Research Topics
| CARL T D'ANGIOSummaryAffiliation: University of Rochester Country: USA Publications
| Collaborators
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Detail Information
Publications
Chemokine mRNA alterations in newborn and adult mouse lung during acute hyperoxiaC T D'Angio
Department of Pediatrics Neonatology, Strong Children s Research Center, University of Rochester, New York, USA
Exp Lung Res 24:685-702. 1998..These differences in the intensity, timing, and distribution of chemokine mRNA abundance between adult and newborn mice may help to explain the marked differences in their susceptibility to oxygen injury...- Active immunization of premature and low birth-weight infants: a review of immunogenicity, efficacy, and tolerabilityCARL T D'ANGIO
Strong Children s Research Center, Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Paediatr Drugs 9:17-32. 2007..A major challenge facing those who care for these infants is the provision of timely immunization... - Measles-mumps-rubella and varicella vaccine responses in extremely preterm infantsCARL T D'ANGIO
Department of Pediatrics, University of Rochester, Rochester, NY 14642, USA
Pediatrics 119:e574-9. 2007..Extremely preterm infants mount lower antibody responses than term infants to several vaccines. The objective of this study was to measure the immunogenicity of measles-mumps-rubella and varicella vaccines in preterm and term children... - Pressure-regulated volume control ventilation vs synchronized intermittent mandatory ventilation for very low-birth-weight infants: a randomized controlled trialCARL T D'ANGIO
Strong Children s Research Center, University of Rochester, Rochester, NY 14642, USA
Arch Pediatr Adolesc Med 159:868-75. 2005.... - Bronchopulmonary dysplasia in preterm infants: pathophysiology and management strategiesCARL T D'ANGIO
Strong Children s Research Center, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Paediatr Drugs 6:303-30. 2004..Future research in BPD will most probably focus on continued incremental improvements in outcome, which are likely to be achieved through the combined effects of many therapeutic modalities... - Differential roles for NF-kappa B in endotoxin and oxygen induction of interleukin-8 in the macrophageCARL T D'ANGIO
Departmentof Pediatrics, Strong Children s Research Center, University of Rochester School of Medicine, NY 14642, USA
Am J Physiol Lung Cell Mol Physiol 286:L30-6. 2004..Although an intact promoter NF-kappa B site is crucial to macrophage IL-8 production, only LPS-stimulated production appears to require additional nuclear translocation of NF-kappa B... - Longitudinal, 15-year follow-up of children born at less than 29 weeks' gestation after introduction of surfactant therapy into a region: neurologic, cognitive, and educational outcomesCARL T D'ANGIO
Department of Pediatrics, Strong Children s Research Center, Golisano Children s Hospital at Strong, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Pediatrics 110:1094-102. 2002..To measure the primary and secondary school-age neurologic, cognitive, and educational outcomes in a cohort of extremely premature infants born after the introduction of exogenous surfactant therapy in a circumscribed region... - Comparison of tracheal aspirate and bronchoalveolar lavage specimens from premature infantsCARL T D'ANGIO
Department of Pediatrics Neonatology, Strong Children s Research Center, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Biol Neonate 82:145-9. 2002..18 ng/ml). IL-8 levels (r = 0.55) and neutrophil proportions (r = 0.51) were moderately correlated between BAL and TA samples. TA specimens may be suitable substitutes for BAL samples in some studies of newborn lung fluid... 
Immunogenicity of trivalent influenza vaccine in extremely low-birth-weight, premature versus term infantsCARL T D'ANGIO
Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Pediatr Infect Dis J 30:570-4. 2011..Influenza vaccine immunogenicity in premature infants is incompletely characterized...- Discordant pulmonary proinflammatory cytokine expression during acute hyperoxia in the newborn rabbitC T D'Angio
Department of Pediatrics Neonatology, Strong Children s Research Center, University of Rochester, New York, USA
Exp Lung Res 25:443-65. 1999..Comparing newborn and adult animals' chemokine response may help explain their differences in hyperoxia susceptibility... - Heptavalent pneumococcal conjugate vaccine immunogenicity in very-low-birth-weight, premature infantsCARL T D'ANGIO
University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Pediatr Infect Dis J 29:600-6. 2010..The heptavalent pneumococcal CRM197 conjugate vaccine (PCV-7) has been incompletely studied in very-low-birth-weight (< or =1500 g) infants... - Vascular endothelial growth factor in pulmonary lavage fluid from premature infants: effects of age and postnatal dexamethasoneC T D'Angio
Department of Pediatrics Neonatology, Strong Children s Research Center, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Biol Neonate 76:266-73. 1999..Lavage VEGF levels were not associated with the development of BPD. We speculate that these DEX- and age-associated changes in VEGF may affect pulmonary angiogenesis... - Do urinary levels of vascular endothelial growth factor predict proliferative retinopathy?C T D'Angio
Strong Children s Research Center, Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Curr Eye Res 22:90-4. 2001..We hypothesized that local increases in VEGF in the vitreous would be reflected in the urine of subjects with PR... - Pathogenesis of bronchopulmonary dysplasiaPatricia R Chess
Department of Pediatrics, University of Rochester, Rochester, NY 14642, USA
Semin Perinatol 30:171-8. 2006..The contribution of hyperoxia and hypoxia, mechanical forces, vascular maldevelopment, inflammation, fluid management, patent ductus arteriosus (PDA), nutrition, and genetics will be discussed... - Normal remodeling of the oxygen-injured lung requires the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1)Rhonda J Staversky
Department of Pediatrics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA
Am J Pathol 161:1383-93. 2002..This observation has important implications for therapeutic strategies designed to attenuate long-term chronic lung disease after oxidant injury... - The role of vascular growth factors in hyperoxia-induced injury to the developing lungCARL T D'ANGIO
Strong Children s Research Center, Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester NY, USA
Front Biosci 7:d1609-23. 2002..Strategies that enhance microvascular integrity, whether through attenuating alterations in vascular growth factors or by other means, also improve the outcome of lung injury. Such therapies may eventually offer hope in human BPD... - Risk factors for umbilical venous catheter-associated thrombosis in very low birth weight infantsShalu Narang
University of Rochester, Rochester, New York 14642, USA
Pediatr Blood Cancer 52:75-9. 2009..The objective of this study was to investigate the risk factors associated with catheter related thrombosis in very low birth weight (VLBW) infants... - Inhaled nitric oxide for premature infants with severe respiratory failureKrisa P Van Meurs
Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, Calif 94304, USA
N Engl J Med 353:13-22. 2005..We conducted a multicenter, randomized, blinded, controlled trial to determine whether inhaled nitric oxide reduced the rate of death or bronchopulmonary dysplasia in such infants... - Maternal age, multiple birth, and extremely low birth weight infantsBetty R Vohr
Department of Pediatrics, The Warren Alpert Medical School of Brown University, Providence, RI, USA
J Pediatr 154:498-503.e2. 2009..To compare the rates of adverse neurodevelopmental outcome or death at 18 to 22 months among extremely low birth weight (ELBW) infants born to mothers >or=4 0 years to the corresponding rates among infants of younger mothers... - Cytokines associated with bronchopulmonary dysplasia or death in extremely low birth weight infantsNamasivayam Ambalavanan
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
Pediatrics 123:1132-41. 2009..The goal was to develop multivariate logistic regression models for the outcome of bronchopulmonary dysplasia and/or death at postmenstrual age of 36 weeks by using clinical and cytokine data from the first 28 days... - In vivo exposure to hyperoxia induces DNA damage in a population of alveolar type II epithelial cellsJason M Roper
Dept. of Pediatrics, Box 850, School of Medicine and Dentistry, Univ. of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA
Am J Physiol Lung Cell Mol Physiol 286:L1045-54. 2004..These data reveal that type II cells exposed to in vivo hyperoxia have oxidized and fragmented DNA. Because type II cells are essential for lung remodeling, our findings raise the possibility that they are proficient in DNA repair... 
An evidence-based catheter bundle alters central venous catheter strategy in newborn infantsMeggan Butler-O'Hara
School of Nursing, University of Rochester, Rochester, NY, USA
J Pediatr 160:972-7.e2. 2012....- Type II epithelial cells are critical target for hyperoxia-mediated impairment of postnatal lung developmentMin Yee
Department of Pediatrics, Box 850, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Ave, NY 14642, USA
Am J Physiol Lung Cell Mol Physiol 291:L1101-11. 2006..These data suggest that perinatal hyperoxia adversely affects alveolar development by disrupting the proper timing of type II cell proliferation and differentiation into type I cells... - Angiogenic factors and alveolar vasculature: development and alterations by injury in very premature baboonsWilliam M Maniscalco
Division of Neonatology, Strong Children s Research Center, Department of Pediatrics, University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA
Am J Physiol Lung Cell Mol Physiol 282:L811-23. 2002..These data suggest that CLD impairs lung microvascular development and that a possible mechanism is disruption of VEGF and Flt-1 expression... - Murine mechanical ventilation stimulates alveolar epithelial cell proliferationPatricia Rose Chess
Departments of Pediatrics and Biomedical Engineering, University of Rochester, Rochester, New York 14642, USA patricia
Exp Lung Res 36:331-41. 2010..Ventilation did not increase apoptosis in alveolar type II cells, as measured by TUNEL staining. Ventilation at low tidal volumes leads to a mild inflammatory response and alveolar epithelial cell proliferation... - Survival in early- and late-term infants with congenital diaphragmatic hernia treated with extracorporeal membrane oxygenationTimothy P Stevens
Division of Neonatology, Department of Pediatrics, Strong Children s Research Center, Golisano Children s Hospital at Strong, Rochester, New York 14642, USA
Pediatrics 110:590-6. 2002..Changes in survival rates of term infants and the factors associated with these changes were assessed over the 25 years that ECMO has been available... - Increased epithelial cell proliferation in very premature baboons with chronic lung diseaseWilliam M Maniscalco
Division of Neonatology, Strong Children s Research Center, Department of Pediatrics, University of Rochester, Rochester, New York 14642, USA
Am J Physiol Lung Cell Mol Physiol 283:L991-L1001. 2002..These data show that the development of chronic lung disease is associated with major alterations in normal patterns of lung-cell proliferation... - Induced p21Cip1 in premature baboons with CLD: implications for alveolar hypoplasiaMICHAEL A O'REILLY
Dept of Pediatrics, Box 850, Univ of Rochester, 601 Elm wood Ave, Rochester, NY 14642, USA
Am J Physiol Lung Cell Mol Physiol 285:L964-71. 2003..These data suggest that p21 may play a role in disorganized proliferation and alveolar hypoplasia seen in newborn chronic lung disease... - Hyperoxic ventilated premature baboons have increased p53, oxidant DNA damage and decreased VEGF expressionWilliam M Maniscalco
Division of Neonatology, Children s Research Center, Pulmonary Biology and Disease Program, University of Rochester School of Medicine, Rochester, NY 14642, USA
Pediatr Res 58:549-56. 2005..The findings suggest that oxidant DNA damage may be a mechanism of increased p53 in hyperoxic fetal lung... - Infant race affects application of clinical guidelines when screening for drugs of abuse in newbornsMarc A Ellsworth
Strong Children s Research Center, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Pediatrics 125:e1379-85. 2010..Established drug-screening criteria may be applied in a manner that considers nonproven risk factors such as race in addition to evidence-based factors... - A randomized trial comparing long-term and short-term use of umbilical venous catheters in premature infants with birth weights of less than 1251 gramsMeggan Butler-O'Hara
Box 651, Neonatology, Golisano Children s Hospital at Strong Children s Research Center, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, New York 14642, USA
Pediatrics 118:e25-35. 2006..Umbilical vein and percutaneous central venous catheters are often used in preterm infants, but they can lead to complications, including infection... - Predictors of death or bronchopulmonary dysplasia in preterm infants with respiratory failureN Ambalavanan
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
J Perinatol 28:420-6. 2008..To identify the variables that predict death/physiologic bronchopulmonary dysplasia (BPD) in preterm infants with severe respiratory failure... - Cytokine elaboration in critically ill infants with bacterial sepsis, necrotizing entercolitis, or sepsis syndrome: correlation with clinical parameters of inflammation and mortalityMary Catherine Harris
Division of Neonatology, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine Philadelphia, Pennsylvania 19104, USA
J Pediatr 147:462-8. 2005.... - Use of computed tomography to categorize the type of tracheal agenesisIndira D Panthagani
Department of Pediatrics, Strong Children s Research Center, University of Rochester Medical Center, Rochester, NY 14642, USA
J Pediatr Surg 44:1044-6. 2009..This rare and fatal condition should always be considered when confronted with a neonate impossible to resuscitate at birth...