsin at Madison, Madison, WI 53705, USA
    Mol Ther 12:860-6. 2005
  3. ncbi request reprint Single hepatic venous injection of liver-specific naked plasmid vector expressing human UGT1A1 leads to long-term correction of hyperbilirubinemia and prevention of chronic bilirubin toxicity in Gunn rats
    Zhen Jia
    Department of Pediatrics, Waisman Center, University of Wisconsin Madison, 53705, USA
    Hum Gene Ther 16:985-95. 2005

Research Grants

Collaborators

  • Zhen Jia

Detail Information

Publications3

  1. ncbi request reprint Nonviral gene transfer into liver and muscle for treatment of hyperbilirubinemia in the gunn rat
    ISTVAN DANKO
    Department of Pediatrics, Waisman Center, University of Wisconsin Madison, Madison, WI 53792, USA
    Hum Gene Ther 15:1279-86. 2004
    ..A 30% decrease in serum bilirubin, if sustained, would provide meaningful clinical benefit for CN-I patients. However, to be clinically useful, this method needs further optimization and stable gene expression must be achieved...
  2. ncbi request reprint Long-term correction of hyperbilirubinemia in the Gunn rat by repeated intravenous delivery of naked plasmid DNA into muscle
    Zhen Jia
    Department of Pediatrics, Waisman Center, University of Wisconsin at Madison, Madison, WI 53705, USA
    Mol Ther 12:860-6. 2005
    ..The procedure is safe and simple, with great clinical potential. Further studies are needed to explain the mechanisms of loss and improve the stability of recombinant hUGT1A1 in muscle...
  3. ncbi request reprint Single hepatic venous injection of liver-specific naked plasmid vector expressing human UGT1A1 leads to long-term correction of hyperbilirubinemia and prevention of chronic bilirubin toxicity in Gunn rats
    Zhen Jia
    Department of Pediatrics, Waisman Center, University of Wisconsin Madison, 53705, USA
    Hum Gene Ther 16:985-95. 2005
    ..Our results provide further evidence of the feasibility of long-term correction of hepatic enzyme deficiencies with plasmid vectors optimized for expression in the liver...

Research Grants1

  1. Muscle-directed gene therapy for Crigler-Najjar Syndrome
    ISTVAN DANKO; Fiscal Year: 2005
    ..effects of gene therapy on chronic bilirubin toxicity (renal tubular damage) will be studied. These studies will provide proof-of-concept data for this gene therapy approach. ..