..Here the richness of our understanding of MYC is reviewed, highlighting new biological insights and opportunities for cancer therapies. ..
Stine Z, Walton Z, Altman B, Hsieh A, Dang C. MYC, Metabolism, and Cancer. Cancer Discov. 2015;5:1024-39 pubmed publisher
..However, because of the reliance of MYC-driven cancers on specific metabolic pathways, synthetic lethal interactions between MYC overexpression and specific enzyme inhibitors provide novel cancer therapeutic opportunities. ..
Dang C. Links between metabolism and cancer. Genes Dev. 2012;26:877-90 pubmed publisher
Dang C. Role of aerobic glycolysis in genetically engineered mouse models of cancer. BMC Biol. 2013;11:3 pubmed publisher
..Hexokinase II is demonstrated to be an essential driver of the observed aerobic glycolysis and the malignancy of the tumors. See research article: http://www.cancerandmetabolism.com/content/1/1/2. ..