Affiliation: University of Kentucky
- Brain microvascular endothelial cell association and distribution of a 5 nm ceria engineered nanomaterialMo Dan
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky Academic Medical Center, Lexington, KY 40536 0596, USA
Int J Nanomedicine 7:4023-36. 2012..Ceria engineered nanomaterials (ENMs) have current commercial applications and both neuroprotective and toxic effects. Our hypothesis is that ceria ENMs can associate with brain capillary cells and/or cross the blood-brain barrier...
- Rat brain pro-oxidant effects of peripherally administered 5 nm ceria 30 days after exposureSarita S Hardas
Department of Chemistry, University of Kentucky, Lexington, KY 40506 0055, USA
Neurotoxicology 33:1147-55. 2012..These results have important implications on the potential use of ceria ENM as therapeutic agents...
- Distribution, elimination, and biopersistence to 90 days of a systemically introduced 30 nm ceria-engineered nanomaterial in ratsRobert A Yokel
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky Academic Medical Center, University of Kentucky, Lexington, Kentucky 40536 0596, USA
Toxicol Sci 127:256-68. 2012..The results support concern about the long-term fate and adverse effects of inert nanoscale metal oxides that distribute throughout the body, are persistently retained, and produce adverse changes...
- Ceria-engineered nanomaterial distribution in, and clearance from, blood: size mattersMo Dan
College of Pharmacy, University of Kentucky, Lexington, KY, USA
Nanomedicine (Lond) 7:95-110. 2012..Characterize different sized ceria-engineered nanomaterial (ENM) distribution in, and clearance from, blood (compared to the cerium ion) following intravenous infusion...
- Biodistribution and biopersistence of ceria engineered nanomaterials: size dependenceRobert A Yokel
Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky, USA
Nanomedicine 9:398-407. 2013....
- Brain distribution and toxicological evaluation of a systemically delivered engineered nanoscale ceriaSarita S Hardas
Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506 0055, USA
Toxicol Sci 116:562-76. 2010..The results are contrary to the hypothesis that a smaller engineered nanomaterial would more readily permeate the BBB...
- Block copolymer cross-linked nanoassemblies improve particle stability and biocompatibility of superparamagnetic iron oxide nanoparticlesMo Dan
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, USA
Pharm Res 30:552-61. 2013..To develop cross-linked nanoassemblies (CNAs) as carriers for superparamagnetic iron oxide nanoparticles (IONPs)...