Josep Dalmau

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Paraneoplastic encephalitis, psychiatric symptoms, and hypoventilation in ovarian teratoma
    Roberta Vitaliani
    Division of Neuro Oncology, Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Neurol 58:594-604. 2005
  2. pmc Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigen
    Eric Lancaster
    Department of Neurology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Lancet Neurol 9:67-76. 2010
  3. pmc Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series
    Meizan Lai
    Department of Neurology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Lancet Neurol 9:776-85. 2010
  4. pmc In vivo effects of antibodies from patients with anti-NMDA receptor encephalitis: further evidence of synaptic glutamatergic dysfunction
    Mario Manto
    FNRS Laboratoire de Neurologie Expérimentale, ULB, Belgium
    Orphanet J Rare Dis 5:31. 2010
  5. pmc Paraneoplastic syndromes of the CNS
    Josep Dalmau
    Division of Neuro Oncology, Department of Neurology, University of Pennsylvania, Philadelphia 19104, USA
    Lancet Neurol 7:327-40. 2008
  6. pmc Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis
    Josep Dalmau
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Lancet Neurol 10:63-74. 2011
  7. pmc Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma
    Josep Dalmau
    Department of Neurology, Division of Neuro Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Neurol 61:25-36. 2007
  8. pmc Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies
    Josep Dalmau
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Lancet Neurol 7:1091-8. 2008
  9. pmc Clinical and immunological diversity of limbic encephalitis: a model for paraneoplastic neurologic disorders
    Josep Dalmau
    Department of Neurology, Section of Neuro Oncology, University of Pennsylvania, 3 Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Hematol Oncol Clin North Am 20:1319-35. 2006
  10. pmc AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location
    Meizan Lai
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Neurol 65:424-34. 2009

Detail Information

Publications71

  1. pmc Paraneoplastic encephalitis, psychiatric symptoms, and hypoventilation in ovarian teratoma
    Roberta Vitaliani
    Division of Neuro Oncology, Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Neurol 58:594-604. 2005
    ..Recognition of this disorder is important because despite the severity of the symptoms, patients usually recover. The location and function of the isolated antigen suggest that the disorder is directly mediated by antibodies...
  2. pmc Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigen
    Eric Lancaster
    Department of Neurology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Lancet Neurol 9:67-76. 2010
    ..Some encephalitides or seizure disorders once thought idiopathic now seem to be immune mediated. We aimed to describe the clinical features of one such disorder and to identify the autoantigen involved...
  3. pmc Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series
    Meizan Lai
    Department of Neurology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Lancet Neurol 9:776-85. 2010
    ..However, antibody testing using cells expressing voltage-gated potassium channels is negative; hence, we aimed to identify the real autoantigen associated with limbic encephalitis...
  4. pmc In vivo effects of antibodies from patients with anti-NMDA receptor encephalitis: further evidence of synaptic glutamatergic dysfunction
    Mario Manto
    FNRS Laboratoire de Neurologie Expérimentale, ULB, Belgium
    Orphanet J Rare Dis 5:31. 2010
    ..Patients' antibodies cause a decrease of the density of NMDA-R and synaptic mediated currents, but the in vivo effects on the extracellular glutamate and glutamatergic transmission are unknown...
  5. pmc Paraneoplastic syndromes of the CNS
    Josep Dalmau
    Division of Neuro Oncology, Department of Neurology, University of Pennsylvania, Philadelphia 19104, USA
    Lancet Neurol 7:327-40. 2008
    ..In this article, we review some classic concepts about PND and recent clinical and immunological developments, focusing on paraneoplastic cerebellar degeneration, opsoclonus-myoclonus, and encephalitides affecting the limbic system...
  6. pmc Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis
    Josep Dalmau
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Lancet Neurol 10:63-74. 2011
    ..On the basis of models of pharmacological or genetic disruption of NMDAR, these antibody effects reveal a probable pathogenic relation between the depletion of receptors and the clinical features of anti-NMDAR encephalitis...
  7. pmc Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma
    Josep Dalmau
    Department of Neurology, Division of Neuro Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Neurol 61:25-36. 2007
    ..To report the autoantigens of a new category of treatment-responsive paraneoplastic encephalitis...
  8. pmc Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies
    Josep Dalmau
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Lancet Neurol 7:1091-8. 2008
    ..We aimed to analyse the clinical and immunological features of patients with the disorder and examine the effects of antibodies against NMDA receptors in neuronal cultures...
  9. pmc Clinical and immunological diversity of limbic encephalitis: a model for paraneoplastic neurologic disorders
    Josep Dalmau
    Department of Neurology, Section of Neuro Oncology, University of Pennsylvania, 3 Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Hematol Oncol Clin North Am 20:1319-35. 2006
    ..This article summarizes the authors' findings of limbic encephalitis and postulates that a similar approach can be used for syndromes involving other areas of the nervous system...
  10. pmc AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location
    Meizan Lai
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Neurol 65:424-34. 2009
    ..To report the clinical and immunological features of a novel autoantigen related to limbic encephalitis (LE) and the effect of patients' antibodies on neuronal cultures...
  11. pmc Cellular and synaptic mechanisms of anti-NMDA receptor encephalitis
    Ethan G Hughes
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 30:5866-75. 2010
    ..The loss of this subtype of glutamate receptors eliminates NMDAR-mediated synaptic function, resulting in the learning, memory, and other behavioral deficits observed in patients with anti-NMDAR encephalitis...
  12. ncbi request reprint Limbic encephalitis and variants related to neuronal cell membrane autoantigens
    Josep Dalmau
    Division of Neuro Oncology, Department of Neurology, Hospital of the University of Pennsylvania, 3400 Spruce Street Philadelphia, PA 19104, USA
    Rinsho Shinkeigaku 48:871-4. 2008
    ..In all, the study of these disorders provides a link between immunologic processes and neuronal events involved in memory, cognition, seizures, and neuronal degeneration...
  13. pmc Evidence for antibody-mediated pathogenesis in anti-NMDAR encephalitis associated with ovarian teratoma
    Erdem Tuzun
    Division of Neuro Oncology, Department of Neurology, Hospital of the University of Pennsylvania, University of Pennsylvania, 3 W Gates, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Acta Neuropathol 118:737-43. 2009
    ....
  14. pmc Investigations of caspr2, an autoantigen of encephalitis and neuromyotonia
    Eric Lancaster
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Ann Neurol 69:303-11. 2011
    ....
  15. pmc Mechanisms underlying autoimmune synaptic encephalitis leading to disorders of memory, behavior and cognition: insights from molecular, cellular and synaptic studies
    Emilia H Moscato
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6074, USA
    Eur J Neurosci 32:298-309. 2010
    ....
  16. pmc Neuronal autoantigens--pathogenesis, associated disorders and antibody testing
    Eric Lancaster
    Department of Neurology, 3 W Gates, 3400 Spruce Street, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nat Rev Neurol 8:380-90. 2012
    ..We also provide an algorithm to identify and assess antibodies that bind to cell-surface and synaptic antigens...
  17. ncbi request reprint Paraneoplastic cerebellar degeneration: Yo-expressing tumor revealed after a 5-year follow-up with FDG-PET
    Rose Marie Mathew
    Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA, United States
    J Neurol Sci 250:153-5. 2006
    ..An overwhelming majority of anti-Yo positive patients eventually develop a detectable malignancy, which argues in favor of a poorly effective or non-sustained anti-tumor immune response...
  18. pmc Encephalitis and antibodies to synaptic and neuronal cell surface proteins
    Eric Lancaster
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurology 77:179-89. 2011
    ..This review provides an update on these syndromes and autoantigens with special emphasis on clinical diagnosis and treatment...
  19. ncbi request reprint Case records of the Massachusetts General Hospital. Case 4-2007. A 56-year-old woman with rapidly progressive vertigo and ataxia
    Josep Dalmau
    Division of Neuro Oncology, Department of Neurology, Hospital of the University of Pennsylvania, University of Pennsylvania, Philadelphia, USA
    N Engl J Med 356:612-20. 2007
  20. pmc Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates
    Beau M Ances
    Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Brain 128:1764-77. 2005
    ....
  21. pmc A patient with encephalitis associated with NMDA receptor antibodies
    Lauren H Sansing
    Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Nat Clin Pract Neurol 3:291-6. 2007
    ..There was muscle rigidity, frequent facial grimacing, rhythmic abdominal contractions, kicking motions of the legs, and intermittent dystonic postures of the right arm...
  22. doi request reprint Psychiatric manifestations of paraneoplastic disorders
    Matthew S Kayser
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 167:1039-50. 2010
    ..They also discuss the broad behavioral findings that highlight the need for psychiatrists to be aware of initial presentations of paraneoplastic disorders...
  23. pmc Adenylate kinase 5 autoimmunity in treatment refractory limbic encephalitis
    Erdem Tuzun
    Division of Neuro Oncology, Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    J Neuroimmunol 186:177-80. 2007
    ..Detection of antibodies to AK5 in LE patients carries a poor prognosis, and suggests the prompt use of aggressive immunosuppression...
  24. ncbi request reprint Clinical analysis of anti-Ma2-associated encephalitis
    Josep Dalmau
    Department of Neurology, 3 W Gates, Division of Neuro Oncology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Brain 127:1831-44. 2004
    ..In young male patients, the primary tumour is usually in the testis, in other patients the leading neoplasm is lung cancer...
  25. pmc Glycine receptor autoimmune spectrum with stiff-man syndrome phenotype
    Andrew McKeon
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    JAMA Neurol 70:44-50. 2013
    ....
  26. pmc Anti-NMDA receptor encephalitis antibody binding is dependent on amino acid identity of a small region within the GluN1 amino terminal domain
    Amy J Gleichman
    Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 32:11082-94. 2012
    ..These findings provide tools for detailed comparison of antibodies across patients and suggest an interaction between antibody binding and channel function...
  27. ncbi request reprint Autoantigen diversity in the opsoclonus-myoclonus syndrome
    Luis Bataller
    Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Ann Neurol 53:347-53. 2003
    ....
  28. doi request reprint Glazed (vision) and confused
    Heather E Moss
    Division of Neuro ophthalmology, Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Surv Ophthalmol 55:169-73. 2010
    ..The clinical presentation, pathophysiology, and therapy of CRMP5 associated paraneoplastic syndromes are discussed...
  29. ncbi request reprint Thymoma, myasthenia gravis, encephalitis, and a novel anticytoplasmic neuronal antibody
    Sami L Khella
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Neurology 69:1302-3. 2007
  30. doi request reprint Neuro-ophthalmologic manifestations of paraneoplastic syndromes
    Melissa W Ko
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Neuroophthalmol 28:58-68. 2008
    ..Most of these disorders are related to immunologic mechanisms presumably triggered by the neoplastic expression of neuronal proteins. Accurate recognition is essential to appropriate management...
  31. ncbi request reprint Current therapies for neuromuscular manifestations of paraneoplastic syndromes
    Myrna R Rosenfeld
    Department of Neurology, Section of Neuro Oncology, 3 West Gates, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Curr Neurol Neurosci Rep 6:77-84. 2006
    ..For the other disorders, adjuvant therapies are for the most part empiric and include a variety of immunosuppressant and immunomodulatory agents...
  32. pmc Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in children and adolescents
    Nicole R Florance
    Division of Neurology, Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Ann Neurol 66:11-8. 2009
    ..To report the clinical features of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in patients < or = 18 years old...
  33. pmc Extreme delta brush: a unique EEG pattern in adults with anti-NMDA receptor encephalitis
    Sarah E Schmitt
    PENN Epilepsy Center, Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, USA
    Neurology 79:1094-100. 2012
    ..To determine continuous EEG (cEEG) patterns that may be unique to anti-NMDA receptor (NMDAR) encephalitis in a series of adult patients with this disorder...
  34. pmc Reversible paraneoplastic encephalitis in three patients with ovarian neoplasms
    Janos L Tanyi
    Division of Gynecologic Oncology, University of Pennsylvania Health System, Philadelphia, PA, USA
    Acta Obstet Gynecol Scand 91:630-4. 2012
    ..Our experience suggests that prompt syndrome recognition followed by tumor removal and immunotherapy usually results in neurological recovery...
  35. pmc The emerging link between autoimmune disorders and neuropsychiatric disease
    Matthew S Kayser
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Neuropsychiatry Clin Neurosci 23:90-7. 2011
    ..In this review, the authors discuss a newly recognized class of synaptic autoimmune encephalitides as well as behavioral and cognitive manifestations of systemic autoimmune diseases...
  36. ncbi request reprint The MAZ protein is an autoantigen of Hodgkin's disease and paraneoplastic cerebellar dysfunction
    Luis Bataller
    Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, USA
    Ann Neurol 53:123-7. 2003
    ..These findings suggest epitope spreading between the Tr antigen and the MAZ-DCC complex and offer a possible model of immune-mediated cerebellar disease...
  37. ncbi request reprint Limbic encephalitis and variants: classification, diagnosis and treatment
    Erdem Tuzun
    Division of Neuro Oncology, Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurologist 13:261-71. 2007
    ..This review focuses in these disorders, framed in a clinically useful immunologic classification of limbic encephalitis...
  38. pmc Paraneoplastic disorders of eye movements
    Shirley H Wray
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Ann N Y Acad Sci 1233:279-84. 2011
    ..Abnormal eye movements in paraneoplastic syndromes offer insights into the pathogenesis of these disorders and the opportunity to test potential therapies, such as new drugs with effects on neuronal channels...
  39. pmc Movement disorders in paraneoplastic and autoimmune disease
    Jessica Panzer
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Curr Opin Neurol 24:346-53. 2011
    ..The most relevant advances in immune-mediated movement disorders are described, with emphasis on the clinical--immunological associations, novel antigens, and treatment...
  40. pmc Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study
    Maarten J Titulaer
    Department of Neurology and Neurosciences, Hospital of the University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA
    Lancet Neurol 12:157-65. 2013
    ..We aimed to assess the presentation of the disease, the spectrum of symptoms, immunotherapies used, timing of improvement, and long-term outcome...
  41. ncbi request reprint Rituximab as potential therapy for paraneoplastic cerebellar degeneration in pediatric Hodgkin disease
    Kee Kiat Yeo
    Thomas Jefferson University, Philadelphia, PA, USA
    Pediatr Blood Cancer 58:986-7. 2012
    ..Based on promising data in adults on the efficacy of rituximab over other immuno suppressive agents in paraneoplastic disorders, he was treated with rituximab with marked improvement of the cerebellar syndrome...
  42. doi request reprint Update on paraneoplastic and autoimmune disorders of the central nervous system
    Myrna R Rosenfeld
    Department of Neurology, Division of Neuro Oncology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Semin Neurol 30:320-31. 2010
    ..This review analyzes the immune responses associated with paraneoplastic and nonparaneoplastic disorders of the central nervous system, and the main clinical features and response to treatment...
  43. ncbi request reprint Functional analysis of CD8+ T cell responses to the onconeural self protein cdr2 in patients with paraneoplastic cerebellar degeneration
    Erica L Carpenter
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, United States
    J Neuroimmunol 193:173-82. 2008
    ..In contrast, viral-specific CD8(+) T cells from healthy volunteers and PCD patients were measurable. These findings are inconsistent with an obligate role for cdr2-1- or cdr2-2-specific CD8(+) T cells in the pathogenesis of PCD...
  44. doi request reprint Anti-N-methyl-D-aspartate receptor encephalitis during pregnancy
    Monisha A Kumar
    Department of Neurology, University of Pennsylvania, Philadelphia, 19104, USA
    Arch Neurol 67:884-7. 2010
    ..To report 3 patients who developed anti-N-methyl-d-aspartate receptor encephalitis during pregnancy...
  45. pmc Clinical Neuropathology practice guide 4-2013: post-herpes simplex encephalitis: N-methyl-Daspartate receptor antibodies are part of the problem
    Romana Hoftberger
    Institute of Neurology, Medical University of Vienna, Austria
    Clin Neuropathol 32:251-4. 2013
    ..It is important to be aware of this differential diagnosis because patients respond to immunotherapy. ..
  46. doi request reprint Update on anti-N-methyl-D-aspartate receptor encephalitis in children and adolescents
    Nicole Florance-Ryan
    Division of Neurology, Department of Pediatrics, Children s Hospital of Philadelphia, and Division of Neuro Oncology, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Pediatr 22:739-44. 2010
    ..We review here the main clinical features and differential diagnosis and provide algorithms of the clinical correlates of antibody-mediated decrease of NMDAR and a suggested treatment approach...
  47. pmc Update on paraneoplastic neurologic disorders
    Myrna R Rosenfeld
    Division of Neuro Oncology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Oncologist 15:603-17. 2010
    ....
  48. doi request reprint Paraneoplastic syndromes causing movement disorders
    Josep Dalmau
    Division of Neuro Oncology, Department of Neurology, University of Pennsylvania, Philadelphia 19104, USA
    Handb Clin Neurol 100:315-21. 2011
    ..Understanding the natural course of each immune-mediated paraneoplastic movement disorder minimizes unnecessary testing and the use of potentially toxic therapies...
  49. ncbi request reprint Paraneoplastic syndromes of the peripheral nerves
    Stacy A Rudnicki
    Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Curr Opin Neurol 18:598-603. 2005
    ..To describe the paraneoplastic disorders of the motor and sensory nerves and neurons, and their immunologic associations...
  50. ncbi request reprint Unusual neuro-ophthalmologic findings in a patient with anti-Yo-associated cerebellar degeneration
    Adam B Cohen
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Neurol Sci 225:153-5. 2004
    ..The prominent neuro-ophthalmologic findings suggest brainstem involvement, which may be a novel manifestation of anti-Yo associated paraneoplastic syndrome...
  51. ncbi request reprint Paraneoplastic neurologic syndromes
    Luis Bataller
    Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Neurol Clin 21:221-47, ix. 2003
    ..PND often develop before the presence of a cancer is known and their recognition may lead to the tumor diagnosis...
  52. doi request reprint Paraneoplastic neuropathies
    Francesc Graus
    aService of Neurology, Hospital Clinic, Universitat de Barcelona bInstitut d Investigació Biomèdica August Pi i Sunyer IDIBAPS cInstitució Catalana de Recerca i Estudis Avançats ICREA, Barcelona, Spain dDepartment of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Curr Opin Neurol 26:489-95. 2013
    ..This review describes relevant advances in paraneoplastic neuropathies with emphasis on particular syndromes and the impact of new therapies...
  53. pmc Paraneoplastic neurological syndromes
    Francesc Graus
    Service of Neurology, Hospital Clinic, Universitat de Barcelona and Institut d Investigació Biomèdica August Pi i Sunyer, Barcelona, Spain
    Curr Opin Neurol 25:795-801. 2012
    ..This review describes relevant advances in paraneoplastic neurological syndromes (PNS) with emphasis on particular syndromes and the impact of antibodies against surface antigens in their management...
  54. pmc Clinical neuropathology practice guide 5-2012: updated guideline for the diagnosis of antineuronal antibodies
    Romana Hoftberger
    Institute of Neurology, Medical University of Vienna, Austria
    Clin Neuropathol 31:337-41. 2012
    ..Selection and proper combination of test systems and appropriate knowledge of the clinical information will provide a maximum of sensitivity and specificity in identifying the associated antibody...
  55. pmc Anti-NMDA-Receptor Encephalitis and Other Synaptic Autoimmune Disorders
    Myrna R Rosenfeld
    Department of Neurology, University of Pennsylvania, 3 W Gates 3400 Spruce St, Philadelphia, PA, 19104, USA
    Curr Treat Options Neurol 13:324-32. 2011
    ..For example, patients with anti-NMDA-receptor encephalitis who had been in a coma or ventilated for 6-10 months have had full recovery after appropriate treatment...
  56. doi request reprint Paraneoplastic neurologic disorders in children
    Elizabeth M Wells
    Department of Neurology, Children s National Medical Center, 111 Michigan Avenue, NW, Washington, DC, 20010, USA
    Curr Neurol Neurosci Rep 11:187-94. 2011
    ..Given the rarity of these conditions, multisite collaborative efforts are needed to develop standardized approaches to characterization and treatment...
  57. pmc Antibodies to metabotropic glutamate receptor 5 in the Ophelia syndrome
    E Lancaster
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurology 77:1698-701. 2011
    ..To report the metabotropic glutamate receptor 5 (mGluR5) as the autoantigen of antibodies from 2 patients with Hodgkin lymphoma (HL) and limbic encephalopathy (Ophelia syndrome)...
  58. pmc Analysis of complement and plasma cells in the brain of patients with anti-NMDAR encephalitis
    E Martinez-Hernandez
    Department of Neurology, University of Pennsylvania, Philadelphia 19104, USA
    Neurology 77:589-93. 2011
    ..We examined whether complement immunoreactivity and antibody-secreting cells (plasma cells/plasmablasts) are present in the brain of these patients...
  59. ncbi request reprint Paraneoplastic neurologic syndromes: approaches to diagnosis and treatment
    Luis Bataller
    Department of Neurology, Hospital La Fe, Valencia, Spain
    Semin Neurol 23:215-24. 2003
    ....
  60. ncbi request reprint Paraneoplastic sensory neuronopathy and spontaneous regression of small cell lung cancer
    Sharlene Gill
    Division of Medical Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada
    Can J Neurol Sci 30:269-71. 2003
    ..Spontaneous tumour regression in small cell lung cancer has previously been suggested in patients with paraneoplastic neurologic syndromes. Rare documentation of this event has occurred in the literature...
  61. ncbi request reprint Neuro-ophthalmology and paraneoplastic syndromes
    Luis Bataller
    Department of Neurology, Hospital Universitario La Fe, Valencia, Spain
    Curr Opin Neurol 17:3-8. 2004
    ..To describe the neuro-ophthalmological manifestations of paraneoplastic syndromes and their immunological associations...
  62. ncbi request reprint Anti-Ma2-associated encephalitis with normal FDG-PET: a case of pseudo-Whipple's disease
    James Castle
    Stanford University, CA, USA
    Nat Clin Pract Neurol 2:566-72; quiz 573. 2006
    ..Examination revealed an atypical parkinsonian appearance with incomplete supranuclear ophthalmoplegia and an unusual oculomotor disorder characterized by both low-amplitude, intermittent opsoclonus, and slow, nystagmoid intrusions...
  63. ncbi request reprint Paraneoplastic recurrent multifocal encephalitis presenting with epilepsia partialis continua
    Melike Mut
    Department of Neurosurgery, University of Virginia, CDW Hospital Drive, P O Box 800212, Charlottesville, VA 22903, USA
    J Neurooncol 72:63-6. 2005
    ..The diagnostic challenges of the highly variable clinical presentations and therapeutic approaches to paraneoplastic multifocal encephalitis are discussed with relevant literature review...
  64. ncbi request reprint Herpes simplex encephalitis in a patient with cancer
    Luis Bataller
    J Neurooncol 78:211. 2006
  65. ncbi request reprint EFA6A-like antibodies in paraneoplastic encephalitis associated with immature ovarian teratoma: a case report
    Reiji Koide
    Department of Neurology, Tokyo Metropolitan Neurological Hospital, 2 6 1 Musashidai, Fuchu, Tokyo 183 0042, Japan
    J Neurooncol 81:71-4. 2007
    ..Antibodies that colocalize with EFA6A are a valuable marker for early diagnosis of a potentially reversible paraneoplastic encephalitis associated with OT...
  66. pmc Severe hypokinesis caused by paraneoplastic anti-Ma2 encephalitis associated with bilateral intratubular germ-cell neoplasm of the testes
    Lumine Matsumoto
    Department of Neurology, The University of Tokyo, Tokyo, Japan
    Mov Disord 22:728-31. 2007
    ..Anti-Ma2 paraneoplastic encephalitis should be considered in patients with severe hypokinesis, and intensive investigation and aggressive approach to treatment is encouraged to prevent progression of the neurological deficits...
  67. ncbi request reprint Antibodies to AChR, MuSK and VGKC in a patient with myasthenia gravis and Morvan's syndrome
    Jordi Diaz-Manera
    Neuromuscular Diseases Section, Department of Neurology, at Hospital de la Santa Creu i Sant Pau in Barcelona, Spain
    Nat Clin Pract Neurol 3:405-10. 2007
    ..Mild limb weakness with severe muscle atrophy and diffuse muscle twitches were observed. The patient had also developed visual hallucinations and persecutory delusions. Her personal and family medical histories were unremarkable...
  68. doi request reprint Treatment-responsive subacute limbic encephalitis and NMDA receptor antibodies in a man
    Maria Elena Novillo-López
    Department of Neurology, Hospital Ramon y Cajal, Madrid, Spain
    Neurology 70:728-9. 2008
  69. doi request reprint Inverse ocular bobbing in a patient with encephalitis associated with antibodies to the N-methyl-D-aspartate receptor
    Haruo Shimazaki
    Division of Neurology, Department of Internal Medicine, Jichi Medical University, Yakushiji 3311 1, Shimotsuke, Tochigi 329 0498, Japan
    Arch Neurol 65:1251. 2008
  70. ncbi request reprint Paraneoplastic neurological syndromes: diagnosis and treatment
    Francesc Graus
    aService of Neurology, Hospital Clinic, Universitat de Barcelona and Institut d Investigació Biomèdica August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Curr Opin Neurol 20:732-7. 2007
    ..The most relevant advances in the field of paraneoplastic neurological syndromes are described, with special emphasis on particular clinical-immunological associations and practical issues for the diagnosis and treatment of these disorders...
  71. ncbi request reprint Anti-Hu antibodies in Merkel cell carcinoma
    John E Greenlee
    Neurology Service, Veterans Affairs Medical Center and Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT 84148, USA
    Ann Neurol 52:111-5. 2002
    ..The patient's serum contained antibodies against the Hu antigen, and the expression of the Hu antigen was demonstrated in the patient's tumor...