Genomes and Genes
Affiliation: University of California
- Genetic mouse models to study blood-brain barrier development and functionFabien Sohet
UCSF Department of Anatomy, 513 Parnassus Ave HSW1301, San Francisco, 94117, California, USA
Fluids Barriers CNS 10:3. 2013....
- The blood-brain barrier in health and diseaseRichard Daneman
Department of Anatomy, University of California San Francisco, CA, USA
Ann Neurol 72:648-72. 2012..I further discuss what is known about BBB dysfunction during CNS injury and disease, as well as methodology used to deliver drugs across the BBB to the CNS...
- The gut immune barrier and the blood-brain barrier: are they so different?Richard Daneman
University of California, San Francisco, Department of Anatomy, San Francisco, CA 94143 0452, USA
Immunity 31:722-35. 2009..These barrier cells interact with different cell types, which dynamically regulate their function, and with a different array of immune cells that survey the physical barrier and provide innate and adaptive immunity...
- Pericytes are required for blood-brain barrier integrity during embryogenesisRichard Daneman
UCSF Department of Anatomy, 513 Parnassus Avenue, HSW1301, San Francisco, California 94143 0452, USA
Nature 468:562-6. 2010..These data indicate that pericyte-endothelial cell interactions are critical to regulate the BBB during development, and disruption of these interactions may lead to BBB dysfunction and neuroinflammation during CNS injury and disease...
- The mouse blood-brain barrier transcriptome: a new resource for understanding the development and function of brain endothelial cellsRichard Daneman
Department of Anatomy, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 5:e13741. 2010..This dataset provides a resource for understanding CNS endothelial cells and their interaction with neural and hematogenous cells...
- Foxc1 is required by pericytes during fetal brain angiogenesisJulie A Siegenthaler
Department of Neurology, Programs in Neuroscience and Developmental Biology, Institute for Regenerative Medicine, UC San Francisco, San Francisco, CA 94158, USA Present address Department of Pediatrics, Denver Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA
Biol Open 2:647-59. 2013..Collectively these data point towards an important role for Foxc1 in certain brain pericyte functions (e.g. vessel morphogenesis) but not others (e.g. barriergenesis). ..
- Blood-brain barrier permeability is increased after acute adult stroke but not neonatal stroke in the ratDavid Fernández-López
Department of Neurology, University of California San Francisco, San Francisco, California 94143 0633, USA
J Neurosci 32:9588-600. 2012..The markedly more integrant BBB in neonatal brain than in adult brain after acute stroke may have major implications for the treatment of neonatal stroke...